{"id":"https://openalex.org/W4295082525","doi":"https://doi.org/10.3390/nu14173638","title":"Therapeutic Potential and Pharmaceutical Development of a Multitargeted Flavonoid Phloretin","display_name":"Therapeutic Potential and Pharmaceutical Development of a Multitargeted Flavonoid Phloretin","publication_year":2022,"publication_date":"2022-09-02","ids":{"openalex":"https://openalex.org/W4295082525","doi":"https://doi.org/10.3390/nu14173638","pmid":"https://pubmed.ncbi.nlm.nih.gov/36079895","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9460114"},"language":"en","primary_location":{"id":"doi:10.3390/nu14173638","doi":"https://doi.org/10.3390/nu14173638","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu14173638","pdf_url":"https://www.mdpi.com/2072-6643/14/17/3638/pdf?version=1662125715","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/14/17/3638/pdf?version=1662125715","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040276048","display_name":"Kartik Tularam Nakhate","orcid":"https://orcid.org/0000-0002-7585-441X","observed_orcids":["https://orcid.org/0000-0002-7585-441X"]},"institutions":[{"id":"https://openalex.org/I4210132590","display_name":"Shri Vile Parle Kelavani Mandal","ror":"https://ror.org/03ddhrn22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210132590","https://openalex.org/I4405260087"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kartik T. Nakhate","raw_affiliation_strings":["Department of Pharmacology, Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India","institution_ids":["https://openalex.org/I4210132590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056806865","display_name":"Hemant Ramachandra Badwaik","orcid":"https://orcid.org/0000-0003-4533-7363","observed_orcids":["https://orcid.org/0000-0003-4533-7363"]},"institutions":[{"id":"https://openalex.org/I4405264754","display_name":"Shri Shankaracharya Professional University","ror":"https://ror.org/02wfvah75","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405264754"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hemant Badwaik","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Bhilai 490020, Chhattisgarh, India"],"raw_orcid":"https://orcid.org/0000-0003-4533-7363","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Bhilai 490020, Chhattisgarh, India","institution_ids":["https://openalex.org/I4405264754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024382277","display_name":"Rajesh Choudhary","orcid":"https://orcid.org/0000-0001-8627-3613","observed_orcids":["https://orcid.org/0000-0001-8627-3613"]},"institutions":[{"id":"https://openalex.org/I4405264754","display_name":"Shri Shankaracharya Professional University","ror":"https://ror.org/02wfvah75","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405264754"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajesh Choudhary","raw_affiliation_strings":["Department of Pharmacology, Shri Shankaracharya College of Pharmaceutical Sciences, Bhilai 490020, Chhattisgarh, India"],"raw_orcid":"https://orcid.org/0000-0001-8627-3613","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Shri Shankaracharya College of Pharmaceutical Sciences, Bhilai 490020, Chhattisgarh, India","institution_ids":["https://openalex.org/I4405264754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030875459","display_name":"Kalyani Sakure","orcid":"https://orcid.org/0000-0002-8964-136X","observed_orcids":["https://orcid.org/0000-0002-8964-136X"]},"institutions":[{"id":"https://openalex.org/I4405259702","display_name":"Rungta College","ror":"https://ror.org/02k0mfd93","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405259702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kalyani Sakure","raw_affiliation_strings":["Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India","institution_ids":["https://openalex.org/I4405259702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043082541","display_name":"Yogeeta O. Agrawal","orcid":"https://orcid.org/0000-0002-3293-5607","observed_orcids":["https://orcid.org/0000-0002-3293-5607"]},"institutions":[{"id":"https://openalex.org/I4210132590","display_name":"Shri Vile Parle Kelavani Mandal","ror":"https://ror.org/03ddhrn22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210132590","https://openalex.org/I4405260087"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogeeta O. Agrawal","raw_affiliation_strings":["Department of Pharmaceutics, Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India","institution_ids":["https://openalex.org/I4210132590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063029157","display_name":"Charu Sharma","orcid":"https://orcid.org/0000-0002-7788-2502","observed_orcids":["https://orcid.org/0000-0002-7788-2502"]},"institutions":[{"id":"https://openalex.org/I201726411","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862","country_code":"AE","type":"education","lineage":["https://openalex.org/I201726411"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Charu Sharma","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates","institution_ids":["https://openalex.org/I201726411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015791582","display_name":"Shreesh Kumar Ojha","orcid":"https://orcid.org/0000-0001-7801-2966","observed_orcids":["https://orcid.org/0000-0001-7801-2966"]},"institutions":[{"id":"https://openalex.org/I201726411","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862","country_code":"AE","type":"education","lineage":["https://openalex.org/I201726411"]}],"countries":["AE"],"is_corresponding":true,"raw_author_name":"Shreesh Ojha","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0001-7801-2966","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates","institution_ids":["https://openalex.org/I201726411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008387075","display_name":"Sameer N. Goyal","orcid":"https://orcid.org/0000-0002-5241-7049","observed_orcids":["https://orcid.org/0000-0002-5241-7049"]},"institutions":[{"id":"https://openalex.org/I4210132590","display_name":"Shri Vile Parle Kelavani Mandal","ror":"https://ror.org/03ddhrn22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210132590","https://openalex.org/I4405260087"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sameer N. Goyal","raw_affiliation_strings":["Department of Pharmacology, Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India","institution_ids":["https://openalex.org/I4210132590"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008387075","https://openalex.org/A5015791582"],"corresponding_institution_ids":["https://openalex.org/I201726411","https://openalex.org/I4210132590"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2722},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2722},"fwci":1.9638,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.88836105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":"17","first_page":"3638","last_page":"3638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phloretin","display_name":"phloretin","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8730000257492065},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.7900000214576721},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/nanoformulations","display_name":"nanoformulations","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pharmacological-mechanisms","display_name":"pharmacological mechanisms","score":0.5960000157356262},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2778423325","wikidata":"https://www.wikidata.org/wiki/Q2268463","display_name":"Phloretin","level":2,"score":0.8799200057983398},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6317052245140076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5593570470809937},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4197048544883728},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26825588941574097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1272001564502716}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010693","descriptor_name":"Phloretin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010693","descriptor_name":"Phloretin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010693","descriptor_name":"Phloretin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/nu14173638","doi":"https://doi.org/10.3390/nu14173638","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu14173638","pdf_url":"https://www.mdpi.com/2072-6643/14/17/3638/pdf?version=1662125715","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9460114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9460114","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:36079895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36079895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:830c486a9ea74b1da770c78f58b5958c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/830c486a9ea74b1da770c78f58b5958c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrients, Vol 14, Iss 3638, p 3638 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/nu14173638","doi":"https://doi.org/10.3390/nu14173638","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu14173638","pdf_url":"https://www.mdpi.com/2072-6643/14/17/3638/pdf?version=1662125715","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3100468040","display_name":null,"funder_award_id":"12R121","funder_id":"https://openalex.org/F4320323593","funder_display_name":"United Arab Emirates University"},{"id":"https://openalex.org/G5011947743","display_name":null,"funder_award_id":"#12R104","funder_id":"https://openalex.org/F4320323593","funder_display_name":"United Arab Emirates University"}],"funders":[{"id":"https://openalex.org/F4320323593","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295082525.pdf","grobid_xml":"https://content.openalex.org/works/W4295082525.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W56821845","https://openalex.org/W561730403","https://openalex.org/W1659079088","https://openalex.org/W1929364878","https://openalex.org/W1940982636","https://openalex.org/W1964971448","https://openalex.org/W1968230070","https://openalex.org/W1968783310","https://openalex.org/W1971467783","https://openalex.org/W1980881885","https://openalex.org/W1980912877","https://openalex.org/W1987710879","https://openalex.org/W1999299474","https://openalex.org/W2001331104","https://openalex.org/W2002760082","https://openalex.org/W2002829388","https://openalex.org/W2005916363","https://openalex.org/W2005928399","https://openalex.org/W2034865940","https://openalex.org/W2035456909","https://openalex.org/W2047616756","https://openalex.org/W2049433120","https://openalex.org/W2050538020","https://openalex.org/W2059481429","https://openalex.org/W2067362965","https://openalex.org/W2070777994","https://openalex.org/W2073349723","https://openalex.org/W2074765740","https://openalex.org/W2075586938","https://openalex.org/W2080122019","https://openalex.org/W2089267755","https://openalex.org/W2097207125","https://openalex.org/W2106908073","https://openalex.org/W2110647117","https://openalex.org/W2113669645","https://openalex.org/W2120702346","https://openalex.org/W2133604166","https://openalex.org/W2137456223","https://openalex.org/W2137887289","https://openalex.org/W2139023159","https://openalex.org/W2142497197","https://openalex.org/W2142828290","https://openalex.org/W2151345870","https://openalex.org/W2153658367","https://openalex.org/W2164039308","https://openalex.org/W2174838977","https://openalex.org/W2178959736","https://openalex.org/W2180893677","https://openalex.org/W2194754781","https://openalex.org/W2201536845","https://openalex.org/W2209625612","https://openalex.org/W2297610049","https://openalex.org/W2325010647","https://openalex.org/W2358709534","https://openalex.org/W2495280310","https://openalex.org/W2515176536","https://openalex.org/W2517155968","https://openalex.org/W2530229391","https://openalex.org/W2549367534","https://openalex.org/W2557881330","https://openalex.org/W2574589117","https://openalex.org/W2577483230","https://openalex.org/W2582983783","https://openalex.org/W2583109428","https://openalex.org/W2586805554","https://openalex.org/W2587662909","https://openalex.org/W2589012280","https://openalex.org/W2591819553","https://openalex.org/W2603132405","https://openalex.org/W2607289819","https://openalex.org/W2735767394","https://openalex.org/W2744976722","https://openalex.org/W2760092485","https://openalex.org/W2760160246","https://openalex.org/W2768245002","https://openalex.org/W2790726018","https://openalex.org/W2801840352","https://openalex.org/W2887293327","https://openalex.org/W2891798110","https://openalex.org/W2895610805","https://openalex.org/W2900139925","https://openalex.org/W2902969101","https://openalex.org/W2903731015","https://openalex.org/W2905236757","https://openalex.org/W2910273753","https://openalex.org/W2916795350","https://openalex.org/W2919297894","https://openalex.org/W2921390227","https://openalex.org/W2929497507","https://openalex.org/W2930226806","https://openalex.org/W2939775499","https://openalex.org/W2943951334","https://openalex.org/W2953917005","https://openalex.org/W2964402186","https://openalex.org/W2966417022","https://openalex.org/W2971073420","https://openalex.org/W2980136515","https://openalex.org/W2980529195","https://openalex.org/W2988893287","https://openalex.org/W2993871393","https://openalex.org/W3003226448","https://openalex.org/W3007580342","https://openalex.org/W3015140241","https://openalex.org/W3022247982","https://openalex.org/W3028026342","https://openalex.org/W3030684663","https://openalex.org/W3045197329","https://openalex.org/W3092374209","https://openalex.org/W3092413063","https://openalex.org/W3094995246","https://openalex.org/W3096700083","https://openalex.org/W3106613739","https://openalex.org/W3121484095","https://openalex.org/W3123165480","https://openalex.org/W3127022319","https://openalex.org/W3127343431","https://openalex.org/W3134874504","https://openalex.org/W3139163186","https://openalex.org/W3149813597","https://openalex.org/W3154159422","https://openalex.org/W3177468222","https://openalex.org/W3181621389","https://openalex.org/W3206556898","https://openalex.org/W3212256078","https://openalex.org/W3215815977","https://openalex.org/W3217444773","https://openalex.org/W4200472376","https://openalex.org/W4206685847","https://openalex.org/W4213182548","https://openalex.org/W4220939572","https://openalex.org/W4224319126","https://openalex.org/W4225253463","https://openalex.org/W4225919736","https://openalex.org/W4282043614","https://openalex.org/W4282945261","https://openalex.org/W4283741569","https://openalex.org/W4283764510","https://openalex.org/W4285601790","https://openalex.org/W4285794735","https://openalex.org/W6602272854","https://openalex.org/W6669352499","https://openalex.org/W6777203865"],"related_works":["https://openalex.org/W4385414672","https://openalex.org/W2921390227","https://openalex.org/W2285089966","https://openalex.org/W4386002033","https://openalex.org/W2591819553","https://openalex.org/W4313646438","https://openalex.org/W4393336977","https://openalex.org/W4385670636","https://openalex.org/W7161029476","https://openalex.org/W1980881885"],"abstract_inverted_index":{"Phloretin":[0,28],"is":[1,79,115],"a":[2],"flavonoid":[3],"of":[4,18,152,171],"the":[5,60,101,108,116,139,144,155,168,178],"dihydrogen":[6],"chalcone":[7],"class,":[8],"present":[9,140],"abundantly":[10],"in":[11,177],"apples":[12],"and":[13,33,55,75,96,132,135,149,161,164,206],"strawberries.":[14],"The":[15],"beneficial":[16],"effects":[17],"phloretin":[19,172],"are":[20,184,188,200],"mainly":[21],"associated":[22,62],"with":[23,63],"its":[24,126,174,195,204],"potent":[25],"antioxidant":[26],"properties.":[27],"modulates":[29],"several":[30],"signaling":[31],"pathways":[32],"molecular":[34,133,150],"mechanisms":[35,148],"to":[36,124,166,193,202],"exhibit":[37],"therapeutic":[38,102,175],"benefits":[39],"against":[40,81],"various":[41,82],"diseases":[42],"including":[43,85],"cancers,":[44],"diabetes,":[45],"liver":[46],"injury,":[47,49],"kidney":[48],"encephalomyelitis,":[50],"ulcerative":[51],"colitis,":[52],"asthma,":[53],"arthritis,":[54],"cognitive":[56],"impairment.":[57],"It":[58,78],"ameliorates":[59],"complications":[61],"diabetes":[64],"such":[65],"as":[66],"cardiomyopathy,":[67],"hypertension,":[68],"depression,":[69],"memory":[70],"impairment,":[71],"delayed":[72],"wound":[73],"healing,":[74],"peripheral":[76],"neuropathy.":[77],"effective":[80],"microbial":[83],"infections":[84],"Salmonella":[86],"typhimurium,":[87],"Listeria":[88],"monocytogenes,":[89],"Mycobacterium":[90],"tuberculosis,":[91],"Escherichia":[92],"coli,":[93],"Candida":[94],"albicans":[95],"methicillin-resistant":[97],"Staphylococcus":[98],"aureus.":[99],"Considering":[100],"benefits,":[103],"it":[104],"generated":[105],"interest":[106],"for":[107,173],"pharmaceutical":[109,169,205],"development.":[110,208],"However,":[111],"poor":[112],"oral":[113],"bioavailability":[114,127],"major":[117],"drawback.":[118],"Therefore,":[119],"efforts":[120],"have":[121],"been":[122],"undertaken":[123],"enhance":[125],"by":[128],"modifying":[129],"physicochemical":[130,160],"properties":[131],"structure,":[134],"developing":[136],"nanoformulations.":[137],"In":[138,191],"review,":[141],"we":[142],"discussed":[143],"pharmacological":[145],"actions,":[146],"underlying":[147],"targets":[151],"phloretin.":[153],"Moreover,":[154],"review":[156],"provides":[157],"insights":[158],"into":[159],"pharmacokinetic":[162],"characteristics,":[163],"approaches":[165],"promote":[167],"development":[170],"applications":[176],"future.":[179],"Although":[180],"convincing":[181],"experimental":[182],"data":[183],"reported,":[185],"human":[186],"studies":[187,199],"not":[189],"available.":[190],"order":[192],"ascertain":[194],"safety,":[196],"further":[197],"preclinical":[198],"needed":[201],"encourage":[203],"clinical":[207]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-09-10T00:00:00"}
