{"id":"https://openalex.org/W4294884772","doi":"https://doi.org/10.1016/j.fmre.2022.08.015","title":"Current AAV-mediated gene therapy in sensorineural hearing loss","display_name":"Current AAV-mediated gene therapy in sensorineural hearing loss","publication_year":2022,"publication_date":"2022-09-07","ids":{"openalex":"https://openalex.org/W4294884772","doi":"https://doi.org/10.1016/j.fmre.2022.08.015","pmid":"https://pubmed.ncbi.nlm.nih.gov/40166123","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11955060"},"language":"en","primary_location":{"id":"doi:10.1016/j.fmre.2022.08.015","doi":"https://doi.org/10.1016/j.fmre.2022.08.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fmre.2022.08.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667325822003569/pdf","source":{"id":"https://openalex.org/S4210177083","display_name":"Fundamental Research","issn_l":"2096-9457","issn":["2096-9457","2667-3258"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2667325822003569/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011079131","display_name":"Jieyu Qi","orcid":"https://orcid.org/0000-0001-8780-0710","observed_orcids":["https://orcid.org/0000-0001-8780-0710"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4210110108","display_name":"Aerospace Center Hospital","ror":"https://ror.org/01yb3sb52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110108"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jieyu Qi","raw_affiliation_strings":["Advanced Technology Research Institute, Beijing Institute of Technology, Jinan 250300, China","Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing 100081, China","State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","State Key Laboratory of Hearing and Balance Science, Beijing Institute of Technology, Beijing 100081, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Technology Research Institute, Beijing Institute of Technology, Jinan 250300, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing 100081, China","institution_ids":["https://openalex.org/I125839683","https://openalex.org/I4210110108"]},{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Hearing and Balance Science, Beijing Institute of Technology, Beijing 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015199363","display_name":"Xiaolong Fu","orcid":"https://orcid.org/0000-0002-3884-0916","observed_orcids":["https://orcid.org/0000-0002-3884-0916"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolong Fu","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":"https://orcid.org/0000-0002-3884-0916","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041015062","display_name":"Liyan Zhang","orcid":"https://orcid.org/0000-0002-1196-4476","observed_orcids":["https://orcid.org/0000-0002-1196-4476"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyan Zhang","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":"https://orcid.org/0000-0002-1196-4476","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018234790","display_name":"Fangzhi Tan","orcid":"https://orcid.org/0000-0002-8230-1784","observed_orcids":["https://orcid.org/0000-0002-8230-1784","https://orcid.org/0009-0007-2962-0552"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangzhi Tan","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053319843","display_name":"Nianci Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nianci Li","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091564109","display_name":"Qiuhan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuhan Sun","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026862189","display_name":"Xiaojie Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojie Hu","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079274583","display_name":"Zuhong He","orcid":"https://orcid.org/0000-0001-6409-4366","observed_orcids":["https://orcid.org/0000-0001-6409-4366","https://orcid.org/0009-0001-6973-5449"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zuhong He","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"],"raw_orcid":"https://orcid.org/0000-0001-6409-4366","affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103209748","display_name":"Ming Xia","orcid":"https://orcid.org/0000-0002-4634-7881","observed_orcids":["https://orcid.org/0000-0002-4634-7881"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Xia","raw_affiliation_strings":["Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China","Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250021, China"],"raw_orcid":"https://orcid.org/0000-0002-4634-7881","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250021, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053689452","display_name":"Renjie Chai","orcid":"https://orcid.org/0000-0002-3885-543X","observed_orcids":["https://orcid.org/0000-0002-3885-543X","https://orcid.org/0000-0002-4204-0305"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]},{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4210110108","display_name":"Aerospace Center Hospital","ror":"https://ror.org/01yb3sb52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110108"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]},{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Renjie Chai","raw_affiliation_strings":["Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China","Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing 100081, China","Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China","Southeast University Shenzhen Research Institute, Shenzhen 518063, China","State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing 100069, China","Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing 100101, China","State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China"],"raw_orcid":"https://orcid.org/0000-0002-3885-543X","affiliations":[{"raw_affiliation_string":"Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China","institution_ids":["https://openalex.org/I199305430"]},{"raw_affiliation_string":"Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing 100081, China","institution_ids":["https://openalex.org/I125839683","https://openalex.org/I4210110108"]},{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]},{"raw_affiliation_string":"Southeast University Shenzhen Research Institute, Shenzhen 518063, China","institution_ids":["https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5053689452","https://openalex.org/A5079274583","https://openalex.org/A5103209748"],"corresponding_institution_ids":["https://openalex.org/I125839683","https://openalex.org/I150229711","https://openalex.org/I183519381","https://openalex.org/I19820366","https://openalex.org/I199305430","https://openalex.org/I4210105806","https://openalex.org/I4210110108","https://openalex.org/I4210116517","https://openalex.org/I4210118397","https://openalex.org/I4210120234","https://openalex.org/I4210163399","https://openalex.org/I4387154005","https://openalex.org/I76569877"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.7524,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.53679654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"192","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.09560000151395798,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensorineural-hearing-loss","display_name":"sensorineural hearing loss","score":0.9599999785423279},{"id":"https://openalex.org/keywords/aav-gene-therapy","display_name":"AAV gene therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/recombinant-adeno-associated-virus","display_name":"recombinant adeno-associated virus","score":0.9440000057220459},{"id":"https://openalex.org/keywords/inner-ear-regeneration","display_name":"inner ear regeneration","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hair-cell-regeneration","display_name":"hair cell regeneration","score":0.9279999732971191},{"id":"https://openalex.org/keywords/stria-vascularis","display_name":"stria vascularis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/spiral-ganglion-neurons","display_name":"spiral ganglion neurons","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ototoxic-drugs","display_name":"ototoxic drugs","score":0.5529999732971191},{"id":"https://openalex.org/keywords/gene-therapy-safety","display_name":"gene therapy safety","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.6590786576271057},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5441282391548157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5250254273414612},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.514863133430481},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4865476191043854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3852825164794922},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2366245687007904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21564334630966187}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.fmre.2022.08.015","doi":"https://doi.org/10.1016/j.fmre.2022.08.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fmre.2022.08.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667325822003569/pdf","source":{"id":"https://openalex.org/S4210177083","display_name":"Fundamental Research","issn_l":"2096-9457","issn":["2096-9457","2667-3258"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:10769019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11955060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40166123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40166123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11955060","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11955060/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundam Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4eb91d1db26d467693e22f20d6618ece","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4eb91d1db26d467693e22f20d6618ece","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fundamental Research, Vol 5, Iss 1, Pp 192-202 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.fmre.2022.08.015","doi":"https://doi.org/10.1016/j.fmre.2022.08.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fmre.2022.08.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667325822003569/pdf","source":{"id":"https://openalex.org/S4210177083","display_name":"Fundamental Research","issn_l":"2096-9457","issn":["2096-9457","2667-3258"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1011270330","display_name":null,"funder_award_id":"2020YFA0113600","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G1144520724","display_name":null,"funder_award_id":"#82071013","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1880609003","display_name":null,"funder_award_id":"2020YFA0112503","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2083639890","display_name":null,"funder_award_id":"JCYJ20190814093401920","funder_id":"https://openalex.org/F4320329791","funder_display_name":"Shenzhen Fundamental Research Program"},{"id":"https://openalex.org/G2296957957","display_name":null,"funder_award_id":"XDA16010303","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G262236214","display_name":null,"funder_award_id":"(BE2019711)","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G288145952","display_name":null,"funder_award_id":"81900937","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3308117525","display_name":null,"funder_award_id":"SKLGE -2109","funder_id":"https://openalex.org/F4320321851","funder_display_name":"Fudan University"},{"id":"https://openalex.org/G3426172395","display_name":null,"funder_award_id":"2021YFS0371","funder_id":"https://openalex.org/F4320322922","funder_display_name":"Department of Science and Technology of Sichuan Province"},{"id":"https://openalex.org/G4210868709","display_name":null,"funder_award_id":"82030029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4832002281","display_name":null,"funder_award_id":"XDA16010303","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5037361530","display_name":null,"funder_award_id":"JCYJ20190814093401920","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5417391657","display_name":null,"funder_award_id":"2021YFA1101300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5591760066","display_name":null,"funder_award_id":"2021YFA1101300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6004314494","display_name":null,"funder_award_id":"JCYJ20210324125608022","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6630886690","display_name":null,"funder_award_id":"XDA16010303","funder_id":"https://openalex.org/F4320321851","funder_display_name":"Fudan University"},{"id":"https://openalex.org/G6911272103","display_name":null,"funder_award_id":"2021YFA1101300","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G6971596443","display_name":null,"funder_award_id":"XDA16010303","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6983853783","display_name":null,"funder_award_id":"2020YFA0112503","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G715276135","display_name":null,"funder_award_id":"XDA16010303","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G7640387804","display_name":null,"funder_award_id":"2020YFA0113600","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7814624945","display_name":null,"funder_award_id":"81970882","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7891576750","display_name":null,"funder_award_id":"2020M681468","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G8030255855","display_name":null,"funder_award_id":"BX20200082","funder_id":"https://openalex.org/F4320335768","funder_display_name":"National Postdoctoral Program for Innovative Talents"},{"id":"https://openalex.org/G8388929666","display_name":null,"funder_award_id":"82000984","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G960661552","display_name":null,"funder_award_id":"JCYJ20210324125608022","funder_id":"https://openalex.org/F4320329791","funder_display_name":"Shenzhen Fundamental Research Program"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322922","display_name":"Department of Science and Technology of Sichuan Province","ror":"https://ror.org/04323m874"},{"id":"https://openalex.org/F4320326863","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866"},{"id":"https://openalex.org/F4320329791","display_name":"Shenzhen Fundamental Research Program","ror":null},{"id":"https://openalex.org/F4320335768","display_name":"National Postdoctoral Program for Innovative Talents","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320336656","display_name":"Thousand Young Talents Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294884772.pdf","grobid_xml":"https://content.openalex.org/works/W4294884772.grobid-xml"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W108875151","https://openalex.org/W1153412892","https://openalex.org/W1197710820","https://openalex.org/W1518729035","https://openalex.org/W1527888432","https://openalex.org/W1540483167","https://openalex.org/W1582366477","https://openalex.org/W1636931877","https://openalex.org/W1809106246","https://openalex.org/W1851407914","https://openalex.org/W1861297144","https://openalex.org/W1955442975","https://openalex.org/W1964986281","https://openalex.org/W1965786463","https://openalex.org/W1965873234","https://openalex.org/W1967164346","https://openalex.org/W1971014753","https://openalex.org/W1974935915","https://openalex.org/W1986733224","https://openalex.org/W1991259792","https://openalex.org/W2001161154","https://openalex.org/W2001987761","https://openalex.org/W2001999470","https://openalex.org/W2007031191","https://openalex.org/W2008523038","https://openalex.org/W2020398834","https://openalex.org/W2020693400","https://openalex.org/W2021767455","https://openalex.org/W2022977561","https://openalex.org/W2027318031","https://openalex.org/W2034060287","https://openalex.org/W2037243367","https://openalex.org/W2037965284","https://openalex.org/W2042585863","https://openalex.org/W2045435533","https://openalex.org/W2045545250","https://openalex.org/W2046488302","https://openalex.org/W2051442157","https://openalex.org/W2053849856","https://openalex.org/W2055648999","https://openalex.org/W2056408540","https://openalex.org/W2056881013","https://openalex.org/W2061001357","https://openalex.org/W2061596706","https://openalex.org/W2063453347","https://openalex.org/W2064815984","https://openalex.org/W2067074806","https://openalex.org/W2072123447","https://openalex.org/W2073217307","https://openalex.org/W2080177691","https://openalex.org/W2083532596","https://openalex.org/W2088523571","https://openalex.org/W2090760184","https://openalex.org/W2105493567","https://openalex.org/W2113001708","https://openalex.org/W2114113677","https://openalex.org/W2118638606","https://openalex.org/W2119268652","https://openalex.org/W2121849645","https://openalex.org/W2133171074","https://openalex.org/W2137701107","https://openalex.org/W2141500911","https://openalex.org/W2142695353","https://openalex.org/W2149402050","https://openalex.org/W2149678280","https://openalex.org/W2151176501","https://openalex.org/W2162903822","https://openalex.org/W2173515145","https://openalex.org/W2210702367","https://openalex.org/W2256579886","https://openalex.org/W2317202809","https://openalex.org/W2326085105","https://openalex.org/W2326146355","https://openalex.org/W2406962855","https://openalex.org/W2473832992","https://openalex.org/W2502831104","https://openalex.org/W2508903105","https://openalex.org/W2512734535","https://openalex.org/W2560561766","https://openalex.org/W2570201053","https://openalex.org/W2580370883","https://openalex.org/W2586573214","https://openalex.org/W2586762515","https://openalex.org/W2605246466","https://openalex.org/W2606848380","https://openalex.org/W2606911774","https://openalex.org/W2708579841","https://openalex.org/W2736065260","https://openalex.org/W2746713428","https://openalex.org/W2756160303","https://openalex.org/W2761092054","https://openalex.org/W2762688646","https://openalex.org/W2765253110","https://openalex.org/W2768859750","https://openalex.org/W2778806019","https://openalex.org/W2786712411","https://openalex.org/W2787324996","https://openalex.org/W2792982593","https://openalex.org/W2806504837","https://openalex.org/W2807140244","https://openalex.org/W2860078943","https://openalex.org/W2894894185","https://openalex.org/W2900871300","https://openalex.org/W2902016625","https://openalex.org/W2904099718","https://openalex.org/W2912960404","https://openalex.org/W2913533437","https://openalex.org/W2915061779","https://openalex.org/W2916730093","https://openalex.org/W2916741137","https://openalex.org/W2953587283","https://openalex.org/W2958529757","https://openalex.org/W2961381744","https://openalex.org/W2969527757","https://openalex.org/W2972242704","https://openalex.org/W2977314311","https://openalex.org/W2979853077","https://openalex.org/W2996373122","https://openalex.org/W2999723488","https://openalex.org/W2999790225","https://openalex.org/W3000219265","https://openalex.org/W3004214582","https://openalex.org/W3004887743","https://openalex.org/W3008199088","https://openalex.org/W3011579630","https://openalex.org/W3032052376","https://openalex.org/W3047433752","https://openalex.org/W3102945151","https://openalex.org/W3105524336","https://openalex.org/W3106805315","https://openalex.org/W3117180466","https://openalex.org/W3133824813","https://openalex.org/W3135262744","https://openalex.org/W3138115672","https://openalex.org/W3147698886","https://openalex.org/W3165652155","https://openalex.org/W3176090684","https://openalex.org/W3178575673","https://openalex.org/W3184876927","https://openalex.org/W3195355685","https://openalex.org/W4200004342","https://openalex.org/W4220775758","https://openalex.org/W4220971806"],"related_works":["https://openalex.org/W2317520310","https://openalex.org/W2022724871","https://openalex.org/W3133696946","https://openalex.org/W3093716528","https://openalex.org/W4411498857","https://openalex.org/W4391172551","https://openalex.org/W2055560219","https://openalex.org/W7119495750","https://openalex.org/W2808058666","https://openalex.org/W4404895093"],"abstract_inverted_index":{"The":[0,47,205],"number":[1],"of":[2,45,49,61,92,132,163,198,214,225],"patients":[3],"with":[4],"hearing":[5,50,118,165,181,189,226],"loss":[6,31,51,119,182,190,227],"is":[7,32,56,99,108,191],"on":[8,43],"the":[9,53,64,96,130,159,209,223],"rise":[10],"due":[11],"to":[12,63,103,111,115,196],"congenital":[13],"abnormalities,":[14],"degenerative":[15],"changes":[16],"in":[17,52,95,126,158,177,222],"old":[18],"age,":[19],"and":[20,35,73,81,84,161,167,201,212],"acquired":[21],"injuries":[22],"such":[23],"as":[24,70,154],"virus":[25,170],"or":[26,89],"ototoxic":[27],"drug-induced":[28],"diseases.":[29,148],"Hearing":[30],"a":[33,122,140,155],"refractory":[34],"disabling":[36],"disease":[37],"that":[38],"has":[39,138,151,173],"serious":[40],"negative":[41],"effects":[42],"quality":[44],"life.":[46],"pathology":[48],"inner":[54,97],"ear":[55,98],"characterized":[57],"by":[58,120,218],"varying":[59],"degrees":[60],"damage":[62],"cochlear":[65],"sensory":[66],"epithelium":[67],"cells":[68,72,94,114],"(such":[69],"hair":[71,113],"supporting":[74],"cells),":[75],"stria":[76],"vascularis":[77],"(including":[78],"marginal,":[79],"intermediate":[80],"basal":[82],"cells)":[83],"spiral":[85],"ganglion":[86],"neurons.":[87],"Regeneration":[88],"direct":[90],"repair":[91],"damaged":[93],"an":[100],"effective":[101],"way":[102],"treat":[104,116],"sensorineural":[105,117,164],"deafness.":[106],"It":[107],"currently":[109],"possible":[110],"regenerate":[112],"FX-322,":[121],"small":[123],"molecule":[124],"drug":[125],"clinical":[127],"trials.":[128],"With":[129],"development":[131],"genetic":[133],"engineering":[134],"technology,":[135],"gene":[136,171,186,215],"therapy":[137,150,172,187,216],"brought":[139],"promising":[141,156],"treatment":[142,160],"strategy":[143],"for":[144,188],"many":[145],"previously":[146],"intractable":[147],"Gene":[149],"been":[152,174],"regarded":[153],"method":[157],"rehabilitation":[162],"loss,":[166],"recombinant":[168,219],"adeno-associated":[169,220],"widely":[175],"used":[176],"fundamental":[178],"research":[179],"into":[180],"treatments.":[183],"At":[184],"present,":[185],"transitioning":[192],"from":[193],"feasibility":[194],"studies":[195],"explorations":[197],"its":[199,202],"safety":[200],"therapeutic":[203],"potential.":[204],"present":[206],"article":[207],"reviews":[208],"concepts,":[210],"strategies,":[211],"applications":[213],"mediated":[217],"viruses":[221],"field":[224],"treatment.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-07T00:00:00"}