{"id":"https://openalex.org/W4295048810","doi":"https://doi.org/10.1002/hep.32771","title":"AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma","display_name":"AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma","publication_year":2022,"publication_date":"2022-09-09","ids":{"openalex":"https://openalex.org/W4295048810","doi":"https://doi.org/10.1002/hep.32771","pmid":"https://pubmed.ncbi.nlm.nih.gov/36083140"},"language":"en","primary_location":{"id":"doi:10.1002/hep.32771","doi":"https://doi.org/10.1002/hep.32771","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.32771","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029813521","display_name":"Christopher L. Bowlus","orcid":"https://orcid.org/0000-0002-3906-6811","observed_orcids":["https://orcid.org/0000-0002-3906-6811"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher L. Bowlus","raw_affiliation_strings":["Division of Gastroenterology, University of California Davis Health, Sacramento, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-3906-6811","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of California Davis Health, Sacramento, California, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090745435","display_name":"Lionel Arriv\u00e9","orcid":"https://orcid.org/0000-0002-0267-109X","observed_orcids":["https://orcid.org/0000-0002-0267-109X","https://orcid.org/0000-0002-6184-6013"]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lionel Arriv\u00e9","raw_affiliation_strings":["H\u00f4pital Saint\u2010Antoine, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint\u2010Antoine, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025092611","display_name":"Annika M Bergquist","orcid":"https://orcid.org/0000-0002-3858-6241","observed_orcids":["https://orcid.org/0000-0002-3858-6241"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Annika Bergquist","raw_affiliation_strings":["Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004770797","display_name":"Mark R. Deneau","orcid":"https://orcid.org/0000-0003-0459-9404","observed_orcids":["https://orcid.org/0000-0003-0459-9404"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Deneau","raw_affiliation_strings":["University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":"https://orcid.org/0000-0003-0459-9404","affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103053815","display_name":"Lisa Forman","orcid":"https://orcid.org/0000-0002-9697-7232","observed_orcids":["https://orcid.org/0000-0002-9697-7232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Forman","raw_affiliation_strings":["University of Colorado, Aurora, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Aurora, Colorado, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006827585","display_name":"Sumera Irie Ilyas","orcid":"https://orcid.org/0000-0002-2709-3003","observed_orcids":["https://orcid.org/0000-0002-2709-3003"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumera I. Ilyas","raw_affiliation_strings":["Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA"],"raw_orcid":"https://orcid.org/0000-0002-2709-3003","affiliations":[{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016152531","display_name":"Keri E. Lunsford","orcid":"https://orcid.org/0000-0002-4156-1774","observed_orcids":["https://orcid.org/0000-0002-4156-1774"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keri E. Lunsford","raw_affiliation_strings":["Rutgers University\u2013New Jersey Medical School, Newark, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers University\u2013New Jersey Medical School, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015556921","display_name":"Mercedes Mart\u00ednez","orcid":"https://orcid.org/0000-0001-6128-0155","observed_orcids":["https://orcid.org/0000-0001-6128-0155"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mercedes Martinez","raw_affiliation_strings":["Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-6128-0155","affiliations":[{"raw_affiliation_string":"Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000789082","display_name":"Gonzalo Sapisoch\u00edn","orcid":"https://orcid.org/0000-0001-9527-8723","observed_orcids":["https://orcid.org/0000-0001-9527-8723"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gonzalo Sapisochin","raw_affiliation_strings":["University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012936802","display_name":"Rachna T. Shroff","orcid":"https://orcid.org/0000-0003-0066-2672","observed_orcids":["https://orcid.org/0000-0003-0066-2672"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachna Shroff","raw_affiliation_strings":["University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035435509","display_name":"James H. Tabibian","orcid":"https://orcid.org/0000-0001-9104-1702","observed_orcids":["https://orcid.org/0000-0001-9104-1702"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Tabibian","raw_affiliation_strings":["David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020017677","display_name":"David N. Assis","orcid":"https://orcid.org/0000-0002-8941-6170","observed_orcids":["https://orcid.org/0000-0002-8941-6170"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David N. Assis","raw_affiliation_strings":["Yale School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5029813521"],"corresponding_institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":33.3253,"has_fulltext":false,"cited_by_count":435,"citation_normalized_percentile":{"value":0.99857964,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"77","issue":"2","first_page":"659","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/biliary-strictures","display_name":"biliary strictures","score":0.7919999957084656},{"id":"https://openalex.org/keywords/obstructive-cholestasis","display_name":"obstructive cholestasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bacterial-cholangitis","display_name":"bacterial cholangitis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/colonoscopy","display_name":"colonoscopy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9279999732971191},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6050000190734863},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/recurrent-cholangitis","display_name":"recurrent cholangitis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/model-for-end-stage-liver-disease","display_name":"Model for End-Stage Liver Disease","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2780615123","wikidata":"https://www.wikidata.org/wiki/Q1058608","display_name":"Primary sclerosing cholangitis","level":3,"score":0.9215341806411743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.775662899017334},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.5133858919143677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40216511487960815},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3844532370567322},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05867603421211243}],"mesh":[{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.32771","doi":"https://doi.org/10.1002/hep.32771","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.32771","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:36083140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36083140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6200000047683716}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5495860461","display_name":null,"funder_award_id":"K08 DK118187","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":507,"referenced_works":["https://openalex.org/W28794996","https://openalex.org/W174851081","https://openalex.org/W179809976","https://openalex.org/W270754910","https://openalex.org/W571628560","https://openalex.org/W1270837331","https://openalex.org/W1466568054","https://openalex.org/W1479884833","https://openalex.org/W1488469491","https://openalex.org/W1492604623","https://openalex.org/W1495391223","https://openalex.org/W1504363060","https://openalex.org/W1507163675","https://openalex.org/W1507977629","https://openalex.org/W1529005194","https://openalex.org/W1529734028","https://openalex.org/W1559553970","https://openalex.org/W1593140847","https://openalex.org/W1623139656","https://openalex.org/W1630116552","https://openalex.org/W1665267469","https://openalex.org/W1717103253","https://openalex.org/W1780679273","https://openalex.org/W1819934472","https://openalex.org/W1820187258","https://openalex.org/W1823805089","https://openalex.org/W1843348728","https://openalex.org/W1851143213","https://openalex.org/W1852446079","https://openalex.org/W1868512026","https://openalex.org/W1869119189","https://openalex.org/W1903842045","https://openalex.org/W1926427620","https://openalex.org/W1945590693","https://openalex.org/W1947200996","https://openalex.org/W1954815786","https://openalex.org/W1964156264","https://openalex.org/W1964509264","https://openalex.org/W1965716049","https://openalex.org/W1966360400","https://openalex.org/W1967176155","https://openalex.org/W1967931951","https://openalex.org/W1968203715","https://openalex.org/W1968221120","https://openalex.org/W1968420912","https://openalex.org/W1968896691","https://openalex.org/W1968970101","https://openalex.org/W1968997441","https://openalex.org/W1969051655","https://openalex.org/W1969058883","https://openalex.org/W1969088024","https://openalex.org/W1969486048","https://openalex.org/W1970681850","https://openalex.org/W1971108757","https://openalex.org/W1971724429","https://openalex.org/W1971845349","https://openalex.org/W1971953145","https://openalex.org/W1971957145","https://openalex.org/W1973268573","https://openalex.org/W1973889287","https://openalex.org/W1974749071","https://openalex.org/W1975044459","https://openalex.org/W1975213560","https://openalex.org/W1975766860","https://openalex.org/W1975836447","https://openalex.org/W1975876595","https://openalex.org/W1977924019","https://openalex.org/W1982819021","https://openalex.org/W1983054413","https://openalex.org/W1984016671","https://openalex.org/W1984319309","https://openalex.org/W1984348904","https://openalex.org/W1985970899","https://openalex.org/W1986107053","https://openalex.org/W1986769168","https://openalex.org/W1987551179","https://openalex.org/W1988380393","https://openalex.org/W1988495477","https://openalex.org/W1991832586","https://openalex.org/W1992267135","https://openalex.org/W1992422883","https://openalex.org/W1992431640","https://openalex.org/W1993535010","https://openalex.org/W1993713046","https://openalex.org/W1994144777","https://openalex.org/W1994216489","https://openalex.org/W1994290878","https://openalex.org/W1995534781","https://openalex.org/W1995850023","https://openalex.org/W1995881489","https://openalex.org/W1996463505","https://openalex.org/W1997112298","https://openalex.org/W1998464796","https://openalex.org/W1998918218","https://openalex.org/W2000042204","https://openalex.org/W2000916879","https://openalex.org/W2001536883","https://openalex.org/W2002400614","https://openalex.org/W2002658934","https://openalex.org/W2003122301","https://openalex.org/W2004017296","https://openalex.org/W2004495348","https://openalex.org/W2005508238","https://openalex.org/W2005901103","https://openalex.org/W2005913737","https://openalex.org/W2006412887","https://openalex.org/W2006853858","https://openalex.org/W2008756039","https://openalex.org/W2010855058","https://openalex.org/W2013099235","https://openalex.org/W2013287589","https://openalex.org/W2013504081","https://openalex.org/W2013920381","https://openalex.org/W2015482578","https://openalex.org/W2016553636","https://openalex.org/W2016966246","https://openalex.org/W2017279958","https://openalex.org/W2018381077","https://openalex.org/W2018468225","https://openalex.org/W2018878564","https://openalex.org/W2019122570","https://openalex.org/W2019796203","https://openalex.org/W2020727683","https://openalex.org/W2020851638","https://openalex.org/W2022470431","https://openalex.org/W2022906877","https://openalex.org/W2023000637","https://openalex.org/W2024385485","https://openalex.org/W2024422356","https://openalex.org/W2024558229","https://openalex.org/W2024645140","https://openalex.org/W2025183385","https://openalex.org/W2025958291","https://openalex.org/W2026781960","https://openalex.org/W2027658027","https://openalex.org/W2028005970","https://openalex.org/W2028790736","https://openalex.org/W2028875662","https://openalex.org/W2029790242","https://openalex.org/W2038409424","https://openalex.org/W2039313149","https://openalex.org/W2041092006","https://openalex.org/W2044701146","https://openalex.org/W2045621636","https://openalex.org/W2046122669","https://openalex.org/W2046318104","https://openalex.org/W2047261154","https://openalex.org/W2047690034","https://openalex.org/W2048204343","https://openalex.org/W2048338530","https://openalex.org/W2048467043","https://openalex.org/W2051299102","https://openalex.org/W2052091173","https://openalex.org/W2052868106","https://openalex.org/W2053194502","https://openalex.org/W2054622940","https://openalex.org/W2055234739","https://openalex.org/W2057373003","https://openalex.org/W2057895743","https://openalex.org/W2058589857","https://openalex.org/W2060163147","https://openalex.org/W2061318890","https://openalex.org/W2061887879","https://openalex.org/W2062515169","https://openalex.org/W2063055202","https://openalex.org/W2063571448","https://openalex.org/W2064387090","https://openalex.org/W2066392072","https://openalex.org/W2066913623","https://openalex.org/W2067035774","https://openalex.org/W2067575315","https://openalex.org/W2069027651","https://openalex.org/W2069124048","https://openalex.org/W2070335189","https://openalex.org/W2070826820","https://openalex.org/W2071335943","https://openalex.org/W2071987840","https://openalex.org/W2072773805","https://openalex.org/W2073467830","https://openalex.org/W2073627942","https://openalex.org/W2073724631","https://openalex.org/W2073850288","https://openalex.org/W2074463646","https://openalex.org/W2074946183","https://openalex.org/W2075054530","https://openalex.org/W2075582271","https://openalex.org/W2075957912","https://openalex.org/W2077034954","https://openalex.org/W2077446805","https://openalex.org/W2078799084","https://openalex.org/W2079540238","https://openalex.org/W2080304201","https://openalex.org/W2080820626","https://openalex.org/W2082412444","https://openalex.org/W2082450983","https://openalex.org/W2082789659","https://openalex.org/W2083500480","https://openalex.org/W2086360108","https://openalex.org/W2086449029","https://openalex.org/W2086537746","https://openalex.org/W2087607880","https://openalex.org/W2089526803","https://openalex.org/W2090292912","https://openalex.org/W2090352184","https://openalex.org/W2090365041","https://openalex.org/W2090694192","https://openalex.org/W2091071330","https://openalex.org/W2091476871","https://openalex.org/W2094250969","https://openalex.org/W2094403737","https://openalex.org/W2094462224","https://openalex.org/W2094518752","https://openalex.org/W2098251346","https://openalex.org/W2098622763","https://openalex.org/W2099019491","https://openalex.org/W2100888621","https://openalex.org/W2101637122","https://openalex.org/W2102720867","https://openalex.org/W2104106441","https://openalex.org/W2104755087","https://openalex.org/W2105407378","https://openalex.org/W2106527863","https://openalex.org/W2106550415","https://openalex.org/W2108329405","https://openalex.org/W2110330006","https://openalex.org/W2112067172","https://openalex.org/W2112729056","https://openalex.org/W2115261608","https://openalex.org/W2118181901","https://openalex.org/W2118422146","https://openalex.org/W2119398548","https://openalex.org/W2119442895","https://openalex.org/W2120070121","https://openalex.org/W2121421374","https://openalex.org/W2121847893","https://openalex.org/W2122339079","https://openalex.org/W2122417766","https://openalex.org/W2122818043","https://openalex.org/W2123182414","https://openalex.org/W2123254707","https://openalex.org/W2123744108","https://openalex.org/W2125054439","https://openalex.org/W2125763073","https://openalex.org/W2129118457","https://openalex.org/W2129613439","https://openalex.org/W2130224571","https://openalex.org/W2130462669","https://openalex.org/W2130483234","https://openalex.org/W2130504424","https://openalex.org/W2132000871","https://openalex.org/W2132474120","https://openalex.org/W2133403920","https://openalex.org/W2138087413","https://openalex.org/W2139489447","https://openalex.org/W2140206473","https://openalex.org/W2146066637","https://openalex.org/W2146286872","https://openalex.org/W2146764867","https://openalex.org/W2147796106","https://openalex.org/W2149726658","https://openalex.org/W2151765319","https://openalex.org/W2154294796","https://openalex.org/W2155082077","https://openalex.org/W2156338590","https://openalex.org/W2156379305","https://openalex.org/W2157797819","https://openalex.org/W2157879872","https://openalex.org/W2158665923","https://openalex.org/W2163729637","https://openalex.org/W2164572633","https://openalex.org/W2171036151","https://openalex.org/W2171621422","https://openalex.org/W2172214117","https://openalex.org/W2175564028","https://openalex.org/W2176508837","https://openalex.org/W2186911163","https://openalex.org/W2192243577","https://openalex.org/W2195334982","https://openalex.org/W2198248975","https://openalex.org/W2219835728","https://openalex.org/W2230144481","https://openalex.org/W2240084905","https://openalex.org/W2259054728","https://openalex.org/W2259743485","https://openalex.org/W2279207235","https://openalex.org/W2289861039","https://openalex.org/W2303705264","https://openalex.org/W2309818502","https://openalex.org/W2313319643","https://openalex.org/W2325237435","https://openalex.org/W2326461674","https://openalex.org/W2329550223","https://openalex.org/W2333767446","https://openalex.org/W2335484642","https://openalex.org/W2335642674","https://openalex.org/W2336309303","https://openalex.org/W2336640150","https://openalex.org/W2337387091","https://openalex.org/W2343310341","https://openalex.org/W2403542285","https://openalex.org/W2408052000","https://openalex.org/W2414177364","https://openalex.org/W2461027708","https://openalex.org/W2471518652","https://openalex.org/W2478338554","https://openalex.org/W2505432564","https://openalex.org/W2509808258","https://openalex.org/W2512631225","https://openalex.org/W2513311778","https://openalex.org/W2518730414","https://openalex.org/W2520639290","https://openalex.org/W2526949029","https://openalex.org/W2530578904","https://openalex.org/W2552444756","https://openalex.org/W2563442740","https://openalex.org/W2564368713","https://openalex.org/W2578806339","https://openalex.org/W2582878252","https://openalex.org/W2591423554","https://openalex.org/W2594051447","https://openalex.org/W2594589478","https://openalex.org/W2600916727","https://openalex.org/W2604455252","https://openalex.org/W2604766632","https://openalex.org/W2607081164","https://openalex.org/W2608134482","https://openalex.org/W2610567779","https://openalex.org/W2611666938","https://openalex.org/W2612561606","https://openalex.org/W2616282068","https://openalex.org/W2618760102","https://openalex.org/W2714801536","https://openalex.org/W2728654001","https://openalex.org/W2736440789","https://openalex.org/W2738454635","https://openalex.org/W2742676285","https://openalex.org/W2744183271","https://openalex.org/W2744484070","https://openalex.org/W2745107259","https://openalex.org/W2745824859","https://openalex.org/W2749610744","https://openalex.org/W2751008768","https://openalex.org/W2752583521","https://openalex.org/W2758842029","https://openalex.org/W2760705731","https://openalex.org/W2763492611","https://openalex.org/W2765525877","https://openalex.org/W2766085363","https://openalex.org/W2770523913","https://openalex.org/W2770576134","https://openalex.org/W2773807652","https://openalex.org/W2775857256","https://openalex.org/W2781744819","https://openalex.org/W2785489657","https://openalex.org/W2786161279","https://openalex.org/W2788255593","https://openalex.org/W2790255143","https://openalex.org/W2790824326","https://openalex.org/W2792688102","https://openalex.org/W2793348982","https://openalex.org/W2794344940","https://openalex.org/W2795027374","https://openalex.org/W2795139401","https://openalex.org/W2799471048","https://openalex.org/W2799994741","https://openalex.org/W2801354201","https://openalex.org/W2801901594","https://openalex.org/W2802270089","https://openalex.org/W2803499191","https://openalex.org/W2803870902","https://openalex.org/W2804761314","https://openalex.org/W2804976764","https://openalex.org/W2805210543","https://openalex.org/W2805603858","https://openalex.org/W2807617765","https://openalex.org/W2808124587","https://openalex.org/W2836466493","https://openalex.org/W2885245587","https://openalex.org/W2886252108","https://openalex.org/W2887729456","https://openalex.org/W2888658265","https://openalex.org/W2889553363","https://openalex.org/W2892708222","https://openalex.org/W2893158640","https://openalex.org/W2894092623","https://openalex.org/W2894736184","https://openalex.org/W2896128890","https://openalex.org/W2896485731","https://openalex.org/W2897217492","https://openalex.org/W2897407175","https://openalex.org/W2901076991","https://openalex.org/W2901520861","https://openalex.org/W2901593774","https://openalex.org/W2905044063","https://openalex.org/W2908361053","https://openalex.org/W2908633127","https://openalex.org/W2909512208","https://openalex.org/W2910565776","https://openalex.org/W2911689495","https://openalex.org/W2913592932","https://openalex.org/W2913893378","https://openalex.org/W2915007024","https://openalex.org/W2917063498","https://openalex.org/W2917384997","https://openalex.org/W2919081348","https://openalex.org/W2921274644","https://openalex.org/W2922428045","https://openalex.org/W2923282967","https://openalex.org/W2924830676","https://openalex.org/W2924865280","https://openalex.org/W2933527433","https://openalex.org/W2933954316","https://openalex.org/W2937317161","https://openalex.org/W2937834684","https://openalex.org/W2944403515","https://openalex.org/W2944749860","https://openalex.org/W2945293240","https://openalex.org/W2946175247","https://openalex.org/W2954128657","https://openalex.org/W2954693066","https://openalex.org/W2961156144","https://openalex.org/W2961961634","https://openalex.org/W2968303438","https://openalex.org/W2969542839","https://openalex.org/W2969845842","https://openalex.org/W2970259043","https://openalex.org/W2970687130","https://openalex.org/W2972046155","https://openalex.org/W2973596517","https://openalex.org/W2973942350","https://openalex.org/W2980974626","https://openalex.org/W2982299231","https://openalex.org/W2982406244","https://openalex.org/W2986917923","https://openalex.org/W2987847454","https://openalex.org/W2993165864","https://openalex.org/W2994687891","https://openalex.org/W2995597707","https://openalex.org/W2995728269","https://openalex.org/W2995815973","https://openalex.org/W2996748935","https://openalex.org/W2996844541","https://openalex.org/W2999002972","https://openalex.org/W3001966225","https://openalex.org/W3004072030","https://openalex.org/W3005117508","https://openalex.org/W3005733169","https://openalex.org/W3006314725","https://openalex.org/W3007840817","https://openalex.org/W3009021313","https://openalex.org/W3010362012","https://openalex.org/W3010944770","https://openalex.org/W3011514631","https://openalex.org/W3013639183","https://openalex.org/W3015488996","https://openalex.org/W3021529656","https://openalex.org/W3021696184","https://openalex.org/W3022210979","https://openalex.org/W3024247862","https://openalex.org/W3025870517","https://openalex.org/W3027906267","https://openalex.org/W3029098519","https://openalex.org/W3029615956","https://openalex.org/W3029639615","https://openalex.org/W3031054651","https://openalex.org/W3035882523","https://openalex.org/W3038081915","https://openalex.org/W3038919059","https://openalex.org/W3039360174","https://openalex.org/W3039919515","https://openalex.org/W3044980231","https://openalex.org/W3049104202","https://openalex.org/W3080194795","https://openalex.org/W3080654265","https://openalex.org/W3087419935","https://openalex.org/W3087505454","https://openalex.org/W3087574823","https://openalex.org/W3087956134","https://openalex.org/W3088069664","https://openalex.org/W3088398815","https://openalex.org/W3088744978","https://openalex.org/W3090328678","https://openalex.org/W3091082020","https://openalex.org/W3097914939","https://openalex.org/W3115817490","https://openalex.org/W3116949252","https://openalex.org/W3116955120","https://openalex.org/W3119803962","https://openalex.org/W3125354155","https://openalex.org/W3134633054","https://openalex.org/W3135365549","https://openalex.org/W3159795713","https://openalex.org/W3161006917","https://openalex.org/W3187119339","https://openalex.org/W3188651548","https://openalex.org/W4220793447","https://openalex.org/W4231121000","https://openalex.org/W4233893512","https://openalex.org/W4240877935","https://openalex.org/W4245751718","https://openalex.org/W4248103353","https://openalex.org/W4248656484","https://openalex.org/W4283808445","https://openalex.org/W4322701389","https://openalex.org/W6911149922","https://openalex.org/W7046234131","https://openalex.org/W7075579662"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"WHAT\u2019S":[0],"NEW":[1],"SINCE":[2],"THE":[3],"2010":[4,816,6634],"GUIDELINES?":[5],"Inclusion":[6],"of":[7,14,32,42,55,92,155,211,249,289,295,314,322,332,346,357,371,379,429,438,470,483,506,521,546,557,602,612,639,653,673,687,702,707,710,715,722,727,742,756,774,791,802,811,824,843,855,863,870,885,911,921,957,963,1008,1036,1046,1069,1073,1085,1093,1107,1109,1158,1195,1202,1212,1217,1228,1237,1269,1286,1300,1322,1336,1346,1395,1406,1411,1414,1423,1547,1562,1572,1594,1604,1611,1634,1640,1645,1649,1659,1690,1809,1818,1824,1827,1875,1894,1897,1922,1939,1943,1951,2027,2051,2077,2092,2133,2141,2162,2208,2279,2309,2360,2367,2379,2427,2429,2447,2457,2484,2491,2520,2537,2542,2569,2574,2580,2588,2597,2605,2620,2630,2662,2698,2742,2746,2810,2829,2842,2904,2931,2943,2953,2963,2972,2983,3036,3044,3059,3064,3088,3114,3127,3165,3198,3247,3277,3333,3339,3357,3451,3485,3488,3492,3552,3604,3629,3649,3653,3668,3734,3737,3764,3776,3781,3787,3844,3881,3916,3923,3935,3940,3986,3998,4002,4022,4036,4053,4063,4068,4086,4130,4138,4143,4151,4195,4203,4218,4234,4253,4263,4277,4283,4290,4337,4350,4379,4408,4417,4476,4500,4537,4546,4567,4571,4578,4586,4604,4680,4710,4729,4744,4751,4759,4798,4938,4946,4970,4982,4989,5016,5027,5050,5062,5078,5082,5091,5121,5124,5140,5159,5184,5224,5228,5240,5283,5326,5396,5399,5452,5478,5480,5514,5529,5579,5608,5633,5640,5648,5654,5715,5719,5754,5779,5791,5815,5842,5898,5931,5960,5965,6090,6122,6127,6131,6156,6162,6193,6207,6225,6250,6280,6300,6369,6391,6400,6412,6457,6462,6470,6517,6535,6562,6570,6598,6618,6643,6670,6682,6687,6735,6787,6845,6852,6857,6864,6871,6880,6962,7049,7065,7071,7084,7092,7099,7127,7147,7161,7167,7191,7207,7219,7276,7296,7311,7316,7343,7383,7395,7436,7463,7483,7503,7522,7543,7635,7647,7653,7662,7740,7753,7769,7774,7782,7787,7798,7827,7847,7936,7953,8002,8007,8011,8016,8021,8025,8032,8049,8060,8076,8102,8106,8114,8120,8147,8154,8185,8189,8198,8206,8215,8232,8240,8274,8301,8321,8345,8355,8366,8374,8379,8385,8393,8412,8432,8455,8471,8489,8543,8601,8687,8697,8713,8740,8743,8756,8779,8791,8795,8811,8819,8833,8843,8851,8855,8861,8903,8996,9082,9128,9141,9146,9170,9207,9377,9411,9470,9504,9525,9554,9580,9601],"guidance":[8,677,737,748,775,783,4864,7737],"for":[9,79,89,146,150,177,217,243,251,256,270,626,647,670,821,831,849,1004,1267,1791,1845,1990,2024,2084,2130,2269,2333,2762,2792,2858,2874,2950,3020,3093,3141,3195,3245,3274,3317,3572,3599,3646,3926,4299,4357,4365,4414,4426,4431,4663,4838,4846,4863,4980,5014,5032,5039,5064,5204,5369,5572,5802,5834,5856,5910,6029,6101,6146,6190,6219,6248,6261,6277,6309,6414,6481,6514,6543,6548,6743,6770,6822,7044,7068,7089,7188,7308,7392,7415,7537,7585,7612,7650,7679,7684,7696,7712,7732,7747,7888,7919,8139,8159,8181,8260,8272,8288,8306,8425,8464,8538,8566,8610,8737,8857,8989,9007,9017,9026,9091,9151,9253,9274,9302,9311,9334,9444,9453,9459,9510,9520,9589],"the":[10,33,43,90,287,293,330,433,442,458,471,507,581,610,671,683,703,708,711,716,725,757,760,766,800,809,815,822,907,922,932,939,961,989,1019,1044,1200,1203,1298,1382,1393,1412,1432,1458,1463,1477,1545,1570,1592,1612,1632,1647,1822,1855,1920,1936,1940,1994,1998,2025,2074,2146,2176,2188,2307,2315,2371,2377,2387,2425,2455,2458,2489,2492,2521,2527,2531,2543,2575,2581,2606,2621,2631,2663,2672,2702,2710,2719,2783,2807,2817,2830,2856,2948,2951,2957,2970,2997,3015,3086,3265,3275,3475,3497,3647,3666,3690,3741,3774,3842,3862,3898,3908,3938,4031,4037,4050,4066,4096,4136,4141,4149,4166,4170,4176,4192,4213,4216,4225,4232,4261,4275,4279,4309,4355,4360,4393,4510,4544,4583,4694,4720,4796,4903,4941,4951,4990,5059,5119,5181,5209,5295,5367,5394,5497,5506,5598,5636,5646,5662,5701,5716,5763,5792,5800,5819,5843,5851,5893,5908,6102,6154,6157,6160,6191,6233,6245,6278,6298,6382,6387,6392,6407,6431,6463,6515,6526,6546,6641,6705,6732,6780,6810,6861,6872,6955,7006,7014,7042,7063,7069,7090,7097,7150,7189,7205,7241,7309,7340,7344,7393,7443,7501,7645,7651,7670,7718,7726,7750,7772,7780,7785,7845,7933,7977,7988,7996,8050,8088,8099,8203,8213,8299,8346,8364,8372,8391,8456,8684,8725,8738,8777,8789,8808,8837,8880,8896,8901,9080,9126,9144,9168,9309,9318,9332,9340,9464,9468,9481,9502,9533,9566,9575],"diagnosis":[11,91,684,832,973,1550,1648,2026,2161,2251,2952,3043,3090,3266,3276,3332,3338,3524,3669,3889,4069,4181,4658,5979,6206,7661,8153],"and":[12,20,29,114,140,167,190,219,260,291,320,336,354,373,376,410,510,565,568,594,597,615,628,685,689,713,731,746,754,839,846,852,880,887,896,909,935,965,1043,1054,1071,1097,1127,1144,1191,1232,1240,1262,1282,1303,1308,1334,1356,1375,1426,1441,1467,1488,1497,1637,1642,1674,1715,1807,1886,1904,1910,1913,1946,1968,1997,2014,2042,2058,2099,2123,2158,2230,2237,2252,2297,2301,2328,2469,2516,2530,2548,2553,2563,2602,2624,2665,2748,2766,2897,2909,2934,2996,3018,3030,3046,3156,3167,3183,3187,3218,3335,3387,3405,3408,3490,3500,3515,3525,3546,3596,3655,3670,3678,3720,3723,3748,3784,3794,3809,3837,3890,3951,4000,4012,4041,4070,4182,4200,4208,4281,4326,4343,4403,4457,4485,4495,4513,4530,4599,4606,4634,4670,4697,4706,4737,4746,4762,4786,4804,4827,4836,4867,4884,4894,4931,4965,5019,5036,5093,5115,5137,5146,5237,5252,5321,5328,5342,5347,5361,5418,5424,5427,5441,5468,5472,5482,5491,5509,5518,5557,5564,5624,5638,5644,5697,5723,5736,5752,5758,5827,5840,5873,5895,6159,6199,6209,6282,6296,6323,6362,6397,6453,6468,6477,6607,6627,6684,6722,6761,6828,6837,6894,6933,6987,7047,7086,7135,7216,7244,7282,7301,7321,7337,7439,7461,7491,7528,7541,7558,7564,7614,7757,7805,7810,7820,7942,7951,7992,8009,8023,8045,8070,8200,8255,8269,8285,8324,8445,8466,8475,8514,8579,8613,8735,8745,8785,8814,8853,8900,8907,8949,8964,8972,9009,9116,9243,9257,9321,9446,9500,9551,9578,9585],"management":[13,686,854,4868,6318,7091,7310,7411,7435,8446,8794],"cholangiocarcinoma":[15,613],"(CCA)":[16,614],"in":[17,136,157,179,199,204,221,228,278,286,292,306,393,408,432,441,457,589,600,664,877,1048,1065,1095,1099,1112,1189,1208,1280,1297,1305,1316,1326,1358,1392,1538,1544,1569,1591,1670,1821,1848,1906,1956,1975,2048,2103,2137,2193,2257,2262,2289,2318,2352,2376,2424,2488,2669,2701,2709,2716,2738,2782,2895,2938,2969,3007,3014,3129,3261,3304,3327,3429,3474,3496,3501,3671,3709,3715,3730,3740,3746,3767,3791,3803,3807,3811,3831,3835,3839,3851,3869,3914,3937,3968,3983,3996,4030,4059,4148,4240,4308,4313,4373,4385,4406,4453,4461,4467,4478,4502,4553,4569,4588,4665,4685,4701,4703,4712,4726,4775,4791,4874,4919,4963,4968,4986,5000,5165,5174,5208,5250,5260,5272,5314,5319,5345,5371,5378,5391,5439,5597,5661,5712,5721,5739,5796,5865,6116,6140,6232,6253,6264,6374,6416,6435,6446,6484,6499,6507,6545,6603,6651,6658,6694,6717,6750,6848,6867,6915,6954,6978,6985,6992,7032,7103,7120,7142,7196,7201,7234,7240,7250,7264,7333,7346,7365,7445,7472,7507,7511,7587,7597,7624,7627,7761,7850,7852,7890,7922,7990,8169,8191,8208,8223,8298,8342,8357,8363,8376,8390,8414,8428,8436,8483,8500,8516,8557,8581,8788,8800,8824,8836,8933,8945,9040,9085,9093,9130,9227,9276,9346,9375,9438,9480,9492,9501,9537],"patients":[18,64,97,137,159,171,230,257,271,522,603,1009,1014,1037,1049,1086,1111,1540,1671,1726,1877,1957,1991,2104,2142,2194,2984,3037,3069,3130,3157,3174,3214,3282,3305,3328,3342,3390,3452,3502,3556,3605,3634,3674,3870,3882,3917,3960,3987,4004,4064,4087,4241,4246,4267,4409,4482,4519,4539,4554,4625,4713,4731,4818,4829,4971,5152,5207,5400,5603,5773,5836,5902,6083,6110,6147,6310,6413,6564,6572,6604,6744,6766,6813,6923,6935,7012,7128,7312,7322,7334,7368,7427,7473,7508,7524,7579,7592,7806,7819,7868,7891,7924,8033,8160,8307,8358,8381,8386,8415,8698,8714,8801,8825,8946,8953,8990,9027,9041,9094,9152,9174,9224,9277,9345,9378,9392,9439,9454,9493,9511,9538],"with":[19,51,65,68,98,108,138,163,172,195,208,214,231,258,272,339,360,416,426,452,454,479,514,523,543,634,762,968,1010,1015,1026,1038,1050,1075,1087,1330,1362,1541,1589,1656,1672,1781,1794,1843,1878,1881,1958,1992,2033,2105,2143,2184,2195,2205,2222,2241,2325,2355,2500,2617,2626,2643,2658,2671,2695,2751,2756,2838,2879,2978,2985,2989,3038,3070,3083,3102,3131,3137,3144,3153,3158,3175,3181,3206,3215,3234,3283,3306,3322,3329,3369,3396,3503,3508,3530,3562,3579,3590,3606,3635,3661,3703,3718,3758,3817,3871,3883,3947,3957,3961,3988,4008,4076,4088,4095,4110,4117,4169,4242,4247,4268,4315,4328,4331,4367,4410,4422,4483,4520,4524,4555,4558,4594,4617,4626,4668,4714,4732,4830,4878,4891,4898,4914,4972,5021,5075,5180,5188,5247,5278,5323,5338,5401,5405,5430,5436,5447,5461,5488,5523,5561,5575,5604,5613,5659,5825,6084,6148,6167,6179,6230,6311,6559,6574,6594,6605,6614,6663,6704,6715,6757,6814,6854,6875,6896,6917,6926,6938,6945,6967,7023,7030,7129,7131,7149,7272,7313,7323,7335,7363,7400,7457,7474,7509,7525,7550,7566,7580,7600,7632,7657,7659,7682,7795,7803,7807,7861,7892,7925,7940,7983,8034,8036,8111,8143,8161,8220,8308,8359,8382,8387,8416,8439,8450,8453,8459,8492,8506,8522,8528,8549,8571,8588,8594,8619,8623,8634,8636,8645,8699,8701,8707,8715,8749,8802,8826,8828,8887,8911,8923,8947,8954,8979,8991,8999,9028,9030,9042,9051,9059,9061,9068,9095,9099,9104,9153,9159,9175,9217,9225,9235,9278,9379,9393,9431,9440,9455,9494,9512,9532,9539],"without":[21,100,1017,1608,2724,3040,3061,3343,4073,4249,4522,4716,5422,7136,8418,8647,8981],"primary":[22,2119],"sclerosing":[23,382,398,495,1564,1692,1828,7325],"cholangitis":[24,60,383,399,488,496,1565,1693,1699,1705,1746,1751,2121,2174,2847,3868,3887,3906,3925,3953,6313,7328,7330,7353,7359,7403,7681,7698,9264,9371],"(PSC)":[25,497],"(Figures":[26],"5,":[27],"8,":[28],"9).":[30,301],"Introduction":[31],"term":[34,2720,2731,2761,2794,2818],"relevant":[35,2819,7397,7689,8426,8434,9018,9304,9441],"stricture,":[36,2468,2775,4146,4325,8641],"defined":[37,2566,2691,2778,9417],"as":[38,1318,1622,1654,1965,2038,2314,2466,2478,2567,2692,2925,2993,3000,3424,3426,4341,4615,4850,5096,5256,5463,5465,5611,5774,5783,6108,6113,6645,6877,7801,7813,7945,8337,8339,8675,9337,9339],"any":[39,572,985,2826,4163,4809,5810,6345,7003,9147],"biliary":[40,215,395,422,448,468,508,527,660,825,1229,1354,1485,1515,1765,1819,1923,2120,2299,2513,2522,2599,2608,2640,2827,2929,3400,4023,4032,4789,5128,5962,6025,6868,8347,8461,8656,8688,9335,9405,9472,9490,9514,9526,9603],"stricture":[41,420,423,446,449,466,469,1768,2604,2688,2733,2798,2820,2828,3943,4123,4132,8369,8389,8435,8458,9305,9556,9604],"common":[44,344,434,459,472,2703,2763,2831,3910,4038,4042,7332,7979],"hepatic":[45,48,443,463,476,2571,2711,2767,2835,4043,4851,5185,5425,5453,5784,8905],"duct":[46,334,436,444,461,474,2410,2416,2609,2705,2712,2765,2768,2833,2911,2918,3992,4017,4040,4044,4153],"or":[47,53,234,284,297,437,462,475,481,1082,1220,1247,1446,1474,1587,1680,1702,1851,1883,2069,2244,2265,2295,2336,2385,2436,2482,2502,2706,2813,2834,2840,2877,3003,3110,3208,3252,3353,3416,3445,3574,3625,4075,4126,4256,4312,4450,4489,4646,4801,4853,4984,5006,5070,5312,5542,5548,5673,5786,5803,5915,5952,5986,5991,6000,6008,6031,6087,6092,6133,6241,6343,6510,6551,6579,6680,6696,6738,6748,6790,6804,6843,6850,7035,7212,7284,7595,7604,7622,7725,8083,8217,8225,8235,8317,8546,8639,8646,8661,8672,8980,8998,9283,9298,9306,9365,9486,9516],"ducts":[49,363,464,477,1325,2532,2600,2836,4101],"associated":[50,338,415,478,513,1329,1361,2324,2837,3529,3660,3702,3757,3946,3956,4116,4877,4890,5074,5246,5277,5435,5460,6593,6613,6662,6703,6714,7029,7093,7271,7456,7860,7982,9103],"signs":[52,480,2839,4280],"symptoms":[54,207,482,1890,1953,1963,1978,2841,3048,3112,3355,3654,4074,4282,6853,7630],"obstructive":[56,484,2843,2899],"cholestasis":[57,485,1363,2552,2844,4932,5125],"and/or":[58,206,324,486,1215,1454,1925,2413,2578,2845,3202,3979,4081,6165,6314,7629,8605,9433,9542],"bacterial":[59,487,1270,2846,3384,3403,3867,3886,3905,3924,3933,3952,7352,7384,7402,7680,7697,9263],"(Table":[61,1574,2848,5767],"1).":[62,1131,2849],"In":[63,96,734,806,987,1602,1631,2116,3033,3055,3173,3213,3280,3341,3965,4120,4187,4224,4274,4435,4623,4841,4902,5117,5150,5495,5849,6472,6525,6689,6708,6919,7005,7154,7350,7519,7591,7907,8057,8631,9173,9223,9260,9498],"equivocal":[66,3236],"MRI":[67,451,1834,2183,2218,2586,2612,2636,2650,2739,2772,8780],"cholangiopancreatography":[69,84,453,837,2185,2220],"(MRI/MRCP)":[70],"findings,":[71,1679,7955],"a":[72,196,239,427,499,532,539,635,679,782,788,803,925,969,1134,1162,1244,1278,1313,1342,1421,1502,1506,1595,1799,1849,1860,1972,2160,2203,2206,2209,2260,2353,2356,2364,2570,2693,2696,2780,2790,2793,2797,2811,2859,2928,3041,3178,3219,3248,3330,3366,3370,3539,3547,3569,3586,3622,3662,3777,3859,3902,3941,3948,3971,4105,4127,4131,4144,4400,4418,4427,4447,4486,4525,4564,4660,4677,4820,4924,5043,5157,5222,5257,5273,5351,5576,5586,5605,6119,6124,6128,6398,6439,6533,6691,6697,6815,6840,6878,6976,6996,7112,7121,7139,7155,7163,7169,7197,7224,7259,7273,7396,7423,7464,7520,7533,7619,7660,7767,7853,7862,7884,7896,7909,7970,8014,8112,8118,8133,8144,8192,8196,8245,8266,8367,8377,8402,8409,8419,8433,8437,8443,8460,8480,8497,8503,8511,8519,8529,8532,8554,8560,8568,8576,8584,8595,8602,8620,8626,8632,8637,8733,8753,8815,8841,8849,8872,9139,9303,9353,9357,9555,9561,9602],"repeated":[73,117,4006,5141,5899,7937,9245],"high\u2010quality":[74,2285,3221,3250],"MRI/MRCP":[75,1857,2344,2381,2445,2747,3180,3237,3251,3257,3642,4114,4134,5397,6186,7902,7914,7941,8107,8482,8513,8578,8978,9322],"should":[76,86,111,130,160,174,225,1535,1628,1661,1667,1797,1836,1863,2186,2199,2233,2329,2389,2734,2867,2946,3080,3104,3190,3225,3238,3271,3289,3300,3324,3347,3638,3726,4259,5656,5821,6150,6182,6202,6227,6628,6767,6792,7305,7360,7387,7412,7552,7568,7582,7665,7676,7693,7714,7962,8312,8441,8478,8495,8509,8552,8574,8616,8892,8915,8941,8968,9011,9023,9063,9155,9186,9193,9213,9237,9323,9367,9387,9435,9449,9507,9528,9557,9605],"be":[77,87,112,116,161,175,188,226,914,946,996,1060,1105,1253,1536,1629,1662,1668,1864,1931,2187,2200,2304,2331,2390,2419,2557,2736,2868,2893,2947,3105,3191,3226,3239,3259,3272,3290,3302,3325,3348,3375,3423,3442,3468,3639,3727,3771,4271,4399,4446,4549,4861,5254,5657,5823,5832,6183,6203,6217,6228,6630,6768,6793,6820,6831,7306,7339,7361,7371,7388,7413,7553,7569,7583,7610,7666,7677,7694,7715,7963,8098,8157,8313,8526,8592,8617,8916,8930,8943,8969,9012,9024,9049,9194,9244,9314,9325,9368,9389,9436,9451,9508,9529,9558],"performed":[78,113,1865,2201,2332,2755,3303,3326,7695,7716,7842,8944,8970,9013,9437,9509],"diagnostic":[80,106,369,642,2082,2128,2190,2347,5044,5392,8204,8444,8537,8565,8609],"purposes.":[81],"Endoscopic":[82,9256],"retrograde":[83,836,2219],"(ERCP)":[85,838],"avoided":[88,3273],"PSC":[93,99,139,147,173,259,290,307,308,342,347,358,372,524,547,561,574,586,606,688,859,864,912,927,949,958,981,1016,1027,1039,1047,1091,1118,1126,1159,1173,1317,1327,1396,1415,1533,1534,1577,1590,1607,1655,1796,1869,1879,1898,1952,1977,1995,2106,2368,2448,2876,2896,2905,2955,2986,3008,3039,3089,3122,3145,3217,3334,3363,3364,3470,3509,3516,3580,3583,3620,3630,3637,3768,3818,3872,3884,3962,4089,4180,4204,4352,4386,4484,4503,4627,4669,4715,4745,4752,4776,4792,4813,4875,4920,4987,5001,5316,5402,5859,5868,5932,5949,5978,6149,6164,6181,6208,6269,6301,6375,6447,6485,6606,6638,6724,6881,6979,7016,7130,7202,7336,7421,7446,7454,7510,7551,7581,7658,7783,7804,8035,8162,8417,8440,8635,8700,8803,8827,8934,8948,8992,9029,9060,9176,9226,9279,9380,9394,9456,9495],"(Figure":[94,165,300,1130,1558,2461,5847,8166,8629],"2).":[95,1559,1575],"known":[101,1154,1621,1653,3078],"inflammatory":[102,515,1491,1748],"bowel":[103,516],"disease":[104,312,517,1367,1383,1402,1763,2459,3002,3368,3395,3459,3519,3608,3614,3683,3691,3742,3899,3927,4097,4167,4760,4810,4858,5811,5963,6035,6289,6409,7303,7345,8914],"(IBD),":[105],"colonoscopy":[107,9158,9199,9216,9234],"histological":[109,355,377,544,1582,2889,3057],"sampling":[110,4926,8454,9006,9430],"may":[115,913,1104,1171,1364,1479,2418,2511,2556,2804,2974,3119,3258,4025,4071,4285,4398,4691,4824,4833,4860,4933,5130,5253,5442,5520,5532,5830,7354,7469,8041,8086,8097,8201,9048,9280],"every":[118,3643,6187,8868,8889,9053],"5":[119,1892,2072,4470,5600,6020,6037,6095,8770],"years":[120,135,1893,3428,3444,3645,4202,4378,4577,5161,5203,5884,5996,6004,6012,6021,6038,6189,8995,9242],"if":[121,192,719,2370,2870,3111,3264,6833,7561,7616,7699,7717,9361],"IBD":[122,340,1051,1088,1170,1573,2980,3006,3045,3060,3065,3079,3115,3118,3128,3358,4248,4521,4559,4652,4657,4671,4717,7094,9131,9229],"is":[123,238,268,282,349,498,511,575,621,662,959,1022,1133,1153,1328,1371,1435,1551,1566,1578,1830,1858,1954,1971,2046,2107,2149,2156,2179,2225,2248,2255,2272,2287,2292,2323,2373,2383,2405,2422,2438,2754,2773,2777,2821,2872,2886,2959,3010,3024,3066,3099,3133,3315,3365,3471,3479,3707,3873,3970,4220,4301,4305,4345,4362,4387,4433,4472,4504,4638,4659,4698,4723,4815,4876,4921,4977,5103,5221,5244,5298,5382,5459,5559,5921,6243,6258,6273,6307,6419,6430,6438,6624,6753,6835,6839,6903,7058,7078,7095,7111,7237,7331,7422,7441,7455,7618,7640,7701,7720,7729,7915,7976,8151,8195,8243,8292,8536,8564,8608,8691,8729,8871,8937,8986,9138,9182,9204,9230,9349,9419,9478,9496],"not":[124,796,1378,2022,2060,2088,2439,2735,2805,3076,3301,3377,3945,3955,4286,4766,4778,4978,5105,5299,5539,5831,6099,6259,6487,6539,6625,6629,7001,7238,7562,7593,7871,8042,8053,8692,8987,9414,9487,9606],"initially":[125],"detected.":[126],"Colon":[127,9072],"cancer":[128,617,1948,4382,4384,7974,8199,8720,8723,9073],"surveillance":[129,7739,7775,7788,7822,7849,7858,7874,7921,8940,8967,9066,9084,9089,9150,9185,9233],"begin":[131,9187],"at":[132,571,771,950,972,984,1031,1839,2250,2393,3085,3107,3350,3523,3888,4027,4065,4113,4133,4463,4533,4612,4620,4656,4808,4819,5809,5858,6205,6532,6825,7054,7499,8132,8331,8625,9036,9161,9167,9188,9239,9246],"age":[133,971,3522,3536,3559,3719,4532,4655,4674,6155,8997,9178,9189,9240],"15":[134,5995,9179,9190,9241],"IBD.":[141,1548,3340,3504],"New":[142],"clinical":[143,180,629,850,1801,2011,2147,2263,2717,2801,3125,3779,3903,4773,4842,4847,4991,5079,5138,5178,5261,5274,5343,5470,5562,5595,5649,5740,5780,5896,5928,6265,6346,6372,6402,6417,6751,7036,7052,7074,7254,7588,7598,7777,9426,9465],"risk":[144,151,611,1428,3164,3571,3598,4137,4172,4194,4217,4233,4297,4319,4356,4361,4413,4499,4545,4661,4679,4696,4709,4844,5077,5183,5467,5551,5565,5578,5607,5765,5778,5801,6089,6121,6130,6214,6597,6617,6981,7275,7756,7797,7952,8818,8902],"tools":[145,4748,5547,6215],"are":[148,697,889,1028,1390,1585,2019,2067,2449,2471,2506,3146,3453,3528,3565,3609,3659,3675,3701,3744,3756,3994,4057,4115,4404,4777,5011,5434,5538,5590,5616,5853,5890,6376,6746,6782,6796,7107,7256,7497,8352,8704,8773,9076,9399],"available":[149,797,5301,5543,7239],"stratification,":[152],"but":[153,359,542,980,1012,1397,2021,2145,2803,3381,3434,3462,4034,4424,4580,4725,4739,5109,5536,5887,6222,6332,6504,6906,6995,7236,7985,8122,8142,9136,9351,9418],"probabilities":[154,5653,5814,6224],"events":[156,4848,5596,5655,5816,6226],"individual":[158,5663,5844,6234,9571],"interpreted":[162,5658,5824,6229],"caution":[164,5660,6231],"4":[166],"Table":[168,665],"3).":[169],"All":[170,7578],"considered":[176,189,576,1537,1669,1831,2869,3106,3227,3260,3349,6218,6821,7307,7389,7584,7611,8244,8314,9025,9326,9452],"participation":[178,7586],"trials;":[181],"however,":[182,2003,6105,6558,7252,7929],"ursodeoxycholic":[183],"acid":[184,6426,6428,6466,7182],"(13\u201323":[185],"mg/kg/day)":[186,6495,6521,6578,6803,6807],"can":[187,391,569,598,982,1916,1930,2171,2303,2892,3374,3679,4161,4270,4793,4806,5626,5798,5807,6216,6763,6819,6830,7338,7609,7830,8156],"continued":[191,6832,7615],"well":[193,5377,5464,8338,8693,9338],"tolerated":[194,6836],"meaningful":[197,804,6656,6841,7620],"improvement":[198,6498,6506,6851,6947],"alkaline":[200,2039],"phosphatase":[201,2040],"(\u03b3\u2010glutamyl":[202],"transferase":[203,2044],"children)":[205,6849,7628],"12":[209,5271,6502,6855,6951,7145,7179,7633],"months":[210,3825,6503,6772,6856,7634,8870,8891],"treatment.":[212,6858,7636],"ERCP":[213,425,2311,2322,3270,4009,5486,5499,5519,7692,8128,8333,8452,8499,8515,8556,8580,8622,9016,9275,9312,9329,9348,9373,9396,9458],"brushings":[216,8463,8624],"cytology":[218,8164,8491,8505,8521,8534,8562,8570,8587,8607,8615,8649,9008,9445],"fluorescent":[220],"situ":[222,8170],"hybridization":[223,8171],"analysis":[224,755,8173,9448],"obtained":[227,3192,4949,5555,5675],"all":[229,772,1539,3281,4028,4738,5206,5835,7791,8241,8765],"suspected":[232,1605,1795,2196,3176,3216],"perihilar":[233,273],"distal":[235],"CCA.":[236,690,2270,8539,8597,8652,9307,9484],"There":[237,1132,1970,2271,7927,8772],"new":[240,657,819,3331],"United":[241,933,940,7242],"Network":[242],"Organ":[244],"Sharing":[245],"policy":[246],"regarding":[247,6384,7771],"standardization":[248],"Model":[250,5909],"End\u2010Stage":[252,5911,5917,6172],"Liver":[253,263,674,2865,4870,4917,4994,4996,5217,5912,5918,6173,6256],"Disease":[254,5913,5919,6174],"exceptions":[255],"recurrent":[261,7377],"cholangitis.":[262,1927,3295],"transplantation":[264,3418],"following":[265,8822,9372],"neoadjuvant":[266],"therapy":[267,625,1374,9259,9403],"recommended":[269,2249,4979,6260,6308,6626,6639,8988],"CCA":[274,3465,3553,4159,4160,4196,4219,4235,4269,4284,4300,4304,4803,7734,7799,7848,7889,7920,8141,8150,8155,8207,8289,8356,8413,8708,8963],"<":[275,2169,3697,3753,4440,4469,6043,6051,6059,6673,6699,7879,8769],"3":[276,4550,5925,8071,8501,8558],"cm":[277],"radial":[279],"diameter":[280,428,2697],"that":[281,348,390,906,1102,1169,1387,1584,2343,2382,2799,2891,3373,3878,3891,4956,5568,6655,6779,7230,7267,7913,8074,8311,8448,8840,9265],"unresectable":[283],"arising":[285],"setting":[288,1546,2378,2971,8365,8392],"absence":[294,1571,1823,4150,7502,9503],"intrahepatic":[296,323,1738,2430,2497,2598,3201,4100,5414,5481,5508,7466],"extrahepatic":[298,325,3203,5483,5510,5961],"metastasis":[299,1739],"TABLE":[302,1686,5924],"1":[303,3262],"-":[304,1688,5926],"Definitions":[305],"Chronic,":[309],"cholestatic":[310,353,590,1301,1677,2030,2936],"liver":[311,549,591,595,840,1080,1762,1811,1852,1861,2035,2544,2564,2576,2633,2667,2681,2685,2860,3223,3253,3298,3394,3410,3417,3458,3493,3594,3800,3822,4292,4771,4953,4975,5017,5677,5906,6034,6508,6720,6993,7432,7451,8898,8913,9291],"likely":[313,2110,3480,3510,5618],"autoimmune":[315,558,578],"origin":[316],"characterized":[317,350,501,537],"by":[318,351,502,538,699,740,765,948,1290,1814,1933,2559,2713,2779,2785,3379,3383,3641,4923,4960,5002,5030,5053,5068,5107,5111,5191,5197,5682,5818,5994,6002,6010,6019,6036,6185,6239,6501,7176,7723,7973,8066,8163,8846,8866,8977,9560],"inflammation":[319,1304,4690],"fibrosis":[321,1302,1321,1761,2525,2885,2908,3766,3788,3796,3828,3852,4800,4822,4832,4873,4909,4939,4983,5018,5034,5092,5097,5108,5213,5327,5339,5473,5588,6200,6251,6262],"bile":[326,333,362,435,460,473,1324,1348,1351,1359,2409,2415,2431,2485,2704,2764,2832,2917,3936,3969,3991,4016,4039,4152,6442,6450,6465,7477],"ducts,":[327,1349],"leading":[328,1509,7289],"to":[329,387,403,682,780,798,808,814,872,931,945,953,977,995,1059,1067,1123,1125,1165,1225,1252,1276,1284,1311,1380,1462,1483,1510,1682,1866,1908,2009,2118,2139,2227,2259,2267,2275,2349,2441,2454,2795,2823,2825,2862,2924,3051,3091,3148,3193,3228,3241,3292,3414,3422,3441,3467,3482,3555,3567,3577,3611,3712,3770,3865,4015,4061,4084,4099,4103,4212,4245,4392,4445,4509,4518,4548,4573,4591,4642,4651,4693,4719,4755,4780,4896,4935,5099,5127,5269,5333,5365,5384,5502,5593,5619,5630,5727,5732,5838,6081,6287,6329,6338,6366,6378,6381,6406,6421,6529,6585,6672,6754,6774,6777,6799,6950,7009,7039,7061,7290,7348,7370,7375,7390,7409,7448,7513,7571,7643,7669,7686,7705,7710,7765,7790,7814,7816,7832,7843,7867,7901,7917,7932,8029,8047,8179,8277,8294,8681,8710,8781,8807,8882,8918,8929,8952,8957,9088,9124,9133,9163,9248,9251,9262,9270,9328,9330,9391,9488,9546,9582,9587],"formation":[331],"strictures,":[335,661,826,1820,3401],"frequently":[337,414,512,587,2057,3012,4629],"Small\u2010duct":[341,1576,3582],"Less":[343,1152],"variant":[345],"typical":[352,1586,3307],"features":[356,370,378,545,556,1639,1658,2446,2903,2915,2945,2962,3197,5421],"normal":[361,540,1596,2078,2434,2501,3207,3716],"on":[364,424,450,529,548,751,759,784,829,1199,1401,1420,1553,1556,1581,1919,2202,2546,2727,2771,3310,3798,3861,4049,4124,4865,5289,5354,5475,5485,5505,5668,5892,6637,7372,7776,8081,8759,8776,9079,9143,9401,9424,9463,9476,9483,9569],"cholangiography":[365,1083,1557],"PSC\u2013AIH":[366],"overlap":[367,1063,1666,2086,2878,2977,3564,6166,7300],"Concurrent":[368],"clinical,":[374,1635],"biochemical,":[375,1636],"AIH":[380,1641,1673,3318,5318,7317,7664,7672],"Secondary":[381],"Biliary":[384,400,4019],"strictures":[385,401,528,1555,2428,2498,2528,2596,2769,3204,4020,4024,4035,4056,4109,4790,4930,8427],"due":[386,402,2266,3481,3711,5126,5837,6380,6584,7764,8806],"identifiable":[388],"causes":[389,1826,1962,4349],"result":[392,8535,8563],"secondary":[394,1563,1691,1825],"cirrhosis":[396,3380,3407,3595,4353,5040,7440,7527,7567,8936,8950,8955,9062],"IgG4":[397,412,2135,2152,2178,3287,7302,7324],"elevated":[404,1947,2034,2054,4332,6817,7133,7602,8038,8094,8325],"IgG4\u2010positive":[405],"plasma":[406],"cells":[407,1231,1257,1265,1293,1487,8219],"tissue":[409,2337,5238,9005,9429],"serum":[411,1810,2093,2134,2177,3286,5226,5755,7980,8982,9290,9294],"elevation":[413],"pancreatic":[417],"involvement":[418],"Dominant":[419,4055],"A":[421,447,551,651,1180,2029,2284,2433,2759,3255,3297,3931,4535,4943,6566,6958,7073,7557,7999,8248,8831],"\u22641.5":[430,2699],"mm":[431,440,2700,2708,4442,4471,8799,8845,8865,9047],"\u22641":[439,2707],"High\u2010grade":[445,4108],">75%":[455],"reduction":[456,2781,6544,6669,6679,6693,6737,6842,6977,7141,7621],"Relevant":[465],"Any":[467],"INTRODUCTION":[489],"AND":[490],"SCOPE":[491,5940],"OF":[492,858,1117,1532,3362,6268],"GUIDANCE":[493],"Primary":[494],"cholangiopathy":[500,1696,1707,1754,1776],"chronic":[503,2935,3977,5372,7450],"fibroinflammatory":[504],"damage":[505],"tree":[509,8348],"(IBD).":[518],"The":[519,777,868,1320,1408,1549,1816,2730,2941,3124,3921,4294,4335,4412,4474,4498,4708,4749,4881,5134,5215,5409,5689,5769,5861,6632,6899,7082,7434,8104,8430,8468,8486,8540,8598,8793,9408,9523,9544],"majority":[520,869],"have":[525,534,554,865,874,904,1040,1089,1149,1183,1222,1272,1312,1398,1798,2087,2126,2341,2854,2987,3052,3077,3161,3391,3460,3538,3568,3885,4045,4104,4592,4630,4783,5042,5569,5585,5679,5761,5904,6326,6364,6496,6653,6660,6888,6908,6989,7246,7405,7546,7840,8043,9121],"fibrotic":[526],"cholangiogram,":[530],"whereas":[531,2165,2913,8013],"minority":[533],"small\u2010duct":[535,1606,1868,2875,2954,3231,3607,3619,3636,4316,5722,5987,6163,6180,7808,9000],"PSC,":[536,627,1646,2144,2361,2538,2973,3071,3177,3199,3285,3486,4702,4733,5118,5379,6281,7529,7851,7893,8383,9100],"cholangiogram":[541,1597],"biopsy.":[550,1853,3254],"small":[552,4438,6912],"percentage":[553],"overlapping":[555,1657,2063],"hepatitis":[559,2968,5373,7556,7559],"(PSC\u2010AIH).":[560],"affects":[562],"both":[563,4704],"male":[564,1020,4322],"female":[566,3526],"individuals":[567,8064],"occur":[570,983,2056,3116,3982,4026,4162,4794,4807,5808,7355,7471],"age.":[573,4303],"an":[577,743,827,1178,1185,1192,1436,1442,1840,2112,2166,2242,2380,2394,2887,2976,3162,3235,3242,3448,3626,5056,6595,6615,6946,7132,7184,7291,7380,7406,7702,8037,8093,8186,8451,8919,9037,9267,9517,9593],"disease,":[579,1941,2493,5717,5907,6393,7425],"though":[580,5380,5789,7453,8764],"pathophysiology":[582],"remains":[583,2363,2789,3267,3631,3929,5144,5403,8804],"poorly":[584,5522],"understood.":[585],"results":[588,723,3843,7249,8297,8477],"damage,":[592]},"counts_by_year":[{"year":2026,"cited_by_count":172},{"year":2025,"cited_by_count":109},{"year":2024,"cited_by_count":90},{"year":2023,"cited_by_count":61},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}