{"id":"https://openalex.org/W4294975643","doi":"https://doi.org/10.1109/embc48229.2022.9871312","title":"Nanoparticle Rigidity for Brain Tumor Cell Uptake","display_name":"Nanoparticle Rigidity for Brain Tumor Cell Uptake","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4294975643","doi":"https://doi.org/10.1109/embc48229.2022.9871312","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086372"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871312","doi":"https://doi.org/10.1109/embc48229.2022.9871312","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871312","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027701357","display_name":"Chung-Fan Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Fan Kuo","raw_affiliation_strings":["University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015450565","display_name":"Fereshtehsadat Mirab","orcid":"https://orcid.org/0000-0002-2178-3863","observed_orcids":["https://orcid.org/0000-0002-2178-3863"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fereshtehsadat Mirab","raw_affiliation_strings":["University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022864217","display_name":"Mohammad Reza Abidian","orcid":"https://orcid.org/0000-0001-5696-5379","observed_orcids":["https://orcid.org/0000-0001-5696-5379"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Reza Abidian","raw_affiliation_strings":["University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001224997","display_name":"Sheereen Majd","orcid":"https://orcid.org/0000-0002-3131-9845","observed_orcids":["https://orcid.org/0000-0002-3131-9845"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheereen Majd","raw_affiliation_strings":["University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Houston,Department of Biomedical Engineering,Houston,TX,USA,77204","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":2.8,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.89038462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2022","issue":null,"first_page":"3927","last_page":"3930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/pegda-hydrogel","display_name":"PEGDA hydrogel","score":0.75},{"id":"https://openalex.org/keywords/nanoliposomes","display_name":"nanoliposomes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.7652894258499146},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.6450668573379517},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6078904867172241},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.580715000629425},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5691624283790588},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.5145246386528015},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.47315916419029236},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45400452613830566},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.44384288787841797},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4356450140476227},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4314005374908447},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09690141677856445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc48229.2022.9871312","doi":"https://doi.org/10.1109/embc48229.2022.9871312","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871312","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G117781682","display_name":"CAREER:Membrane-Mimicking Nanomaterials with Tunable Elasticity for Selective and Efficient Intracellular Delivery","funder_award_id":"1753328","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2030574023","https://openalex.org/W2076226743","https://openalex.org/W2078057254","https://openalex.org/W2137925796","https://openalex.org/W2284054021","https://openalex.org/W2340662778","https://openalex.org/W2341984331","https://openalex.org/W2425447366","https://openalex.org/W2550788816","https://openalex.org/W2584466409","https://openalex.org/W2753425539","https://openalex.org/W2782175732","https://openalex.org/W2788153154","https://openalex.org/W2803361339","https://openalex.org/W2905651950","https://openalex.org/W2911912069","https://openalex.org/W2942110717","https://openalex.org/W2979665584","https://openalex.org/W2981632193","https://openalex.org/W3034059423","https://openalex.org/W3101861808"],"related_works":["https://openalex.org/W4292394445","https://openalex.org/W2137925796","https://openalex.org/W2963244720","https://openalex.org/W2977303171","https://openalex.org/W2884261370","https://openalex.org/W2782175732","https://openalex.org/W4409441134","https://openalex.org/W4415356788","https://openalex.org/W2788153154","https://openalex.org/W2120322972"],"abstract_inverted_index":{"Nanoparticles":[0],"(NPs)":[1],"have":[2,30,41],"emerged":[3],"as":[4,26,45,135],"versatile":[5],"and":[6,28,53,96,115,144,168,186,198,235],"widely":[7],"used":[8],"platforms":[9],"for":[10,49,263],"a":[11,46,104,121,160,194],"variety":[12],"of":[13,21,83,94,100,113,124,128,228,233,259],"biomedical":[14],"applications.":[15],"For":[16],"delivery":[17],"purposes,":[18],"while":[19],"some":[20],"NPs'":[22,43,61],"physiochemical":[23],"aspects":[24],"such":[25],"size":[27,162],"shape":[29],"been":[31],"extensively":[32],"studied,":[33],"their":[34,50,64,153],"mechanical":[35],"properties":[36],"remain":[37],"understudied.":[38],"Recent":[39],"studies":[40],"reported":[42],"rigidity":[44,62,248],"significant":[47,122],"factor":[48],"cell":[51,106],"interactions":[52,65],"uptake.":[54],"Here,":[55],"we":[56,77,218],"aim":[57],"to":[58,119,132,165,172,208,211],"study":[59,97],"how":[60,246],"affects":[63],"with":[66,74,110,193,213,230],"brain":[67,264],"glioma":[68,250],"tumor":[69,251],"cells.":[70],"To":[71],"produce":[72],"NPs":[73,102,158],"different":[75,84],"rigidities,":[76],"encapsulate":[78],"poly(ethylene":[79],"glycol)":[80],"diacrylate":[81],"(PEGDA)":[82],"volume":[85,111,237],"ratios":[86,112],"(0,":[87],"10,":[88],"30":[89,199],"v/v%)":[90],"within":[91],"the":[92,98,125,129,226],"lumen":[93],"nanoliposomes":[95],"uptake":[99,206,227],"these":[101],"in":[103,152],"glioblastoma":[105],"line":[107],"U87.":[108],"PEGDA":[109,231],"10":[114,234],"30%":[116,236],"were":[117],"selected":[118],"provide":[120],"increase":[123],"elastic":[126],"modulus":[127],"hydrogel":[130],"(0.1":[131],"4":[133],"MPa)":[134],"determined":[136],"by":[137],"compression":[138],"testing.":[139],"Dynamic":[140],"light":[141],"scattering":[142],"(DLS)":[143],"zeta":[145],"potential":[146],"measurements":[147],"indicated":[148],"that":[149,178,191],"despite":[150],"differences":[151],"core":[154,196,232],"formulation,":[155],"all":[156,179],"examined":[157],"had":[159,202],"similar":[161],"range":[163],"(106":[164],"132":[166],"nm)":[167],"surface":[169],"charge":[170],"(-2.0":[171],"-3.0":[173],"mV).":[174],"Confocal":[175],"microscopy":[176],"revealed":[177],"NP":[180,247],"groups":[181],"accumulated":[182],"inside":[183],"U87":[184],"cells,":[185],"flow":[187],"cytometry":[188],"data":[189],"showed":[190],"liposomes":[192,212,229],"gel":[195],"(10":[197],"v/v%":[200],"PEGDA)":[201],"significantly":[203],"higher":[204],"cellular":[205,252],"(up":[207],"9-fold),":[209],"compared":[210],"an":[214,243],"aqueous":[215],"core.":[216],"Notably,":[217],"did":[219],"not":[220],"find":[221],"any":[222],"substantial":[223],"difference":[224],"between":[225],"ratios.":[238],"Clinical":[239],"Relevance-":[240],"By":[241],"providing":[242],"insight":[244],"into":[245],"influences":[249],"uptake,":[253],"this":[254],"work":[255],"would":[256],"enable":[257],"development":[258],"more":[260],"effective":[261],"therapeutics":[262],"cancer.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-08T00:00:00"}