{"id":"https://openalex.org/W4294550826","doi":"https://doi.org/10.1016/j.isci.2022.105056","title":"Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways","display_name":"Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways","publication_year":2022,"publication_date":"2022-09-03","ids":{"openalex":"https://openalex.org/W4294550826","doi":"https://doi.org/10.1016/j.isci.2022.105056","pmid":"https://pubmed.ncbi.nlm.nih.gov/36134336","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9483809"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2022.105056","doi":"https://doi.org/10.1016/j.isci.2022.105056","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105056","pdf_url":"http://www.cell.com/article/S2589004222013281/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2589004222013281/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048375249","display_name":"Emanuele Bosi","orcid":"https://orcid.org/0000-0002-4769-8667","observed_orcids":["https://orcid.org/0000-0002-4769-8667"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Emanuele Bosi","raw_affiliation_strings":["Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genova, Italy","Department of Experimental and Clinical Medicine, Pancreatic Islets Laboratory, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Pancreatic Islets Laboratory, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000550995","display_name":"Piero Marchetti","orcid":"https://orcid.org/0000-0003-4907-0635","observed_orcids":["https://orcid.org/0000-0003-4907-0635"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Marchetti","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, Pancreatic Islets Laboratory, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Pancreatic Islets Laboratory, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA","GB","SG"],"is_corresponding":false,"raw_author_name":"Guy Allen Rutter","raw_affiliation_strings":["CR-CHUM and Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada","Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CR-CHUM and Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064248322","display_name":"Decio Laks Eizirik","orcid":"https://orcid.org/0000-0003-2453-5889","observed_orcids":["https://orcid.org/0000-0003-2453-5889"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Decio Laks Eizirik","raw_affiliation_strings":["ULB Center for Diabetes Research, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ULB Center for Diabetes Research, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5048375249"],"corresponding_institution_ids":["https://openalex.org/I108290504","https://openalex.org/I83816512"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":8.1658,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.98718195,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"25","issue":"10","first_page":"105056","last_page":"105056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.12950000166893005,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-alpha-cells","display_name":"alpha cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.9850000143051147},{"id":"https://openalex.org/keywords/arx","display_name":"ARX","score":0.75},{"id":"https://openalex.org/keywords/mafb","display_name":"MAFB","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7979999780654907},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.996999979019165},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8820000290870667},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.723139762878418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6834510564804077},{"id":"https://openalex.org/C2777300450","wikidata":"https://www.wikidata.org/wiki/Q2995031","display_name":"Alpha cell","level":5,"score":0.6661144495010376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44965577125549316},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43999382853507996},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4219374358654022},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.418710857629776},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39279621839523315},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34628134965896606},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.28311681747436523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2812368869781494},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16121885180473328},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.16015273332595825},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.11282625794410706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10183140635490417},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[],"locations_count":11,"locations":[{"id":"doi:10.1016/j.isci.2022.105056","doi":"https://doi.org/10.1016/j.isci.2022.105056","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105056","pdf_url":"http://www.cell.com/article/S2589004222013281/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.1101/2022.02.22.481528","doi":"https://doi.org/10.1101/2022.02.22.481528","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.22.481528","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/02/25/2022.02.22.481528.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.2139/ssrn.4046141","doi":"https://doi.org/10.2139/ssrn.4046141","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4046141","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9483809","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9483809","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:36134336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36134336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/1169488","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11568/1169488","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/372662","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/372662","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, 25 (10","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3d50bb63ec9c47b0a381164e3b5b3cb8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3d50bb63ec9c47b0a381164e3b5b3cb8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 25, Iss 10, Pp 105056- (2022)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/164615","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/164615","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:iris.unige.it:11567/1221876","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/1221876","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/99962","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/99962","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2022.105056","doi":"https://doi.org/10.1016/j.isci.2022.105056","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105056","pdf_url":"http://www.cell.com/article/S2589004222013281/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1800554090","display_name":"Genetic and nutritional control of pancreatic beta cell identity.","funder_award_id":"MR/R022259/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1951191603","display_name":null,"funder_award_id":"U01-DK-123594","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G2021752256","display_name":"Roles of GWA genes in controlling pancreatic beta cell function and mass.","funder_award_id":"MR/K001981/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2703204958","display_name":null,"funder_award_id":"RRID: SCR_014393","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G2982259761","display_name":"Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA","funder_award_id":"945268","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3206650756","display_name":null,"funder_award_id":"UC4-DK-112217","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G3263676207","display_name":"Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes","funder_award_id":"667191","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3483691449","display_name":null,"funder_award_id":"115797","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3545490237","display_name":"Role of mitochondrial calcium transport in the regulation of insulin secretion","funder_award_id":"BB/J015873/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3555678735","display_name":"Human Pancreas Analysis Program-T2D","funder_award_id":"U01DK123716","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3692210962","display_name":null,"funder_award_id":"#2018.10.002","funder_id":"https://openalex.org/F4320321708","funder_display_name":"Diabetes Fonds"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4373937310","display_name":"Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881","funder_award_id":"115881","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4532122745","display_name":null,"funder_award_id":"945268","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4668236749","display_name":"Penn integrated Human Pancreas procurement and Analysis Program","funder_award_id":"1uc4dk112217-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4849004728","display_name":null,"funder_award_id":"SCR_014393","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G5012876555","display_name":null,"funder_award_id":"U01-DK-123716","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G560916241","display_name":null,"funder_award_id":"115797]","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G5673545276","display_name":null,"funder_award_id":"R022259","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5829796202","display_name":"Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification","funder_award_id":"16.0097","funder_id":"https://openalex.org/F4320335238","funder_display_name":"Staatssekretariat f\u00fcr Bildung, Forschung und Innovation"},{"id":"https://openalex.org/G6499055791","display_name":"Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes \u2013 Sofia ref.: 115797","funder_award_id":"115797","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G678222046","display_name":"Coordination and Advancement of sub-Saharan Africa-EU Science & Technology Cooperation Network","funder_award_id":"212625","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7328074751","display_name":null,"funder_award_id":"115881","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G7364922087","display_name":"Integrated Program for Human Pancreas Procurement and Analysis","funder_award_id":"UC4DK112232","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7696965656","display_name":null,"funder_award_id":"115797","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G8041914798","display_name":null,"funder_award_id":"16.0097","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G8075407775","display_name":null,"funder_award_id":"945268","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G8312218698","display_name":null,"funder_award_id":"115797","funder_id":"https://openalex.org/F4320309446","funder_display_name":"Leona M. and Harry B. Helmsley Charitable Trust"},{"id":"https://openalex.org/G8454438558","display_name":null,"funder_award_id":"UC4-DK-112232","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G8459268062","display_name":"Roles of the type 2 diabetes (T2D)-associated gene C2cd4a in regulating glucose homeostasis in the mouse","funder_award_id":"MR/R014329/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G9000168923","display_name":null,"funder_award_id":"212625/Z/18/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G9000858089","display_name":"Interferon Signaling in the T1D Islet Microenvironment","funder_award_id":"U01DK127786","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000882213","display_name":"Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D)","funder_award_id":"U01DK123594","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320316367","display_name":"Gouvernement Wallon","ror":"https://ror.org/00jv65847"},{"id":"https://openalex.org/F4320317722","display_name":"Human Islet Research Network","ror":null},{"id":"https://openalex.org/F4320318001","display_name":"R\u00e9gion de Bruxelles-Capitale","ror":"https://ror.org/03h3ed239"},{"id":"https://openalex.org/F4320318621","display_name":"Waalse Gewest","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320321708","display_name":"Diabetes Fonds","ror":"https://ror.org/04ch2g225"},{"id":"https://openalex.org/F4320322852","display_name":"Innoviris","ror":"https://ror.org/04af9zr29"},{"id":"https://openalex.org/F4320323175","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"},{"id":"https://openalex.org/F4320331698","display_name":"Walloon excellence in life sciences and biotechnology","ror":"https://ror.org/04qbvw321"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320335238","display_name":"Staatssekretariat f\u00fcr Bildung, Forschung und Innovation","ror":"https://ror.org/01kw63t33"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294550826.pdf","grobid_xml":"https://content.openalex.org/works/W4294550826.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W29530928","https://openalex.org/W197220479","https://openalex.org/W1965727325","https://openalex.org/W1984607812","https://openalex.org/W1987000412","https://openalex.org/W1989277387","https://openalex.org/W2010481034","https://openalex.org/W2012046618","https://openalex.org/W2024108088","https://openalex.org/W2047708866","https://openalex.org/W2055093639","https://openalex.org/W2059802140","https://openalex.org/W2069225280","https://openalex.org/W2097763382","https://openalex.org/W2103017472","https://openalex.org/W2120598046","https://openalex.org/W2127238864","https://openalex.org/W2130410032","https://openalex.org/W2136729555","https://openalex.org/W2145869245","https://openalex.org/W2154438179","https://openalex.org/W2154785285","https://openalex.org/W2159482845","https://openalex.org/W2159570963","https://openalex.org/W2166243077","https://openalex.org/W2169456326","https://openalex.org/W2190545194","https://openalex.org/W2214074259","https://openalex.org/W2222326255","https://openalex.org/W2291598966","https://openalex.org/W2292633092","https://openalex.org/W2338973074","https://openalex.org/W2558632230","https://openalex.org/W2607031541","https://openalex.org/W2789497201","https://openalex.org/W2789611122","https://openalex.org/W2800392236","https://openalex.org/W2885499809","https://openalex.org/W2897805491","https://openalex.org/W2897922438","https://openalex.org/W2899548656","https://openalex.org/W2931036699","https://openalex.org/W2940256315","https://openalex.org/W2945198601","https://openalex.org/W2948064054","https://openalex.org/W2948535577","https://openalex.org/W2949237386","https://openalex.org/W2950595506","https://openalex.org/W2952872148","https://openalex.org/W2967177832","https://openalex.org/W2969718750","https://openalex.org/W2985506230","https://openalex.org/W3008278692","https://openalex.org/W3010766518","https://openalex.org/W3024506005","https://openalex.org/W3024542293","https://openalex.org/W3028068117","https://openalex.org/W3028837315","https://openalex.org/W3108600352","https://openalex.org/W3114078084","https://openalex.org/W3118955581","https://openalex.org/W4220747142","https://openalex.org/W4231254854","https://openalex.org/W4237335579","https://openalex.org/W4241883936","https://openalex.org/W4294216483","https://openalex.org/W6777692119","https://openalex.org/W6813094581"],"related_works":["https://openalex.org/W4214738129","https://openalex.org/W4414681896","https://openalex.org/W4407925257","https://openalex.org/W2551194178","https://openalex.org/W3035370453","https://openalex.org/W7133503592","https://openalex.org/W3205215991","https://openalex.org/W2523419694","https://openalex.org/W2922283250","https://openalex.org/W4415588081"],"abstract_inverted_index":{"Abstract":[0],"Glucagon":[1],"secretion":[2],"is":[3],"perturbed":[4],"in":[5,88,95,112,124,142,156,194],"both":[6,54,76],"type":[7,10],"1":[8],"and":[9,43,56,85,91,144,197],"2":[11],"diabetes":[12],"(T1D,":[13],"T2D)":[14],"the":[15,19,168,183],"pathophysiological":[16],"changes":[17,141],"at":[18],"level":[20],"of":[21,62,82,170],"individual":[22],"pancreatic":[23],"alpha":[24,48,66,113,120,171],"cells":[25,114,121,172],"are":[26,180],"still":[27],"largely":[28],"obscure.":[29],"Using":[30],"recently-curated":[31],"single-cell":[32],"RNA":[33],"data":[34],"from":[35,115,137],"human":[36],"donors":[37],"with":[38,53,65,101,127],"either":[39],"T1D":[40,119,196],"or":[41],"T2D":[42,116,138],"appropriate":[44],"controls,":[45],"we":[46],"leveraged":[47],"cell":[49,67],"transcriptomic":[50],"alterations":[51,123,169],"consistent":[52],"common":[55,74],"discrete":[57],"pathways.":[58],"Firstly,":[59],"altered":[60],"expression":[61,81],"genes":[63,84,86,99,125,147],"associated":[64,100,126],"identity":[68],"(":[69,106,131,148],"ARX,":[70],"MAFB":[71],")":[72,109,134,152],"was":[73],"to":[75,166,182,188],"diseases.":[77],"In":[78],"contrast,":[79],"increased":[80],"cytokine-regulated":[83],"involved":[87],"glucagon":[89],"biosynthesis":[90],"processing":[92],"were":[93,110,154],"apparent":[94],"T1D,":[96],"whereas":[97],"mitochondrial":[98],"reactive":[102],"oxygen":[103],"species":[104],"generation":[105],"COX7B,":[107],"NQO2":[108],"dysregulated":[111],"patients.":[117],"Conversely,":[118],"displayed":[122],"autoimmune-induced":[128],"ER":[129],"stress":[130],"ERLEC1,":[132],"HSP90":[133],"whilst":[135],"those":[136],"patients":[139],"showed":[140],"glycolytic":[143],"citrate":[145],"cycle":[146],"LDH,":[149],"PDHB,":[150],"PDK4":[151],"which":[153],"unaffected":[155],"T1D.":[157],"These":[158],"findings":[159],"suggest":[160],"that":[161,178],"despite":[162],"some":[163],"similarities":[164],"related":[165],"loss-of-function,":[167],"present":[173],"important":[174],"disease-specific":[175],"signatures,":[176],"suggesting":[177],"they":[179],"secondary":[181],"main":[184],"pathogenic":[185],"events":[186],"characteristic":[187],"each":[189],"disease,":[190],"namely":[191],"immune-mediated-or":[192],"metabolic-mediated-stress":[193],"respectively":[195],"T2D.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-04T00:00:00"}
