{"id":"https://openalex.org/W4294876529","doi":"https://doi.org/10.1038/s41598-022-19576-9","title":"Untargeted ultra-high-resolution mass spectrometry metabolomic profiling of blood serum in bladder cancer","display_name":"Untargeted ultra-high-resolution mass spectrometry metabolomic profiling of blood serum in bladder cancer","publication_year":2022,"publication_date":"2022-09-07","ids":{"openalex":"https://openalex.org/W4294876529","doi":"https://doi.org/10.1038/s41598-022-19576-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/36071106","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9452537"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-19576-9","doi":"https://doi.org/10.1038/s41598-022-19576-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-19576-9","pdf_url":"https://www.nature.com/articles/s41598-022-19576-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-19576-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026900150","display_name":"Joanna Nizio\u0142","orcid":"https://orcid.org/0000-0002-4783-8615","observed_orcids":["https://orcid.org/0000-0002-4783-8615"]},"institutions":[{"id":"https://openalex.org/I111664937","display_name":"Rzesz\u00f3w University of Technology","ror":"https://ror.org/056xse072","country_code":"PL","type":"education","lineage":["https://openalex.org/I111664937"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Joanna Nizio\u0142","raw_affiliation_strings":["Faculty of Chemistry, Rzesz\u00f3w University of Technology, 6 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland. jniziol@prz.edu.pl","Faculty of Chemistry, Rzesz\u00f3w University of Technology, 6 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Rzesz\u00f3w University of Technology, 6 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland. jniziol@prz.edu.pl","institution_ids":["https://openalex.org/I111664937"]},{"raw_affiliation_string":"Faculty of Chemistry, Rzesz\u00f3w University of Technology, 6 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland","institution_ids":["https://openalex.org/I111664937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039436537","display_name":"Krzysztof Ossoli\u0144ski","orcid":"https://orcid.org/0000-0002-2650-8326","observed_orcids":["https://orcid.org/0000-0002-2650-8326"]},"institutions":[{"id":"https://openalex.org/I4210102835","display_name":"John Paul II Hospital","ror":"https://ror.org/01apd5369","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210102835"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof Ossoli\u0144ski","raw_affiliation_strings":["Department of Urology, John Paul II Hospital, Grunwaldzka 4 St., 36-100, Kolbuszowa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, John Paul II Hospital, Grunwaldzka 4 St., 36-100, Kolbuszowa, Poland","institution_ids":["https://openalex.org/I4210102835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020000384","display_name":"Aneta P\u0142aza\u2010Altamer","orcid":"https://orcid.org/0000-0003-1719-8730","observed_orcids":["https://orcid.org/0000-0003-1719-8730"]},"institutions":[{"id":"https://openalex.org/I111664937","display_name":"Rzesz\u00f3w University of Technology","ror":"https://ror.org/056xse072","country_code":"PL","type":"education","lineage":["https://openalex.org/I111664937"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aneta P\u0142aza-Altamer","raw_affiliation_strings":["Doctoral School of Engineering and Technical Sciences at the Rzesz\u00f3w University of Technology, 8 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral School of Engineering and Technical Sciences at the Rzesz\u00f3w University of Technology, 8 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland","institution_ids":["https://openalex.org/I111664937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079121346","display_name":"Artur Ko\u0142odziej","orcid":"https://orcid.org/0000-0002-9222-0937","observed_orcids":["https://orcid.org/0000-0002-9222-0937"]},"institutions":[{"id":"https://openalex.org/I111664937","display_name":"Rzesz\u00f3w University of Technology","ror":"https://ror.org/056xse072","country_code":"PL","type":"education","lineage":["https://openalex.org/I111664937"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Artur Ko\u0142odziej","raw_affiliation_strings":["Doctoral School of Engineering and Technical Sciences at the Rzesz\u00f3w University of Technology, 8 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral School of Engineering and Technical Sciences at the Rzesz\u00f3w University of Technology, 8 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland","institution_ids":["https://openalex.org/I111664937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074029776","display_name":"Anna Ossoli\u0144ska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102835","display_name":"John Paul II Hospital","ror":"https://ror.org/01apd5369","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210102835"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Ossoli\u0144ska","raw_affiliation_strings":["Department of Urology, John Paul II Hospital, Grunwaldzka 4 St., 36-100, Kolbuszowa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, John Paul II Hospital, Grunwaldzka 4 St., 36-100, Kolbuszowa, Poland","institution_ids":["https://openalex.org/I4210102835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086387218","display_name":"Tadeusz Ossoli\u0144ski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102835","display_name":"John Paul II Hospital","ror":"https://ror.org/01apd5369","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210102835"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tadeusz Ossoli\u0144ski","raw_affiliation_strings":["Department of Urology, John Paul II Hospital, Grunwaldzka 4 St., 36-100, Kolbuszowa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, John Paul II Hospital, Grunwaldzka 4 St., 36-100, Kolbuszowa, Poland","institution_ids":["https://openalex.org/I4210102835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081403998","display_name":"Tomasz Ruman","orcid":"https://orcid.org/0000-0002-9899-8627","observed_orcids":["https://orcid.org/0000-0002-9899-8627"]},"institutions":[{"id":"https://openalex.org/I111664937","display_name":"Rzesz\u00f3w University of Technology","ror":"https://ror.org/056xse072","country_code":"PL","type":"education","lineage":["https://openalex.org/I111664937"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Ruman","raw_affiliation_strings":["Faculty of Chemistry, Rzesz\u00f3w University of Technology, 6 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Rzesz\u00f3w University of Technology, 6 Powsta\u0144c\u00f3w Warszawy Ave., 35-959, Rzeszow, Poland","institution_ids":["https://openalex.org/I111664937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026900150"],"corresponding_institution_ids":["https://openalex.org/I111664937"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":1.8383,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.8678166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"15156","last_page":"15156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":1.0},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.7580000162124634},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5509999990463257},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.4429999887943268},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8799999952316284},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6940000057220459},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7033417820930481},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6549962162971497},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5529763102531433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3787478804588318},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35642874240875244},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32311975955963135},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.316828191280365},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2637636661529541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24686849117279053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2071099579334259}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044967","descriptor_name":"Serum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-022-19576-9","doi":"https://doi.org/10.1038/s41598-022-19576-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-19576-9","pdf_url":"https://www.nature.com/articles/s41598-022-19576-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1750599/v1","doi":"https://doi.org/10.21203/rs.3.rs-1750599/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1750599/v1","pdf_url":"https://www.researchsquare.com/article/rs-1750599/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9452537","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9452537","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:36071106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36071106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cff1796d372745448ae908543c061547","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cff1796d372745448ae908543c061547","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-19576-9","doi":"https://doi.org/10.1038/s41598-022-19576-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-19576-9","pdf_url":"https://www.nature.com/articles/s41598-022-19576-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6229966190","display_name":null,"funder_award_id":"UMO-2018/31/D/ST4/00109","funder_id":"https://openalex.org/F4320322650","funder_display_name":"Narodowym Centrum Nauki"}],"funders":[{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294876529.pdf","grobid_xml":"https://content.openalex.org/works/W4294876529.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1981103217","https://openalex.org/W1986057581","https://openalex.org/W2003451170","https://openalex.org/W2020540026","https://openalex.org/W2023291765","https://openalex.org/W2034420332","https://openalex.org/W2048953066","https://openalex.org/W2058859313","https://openalex.org/W2069334493","https://openalex.org/W2073539742","https://openalex.org/W2075373098","https://openalex.org/W2101465480","https://openalex.org/W2131004665","https://openalex.org/W2135435176","https://openalex.org/W2143777550","https://openalex.org/W2165517686","https://openalex.org/W2166903871","https://openalex.org/W2167162818","https://openalex.org/W2218177556","https://openalex.org/W2258988863","https://openalex.org/W2505562507","https://openalex.org/W2516506539","https://openalex.org/W2580767461","https://openalex.org/W2586634784","https://openalex.org/W2604245363","https://openalex.org/W2604528722","https://openalex.org/W2605206457","https://openalex.org/W2606757876","https://openalex.org/W2742148207","https://openalex.org/W2761840475","https://openalex.org/W2778763552","https://openalex.org/W2779095753","https://openalex.org/W2793750934","https://openalex.org/W2799539744","https://openalex.org/W2907510504","https://openalex.org/W2910700916","https://openalex.org/W2917267891","https://openalex.org/W2938861144","https://openalex.org/W2939465166","https://openalex.org/W2988486502","https://openalex.org/W2998542657","https://openalex.org/W3000043013","https://openalex.org/W3003337459","https://openalex.org/W3006740918","https://openalex.org/W3023149146","https://openalex.org/W3025473344","https://openalex.org/W3028284515","https://openalex.org/W3082821198","https://openalex.org/W3084189254","https://openalex.org/W3106102469","https://openalex.org/W3128646645","https://openalex.org/W3133959030","https://openalex.org/W3137204325","https://openalex.org/W3159995035","https://openalex.org/W3215022912","https://openalex.org/W7027551224"],"related_works":["https://openalex.org/W4380992181","https://openalex.org/W2605206457","https://openalex.org/W4323044998","https://openalex.org/W4294192411","https://openalex.org/W2034420332","https://openalex.org/W2944479599","https://openalex.org/W7038189272","https://openalex.org/W4390661982","https://openalex.org/W4214689009","https://openalex.org/W4377246672"],"abstract_inverted_index":{"Bladder":[0],"cancer":[1,7,181],"(BC)":[2],"is":[3,16,46],"a":[4],"common":[5],"urological":[6],"of":[8,29,59,81,116,143,158,165,179],"high":[9],"mortality":[10],"and":[11,24,34,98,127,141,146,172,182],"recurrence":[12,28],"rates.":[13],"Currently,":[14],"cystoscopy":[15],"performed":[17],"as":[18],"standard":[19],"examination":[20],"for":[21,27,50,77,177],"the":[22,30,57],"diagnosis":[23],"subsequent":[25],"monitoring":[26],"patients.":[31],"Frequent":[32],"expensive":[33],"invasive":[35,174],"procedures":[36],"may":[37,168],"deterrent":[38],"patients":[39,112,145],"from":[40,93,113],"regular":[41],"follow-up":[42],"screening,":[43],"therefore":[44],"it":[45],"important":[47],"to":[48,54,86,136,153],"look":[49],"new":[51],"non-invasive":[52],"methods":[53],"aid":[55],"in":[56,123],"detection":[58,178],"recurrent":[60,183],"and/or":[61],"primary":[62],"BC.":[63,159],"In":[64],"this":[65],"study,":[66],"ultra-high-performance":[67],"liquid":[68],"chromatography":[69],"coupled":[70],"with":[71,102],"ultra-high-resolution":[72],"mass":[73],"spectrometry":[74],"was":[75],"employed":[76],"non-targeted":[78],"metabolomic":[79],"profiling":[80],"200":[82],"human":[83],"serum":[84,131,149,166],"samples":[85],"identify":[87],"biochemical":[88],"signatures":[89],"that":[90,108,163],"differentiate":[91,109,154],"BC":[92,111,144],"non-cancer":[94],"controls":[95],"(NCs).":[96],"Univariate":[97],"multivariate":[99],"statistical":[100],"analyses":[101],"external":[103],"validation":[104,128],"revealed":[105],"twenty-seven":[106],"metabolites":[107,118,132,150,167],"between":[110,139,155],"NCs.":[114],"Abundances":[115],"these":[117],"displayed":[119],"statistically":[120],"significant":[121],"differences":[122],"two":[124],"independent":[125],"training":[126],"sets.":[129],"Twenty-three":[130],"were":[133,151],"also":[134],"found":[135,152],"be":[137],"distinguishing":[138],"low-":[140],"high-grade":[142],"controls.":[147],"Thirty-seven":[148],"different":[156],"stages":[157],"The":[160],"results":[161],"suggest":[162],"measurement":[164],"provide":[169],"more":[170],"facile":[171],"less":[173],"diagnostic":[175],"methodology":[176],"bladder":[180],"disease":[184],"management.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-09-07T00:00:00"}