{"id":"https://openalex.org/W4294861071","doi":"https://doi.org/10.1177/1934578x221124752","title":"Berberine Promotes A549 Cell Apoptosis and Autophagy via miR-144","display_name":"Berberine Promotes A549 Cell Apoptosis and Autophagy via miR-144","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4294861071","doi":"https://doi.org/10.1177/1934578x221124752"},"language":"en","primary_location":{"id":"doi:10.1177/1934578x221124752","doi":"https://doi.org/10.1177/1934578x221124752","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x221124752","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/1934578x221124752","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086141193","display_name":"Zhiyan Gao","orcid":"https://orcid.org/0000-0002-0014-4827","observed_orcids":["https://orcid.org/0000-0002-0014-4827"]},"institutions":[{"id":"https://openalex.org/I4210121023","display_name":"Chifeng Municipal Hospital","ror":"https://ror.org/02j136k79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121023"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyan Gao","raw_affiliation_strings":["Department of Oncology, Chifeng Hospital, Chifeng, Inner Mongolia, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Chifeng Hospital, Chifeng, Inner Mongolia, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210121023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101009562","display_name":"Chang Tan","orcid":"https://orcid.org/0000-0001-7564-2946","observed_orcids":["https://orcid.org/0000-0001-7564-2946"]},"institutions":[{"id":"https://openalex.org/I4210121023","display_name":"Chifeng Municipal Hospital","ror":"https://ror.org/02j136k79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121023"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Tan","raw_affiliation_strings":["Department of Oncology, Chifeng Hospital, Chifeng, Inner Mongolia, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Chifeng Hospital, Chifeng, Inner Mongolia, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210121023"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077553630","display_name":"Rula Sha","orcid":"https://orcid.org/0000-0002-6014-7253","observed_orcids":["https://orcid.org/0000-0002-6014-7253"]},"institutions":[{"id":"https://openalex.org/I4210124900","display_name":"Inner Mongolia People's Hospital","ror":"https://ror.org/02yng3249","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rula Sha","raw_affiliation_strings":["Department of Oncology, Inner Mongolia Peoples\u2019 Hospital, Inner Mongolia, Hohhot, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-6014-7253","affiliations":[{"raw_affiliation_string":"Department of Oncology, Inner Mongolia Peoples\u2019 Hospital, Inner Mongolia, Hohhot, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210124900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077553630"],"corresponding_institution_ids":["https://openalex.org/I4210124900"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.6495,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62761589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":1.0},{"id":"https://openalex.org/keywords/mir-144","display_name":"miR-144","score":0.984000027179718},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":1.0},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.977125883102417},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8973119258880615},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.8069052696228027},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7916716933250427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6215866804122925},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5630140900611877},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.49332156777381897},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4716217815876007},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45288941264152527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2388317883014679},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1539609134197235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06325286626815796}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/1934578x221124752","doi":"https://doi.org/10.1177/1934578x221124752","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x221124752","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:43fcded5b96a46dbb33af5544c903375","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/43fcded5b96a46dbb33af5544c903375","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Natural Product Communications, Vol 17 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1934578x221124752","doi":"https://doi.org/10.1177/1934578x221124752","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x221124752","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2064039900","https://openalex.org/W2611455529","https://openalex.org/W3005943623","https://openalex.org/W3006935204","https://openalex.org/W3048609107","https://openalex.org/W3049631170","https://openalex.org/W3082704790","https://openalex.org/W3093260119","https://openalex.org/W3093463010","https://openalex.org/W3109478076","https://openalex.org/W3112791591","https://openalex.org/W3112875074","https://openalex.org/W3114793470","https://openalex.org/W3116385138","https://openalex.org/W3118938693","https://openalex.org/W3119431140","https://openalex.org/W3121857335","https://openalex.org/W3123085107","https://openalex.org/W3125816695","https://openalex.org/W4241507163"],"related_works":["https://openalex.org/W3039595177","https://openalex.org/W2074310251","https://openalex.org/W2746017311","https://openalex.org/W2064039900","https://openalex.org/W2894527134","https://openalex.org/W2584048291","https://openalex.org/W2021011812","https://openalex.org/W4286212700","https://openalex.org/W3031651985","https://openalex.org/W1989028419"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"explore":[2],"the":[3,19,101],"effects":[4],"of":[5,35,103],"berberine":[6,61],"on":[7],"A549":[8,55,67,80,97,111],"lung":[9],"cancer":[10],"cells":[11],"and":[12,18,21,47,71,87,90,106,113],"corresponding":[13],"changes":[14],"in":[15],"miR-144":[16,36,76],"expression,":[17],"apoptosis":[20,70,82,112],"autophagy":[22,98,114],"pathways.":[23],"Methods:":[24],"Cell":[25],"proliferation":[26,56,68],"was":[27,57],"detected":[28],"by":[29,37,83,99],"cell":[30,81],"counting":[31],"Kit-8.":[32],"The":[33],"expression":[34,89,102],"quantitative":[38],"PCR,":[39],"caspase-3,":[40],"caspase-3":[41,85],"cleaved,":[42],"Bcl-2,":[43],"Bax,":[44],"beclin-1,":[45,104],"LC3I,":[46,105],"LC3II":[48],"were":[49],"assessed":[50],"using":[51],"Western":[52],"blot.":[53],"Results:":[54],"reduced":[58],"with":[59],"increasing":[60],"concentration.":[62],"Berberine":[63,78,94,109],"appeared":[64],"to":[65],"suppress":[66],"through":[69],"autophagy,":[72],"and,":[73],"additionally,":[74],"enhanced":[75],"expression.":[77,93],"promoted":[79,96],"inhibiting":[84],"cleavage":[86],"Bcl-2":[88],"promoting":[91],"Bax":[92],"also":[95],"raising":[100],"LC3II.":[107],"Conclusions:":[108],"promotes":[110],"via":[115],"miR-144.":[116]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-07T00:00:00"}
