{"id":"https://openalex.org/W4294991995","doi":"https://doi.org/10.1021/acsbiomaterials.2c00596","title":"Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway","display_name":"Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway","publication_year":2022,"publication_date":"2022-09-08","ids":{"openalex":"https://openalex.org/W4294991995","doi":"https://doi.org/10.1021/acsbiomaterials.2c00596","pmid":"https://pubmed.ncbi.nlm.nih.gov/36073984"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.2c00596","doi":"https://doi.org/10.1021/acsbiomaterials.2c00596","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.2c00596","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079151268","display_name":"Jiahe Guo","orcid":"https://orcid.org/0009-0008-8828-8155","observed_orcids":["https://orcid.org/0009-0008-8828-8155"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahe Guo","raw_affiliation_strings":["Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101672232","display_name":"Xiaofan Yang","orcid":"https://orcid.org/0000-0002-0997-0973","observed_orcids":["https://orcid.org/0000-0002-0997-0973"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofan Yang","raw_affiliation_strings":["Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394996","display_name":"Jing Chen","orcid":"https://orcid.org/0009-0004-4504-7782","observed_orcids":["https://orcid.org/0009-0004-4504-7782"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":["Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101603700","display_name":"Cheng Wang","orcid":"https://orcid.org/0000-0003-0548-7172","observed_orcids":["https://orcid.org/0000-0003-0548-7172"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Wang","raw_affiliation_strings":["Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624617","display_name":"Yu Kang","orcid":"https://orcid.org/0000-0002-0999-8802","observed_orcids":["https://orcid.org/0000-0002-0999-8802","https://orcid.org/0000-0002-8706-3252"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Kang","raw_affiliation_strings":["Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987356","display_name":"Tao Jiang","orcid":"https://orcid.org/0000-0001-8835-2905","observed_orcids":["https://orcid.org/0000-0001-8835-2905"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Jiang","raw_affiliation_strings":["Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337209","display_name":"Min Chen","orcid":"https://orcid.org/0000-0002-0960-4447","observed_orcids":["https://orcid.org/0000-0002-0960-4447","https://orcid.org/0009-0000-9066-8247","https://orcid.org/0009-0009-2371-5547","https://orcid.org/0000-0002-9478-105X","https://orcid.org/0009-0004-7529-010X"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Chen","raw_affiliation_strings":["Department of Hand and Foot Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518000, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518000, Guangdong, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621748","display_name":"Wenqing Li","orcid":"https://orcid.org/0000-0002-8336-5552","observed_orcids":["https://orcid.org/0000-0002-8336-5552","https://orcid.org/0009-0002-3470-4148"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenqing Li","raw_affiliation_strings":["Department of Hand and Foot Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518000, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hand and Foot Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518000, Guangdong, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025306901","display_name":"Chuchao Zhou","orcid":"https://orcid.org/0000-0002-4115-6277","observed_orcids":["https://orcid.org/0000-0002-4115-6277","https://orcid.org/0009-0005-7904-8465"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chuchao Zhou","raw_affiliation_strings":["Department of Plastic Surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042192237","display_name":"Zhenbing Chen","orcid":"https://orcid.org/0000-0003-2828-866X","observed_orcids":["https://orcid.org/0000-0003-2828-866X","https://orcid.org/0000-0002-9388-791X"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenbing Chen","raw_affiliation_strings":["Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":"https://orcid.org/0000-0003-2828-866X","affiliations":[{"raw_affiliation_string":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025306901","https://openalex.org/A5042192237"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122","https://openalex.org/I47720641"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9079,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.66412569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"8","issue":"10","first_page":"4524","last_page":"4534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12195","display_name":"Aerogels and thermal insulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astaxanthin","display_name":"astaxanthin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7509999871253967},{"id":"https://openalex.org/keywords/critical-sized-bone-defects","display_name":"critical-size bone defect","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nrf2-signaling-pathway","display_name":"Nrf2 signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/skull-defects","display_name":"cranial defects","score":0.6710000038146973},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.6430000066757202},{"id":"https://openalex.org/keywords/covalent-cross-linking","display_name":"covalent cross-linking","score":0.9150000214576721},{"id":"https://openalex.org/keywords/bone-grafting","display_name":"bone grafting","score":0.5270000100135803},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.763290286064148},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.6388664841651917},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5582094192504883},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5304920673370361},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5004880428314209},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4428645074367523},{"id":"https://openalex.org/C2780962900","wikidata":"https://www.wikidata.org/wiki/Q413740","display_name":"Astaxanthin","level":3,"score":0.42809027433395386},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4265476167201996},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.353521466255188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24727901816368103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12241190671920776},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07336071133613586},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024341","descriptor_name":"Xanthophylls","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsbiomaterials.2c00596","doi":"https://doi.org/10.1021/acsbiomaterials.2c00596","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.2c00596","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},{"id":"pmid:36073984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36073984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1615611532","display_name":null,"funder_award_id":"81772094","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G43503746","display_name":null,"funder_award_id":"81974289","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4374123699","display_name":null,"funder_award_id":"81901981","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6814076834","display_name":null,"funder_award_id":"2020BCB031","funder_id":"https://openalex.org/F4320330031","funder_display_name":"Science and Technology Department of Hubei Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320330031","display_name":"Science and Technology Department of Hubei Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1410919618","https://openalex.org/W1565527343","https://openalex.org/W1981549657","https://openalex.org/W2088789328","https://openalex.org/W2288587909","https://openalex.org/W2339310769","https://openalex.org/W2340338776","https://openalex.org/W2432130119","https://openalex.org/W2463100003","https://openalex.org/W2556322564","https://openalex.org/W2568405408","https://openalex.org/W2611844176","https://openalex.org/W2766387150","https://openalex.org/W2767054503","https://openalex.org/W2770411658","https://openalex.org/W2772903769","https://openalex.org/W2800126426","https://openalex.org/W2802266362","https://openalex.org/W2803073527","https://openalex.org/W2885341903","https://openalex.org/W2890125383","https://openalex.org/W2892361598","https://openalex.org/W2893267824","https://openalex.org/W2897677914","https://openalex.org/W2904747112","https://openalex.org/W2909489811","https://openalex.org/W2921040130","https://openalex.org/W2954760807","https://openalex.org/W2962823090","https://openalex.org/W2970086955","https://openalex.org/W2970172987","https://openalex.org/W2970641451","https://openalex.org/W3013637682","https://openalex.org/W3014702865","https://openalex.org/W3017263212","https://openalex.org/W3032045496","https://openalex.org/W3032793454","https://openalex.org/W3041018901","https://openalex.org/W3045513448","https://openalex.org/W3049585871","https://openalex.org/W3082092055","https://openalex.org/W3088120666","https://openalex.org/W3100448104","https://openalex.org/W3101118998","https://openalex.org/W3103886552","https://openalex.org/W3118825867","https://openalex.org/W3126793131","https://openalex.org/W3132010090","https://openalex.org/W3138359647","https://openalex.org/W3166081179","https://openalex.org/W3197482769","https://openalex.org/W3204098269","https://openalex.org/W3207631461","https://openalex.org/W3208370587","https://openalex.org/W3214011489"],"related_works":["https://openalex.org/W2970086955","https://openalex.org/W4413750991","https://openalex.org/W4401965504","https://openalex.org/W7117689433","https://openalex.org/W4409728997","https://openalex.org/W2789911988","https://openalex.org/W7208717911","https://openalex.org/W4393226380","https://openalex.org/W2912670545","https://openalex.org/W2803348105"],"abstract_inverted_index":{"Bone":[0],"regeneration":[1,131],"of":[2,32,68,156],"critical-sized":[3],"bone":[4,130,146,161],"defects":[5,118],"(CSBDs)":[6],"with":[7],"biomimetic":[8],"collagen-based":[9],"aerogels":[10,54,75,87,95,127,159],"remains":[11],"a":[12,60,144,153],"significant":[13],"challenge":[14],"due":[15,81],"to":[16,41,82],"the":[17,21,48,65,106,137],"oxidative":[18,25,134],"stress":[19,26,135],"on":[20],"microenvironment.":[22],"The":[23,72,85],"excessive":[24],"could":[27],"induce":[28],"apoptosis":[29],"and":[30,70,78,91,141],"dysfunction":[31],"host-derived":[33],"cells.":[34],"Astaxanthin":[35],"(ATX)":[36],"exhibits":[37],"excellent":[38,89,111],"antioxidant":[39,52,98,158],"ability":[40],"block":[42],"free":[43],"radical":[44],"chain":[45],"reactions.":[46],"In":[47],"present":[49],"study,":[50],"hybrid":[51],"collagen-derived":[53],"(ATX-Col":[55],"aerogels)":[56],"were":[57,119],"fabricated":[58],"by":[59,100,104,132],"simple":[61,154],"one-step":[62],"method":[63,155],"through":[64],"covalent":[66],"cross-linking":[67],"Col":[69],"ATX.":[71],"resulting":[73],"ATX-Col":[74,86,94,122,126],"show":[76],"porous":[77],"interconnected":[79],"structures":[80],"freeze-drying":[83],"strategies.":[84],"exhibited":[88],"biocompatibility":[90],"biosafety.":[92],"Furthermore,":[93],"demonstrated":[96],"favorable":[97],"capacity":[99],"eliminating":[101],"intracellular":[102],"ROS":[103],"activating":[105],"NRF2":[107,138],"signaling":[108,139],"pathway.":[109],"Finally,":[110],"reparative":[112],"effects":[113],"in":[114,121],"repairing":[115],"rat":[116],"cranial":[117],"observed":[120],"aerogels.":[123],"Taken":[124],"together,":[125],"can":[128],"accelerate":[129],"relieving":[133],"via":[136],"pathway":[140],"act":[142],"as":[143],"potential":[145],"graft":[147],"for":[148,160],"CSBD.":[149],"This":[150],"study":[151],"provides":[152],"developing":[157],"regeneration.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-09T00:00:00"}
