{"id":"https://openalex.org/W4294844282","doi":"https://doi.org/10.1249/01.mss.0000877080.67155.af","title":"Early Muscle Gene Expression Changes With Eccentric Exercise Uniquely Associated With Peak Strength Loss","display_name":"Early Muscle Gene Expression Changes With Eccentric Exercise Uniquely Associated With Peak Strength Loss","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4294844282","doi":"https://doi.org/10.1249/01.mss.0000877080.67155.af"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000877080.67155.af","doi":"https://doi.org/10.1249/01.mss.0000877080.67155.af","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000877080.67155.af","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020771852","display_name":"Dakota Tiede","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dakota Tiede","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068225719","display_name":"Michael R. Deyhle","orcid":"https://orcid.org/0000-0001-8526-4758","observed_orcids":["https://orcid.org/0000-0001-8526-4758"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Deyhle","raw_affiliation_strings":["The University of New Mexico, Albuquerque, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of New Mexico, Albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Carey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Carey","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Xin","raw_affiliation_strings":["The University of Mississippi, Oxford, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Mississippi, Oxford, MS","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033326925","display_name":"Robert D. Hyldahl","orcid":"https://orcid.org/0000-0003-4961-1868","observed_orcids":["https://orcid.org/0000-0003-4961-1868"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Hyldahl","raw_affiliation_strings":["Brigham Young University, Provo, UT. (Sponsor: Monica J. Hubal, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham Young University, Provo, UT. (Sponsor: Monica J. Hubal, FACSM)","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021612557","display_name":"Monica J. Hubal","orcid":"https://orcid.org/0000-0001-6579-6036","observed_orcids":["https://orcid.org/0000-0001-6579-6036"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica J. Hubal","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IN","Brigham Young University, Provo, UT. (Sponsor: Monica J. Hubal, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Brigham Young University, Provo, UT. (Sponsor: Monica J. Hubal, FACSM)","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"9S","first_page":"163","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10157","display_name":"Sports Performance and Training","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eccentric-exercise","display_name":"eccentric exercise","score":0.9900000095367432},{"id":"https://openalex.org/keywords/exercise-induced-muscle-damage","display_name":"exercise-induced muscle damage","score":0.9639999866485596},{"id":"https://openalex.org/keywords/muscle-gene-expression","display_name":"muscle gene expression","score":0.8640000224113464},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glutamate-receptor-signaling","display_name":"glutamate receptor signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/serotonin-receptor-signaling","display_name":"serotonin receptor signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neurotransmitter-pathways","display_name":"neurotransmitter pathways","score":0.722000002861023},{"id":"https://openalex.org/keywords/muscle-dysfunction","display_name":"muscle dysfunction","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.7502961158752441},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5728824138641357},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.5463082194328308},{"id":"https://openalex.org/C100784341","wikidata":"https://www.wikidata.org/wiki/Q1340491","display_name":"Eccentric","level":2,"score":0.5318723917007446},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.49495548009872437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46000105142593384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3928612470626831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3868473768234253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36115482449531555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20111620426177979},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000877080.67155.af","doi":"https://doi.org/10.1249/01.mss.0000877080.67155.af","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000877080.67155.af","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387052665","https://openalex.org/W4391383790","https://openalex.org/W3181976268","https://openalex.org/W2064816134","https://openalex.org/W2109909780","https://openalex.org/W2947082630","https://openalex.org/W2047422629","https://openalex.org/W2097747474","https://openalex.org/W4391986372","https://openalex.org/W1980042529"],"abstract_inverted_index":{"PURPOSE:":[0],"Novel":[1],"eccentric":[2,70],"(ECC)":[3,71],"exercise":[4,66],"typically":[5],"leads":[6],"to":[7,37,104,155,179,191,193,207,275,285,314,324],"strength":[8,42,85,133,145,170,195,209,222,279,309],"loss":[9,43,134,146,171,310],"that":[10,136,283],"persists":[11],"for":[12,25],"several":[13,292],"days":[14],"after":[15],"exercise,":[16],"which":[17],"varies":[18],"widely":[19],"between":[20,127],"subjects.":[21],"The":[22,117],"mechanisms":[23],"responsible":[24],"this":[26],"variation":[27,276],"are":[28],"poorly":[29],"understood.":[30],"Here,":[31],"we":[32,263],"identified":[33],"biological":[34],"processes":[35],"related":[36,272],"the":[38,87,99,111,125,286],"extent":[39,287],"of":[40,86,124,177,258,288,308],"peak":[41,132,144,194,208,221,278],"via":[44],"global":[45,106],"gene":[46,107,128,150,269],"expression":[47,108,129,151,270],"profiling.":[48],"METHODS:":[49],"In":[50,255],"a":[51,81,93,121,175,256],"previously":[52],"published":[53],"study,":[54],"vastus":[55],"lateralis":[56],"biopsies":[57],"were":[58,162,202],"collected":[59],"from":[60,135],"35":[61],"young":[62],"men":[63],"3hr":[64],"post-ECC":[65,147],"(100":[67],"maximal":[68],"voluntary":[69],"actions":[72],"on":[73,92,110],"isokinetic":[74],"dynamometer,":[75],"non-exercised":[76],"contralateral":[77],"leg":[78],"(CON)":[79],"as":[80,295,297,302],"control).":[82],"Maximal":[83],"isometric":[84],"knee":[88],"extensors":[89],"was":[90,102],"assessed":[91,264],"Biodex":[94],"dynamometer.":[95],"RNA":[96],"isolated":[97],"using":[98,164],"TRIzol":[100],"method":[101],"used":[103],"generate":[105],"profiles":[109],"Agilent":[112],"Whole":[113],"Genome":[114],"Microarray":[115],"platform.":[116],"current":[118],"study":[119,138],"is":[120],"retrospective":[122],"analysis":[123,213],"relationship":[126],"changes":[130,266,274],"and":[131,199,204,246,271,318],"previous":[137],"(GSE23697).":[139],"Partek":[140],"Genomics":[141],"Suite":[142],"correlated":[143,206],"(0-5d)":[148],"with":[149,174,220],"in":[152,267,277,321],"ECC":[153,189],"relative":[154],"intra-subject":[156],"paired":[157],"CON.":[158],"Correlated":[159],"genes":[160,186,201],"(p<0.05)":[161,187,218],"analyzed":[163],"Ingenuity":[165],"Pathway":[166,212],"Analysis.":[167],"RESULTS:":[168],"Peak":[169],"averaged":[172],"50.7\u00b120.1%":[173],"range":[176],"9.7%":[178],"96.0%.":[180],"Pearson":[181],"linear":[182],"correlation":[183],"detected":[184],"2333":[185],"relating":[188],"(relative":[190],"CON)":[192],"loss,":[196,210,223],"where":[197],"2201":[198],"132":[200],"positively":[203],"negatively":[205],"respectively.":[211],"found":[214],"37":[215],"canonical":[216],"pathways":[217,282,300],"associated":[219],"including:":[224],"glutamate":[225],"receptor":[226,233,240],"signaling":[227,234,241,249,299],"(14":[228],"genes;":[229,236,243,251],"-log":[230,237,244,252],"p-value=3.22),":[231],"serotonin":[232],"(9":[235],"p-value=2.22),":[238],"GABA":[239],"(18":[242],"p-value=1.78),":[245],"cAMP":[247],"mediated":[248],"(27":[250],"p-value=1.58).":[253],"CONCLUSION:":[254],"model":[257],"moderate":[259],"exercise-induced":[260],"muscle":[261,268,289,316],"damage,":[262],"early":[265,306],"these":[273],"loss.":[280],"Biological":[281],"relate":[284],"dysfunction":[290,317,325],"include":[291],"neurotransmitter":[293],"pathways,":[294],"well":[296],"cell":[298],"such":[301],"cAMP.":[303],"Insight":[304],"into":[305],"drivers":[307],"could":[311],"identify":[312],"targets":[313],"reduce":[315],"optimize":[319],"recovery":[320],"those":[322],"prone":[323],"following":[326],"exercise.":[327]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-09-07T00:00:00"}
