{"id":"https://openalex.org/W4294473387","doi":"https://doi.org/10.1136/gutjnl-2022-iddf.55","title":"IDDF2022-ABS-0128 A novel pathogen enterococcus hirae induced dysbiosis in the stomach and the genomic instability to promote gastric cancer","display_name":"IDDF2022-ABS-0128 A novel pathogen enterococcus hirae induced dysbiosis in the stomach and the genomic instability to promote gastric cancer","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4294473387","doi":"https://doi.org/10.1136/gutjnl-2022-iddf.55"},"language":"en","primary_location":{"id":"doi:10.1136/gutjnl-2022-iddf.55","doi":"https://doi.org/10.1136/gutjnl-2022-iddf.55","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gutjnl-2022-iddf.55","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Gastroenterology","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010910230","display_name":"Batsaikhan Saruuljavkhlan","orcid":"https://orcid.org/0000-0003-3258-4453","observed_orcids":["https://orcid.org/0000-0003-3258-4453"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Batsaikhan Saruuljavkhlan","raw_affiliation_strings":["Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan","institution_ids":["https://openalex.org/I188815454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058492775","display_name":"Boldbaatar Gantuya","orcid":"https://orcid.org/0000-0003-4293-0532","observed_orcids":["https://orcid.org/0000-0003-4293-0532"]},"institutions":[{"id":"https://openalex.org/I4210093101","display_name":"Mongolian National University of Medical Sciences","ror":"https://ror.org/00gcpds33","country_code":"MN","type":"education","lineage":["https://openalex.org/I4210093101"]}],"countries":["MN"],"is_corresponding":false,"raw_author_name":"Boldbaatar Gantuya","raw_affiliation_strings":["Department of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia","institution_ids":["https://openalex.org/I4210093101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071115771","display_name":"Junko K. Akada","orcid":"https://orcid.org/0000-0003-2663-9358","observed_orcids":["https://orcid.org/0000-0003-2663-9358"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Akada","raw_affiliation_strings":["Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan","institution_ids":["https://openalex.org/I188815454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114549543","display_name":"Takashi Matsumoto","orcid":"https://orcid.org/0000-0002-6899-1686","observed_orcids":["https://orcid.org/0000-0002-6899-1686"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Matsumoto","raw_affiliation_strings":["Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan","institution_ids":["https://openalex.org/I188815454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007358249","display_name":"Ricky Indra Alfaray","orcid":"https://orcid.org/0000-0001-7721-9455","observed_orcids":["https://orcid.org/0000-0001-7721-9455"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ricky Indra Alfaray","raw_affiliation_strings":["Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan","institution_ids":["https://openalex.org/I188815454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043486253","display_name":"Khasag Oyuntsetseg","orcid":"https://orcid.org/0000-0003-3037-5922","observed_orcids":["https://orcid.org/0000-0003-3037-5922"]},"institutions":[{"id":"https://openalex.org/I4210093101","display_name":"Mongolian National University of Medical Sciences","ror":"https://ror.org/00gcpds33","country_code":"MN","type":"education","lineage":["https://openalex.org/I4210093101"]}],"countries":["MN"],"is_corresponding":false,"raw_author_name":"Khasag Oyuntsetseg","raw_affiliation_strings":["Endoscopy Unit, Mongolia\u2014Japan teaching hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endoscopy Unit, Mongolia\u2014Japan teaching hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia","institution_ids":["https://openalex.org/I4210093101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025363291","display_name":"Yoshio Yamaoka","orcid":"https://orcid.org/0000-0002-1222-5819","observed_orcids":["https://orcid.org/0000-0002-1222-5819"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Yamaoka","raw_affiliation_strings":["Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan","institution_ids":["https://openalex.org/I188815454"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13217391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A49.2","last_page":"A49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterococcus-hirae","display_name":"Enterococcus hirae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8339999914169312},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gastric-epithelial-cells","display_name":"gastric epithelial cells","score":0.6420000195503235},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.6840000152587891},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bacterial-coinfection","display_name":"bacterial co-infection","score":0.6880000233650208},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6140000224113464},{"id":"https://openalex.org/keywords/ags-cells","display_name":"AGS cells","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.42100000381469727},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.6600000262260437},{"id":"https://openalex.org/keywords/pore-forming-toxins","display_name":"pore-forming toxins","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2779734138","wikidata":"https://www.wikidata.org/wiki/Q16981651","display_name":"Enterococcus hirae","level":4,"score":0.9909446239471436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5224127769470215},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4850958585739136},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4789212942123413},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4164188504219055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3505590260028839},{"id":"https://openalex.org/C2780585763","wikidata":"https://www.wikidata.org/wiki/Q517258","display_name":"Enterococcus","level":3,"score":0.25779521465301514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16893884539604187},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/gutjnl-2022-iddf.55","doi":"https://doi.org/10.1136/gutjnl-2022-iddf.55","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gutjnl-2022-iddf.55","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Gastroenterology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3009787955","https://openalex.org/W2607462950","https://openalex.org/W2909735934","https://openalex.org/W3157520457","https://openalex.org/W4323977904","https://openalex.org/W4385477141","https://openalex.org/W3217252799","https://openalex.org/W4406253206","https://openalex.org/W4315475083","https://openalex.org/W3044320347"],"abstract_inverted_index":{"Background":[0],"Previous":[1],"our":[2],"microbiome":[3],"analysis":[4],"indicates":[5],"that":[6,323],"Enterococcus":[7,268,327],"sp.":[8],"predominance":[9],"of":[10,40,45,69,125,136,153,165,173,185,198,254,290,304,326],"microbial":[11],"composition":[12],"has":[13],"been":[14],"determined":[15],"in":[16,58,167,208,275,285,332,335],"patients":[17],"with":[18,235],"gastric":[19,60,122,291,313],"cancer":[20],"(GC)":[21],"by":[22,74,85,141,179],"16S":[23],"rRNA":[24],"metagenomic":[25],"analysis.":[26],"We":[27,215],"aimed":[28],"to":[29,248],"determine":[30],"whether":[31,217],"this":[32,305],"bacterium":[33],"could":[34,202,238],"promote":[35],"the":[36,100,121,130,171,196,240,276,280,287,302,308,312],"emergence":[37],"and":[38,48,90,110,156,163,175,188,205,261,338],"progression":[39],"GC.":[41],"Methods":[42],"The":[43,66,78,133,251],"effects":[44],"E.":[46,108,115,137,144,154,189,200,220,236,255,272],"hirae":[47,109,116,138,155,190,201,237,256],"Helicobacter":[49],"pylori":[50,112,158,187,244,297],"(clinical":[51],"strain":[52],"Mon-Ke2":[53],"as":[54,212,293,295],"control)":[55],"were":[56,83,97],"assessed":[57,84],"a":[59,126,192],"epithelial":[61],"cell":[62,67,161,246],"line":[63],"(AGS":[64],"cells).":[65],"toxicity":[68],"AGS":[70,95,146,168,209,232],"cells":[71,96,147,210,233],"is":[72,316],"identified":[73],"lactate":[75],"dehydrogenase":[76],"levels.":[77],"DNA":[79,228,333],"double-strand":[80],"breaks":[81],"(DSBs)":[82],"gamma-H2AX":[86],"expressions":[87,105],"using":[88,311],"immunoblotting;":[89],"single-cell":[91],"gel":[92],"electrophoresis":[93],"(SCGE).":[94],"analyzed":[98],"for":[99,129,282],"rapid":[101],"oxygen":[102],"species":[103,325],"(ROS)":[104],"response":[106],"after":[107],"H.":[111,157,186,213,243,296],"infections.":[113],"Results":[114],"was":[117,139,177],"successfully":[118],"isolated":[119],"from":[120,231],"mucosal":[123],"specimen":[124],"GC":[127],"patient":[128],"first":[131],"time.":[132],"whole-genome":[134],"sequence":[135],"confirmed":[140,178],"next-generation":[142],"sequencing.":[143],"hirae-infected":[145],"showed":[148],"abnormal":[149],"morphological":[150],"changes.":[151],"Infections":[152],"significantly":[159],"induced":[160],"death":[162],"expression":[164,172],"gH2AX":[166,174],"cells.":[169,340],"Besides,":[170],"DSBs":[176],"SCGE":[180],"comet":[181],"formation.":[182],"Interestingly,":[183],"co-infection":[184],"had":[191],"synergistic":[193],"effect":[194],"on":[195,307],"severity":[197],"DSBs.":[199],"induce":[203,239,249,328],"intranucleus":[204],"mitochondrial":[206],"ROS":[207],"same":[211],"pylori.":[214],"investigated":[216],"only":[218],"live":[219],"hirae,":[221],"or":[222],"its":[223],"released":[224],"factor(s)":[225],"can":[226],"cause":[227],"damage.":[229],"Supernatant":[230],"infected":[234],"gH2AX,":[241],"whereas":[242],"required":[245],"adhesion":[247],"gH2AX.":[250],"complete":[252],"genome":[253],"totally":[257],"contained":[258],"2570":[259],"genes":[260,266],"10":[262],"known":[263],"virulence":[264],"factor":[265],"(e.g.,":[267],"pore-forming":[269],"toxin).":[270],"Conclusions":[271],"hirae-related":[273],"dysbiosis":[274],"stomach":[277],"might":[278],"increase":[279],"risk":[281],"GC,":[283],"resulting":[284,331],"gained":[286],"genomic":[288],"instability":[289],"cells,":[292],"well":[294],"infection.":[298],"Further":[299],"research":[300],"investigating":[301],"impacts":[303],"pathogen":[306],"human":[309],"host":[310],"organoid":[314],"model":[315],"needed":[317],"since":[318],"several":[319],"studies":[320],"have":[321],"shown":[322],"other":[324],"cancer-promoting":[329],"events":[330],"damage":[334],"gastric/colonic":[336],"mucosa,":[337],"hepatic":[339]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-03T00:00:00"}
