{"id":"https://openalex.org/W4294771035","doi":"https://doi.org/10.1002/art.42342","title":"Efficacy and Safety of Botulinum Toxin in Adults with Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Multicenter, Randomized, Double\u2010Blind , Placebo\u2010Controlled Study","display_name":"Efficacy and Safety of Botulinum Toxin in Adults with Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Multicenter, Randomized, Double\u2010Blind , Placebo\u2010Controlled Study","publication_year":2022,"publication_date":"2022-09-06","ids":{"openalex":"https://openalex.org/W4294771035","doi":"https://doi.org/10.1002/art.42342","pmid":"https://pubmed.ncbi.nlm.nih.gov/36066501"},"language":"en","primary_location":{"id":"doi:10.1002/art.42342","doi":"https://doi.org/10.1002/art.42342","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.42342","pdf_url":null,"source":{"id":"https://openalex.org/S4210186158","display_name":"Arthritis & Rheumatology","issn_l":"2326-5191","issn":["2326-5191","2326-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017975663","display_name":"Patricia Senet","orcid":"https://orcid.org/0000-0002-9253-8419","observed_orcids":["https://orcid.org/0000-0002-9253-8419"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patricia Senet","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de Dermatologie, Centre Hospitalier Universitaire Tenon, Groupe Hospitalier Sorbonne Universit\u00e9  Paris France"],"raw_orcid":"https://orcid.org/0000-0002-9253-8419","affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de Dermatologie, Centre Hospitalier Universitaire Tenon, Groupe Hospitalier Sorbonne Universit\u00e9  Paris France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210166768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107168337","display_name":"H. Maillard","orcid":"https://orcid.org/0000-0002-2122-3663","observed_orcids":["https://orcid.org/0000-0002-2122-3663"]},"institutions":[{"id":"https://openalex.org/I4210125982","display_name":"Centre Hospitalier du Mans","ror":"https://ror.org/03bf2nz41","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210125982"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Maillard","raw_affiliation_strings":["Service de Dermatologie Centre Hospitalier Le Mans  Le Mans France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Dermatologie Centre Hospitalier Le Mans  Le Mans France","institution_ids":["https://openalex.org/I4210125982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003360902","display_name":"\u00c9lisabeth Diot","orcid":"https://orcid.org/0000-0003-3507-8337","observed_orcids":["https://orcid.org/0000-0003-3507-8337"]},"institutions":[{"id":"https://openalex.org/I4210095477","display_name":"Centre Hospitalier Universitaire de Tours","ror":"https://ror.org/00jpq0w62","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210095477"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabeth Diot","raw_affiliation_strings":["Service de M\u00e9decine Interne et Immunologie Clinique Centre Hospitalier Universitaire Bretonneau\u2013Tours  Tours France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Interne et Immunologie Clinique Centre Hospitalier Universitaire Bretonneau\u2013Tours  Tours France","institution_ids":["https://openalex.org/I4210095477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000170234","display_name":"I. Lazareth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135272","display_name":"H\u00f4pital Paris Saint-Joseph","ror":"https://ror.org/046bx1082","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135272","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Lazareth","raw_affiliation_strings":["Service de M\u00e9decine Vasculaire H\u00f4pital Saint\u2010Joseph  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Vasculaire H\u00f4pital Saint\u2010Joseph  Paris France","institution_ids":["https://openalex.org/I4210135272"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005052958","display_name":"S. Blaise","orcid":"https://orcid.org/0000-0001-7238-112X","observed_orcids":["https://orcid.org/0000-0001-7238-112X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Blaise","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm, HP2  Grenoble France"],"raw_orcid":"https://orcid.org/0000-0001-7238-112X","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm, HP2  Grenoble France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031791085","display_name":"Jean\u2010Philippe Arnault","orcid":"https://orcid.org/0000-0001-6156-473X","observed_orcids":["https://orcid.org/0000-0001-6156-473X"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Philippe Arnault","raw_affiliation_strings":["Service de Dermatologie Centre Hospitalier Universitaire Amiens\u2013Picardie  Amiens France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Dermatologie Centre Hospitalier Universitaire Amiens\u2013Picardie  Amiens France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111254046","display_name":"Marc\u2010Antoine Pistorius","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc\u2010Antoine Pistorius","raw_affiliation_strings":["Service de M\u00e9decine Interne Centre Hospitalier Universitaire  Nantes France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Interne Centre Hospitalier Universitaire  Nantes France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110451397","display_name":"Carine Boulon","orcid":"https://orcid.org/0000-0002-5508-8906","observed_orcids":["https://orcid.org/0000-0002-5508-8906"]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carine Boulon","raw_affiliation_strings":["Service de M\u00e9decine Vasculaire Centre Hospitalier Universitaire St\u2010Andr\u00e9  Bordeaux France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Vasculaire Centre Hospitalier Universitaire St\u2010Andr\u00e9  Bordeaux France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059726114","display_name":"Olivier Cogrel","orcid":"https://orcid.org/0000-0002-8878-8351","observed_orcids":["https://orcid.org/0000-0002-8878-8351"]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Cogrel","raw_affiliation_strings":["Unit\u00e9 de Dermatologie Interventionnelle, Service de Dermatologie Centre Hospitalier Universitaire  Bordeaux France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Dermatologie Interventionnelle, Service de Dermatologie Centre Hospitalier Universitaire  Bordeaux France","institution_ids":["https://openalex.org/I3018323443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027549641","display_name":"Ursula Warzocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210129146","display_name":"H\u00f4pital Avicenne","ror":"https://ror.org/03n6vs369","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ursula Warzocha","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de M\u00e9decine Interne Centre Hospitalier Universitaire Avicenne  Bobigny France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de M\u00e9decine Interne Centre Hospitalier Universitaire Avicenne  Bobigny France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112215436","display_name":"S\u00e9bastien Rivi\u00e8re","orcid":"https://orcid.org/0000-0001-6328-618X","observed_orcids":["https://orcid.org/0000-0001-6328-618X"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Rivi\u00e8re","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de M\u00e9decine Interne, Centre Hospitalier Universitaire Saint\u2010Antoine, Groupe Hospitalier Sorbonne Universit\u00e9  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de M\u00e9decine Interne, Centre Hospitalier Universitaire Saint\u2010Antoine, Groupe Hospitalier Sorbonne Universit\u00e9  Paris France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055210635","display_name":"Julie Malloizel\u2010Delaunay","orcid":"https://orcid.org/0000-0002-9836-5029","observed_orcids":["https://orcid.org/0000-0002-9836-5029"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Malloizel\u2010Delaunay","raw_affiliation_strings":["Service de M\u00e9decine Vasculaire Centre Hospitalier Universitaire  Toulouse France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Vasculaire Centre Hospitalier Universitaire  Toulouse France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108125508","display_name":"Am\u00e9lie Servettaz","orcid":"https://orcid.org/0000-0001-5701-3863","observed_orcids":["https://orcid.org/0000-0001-5701-3863"]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Am\u00e9lie Servettaz","raw_affiliation_strings":["Service de M\u00e9decine Interne Maladies Infectieuses, Immunologie Clinique, H\u00f4pital Robert\u2010Debr\u00e9, Centre Hospitalier Universitaire  Reims France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Interne Maladies Infectieuses, Immunologie Clinique, H\u00f4pital Robert\u2010Debr\u00e9, Centre Hospitalier Universitaire  Reims France","institution_ids":["https://openalex.org/I4210105796","https://openalex.org/I4210126712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029139859","display_name":"Bruno Sassolas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132604","display_name":"Centre Hospitalier R\u00e9gional Universitaire de Brest","ror":"https://ror.org/03evbwn87","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210132604","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Sassolas","raw_affiliation_strings":["D\u00e9partement de M\u00e9decine Interne et Pneumologie H\u00f4pital de la Cavale Blanche, Centre Hospitalier R\u00e9gional Universitaire  Brest France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Interne et Pneumologie H\u00f4pital de la Cavale Blanche, Centre Hospitalier R\u00e9gional Universitaire  Brest France","institution_ids":["https://openalex.org/I4210132604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018760953","display_name":"Manuelle A Viguier","orcid":"https://orcid.org/0000-0001-9049-8700","observed_orcids":["https://orcid.org/0000-0001-9049-8700"]},"institutions":[{"id":"https://openalex.org/I4400008972","display_name":"Immuno-R\u00e9gulation des Maladies Auto- immunes Inflammatoires et Cancer","ror":"https://ror.org/04916qv51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4400008972","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manuelle Viguier","raw_affiliation_strings":["Service de Dermatologie\u2013V\u00e9n\u00e9r\u00e9ologie H\u00f4pital Robert\u2010Debr\u00e9, Universit\u00e9 Reims Champagne Ardenne, IRMAIC, EA7509  Reims France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Dermatologie\u2013V\u00e9n\u00e9r\u00e9ologie H\u00f4pital Robert\u2010Debr\u00e9, Universit\u00e9 Reims Champagne Ardenne, IRMAIC, EA7509  Reims France","institution_ids":["https://openalex.org/I4400008972","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012199757","display_name":"J.\u2010B. Monfort","orcid":"https://orcid.org/0000-0002-4792-2622","observed_orcids":["https://orcid.org/0000-0002-4792-2622"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Benoit Monfort","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de Dermatologie, Centre Hospitalier Universitaire Tenon, Groupe Hospitalier Sorbonne Universit\u00e9  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris, and Service de Dermatologie, Centre Hospitalier Universitaire Tenon, Groupe Hospitalier Sorbonne Universit\u00e9  Paris France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210166768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082438928","display_name":"Sol\u00e8ne Janique","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210111631","display_name":"H\u00f4pital Fernand-Widal","ror":"https://ror.org/01zkyzz15","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210111631"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sol\u00e8ne Janique","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris, Unit\u00e9 de Recherche Clinique, Centre Hospitalier Universitaire Fernand\u2010Widal  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris, Unit\u00e9 de Recherche Clinique, Centre Hospitalier Universitaire Fernand\u2010Widal  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210111631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088096181","display_name":"\u00c9ric Vicaut","orcid":"https://orcid.org/0000-0001-6303-8557","observed_orcids":["https://orcid.org/0000-0001-6303-8557"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210111631","display_name":"H\u00f4pital Fernand-Widal","ror":"https://ror.org/01zkyzz15","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210111631"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Vicaut","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris, Unit\u00e9 de Recherche Clinique, Centre Hospitalier Universitaire Fernand\u2010Widal  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris, Unit\u00e9 de Recherche Clinique, Centre Hospitalier Universitaire Fernand\u2010Widal  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210111631"]}]},{"author_position":"last","author":{"id":null,"display_name":"the BRASS collaborators","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the BRASS collaborators","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":21,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4800,"currency":"USD","value_usd":4800},"apc_paid":null,"fwci":3.978,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.95246948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"75","issue":"3","first_page":"459","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12625","display_name":"Sympathectomy and Hyperhidrosis Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/raynaud-s-phenomenon","display_name":"Raynaud's phenomenon","score":0.9129999876022339},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hand-function","display_name":"hand function","score":0.7110000252723694},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hand-muscle-weakness","display_name":"hand muscle weakness","score":0.8539999723434448},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.7400112748146057},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.7395950555801392},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7342155575752258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6019101142883301},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.5914146900177002},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5286462903022766},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5015196800231934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3107781410217285},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2926762104034424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21745920181274414},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1792893409729004},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.130570650100708},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006225","descriptor_name":"Hand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011928","descriptor_name":"Raynaud Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011928","descriptor_name":"Raynaud Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/art.42342","doi":"https://doi.org/10.1002/art.42342","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.42342","pdf_url":null,"source":{"id":"https://openalex.org/S4210186158","display_name":"Arthritis & Rheumatology","issn_l":"2326-5191","issn":["2326-5191","2326-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatology","raw_type":"journal-article"},{"id":"pmid:36066501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36066501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & rheumatology (Hoboken, N.J.)","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:HAL:hal-04479694v1","doi":null,"is_oa":false,"landing_page_url":"https://ut3-toulouseinp.hal.science/hal-04479694","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arthritis & rheumatology, 2022, 75 (3), pp.459-467. ⟨10.1002/art.42342⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1530430155","https://openalex.org/W1971548094","https://openalex.org/W1971579798","https://openalex.org/W1986217196","https://openalex.org/W2002964680","https://openalex.org/W2006247723","https://openalex.org/W2011299927","https://openalex.org/W2019728745","https://openalex.org/W2040159432","https://openalex.org/W2060886278","https://openalex.org/W2066618745","https://openalex.org/W2089390875","https://openalex.org/W2089752909","https://openalex.org/W2096107056","https://openalex.org/W2121837363","https://openalex.org/W2164096595","https://openalex.org/W2308899339","https://openalex.org/W2315192425","https://openalex.org/W2324103170","https://openalex.org/W2394768513","https://openalex.org/W2508060872","https://openalex.org/W2520763913","https://openalex.org/W2527998611","https://openalex.org/W2549071917","https://openalex.org/W2607246919","https://openalex.org/W2614864499","https://openalex.org/W2615865527","https://openalex.org/W2774833117","https://openalex.org/W2896265238","https://openalex.org/W2926158773","https://openalex.org/W2971478948","https://openalex.org/W3006838147","https://openalex.org/W3027178403","https://openalex.org/W3046621980","https://openalex.org/W3160687609","https://openalex.org/W3165342761","https://openalex.org/W3183611341","https://openalex.org/W3215468816","https://openalex.org/W4255316846","https://openalex.org/W6642878216","https://openalex.org/W6646529416"],"related_works":["https://openalex.org/W4224250619","https://openalex.org/W1530430155","https://openalex.org/W2604342896","https://openalex.org/W4317779793","https://openalex.org/W4200030178","https://openalex.org/W2751989976","https://openalex.org/W3207611555","https://openalex.org/W6946416150","https://openalex.org/W2607246919","https://openalex.org/W3158556098"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"whether":[3],"a":[4],"single":[5],"session":[6,66],"of":[7,22,48,57,84,128,170,186,246],"botulinum":[8],"toxin":[9],"type":[10],"A":[11],"(BTA)":[12],"injections":[13,53,249],"into":[14,54],"both":[15,58],"hands":[16,59],"more":[17,222],"effectively":[18],"decreases":[19],"the":[20,46,55,74,78,82,97,102,125,135,187,229],"frequency":[21],"systemic":[23],"sclerosis-associated":[24],"Raynaud's":[25,166],"phenomenon":[26],"(SSc-RP)":[27],"episodes":[28,86,131],"than":[29],"placebo.":[30],"METHODS:":[31],"This":[32],"multicenter,":[33],"randomized,":[34],"double-blind,":[35],"placebo-controlled,":[36],"parallel-group":[37],"phase":[38],"III":[39],"trial":[40],"in":[41,67,77,81,134,165],"patients":[42,113],"with":[43,101],"SSc-RP":[44],"assessed":[45,172,182],"effect":[47,245],"50-unit":[49],"BTA":[50,136,214,248],"or":[51],"placebo":[52,116,138],"palms":[56],"around":[60],"each":[61],"neurovascular":[62],"bundle":[63],"during":[64],"1":[65],"winter.":[68],"The":[69,107,213],"primary":[70,230],"end":[71,233],"point":[72],"was":[73],"between-group":[75],"difference":[76],"median":[79,126],"change":[80,141,164],"number":[83,127],"RP":[85,130],"from":[87,198],"baseline":[88,199],"(day":[89],"0)":[90],"to":[91,200,250],"4":[92,119],"weeks":[93,120,202],"postinjection.":[94],"Values":[95],"between":[96,211],"groups":[98,139],"were":[99,235],"compared":[100],"Wilcoxon":[103],"rank-sum":[104],"test.":[105],"RESULTS:":[106],"intent-to-treat":[108],"analysis":[109],"included":[110],"46":[111],"BTA-treated":[112],"and":[114,137,150,179,190,193,205,237],"44":[115],"recipients.":[117],"At":[118],"after":[121],"assigned":[122],"treatment":[123],"injections,":[124],"daily":[129],"decreased":[132],"comparably":[133],"(median":[140],"-1":[142,151],"episode/day":[143,152],"[interquartile":[144],"range":[145],"(IQR)":[146],"-1.5,":[147],"0":[148,155],"episodes/day]":[149],"[IQR":[153],"-2.5,":[154],"episodes/day],":[156],"respectively)":[157],"(P":[158,224],"=":[159,225],"0.77":[160],"versus":[161],"placebo).":[162],"Moreover,":[163],"Condition":[167],"Score,":[168],"quality":[169],"life":[171],"by":[173,183],"Health":[174],"Assessment":[175],"Questionnaire":[176],"disability":[177],"index,":[178],"hand":[180,218],"function":[181],"shortened":[184],"Disabilities":[185],"Arm,":[188],"Shoulder,":[189],"Hand":[191,195],"(QuickDASH)":[192],"Cochin":[194],"Function":[196],"Scale":[197],"follow-up":[201],"4,":[203],"12,":[204],"24":[206],"did":[207],"not":[208,241],"differ":[209],"significantly":[210,221],"groups.":[212],"group":[215],"experienced":[216],"transient":[217],"muscle":[219],"weakness":[220],"frequently":[223],"0.003).":[226],"CONCLUSION:":[227],"Neither":[228],"nor":[231],"secondary":[232],"points":[234],"reached,":[236],"our":[238],"results":[239],"do":[240],"support":[242],"any":[243],"beneficial":[244],"palmar":[247],"treat":[251],"SSc-RP.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-06T00:00:00"}