{"id":"https://openalex.org/W4294770130","doi":"https://doi.org/10.31138/mjr.33.2.176","title":"TGF-\u03b21/Smad Signalling in Proliferative Glomerulonephritis Associated with Autoimmune Diseases","display_name":"TGF-\u03b21/Smad Signalling in Proliferative Glomerulonephritis Associated with Autoimmune Diseases","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4294770130","doi":"https://doi.org/10.31138/mjr.33.2.176","pmid":"https://pubmed.ncbi.nlm.nih.gov/36128207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9450207"},"language":"en","primary_location":{"id":"doi:10.31138/mjr.33.2.176","doi":"https://doi.org/10.31138/mjr.33.2.176","is_oa":true,"landing_page_url":"https://doi.org/10.31138/mjr.33.2.176","pdf_url":"https://doi.org/10.31138/mjr.33.2.176","source":{"id":"https://openalex.org/S4210235892","display_name":"Mediterranean Journal of Rheumatology","issn_l":"2529-198X","issn":["2529-198X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-4","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Rheumatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.31138/mjr.33.2.176","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058036500","display_name":"Aglaia Chalkia","orcid":"https://orcid.org/0000-0002-5963-3246","observed_orcids":["https://orcid.org/0000-0002-5963-3246"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Aglaia Chalkia","raw_affiliation_strings":["Nephrology Department, Hippokration General Hospital, Athens, Greece,","st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, Hippokration General Hospital, Athens, Greece,","institution_ids":["https://openalex.org/I4210165841"]},{"raw_affiliation_string":"st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113929536","display_name":"Harikleia Gakiopoulou","orcid":"https://orcid.org/0000-0002-2247-3613","observed_orcids":["https://orcid.org/0000-0002-2247-3613"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Harikleia Gakiopoulou","raw_affiliation_strings":["1st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,","Attikon University Hospital, Athens, Greece,","Department of Medicine and Laboratory, Clinical Immunology -Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Attikon University Hospital, Athens, Greece,","institution_ids":["https://openalex.org/I4210140282"]},{"raw_affiliation_string":"Department of Medicine and Laboratory, Clinical Immunology -Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021124852","display_name":"Irini Theochari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Irini Theochari","raw_affiliation_strings":["1st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,","Attikon University Hospital, Athens, Greece,","Department of Medicine and Laboratory, Clinical Immunology -Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Attikon University Hospital, Athens, Greece,","institution_ids":["https://openalex.org/I4210140282"]},{"raw_affiliation_string":"Department of Medicine and Laboratory, Clinical Immunology -Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017439064","display_name":"Periklis G. Foukas","orcid":"https://orcid.org/0000-0002-6053-7841","observed_orcids":["https://orcid.org/0000-0002-6053-7841"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Periklis G. Foukas","raw_affiliation_strings":["2nd Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Attikon University Hospital, Athens, Greece,","Attikon University Hospital, Athens, Greece,","Department of Medicine and Laboratory, Clinical Immunology -Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Attikon University Hospital, Athens, Greece,","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]},{"raw_affiliation_string":"Attikon University Hospital, Athens, Greece,","institution_ids":["https://openalex.org/I4210140282"]},{"raw_affiliation_string":"Department of Medicine and Laboratory, Clinical Immunology -Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071905620","display_name":"Dimitrios Vassilopoulos","orcid":"https://orcid.org/0000-0003-2288-3863","observed_orcids":["https://orcid.org/0000-0003-2288-3863"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Vassilopoulos","raw_affiliation_strings":["2nd Department of Medicine and Laboratory, Clinical Immunology - Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","Attikon University Hospital, Athens, Greece,","Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens,","Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Medicine and Laboratory, Clinical Immunology - Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Attikon University Hospital, Athens, Greece,","institution_ids":["https://openalex.org/I4210140282"]},{"raw_affiliation_string":"Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens,","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Nephrology Department Hippokration General Hospital Vasilissis Sofias 108, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113210846","display_name":"Dimitrios I. Petras","orcid":"https://orcid.org/0000-0003-4469-094X","observed_orcids":["https://orcid.org/0000-0003-4469-094X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Petras","raw_affiliation_strings":["Nephrology Department, Hippokration General Hospital, Athens, Greece,","st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, Hippokration General Hospital, Athens, Greece,","institution_ids":["https://openalex.org/I4210165841"]},{"raw_affiliation_string":"st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece,","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058036500"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"],"apc_list":null,"apc_paid":null,"fwci":0.2008,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.15066583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"2","first_page":"176","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.14489999413490295,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proliferative-glomerulonephritis","display_name":"proliferative glomerulonephritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/anca-associated-vasculitis","display_name":"ANCA-associated vasculitis","score":1.0},{"id":"https://openalex.org/keywords/autoimmune-kidney-disease","display_name":"autoimmune kidney disease","score":0.6340000033378601},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/macrophage-chemotaxis","display_name":"macrophage chemotaxis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/epigenetic-effects","display_name":"epigenetic effects","score":0.8769999742507935},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6166964173316956},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.5804105997085571},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.5511073470115662},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.527543306350708},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5251272320747375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49873995780944824},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4691048562526703},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4212881326675415},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.41539067029953003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3427068591117859},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.24792751669883728},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19228801131248474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17708635330200195},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.31138/mjr.33.2.176","doi":"https://doi.org/10.31138/mjr.33.2.176","is_oa":true,"landing_page_url":"https://doi.org/10.31138/mjr.33.2.176","pdf_url":"https://doi.org/10.31138/mjr.33.2.176","source":{"id":"https://openalex.org/S4210235892","display_name":"Mediterranean Journal of Rheumatology","issn_l":"2529-198X","issn":["2529-198X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-4","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Rheumatology","raw_type":"journal-article"},{"id":"pmid:36128207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36128207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean journal of rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9450207","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9450207/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterr J Rheumatol","raw_type":"Text"},{"id":"pmh:https://cyberleninka.ru/article/n/tgf-1-smad-signalling-in-proliferative-glomerulonephritis-associated-with-autoimmune-diseases","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/tgf-1-smad-signalling-in-proliferative-glomerulonephritis-associated-with-autoimmune-diseases","pdf_url":null,"source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":{"id":"doi:10.31138/mjr.33.2.176","doi":"https://doi.org/10.31138/mjr.33.2.176","is_oa":true,"landing_page_url":"https://doi.org/10.31138/mjr.33.2.176","pdf_url":"https://doi.org/10.31138/mjr.33.2.176","source":{"id":"https://openalex.org/S4210235892","display_name":"Mediterranean Journal of Rheumatology","issn_l":"2529-198X","issn":["2529-198X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","poland-20","russia-white-list-4","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294770130.pdf","grobid_xml":"https://content.openalex.org/works/W4294770130.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W7538965","https://openalex.org/W161951250","https://openalex.org/W1482409286","https://openalex.org/W1919436047","https://openalex.org/W1967902842","https://openalex.org/W1985859986","https://openalex.org/W1995154395","https://openalex.org/W1995555978","https://openalex.org/W1997314757","https://openalex.org/W2009729476","https://openalex.org/W2036044995","https://openalex.org/W2036094765","https://openalex.org/W2041606385","https://openalex.org/W2055953242","https://openalex.org/W2060537220","https://openalex.org/W2071478225","https://openalex.org/W2080505183","https://openalex.org/W2082322877","https://openalex.org/W2096280264","https://openalex.org/W2097374264","https://openalex.org/W2097887036","https://openalex.org/W2099515182","https://openalex.org/W2107724630","https://openalex.org/W2114650700","https://openalex.org/W2119315749","https://openalex.org/W2123182868","https://openalex.org/W2124691017","https://openalex.org/W2126411597","https://openalex.org/W2131211068","https://openalex.org/W2132803823","https://openalex.org/W2145979480","https://openalex.org/W2148091013","https://openalex.org/W2149295409","https://openalex.org/W2153084809","https://openalex.org/W2154568166","https://openalex.org/W2156126395","https://openalex.org/W2158118120","https://openalex.org/W2159706204","https://openalex.org/W2163169229","https://openalex.org/W2168020089","https://openalex.org/W2198068262","https://openalex.org/W2324419097","https://openalex.org/W2328350664","https://openalex.org/W2342679639","https://openalex.org/W2398853487","https://openalex.org/W2466464742","https://openalex.org/W2559257586","https://openalex.org/W2562640620","https://openalex.org/W2592043891","https://openalex.org/W2618920555","https://openalex.org/W2749925549","https://openalex.org/W2770476385","https://openalex.org/W2774296853","https://openalex.org/W2793723228","https://openalex.org/W2892636550","https://openalex.org/W2946877152","https://openalex.org/W2957655841","https://openalex.org/W3008074101","https://openalex.org/W3034741741","https://openalex.org/W3132786455","https://openalex.org/W3138712581","https://openalex.org/W3197169977","https://openalex.org/W4313197481","https://openalex.org/W6678609131"],"related_works":["https://openalex.org/W2385629254","https://openalex.org/W4229058201","https://openalex.org/W4380448410","https://openalex.org/W3197169977","https://openalex.org/W4396991785","https://openalex.org/W2064606484","https://openalex.org/W7215100801","https://openalex.org/W2091245443","https://openalex.org/W2393909496","https://openalex.org/W2097888088"],"abstract_inverted_index":{"Glomerulonephritis":[0],"is":[1,42,96,175],"a":[2,13,43],"common":[3],"cause":[4,15],"of":[5,16,71,76,101,150,153,167],"chronic":[6,49],"kidney":[7],"disease,":[8],"which":[9,123,174],"has":[10],"emerged":[11],"as":[12,23,116,118,136],"major":[14],"end-stage":[17],"renal":[18,50,72,143],"disease.":[19],"Autoimmune":[20],"diseases,":[21,51],"such":[22],"Systemic":[24],"Lupus":[25],"Erythematosus":[26],"(SLE)":[27],"and":[28,56,80,112,129,160,169],"ANCA-associated":[29],"vasculitis":[30],"(AAV)":[31],"are":[32],"often":[33],"associated":[34,176],"with":[35,45,106,177],"proliferative":[36,172],"glomerulonephritis.":[37],"Transforming":[38],"growth":[39],"factor-\u03b21":[40],"(TGF-\u03b21)":[41],"cytokine":[44],"pleiotropic":[46],"effects":[47,103,131],"in":[48,54,57,68,158,161,164,171],"based":[52],"on":[53],"vivo":[55,159],"vitro":[58,162],"studies.":[59],"The":[60,99],"Smad-dependent":[61],"signalling":[62,95,111,141,155],"pathway":[63,156],"plays":[64],"an":[65,148],"important":[66],"role":[67,152],"the":[69,93,102,107,119,151,165],"regulation":[70],"fibrosis":[73],"(excessive":[74],"production":[75],"extracellular":[77],"matrix":[78],"[ECM])":[79],"inflammation.":[81],"However,":[82],"clinical":[83],"trials":[84],"targeting":[85],"TGF-\u03b21":[86,110,124],"have":[87,132],"presented":[88],"disappointing":[89],"results,":[90],"suggesting":[91],"that":[92],"downstream":[94,114],"quite":[97],"complex.":[98],"diversity":[100],"may":[104],"associate":[105],"interactions":[108],"between":[109],"other":[113],"signalling,":[115],"well":[117],"different":[120],"cellular":[121],"responses,":[122],"promotes.":[125],"Recently,":[126],"macrophage":[127],"chemoattract":[128],"epigenetic":[130],"also":[133],"been":[134],"identified":[135],"new":[137],"mechanisms,":[138],"wherefore":[139],"TGF-\u03b21/Smad":[140,154],"mediates":[142],"injury.":[144],"This":[145],"review":[146],"provides":[147],"overview":[149],"from":[157],"studies":[163],"pathogenesis":[166],"glomerulonephritis":[168],"particularly":[170],"glomerulonephritis,":[173],"autoimmune":[178],"diseases.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-06T00:00:00"}