{"id":"https://openalex.org/W4294636745","doi":"https://doi.org/10.1038/s43856-022-00172-x","title":"Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice","display_name":"Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice","publication_year":2022,"publication_date":"2022-09-05","ids":{"openalex":"https://openalex.org/W4294636745","doi":"https://doi.org/10.1038/s43856-022-00172-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/36082175","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9445170"},"language":"en","primary_location":{"id":"doi:10.1038/s43856-022-00172-x","doi":"https://doi.org/10.1038/s43856-022-00172-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43856-022-00172-x","pdf_url":"https://www.nature.com/articles/s43856-022-00172-x.pdf","source":{"id":"https://openalex.org/S4210167893","display_name":"Communications Medicine","issn_l":"2730-664X","issn":["2730-664X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s43856-022-00172-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112862450","display_name":"Hiroko Okawa","orcid":"https://orcid.org/0009-0006-2922-3461","observed_orcids":["https://orcid.org/0009-0006-2922-3461"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroko Okawa","raw_affiliation_strings":["Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, 980-8575 Japan","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Japan","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, 980-8575 Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087258728","display_name":"Takeru Kondo","orcid":"https://orcid.org/0009-0002-1560-1741","observed_orcids":["https://orcid.org/0009-0002-1560-1741"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takeru Kondo","raw_affiliation_strings":["Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, 980-8575 Japan","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Japan","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, 980-8575 Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086824064","display_name":"Akishige Hokugo","orcid":"https://orcid.org/0000-0002-7097-3364","observed_orcids":["https://orcid.org/0000-0002-7097-3364"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Akishige Hokugo","raw_affiliation_strings":["Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at UCLA, Los Angeles, USA","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA"],"raw_orcid":"https://orcid.org/0000-0002-7097-3364","affiliations":[{"raw_affiliation_string":"Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083671773","display_name":"Philip Cherian","orcid":"https://orcid.org/0000-0002-1070-6483","observed_orcids":["https://orcid.org/0000-0002-1070-6483"]},"institutions":[{"id":"https://openalex.org/I4210144182","display_name":"BioVinc (United States)","ror":"https://ror.org/04dk78q10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144182"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Cherian","raw_affiliation_strings":["BioVinc LLC, Pasadena, CA 91107 USA","BioVinc LLC, Pasadena, USA"],"raw_orcid":"https://orcid.org/0000-0002-1070-6483","affiliations":[{"raw_affiliation_string":"BioVinc LLC, Pasadena, CA 91107 USA","institution_ids":["https://openalex.org/I4210144182"]},{"raw_affiliation_string":"BioVinc LLC, Pasadena, USA","institution_ids":["https://openalex.org/I4210144182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044607755","display_name":"Oskar Sundberg","orcid":"https://orcid.org/0009-0004-0869-9191","observed_orcids":["https://orcid.org/0009-0004-0869-9191"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oskar Sundberg","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, CA 90089 USA","Department of Chemistry, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022369839","display_name":"Jesus J. Campagna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus J. Campagna","raw_affiliation_strings":["Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA","Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041489306","display_name":"B. A. Kashemirov","orcid":"https://orcid.org/0000-0001-7175-9960","observed_orcids":["https://orcid.org/0000-0001-7175-9960"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris A. Kashemirov","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, CA 90089 USA","Department of Chemistry, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038640264","display_name":"Varghese John","orcid":"https://orcid.org/0000-0001-7675-2426","observed_orcids":["https://orcid.org/0000-0001-7675-2426"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varghese John","raw_affiliation_strings":["Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA","Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080904737","display_name":"Shuting Sun","orcid":"https://orcid.org/0000-0002-3635-9029","observed_orcids":["https://orcid.org/0000-0002-3635-9029"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210144182","display_name":"BioVinc (United States)","ror":"https://ror.org/04dk78q10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144182"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuting Sun","raw_affiliation_strings":["BioVinc LLC, Pasadena, CA 91107 USA","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","BioVinc LLC, Pasadena, USA","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioVinc LLC, Pasadena, CA 91107 USA","institution_ids":["https://openalex.org/I4210144182"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"BioVinc LLC, Pasadena, USA","institution_ids":["https://openalex.org/I4210144182"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070859925","display_name":"Frank H. Ebetino","orcid":"https://orcid.org/0000-0002-9133-1360","observed_orcids":["https://orcid.org/0000-0002-9133-1360"]},"institutions":[{"id":"https://openalex.org/I4210144182","display_name":"BioVinc (United States)","ror":"https://ror.org/04dk78q10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144182"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank H. Ebetino","raw_affiliation_strings":["BioVinc LLC, Pasadena, CA 91107 USA","BioVinc LLC, Pasadena, USA"],"raw_orcid":"https://orcid.org/0000-0002-9133-1360","affiliations":[{"raw_affiliation_string":"BioVinc LLC, Pasadena, CA 91107 USA","institution_ids":["https://openalex.org/I4210144182"]},{"raw_affiliation_string":"BioVinc LLC, Pasadena, USA","institution_ids":["https://openalex.org/I4210144182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011933351","display_name":"Charles E. McKenna","orcid":"https://orcid.org/0000-0002-3540-6663","observed_orcids":["https://orcid.org/0000-0002-3540-6663"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles E. McKenna","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, CA 90089 USA","Department of Chemistry, University of Southern California, Los Angeles, USA"],"raw_orcid":"https://orcid.org/0000-0002-3540-6663","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005022757","display_name":"Ichiro Nishimura","orcid":"https://orcid.org/0000-0002-3749-9445","observed_orcids":["https://orcid.org/0000-0002-3749-9445"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ichiro Nishimura","raw_affiliation_strings":["Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA"],"raw_orcid":"https://orcid.org/0000-0002-3749-9445","affiliations":[{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005022757","https://openalex.org/A5011933351","https://openalex.org/A5080904737","https://openalex.org/A5086824064"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I161318765","https://openalex.org/I4210144182"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.7316,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70138284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"112","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphosphonate-related-osteonecrosis-of-the-jaw","display_name":"bisphosphonate-related osteonecrosis of the jaw","score":0.996999979019165},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nitrogen-containing-bisphosphonates","display_name":"nitrogen-containing bisphosphonates","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hydroxyapatite-binding","display_name":"hydroxyapatite binding","score":0.718999981880188},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.5479999780654907},{"id":"https://openalex.org/keywords/gingivitis","display_name":"gingivitis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/oral-wound-healing","display_name":"oral wound healing","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.7692161798477173},{"id":"https://openalex.org/C2777556957","wikidata":"https://www.wikidata.org/wiki/Q2377991","display_name":"Osteonecrosis of the jaw","level":4,"score":0.7552017569541931},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6157866716384888},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5109869241714478},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.5064975023269653},{"id":"https://openalex.org/C202271784","wikidata":"https://www.wikidata.org/wiki/Q189218","display_name":"Molar","level":2,"score":0.48443368077278137},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4558687210083008},{"id":"https://openalex.org/C2776326535","wikidata":"https://www.wikidata.org/wiki/Q218507","display_name":"Zoledronic acid","level":2,"score":0.4256196916103363},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4115530848503113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33258533477783203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25539880990982056},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2083621323108673}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s43856-022-00172-x","doi":"https://doi.org/10.1038/s43856-022-00172-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43856-022-00172-x","pdf_url":"https://www.nature.com/articles/s43856-022-00172-x.pdf","source":{"id":"https://openalex.org/S4210167893","display_name":"Communications Medicine","issn_l":"2730-664X","issn":["2730-664X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9445170","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9445170","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Med (Lond)","raw_type":"Text"},{"id":"pmid:36082175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36082175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fa4c14d86d1e48f7abda46536e834eaf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa4c14d86d1e48f7abda46536e834eaf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Medicine, Vol 2, Iss 1, Pp 1-17 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s43856-022-00172-x","doi":"https://doi.org/10.1038/s43856-022-00172-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43856-022-00172-x","pdf_url":"https://www.nature.com/articles/s43856-022-00172-x.pdf","source":{"id":"https://openalex.org/S4210167893","display_name":"Communications Medicine","issn_l":"2730-664X","issn":["2730-664X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3019907526","display_name":"EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION PROJECTS","funder_award_id":"C06RR014529","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4723739347","display_name":null,"funder_award_id":"R01DE022552","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G484614224","display_name":"Competitive Equilibrium-based Displacement of Bisphosphonates as Novel Therapeutic Approach for BRONJ","funder_award_id":"R44DE025524","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5747008686","display_name":null,"funder_award_id":"19J117670","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7551192648","display_name":"Oral Mucosa Barrier and Bisphosphonate-related Osteonecrosis of the Jaw","funder_award_id":"R01DE022552","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G78853053","display_name":null,"funder_award_id":"19J117670","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G972415694","display_name":null,"funder_award_id":"R44DE025524","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320323584","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294636745.pdf","grobid_xml":"https://content.openalex.org/works/W4294636745.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1523848206","https://openalex.org/W1533900546","https://openalex.org/W1548328806","https://openalex.org/W1959904772","https://openalex.org/W1967261754","https://openalex.org/W1971661467","https://openalex.org/W1988968838","https://openalex.org/W1996589664","https://openalex.org/W2005566927","https://openalex.org/W2008623276","https://openalex.org/W2009897665","https://openalex.org/W2013801985","https://openalex.org/W2017267215","https://openalex.org/W2025672294","https://openalex.org/W2028946041","https://openalex.org/W2031851347","https://openalex.org/W2049146115","https://openalex.org/W2052666656","https://openalex.org/W2054169450","https://openalex.org/W2058889454","https://openalex.org/W2066864375","https://openalex.org/W2084865918","https://openalex.org/W2092759151","https://openalex.org/W2102975924","https://openalex.org/W2111530910","https://openalex.org/W2130964548","https://openalex.org/W2133503719","https://openalex.org/W2133737057","https://openalex.org/W2134967712","https://openalex.org/W2147357420","https://openalex.org/W2149852370","https://openalex.org/W2162027849","https://openalex.org/W2163048481","https://openalex.org/W2254661746","https://openalex.org/W2293416144","https://openalex.org/W2333102461","https://openalex.org/W2509370936","https://openalex.org/W2594055646","https://openalex.org/W2604355020","https://openalex.org/W2605362630","https://openalex.org/W2609800424","https://openalex.org/W2782509842","https://openalex.org/W2796965506","https://openalex.org/W2884212122","https://openalex.org/W2885151425","https://openalex.org/W2896857921","https://openalex.org/W2912633226","https://openalex.org/W2924685691","https://openalex.org/W2941470624","https://openalex.org/W2980139488","https://openalex.org/W2986158870","https://openalex.org/W2997700279","https://openalex.org/W3012844483","https://openalex.org/W3022724788","https://openalex.org/W3024949407","https://openalex.org/W3125255832","https://openalex.org/W3132396655","https://openalex.org/W3137880738","https://openalex.org/W4212766363"],"related_works":["https://openalex.org/W2924685691","https://openalex.org/W4293176446","https://openalex.org/W4410837724","https://openalex.org/W1992249390","https://openalex.org/W2111638425","https://openalex.org/W2203719487","https://openalex.org/W2789689427","https://openalex.org/W2912623752","https://openalex.org/W355646112","https://openalex.org/W2584595858"],"abstract_inverted_index":{"Background:":[0],"Bisphosphonate-related":[1],"osteonecrosis":[2,184,216],"of":[3,14,65,70,79,92,125,215,235,248],"the":[4,63,66,122,187,194,233,245],"jaw":[5,195],"(BRONJ)":[6],"is":[7,31,158,227],"a":[8,96,115,130,228],"rare":[9],"but":[10],"serious":[11],"side":[12],"effect":[13,64],"nitrogen-containing":[15],"bisphosphonate":[16],"drugs":[17],"(N-BPs)":[18],"frequently":[19],"prescribed":[20],"to":[21,50,121,139,160,186,193,231],"reduce":[22],"skeletal-related":[23],"events":[24],"in":[25,114,163,166,217,225,251],"bone":[26,51,210],"malignancies":[27],"and":[28,41,105,143,152,212],"osteoporosis.":[29],"BRONJ":[30,242],"associated":[32,240],"with":[33,95,128,183,223,241],"abnormal":[34,236],"oral":[35,144,204,237],"wound":[36,77,145,181,238],"healing":[37,78,146,182,239],"after":[38],"dentoalveolar":[39],"surgery":[40],"tooth":[42,75,179,199],"extraction.":[43],"We":[44],"previously":[45],"found":[46],"that":[47],"N-BP":[48,71,87,250],"chemisorbed":[49],"mineral":[52],"hydroxyapatite":[53],"was":[54,103,108,147],"dissociated":[55],"by":[56],"secondary":[57],"applied":[58,113,191],"N-BP.":[59,132],"This":[60],"study":[61],"investigated":[62],"surface":[67],"equilibrium-based":[68],"removal":[69],"from":[72],"jawbone":[73],"on":[74],"extraction":[76,142,180,200,208],"zoledronate":[80],"(ZOL)-treated":[81],"mice.":[82,219],"Methods:":[83],"A":[84],"pharmacologically":[85],"inactive":[86,162],"derivative":[88],"(the":[89],"4-pyridyl":[90],"isomer":[91],"risedronate":[93],"equipped":[94],"near-infrared":[97],"800CW":[98],"fluorescent":[99],"imaging":[100],"dye,":[101],"800CW-pRIS)":[102],"designed":[104],"synthesized.":[106],"800CW-pRIS":[107,157,190],"intra-orally":[109],"injected":[110],"or":[111,253],"topically":[112,192],"deformable":[116],"nano-scale":[117],"vesicle":[118],"formulation":[119],"(DNV)":[120],"palatal":[123],"tissue":[124],"mice":[126,136,176],"pretreated":[127],"ZOL,":[129],"potent":[131],"The":[133],"female":[134],"C56BL6/J":[135],"were":[137],"subjected":[138],"maxillary":[140],"molar":[141],"compared":[148],"for":[149,173],"800CW-pRIS/ZOL,":[150],"ZOL":[151],"untreated":[153,188],"control":[154],"groups.":[155],"Results:":[156],"confirmed":[159],"be":[161],"inhibiting":[164],"prenylation":[165],"cultured":[167],"osteoclasts":[168],"while":[169,243],"retaining":[170,244],"high":[171],"affinity":[172],"hydroxyapatite.":[174],"ZOL-injected":[175,218],"exhibit":[177],"delayed":[178],"relative":[185],"controls.":[189],"one":[196],"week":[197],"before":[198],"significantly":[201],"reduces":[202],"gingival":[203],"barrier":[205],"inflammation,":[206],"improves":[207],"socket":[209],"regeneration,":[211],"prevents":[213],"development":[214],"Conclusions:":[220],"Topical":[221],"pre-treatment":[222],"800CW-RIS":[224],"DNV":[226],"promising":[229],"approach":[230],"prevent":[232],"complication":[234],"anti-resorptive":[246],"benefit":[247],"legacy":[249],"appendicular":[252],"vertebrate":[254],"bones.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-09-05T00:00:00"}