{"id":"https://openalex.org/W4294875681","doi":"https://doi.org/10.1038/s41585-022-00642-w","title":"Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction","display_name":"Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction","publication_year":2022,"publication_date":"2022-09-07","ids":{"openalex":"https://openalex.org/W4294875681","doi":"https://doi.org/10.1038/s41585-022-00642-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/36071153","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9842101"},"language":"en","primary_location":{"id":"doi:10.1038/s41585-022-00642-w","doi":"https://doi.org/10.1038/s41585-022-00642-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41585-022-00642-w","pdf_url":null,"source":{"id":"https://openalex.org/S67216020","display_name":"Nature Reviews Urology","issn_l":"1759-4812","issn":["1759-4812","1759-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Urology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9842101","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039368770","display_name":"Lori Ann Birder","orcid":"https://orcid.org/0000-0002-3393-2256","observed_orcids":["https://orcid.org/0000-0002-3393-2256"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lori A. Birder","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. lbirder@pitt.edu","Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. lbirder@pitt.edu","Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. lbirder@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. lbirder@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005780035","display_name":"Edwin Kerry Jackson","orcid":"https://orcid.org/0000-0002-8101-6009","observed_orcids":["https://orcid.org/0000-0002-8101-6009"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin K. Jackson","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039368770"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.4681,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.44385027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"19","issue":"11","first_page":"681","last_page":"687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purine-nucleoside-phosphorylase","display_name":"purine nucleoside phosphorylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lower-urinary-tract-dysfunction","display_name":"lower urinary tract dysfunction","score":0.9850000143051147},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.7979999780654907},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6499999761581421},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.47099998593330383},{"id":"https://openalex.org/keywords/bladder-function","display_name":"bladder function","score":0.34200000762939453},{"id":"https://openalex.org/keywords/voiding-dysfunction","display_name":"voiding dysfunction","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71615608","wikidata":"https://www.wikidata.org/wiki/Q24720082","display_name":"Purine nucleoside phosphorylase","level":4,"score":0.8997344970703125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7242947220802307},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6951100826263428},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.6036799550056458},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.5389832258224487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46090778708457947},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3813239634037018},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18068647384643555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13560345768928528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1261293888092041}],"mesh":[{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014521","descriptor_name":"Urethra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014554","descriptor_name":"Urination","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014570","descriptor_name":"Urologic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41585-022-00642-w","doi":"https://doi.org/10.1038/s41585-022-00642-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41585-022-00642-w","pdf_url":null,"source":{"id":"https://openalex.org/S67216020","display_name":"Nature Reviews Urology","issn_l":"1759-4812","issn":["1759-4812","1759-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Urology","raw_type":"journal-article"},{"id":"pmid:36071153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36071153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Urology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9842101","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9842101","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Urol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9842101","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9842101","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Urol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7407417088","display_name":"Bladder Mucosal Dysfunction During Aging","funder_award_id":"R01AG056944","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7582243716","display_name":"Pittsburgh Center for Kidney Research","funder_award_id":"P30DK079307","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W133351311","https://openalex.org/W1523213544","https://openalex.org/W1585934435","https://openalex.org/W1598157062","https://openalex.org/W1827056541","https://openalex.org/W1964370987","https://openalex.org/W1972098832","https://openalex.org/W1975481055","https://openalex.org/W1984638737","https://openalex.org/W1986066202","https://openalex.org/W1986949112","https://openalex.org/W1987396298","https://openalex.org/W2006732267","https://openalex.org/W2016789150","https://openalex.org/W2027364591","https://openalex.org/W2030358013","https://openalex.org/W2034862605","https://openalex.org/W2036788528","https://openalex.org/W2037062407","https://openalex.org/W2040391628","https://openalex.org/W2041628769","https://openalex.org/W2046378591","https://openalex.org/W2049450990","https://openalex.org/W2050263292","https://openalex.org/W2056584490","https://openalex.org/W2058158200","https://openalex.org/W2061426837","https://openalex.org/W2064977054","https://openalex.org/W2069519394","https://openalex.org/W2072184602","https://openalex.org/W2072754530","https://openalex.org/W2075323044","https://openalex.org/W2085621010","https://openalex.org/W2087613565","https://openalex.org/W2088372949","https://openalex.org/W2092281480","https://openalex.org/W2102121050","https://openalex.org/W2107060734","https://openalex.org/W2111342463","https://openalex.org/W2115659532","https://openalex.org/W2133580420","https://openalex.org/W2136499248","https://openalex.org/W2143307859","https://openalex.org/W2147551208","https://openalex.org/W2147933097","https://openalex.org/W2165040339","https://openalex.org/W2182801338","https://openalex.org/W2186978764","https://openalex.org/W2193792657","https://openalex.org/W2264164601","https://openalex.org/W2292028295","https://openalex.org/W2325707043","https://openalex.org/W2329218732","https://openalex.org/W2408044732","https://openalex.org/W2410691357","https://openalex.org/W2461769126","https://openalex.org/W2508478749","https://openalex.org/W2517386463","https://openalex.org/W2526464146","https://openalex.org/W2554805821","https://openalex.org/W2601394082","https://openalex.org/W2607413868","https://openalex.org/W2609514370","https://openalex.org/W2612366643","https://openalex.org/W2754814296","https://openalex.org/W2796215289","https://openalex.org/W2808036417","https://openalex.org/W2898602369","https://openalex.org/W2901806837","https://openalex.org/W2972049083","https://openalex.org/W2973210821","https://openalex.org/W2995591996","https://openalex.org/W3006075601","https://openalex.org/W3013061397","https://openalex.org/W3039060987","https://openalex.org/W3081974143","https://openalex.org/W3085304909","https://openalex.org/W3092909568","https://openalex.org/W3125249206","https://openalex.org/W3158797192","https://openalex.org/W3166450549","https://openalex.org/W4206179082"],"related_works":["https://openalex.org/W3085304909","https://openalex.org/W3201831722","https://openalex.org/W2795694100","https://openalex.org/W2796140899","https://openalex.org/W4405961360","https://openalex.org/W381379603","https://openalex.org/W4387115717","https://openalex.org/W4403348121","https://openalex.org/W4246473650","https://openalex.org/W7141445611"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-07T00:00:00"}