{"id":"https://openalex.org/W4294599666","doi":"https://doi.org/10.1007/s00204-022-03356-5","title":"Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment","display_name":"Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment","publication_year":2022,"publication_date":"2022-09-05","ids":{"openalex":"https://openalex.org/W4294599666","doi":"https://doi.org/10.1007/s00204-022-03356-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/36063173","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9584981"},"language":"en","primary_location":{"id":"doi:10.1007/s00204-022-03356-5","doi":"https://doi.org/10.1007/s00204-022-03356-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-022-03356-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-022-03356-5.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00204-022-03356-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039656905","display_name":"Abdulkarim Najjar","orcid":"https://orcid.org/0000-0003-4620-9830","observed_orcids":["https://orcid.org/0000-0003-4620-9830"]},"institutions":[{"id":"https://openalex.org/I106618798","display_name":"Beiersdorf (Germany)","ror":"https://ror.org/04aqg9s78","country_code":"DE","type":"company","lineage":["https://openalex.org/I106618798"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Abdulkarim Najjar","raw_affiliation_strings":["Beiersdorf AG, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beiersdorf AG, Hamburg, Germany","institution_ids":["https://openalex.org/I106618798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084547667","display_name":"Ans Punt","orcid":"https://orcid.org/0000-0002-2056-4634","observed_orcids":["https://orcid.org/0000-0002-2056-4634"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ans Punt","raw_affiliation_strings":["Wageningen Food Safety Research, Wageningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wageningen Food Safety Research, Wageningen, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047390888","display_name":"John F. Wambaugh","orcid":"https://orcid.org/0000-0002-4024-534X","observed_orcids":["https://orcid.org/0000-0002-4024-534X"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Wambaugh","raw_affiliation_strings":["Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015276700","display_name":"Alicia Paini","orcid":"https://orcid.org/0000-0002-0669-1872","observed_orcids":["https://orcid.org/0000-0002-0669-1872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alicia Paini","raw_affiliation_strings":["esqLABS GmbH, Saterland, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"esqLABS GmbH, Saterland, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065039350","display_name":"Corie A. Ellison","orcid":"https://orcid.org/0000-0002-1069-5139","observed_orcids":["https://orcid.org/0000-0002-1069-5139"]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corie Ellison","raw_affiliation_strings":["The Procter and Gamble Company, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Procter and Gamble Company, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083838632","display_name":"Styliani Fragki","orcid":"https://orcid.org/0000-0002-7081-4021","observed_orcids":["https://orcid.org/0000-0002-7081-4021"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Styliani Fragki","raw_affiliation_strings":["National Institute for Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080905365","display_name":"Enrica Bianchi","orcid":"https://orcid.org/0000-0002-8135-9730","observed_orcids":["https://orcid.org/0000-0002-8135-9730"]},"institutions":[{"id":"https://openalex.org/I4210121787","display_name":"Corteva (United States)","ror":"https://ror.org/02pm1jf23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121787"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enrica Bianchi","raw_affiliation_strings":["Corteva Agriscience, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corteva Agriscience, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4210121787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001452107","display_name":"Fagen Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fagen Zhang","raw_affiliation_strings":["The Dow Chemical Company, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066625722","display_name":"Joost Westerhout","orcid":"https://orcid.org/0000-0001-9068-0916","observed_orcids":["https://orcid.org/0000-0001-9068-0916"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost Westerhout","raw_affiliation_strings":["The Netherlands Organisation for Applied Scientific Research TNO, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Netherlands Organisation for Applied Scientific Research TNO, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dennis Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dennis Mueller","raw_affiliation_strings":["Research and Development, Crop Science, Bayer AG, Monheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Crop Science, Bayer AG, Monheim, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040371597","display_name":"Hequn Li","orcid":"https://orcid.org/0000-0002-5529-9236","observed_orcids":["https://orcid.org/0000-0002-5529-9236"]},"institutions":[{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hequn Li","raw_affiliation_strings":["Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, UK","institution_ids":["https://openalex.org/I1342131907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045586420","display_name":"Quan Shi","orcid":"https://orcid.org/0000-0001-8491-9548","observed_orcids":["https://orcid.org/0000-0001-8491-9548"]},"institutions":[{"id":"https://openalex.org/I7923278","display_name":"Shell (Netherlands)","ror":"https://ror.org/00b5m4j81","country_code":"NL","type":"company","lineage":["https://openalex.org/I7923278"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Quan Shi","raw_affiliation_strings":["Shell Global Solutions International B.V, The Hague, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shell Global Solutions International B.V, The Hague, The Netherlands","institution_ids":["https://openalex.org/I7923278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078090457","display_name":"Timothy W. Gant","orcid":"https://orcid.org/0000-0001-9057-4937","observed_orcids":["https://orcid.org/0000-0001-9057-4937"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy W. Gant","raw_affiliation_strings":["School of Public Health, Faculty of Medicine, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Faculty of Medicine, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077461139","display_name":"Phil Botham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Phil Botham","raw_affiliation_strings":["Syngenta, Jealott's Hill, Bracknell, Berkshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta, Jealott's Hill, Bracknell, Berkshire, UK","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030210348","display_name":"R. Bars","orcid":"https://orcid.org/0000-0002-8125-9385","observed_orcids":["https://orcid.org/0000-0002-8125-9385"]},"institutions":[{"id":"https://openalex.org/I4210166400","display_name":"Bayer (France)","ror":"https://ror.org/05cm0es58","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210166400","https://openalex.org/I67348948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9mi Bars","raw_affiliation_strings":["Crop Science Division, Bayer S.A.S., Sophia Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Science Division, Bayer S.A.S., Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210166400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010620767","display_name":"Aldert H. Piersma","orcid":"https://orcid.org/0000-0002-1943-7793","observed_orcids":["https://orcid.org/0000-0002-1943-7793"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aldert Piersma","raw_affiliation_strings":["National Institute for Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110745028","display_name":"Ben van Ravenzwaay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben van Ravenzwaay","raw_affiliation_strings":["Environmental Sciences Consulting, Altrip, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Sciences Consulting, Altrip, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065553201","display_name":"Nynke I. Kramer","orcid":"https://orcid.org/0000-0002-3281-1815","observed_orcids":["https://orcid.org/0000-0002-3281-1815"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Nynke I. Kramer","raw_affiliation_strings":["Toxicology Division, Wageningen University, PO Box 8000, 6700 EA, Wageningen, The Netherlands. nynke.kramer@wur.nl","Toxicology Division, Wageningen University, PO Box 8000, 6700 EA, Wageningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3281-1815","affiliations":[{"raw_affiliation_string":"Toxicology Division, Wageningen University, PO Box 8000, 6700 EA, Wageningen, The Netherlands. nynke.kramer@wur.nl","institution_ids":["https://openalex.org/I913481162"]},{"raw_affiliation_string":"Toxicology Division, Wageningen University, PO Box 8000, 6700 EA, Wageningen, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5065553201"],"corresponding_institution_ids":["https://openalex.org/I913481162"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":9.6887,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.99162092,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"96","issue":"12","first_page":"3407","last_page":"3419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/physiologically-based-kinetic-modeling","display_name":"physiologically based kinetic modeling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-extrapolation","display_name":"in vitro-in vivo extrapolation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chemical-risk-assessment","display_name":"chemical risk assessment","score":0.8109999895095825},{"id":"https://openalex.org/keywords/regulatory-acceptance","display_name":"regulatory acceptance","score":0.734000027179718},{"id":"https://openalex.org/keywords/new-approach-methodologies","display_name":"new approach methodologies","score":0.8220000267028809},{"id":"https://openalex.org/keywords/alternatives-to-animal-testing","display_name":"alternatives to animal testing","score":0.8040000200271606},{"id":"https://openalex.org/keywords/read-across","display_name":"read-across","score":0.7950000166893005},{"id":"https://openalex.org/keywords/model-standardization","display_name":"model standardization","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6764979958534241},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.580696702003479},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5529659390449524},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5497310161590576},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.5070168972015381},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.4297827184200287},{"id":"https://openalex.org/C49261128","wikidata":"https://www.wikidata.org/wiki/Q1132455","display_name":"Hazard","level":2,"score":0.4241960346698761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20671743154525757},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18249312043190002},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15248450636863708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12979191541671753},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1007/s00204-022-03356-5","doi":"https://doi.org/10.1007/s00204-022-03356-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-022-03356-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-022-03356-5.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9584981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9584981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arch Toxicol","raw_type":"Text"},{"id":"pmid:36063173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36063173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/602586","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/towards-best-use-and-regulatory-acceptance-of-generic-physiologic","pdf_url":"https://edepot.wur.nl/577879","source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 0340-5761","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:oai-pmh.tno.nl:54957","doi":null,"is_oa":true,"landing_page_url":"https://resolver.tno.nl/uuid:276c7d8c-f899-43f6-86a8-1fe936bf1a11","pdf_url":"https://publications.tno.nl/publication/34640018/gt50H9/najjar-2022-towards.pdf","source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Toxicology, 96(12), pp. 3407-3419.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:rivm.openrepository.com:10029/626082","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/626082","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of toxicology","raw_type":"Article"},{"id":"pmh:oai:rivm.openrepository.com:10029/654290","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/654290","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:rivm:oai:rivm.openrepository.com:10029/626082","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/626082","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/602586","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/towards-best-use-and-regulatory-acceptance-of-generic-physiologic","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Toxicology, 96(12), 3407 - 3419","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00204-022-03356-5","doi":"https://doi.org/10.1007/s00204-022-03356-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-022-03356-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-022-03356-5.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"},{"id":"https://openalex.org/F4320311647","display_name":"Merck KGaA","ror":"https://ror.org/04b2dty93"},{"id":"https://openalex.org/F4320315318","display_name":"European Food Safety Authority","ror":"https://ror.org/056nc1c48"},{"id":"https://openalex.org/F4320318095","display_name":"National Institute for Health Research Health Protection Research Unit","ror":null},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320353","display_name":"Health and Safety Executive","ror":"https://ror.org/00av5yz18"},{"id":"https://openalex.org/F4320328182","display_name":"Ministerie van Landbouw, Natuur en Voedselkwaliteit","ror":"https://ror.org/03b1hdw57"},{"id":"https://openalex.org/F4320335333","display_name":"Bundesinstitut f\u00fcr Risikobewertung","ror":"https://ror.org/03k3ky186"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294599666.pdf","grobid_xml":"https://content.openalex.org/works/W4294599666.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W1574554412","https://openalex.org/W1879339955","https://openalex.org/W1976148540","https://openalex.org/W1982437193","https://openalex.org/W1982484840","https://openalex.org/W1983118095","https://openalex.org/W1986721460","https://openalex.org/W2004462262","https://openalex.org/W2007881936","https://openalex.org/W2009316291","https://openalex.org/W2010604119","https://openalex.org/W2013146296","https://openalex.org/W2014869287","https://openalex.org/W2019820822","https://openalex.org/W2026015795","https://openalex.org/W2027143209","https://openalex.org/W2034705752","https://openalex.org/W2041053997","https://openalex.org/W2041777107","https://openalex.org/W2042570457","https://openalex.org/W2053964066","https://openalex.org/W2059339640","https://openalex.org/W2059390515","https://openalex.org/W2070320306","https://openalex.org/W2075288278","https://openalex.org/W2083359113","https://openalex.org/W2086716920","https://openalex.org/W2087759076","https://openalex.org/W2096127677","https://openalex.org/W2102428965","https://openalex.org/W2113830209","https://openalex.org/W2120152745","https://openalex.org/W2120398079","https://openalex.org/W2124436671","https://openalex.org/W2131015638","https://openalex.org/W2131056563","https://openalex.org/W2134794720","https://openalex.org/W2143645910","https://openalex.org/W2147168021","https://openalex.org/W2147334256","https://openalex.org/W2153076819","https://openalex.org/W2156433146","https://openalex.org/W2167169197","https://openalex.org/W2168052206","https://openalex.org/W2168098990","https://openalex.org/W2170173246","https://openalex.org/W2329671310","https://openalex.org/W2341647963","https://openalex.org/W2411619353","https://openalex.org/W2414768696","https://openalex.org/W2417896715","https://openalex.org/W2522795135","https://openalex.org/W2534932042","https://openalex.org/W2665886429","https://openalex.org/W2734700870","https://openalex.org/W2745718614","https://openalex.org/W2751533746","https://openalex.org/W2761819312","https://openalex.org/W2763017468","https://openalex.org/W2772288444","https://openalex.org/W2783299760","https://openalex.org/W2791653123","https://openalex.org/W2801132877","https://openalex.org/W2885479476","https://openalex.org/W2890045460","https://openalex.org/W2890253893","https://openalex.org/W2896463595","https://openalex.org/W2903889205","https://openalex.org/W2914645825","https://openalex.org/W2918771416","https://openalex.org/W2921702122","https://openalex.org/W2928070133","https://openalex.org/W2930584951","https://openalex.org/W2947336471","https://openalex.org/W2963921098","https://openalex.org/W2964042848","https://openalex.org/W2974510211","https://openalex.org/W2977793452","https://openalex.org/W2980356024","https://openalex.org/W2990638664","https://openalex.org/W2994862617","https://openalex.org/W2995593899","https://openalex.org/W3004147540","https://openalex.org/W3023757279","https://openalex.org/W3032761836","https://openalex.org/W3033254362","https://openalex.org/W3047564146","https://openalex.org/W3049726463","https://openalex.org/W3088551747","https://openalex.org/W3089412949","https://openalex.org/W3090027209","https://openalex.org/W3096410258","https://openalex.org/W3118021898","https://openalex.org/W3127947578","https://openalex.org/W3134421859","https://openalex.org/W3153560487","https://openalex.org/W3156769201","https://openalex.org/W3164774776","https://openalex.org/W3171785246","https://openalex.org/W3182463521","https://openalex.org/W3216585077","https://openalex.org/W4200463417","https://openalex.org/W4205854072","https://openalex.org/W4206917753","https://openalex.org/W4255768676"],"related_works":["https://openalex.org/W4285728785","https://openalex.org/W2899563949","https://openalex.org/W3134421859","https://openalex.org/W4307454629","https://openalex.org/W4400155347","https://openalex.org/W4297464528","https://openalex.org/W2751533746","https://openalex.org/W3028599812","https://openalex.org/W7116726251","https://openalex.org/W4296205124"],"abstract_inverted_index":{"With":[0],"an":[1,54,112,225],"increasing":[2,226],"need":[3,17],"to":[4,18,63,77,168,189,201,237],"incorporate":[5],"new":[6],"approach":[7,85,175],"methodologies":[8],"(NAMs)":[9],"in":[10,26,48,57,59,64,90,92,105,155,159,190,220,240],"chemical":[11,100,209],"risk":[12,101,181,210],"assessment":[13,102],"and":[14,127,144,147,171,206],"the":[15,23,44,51,156,221,230],"concomitant":[16],"phase":[19],"out":[20],"animal":[21],"testing,":[22],"interpretation":[24],"of":[25,46,50,111,158,208,213],"vitro":[27,60,106],"assay":[28],"readouts":[29],"for":[30,98,134,150,176,180,244],"quantitative":[31,91],"hazard":[32],"characterisation":[33],"becomes":[34],"more":[35],"important.":[36],"Physiologically":[37],"based":[38,103],"kinetic":[39],"(PBK)":[40],"models,":[41,138],"which":[42],"simulate":[43],"fate":[45],"chemicals":[47],"tissues":[49],"body,":[52],"play":[53],"essential":[55,76],"role":[56],"extrapolating":[58],"effect":[61],"concentrations":[62],"vivo":[65,94,160,191],"bioequivalent":[66],"exposures.":[67],"As":[68],"PBK-based":[69],"testing":[70],"approaches":[71,81,217,243],"evolve,":[72],"it":[73],"will":[74],"become":[75],"standardise":[78],"PBK":[79,137,177,215,241],"modelling":[80,216,242],"towards":[82],"a":[83,173],"consensus":[84],"that":[86,119],"can":[87,120],"be":[88],"used":[89],"vitro-to-in":[93],"extrapolation":[95],"(QIVIVE)":[96],"studies":[97,200],"regulatory":[99,122,245],"on":[104,109,229],"assays.":[107],"Based":[108],"results":[110],"ECETOC":[113],"expert":[114],"workshop,":[115],"steps":[116,233],"are":[117,218],"recommended":[118],"improve":[121],"adoption:":[123],"(1)":[124],"define":[125,148],"context":[126],"implementation,":[128],"taking":[129],"into":[130],"consideration":[131],"model":[132,178,185],"complexity":[133],"building":[135],"fit-for-purpose":[136],"(2)":[139],"harmonise":[140],"physiological":[141],"input":[142],"parameters":[143],"their":[145],"distribution":[146],"criteria":[149],"quality":[151],"chemical-specific":[152],"parameters,":[153],"especially":[154],"absence":[157],"data,":[161],"(3)":[162],"apply":[163],"Good":[164],"Modelling":[165],"Practices":[166],"(GMP)":[167],"achieve":[169],"transparency":[170],"design":[172],"stepwise":[174],"development":[179],"assessors,":[182],"(4)":[183],"evaluate":[184],"predictions":[186],"using":[187],"alternatives":[188],"PK":[192],"data":[193],"including":[194],"read-across":[195],"approaches,":[196],"(5)":[197],"use":[198],"case":[199],"facilitate":[202],"discussions":[203],"between":[204],"modellers":[205],"regulators":[207],"assessment.":[211],"Proof-of-concepts":[212],"generic":[214],"published":[219],"scientific":[222],"literature":[223],"at":[224],"rate.":[227],"Working":[228],"previously":[231],"proposed":[232],"is,":[234],"therefore,":[235],"needed":[236],"gain":[238],"confidence":[239],"use.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-09-05T00:00:00"}