{"id":"https://openalex.org/W4294437410","doi":"https://doi.org/10.1016/j.hpr.2022.300671","title":"Malignant hepatic vascular neoplasm with novel RAF1 and GNA11 mutations: Risk stratification considerations for hepatic small vessel neoplasm (HSVN)","display_name":"Malignant hepatic vascular neoplasm with novel RAF1 and GNA11 mutations: Risk stratification considerations for hepatic small vessel neoplasm (HSVN)","publication_year":2022,"publication_date":"2022-08-06","ids":{"openalex":"https://openalex.org/W4294437410","doi":"https://doi.org/10.1016/j.hpr.2022.300671"},"language":"en","primary_location":{"id":"doi:10.1016/j.hpr.2022.300671","doi":"https://doi.org/10.1016/j.hpr.2022.300671","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpr.2022.300671","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000834/pdf","source":{"id":"https://openalex.org/S4210225720","display_name":"Human Pathology Reports","issn_l":"2772-736X","issn":["2772-736X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000834/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080273545","display_name":"Naoki Akanuma","orcid":"https://orcid.org/0000-0002-4165-1550","observed_orcids":["https://orcid.org/0000-0002-4165-1550"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoki Akanuma","raw_affiliation_strings":["University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061370294","display_name":"Nancy M. Joseph","orcid":"https://orcid.org/0000-0001-6840-6953","observed_orcids":["https://orcid.org/0000-0001-6840-6953"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy M. Joseph","raw_affiliation_strings":["University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084494097","display_name":"Matthew D. Stachler","orcid":"https://orcid.org/0000-0003-0958-0286","observed_orcids":["https://orcid.org/0000-0003-0958-0286"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Stachler","raw_affiliation_strings":["University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025355070","display_name":"Spencer C. Behr","orcid":"https://orcid.org/0000-0001-9400-0543","observed_orcids":["https://orcid.org/0000-0001-9400-0543"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Spencer Behr","raw_affiliation_strings":["University of California, San Francisco, Department of Radiology, San Francisco, CA 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Department of Radiology, San Francisco, CA 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043348214","display_name":"Toshiyuki Takahashi","orcid":"https://orcid.org/0000-0002-8783-3528","observed_orcids":["https://orcid.org/0000-0002-8783-3528"]},"institutions":[{"id":"https://openalex.org/I4405257923","display_name":"Hokkaido Gastroenterology Hospital","ror":"https://ror.org/05tq2c590","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405257923"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Takahashi","raw_affiliation_strings":["Department of Pathology, Hokkaido Gastroenterology Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hokkaido Gastroenterology Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4405257923"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043906736","display_name":"Ryan M. Gill","orcid":"https://orcid.org/0000-0001-6229-7928","observed_orcids":["https://orcid.org/0000-0001-6229-7928"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan M. Gill","raw_affiliation_strings":["University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Department of Pathology, San Francisco, CA 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043906736"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":880,"currency":"USD","value_usd":880},"apc_paid":{"value":880,"currency":"USD","value_usd":880},"fwci":0.4179,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59540668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"29","issue":null,"first_page":"300671","last_page":"300671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.24150000512599945,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raf1-mutation","display_name":"RAF1 mutation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gna11-mutation","display_name":"GNA11 mutation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gnaq","display_name":"GNAQ","score":0.6449999809265137},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/splenic-metastasis","display_name":"splenic metastasis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9300000071525574},{"id":"https://openalex.org/keywords/novel-mutations","display_name":"novel mutations","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2779176653","wikidata":"https://www.wikidata.org/wiki/Q18026236","display_name":"GNAQ","level":4,"score":0.9537844657897949},{"id":"https://openalex.org/C2780635560","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplasm","level":2,"score":0.6605051755905151},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5837475657463074},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.42424148321151733},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41220754384994507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38157665729522705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3246793746948242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26735344529151917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08390909433364868},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.054838985204696655}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.hpr.2022.300671","doi":"https://doi.org/10.1016/j.hpr.2022.300671","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpr.2022.300671","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000834/pdf","source":{"id":"https://openalex.org/S4210225720","display_name":"Human Pathology Reports","issn_l":"2772-736X","issn":["2772-736X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e8c5a8c157014e2580217a4392916e10","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e8c5a8c157014e2580217a4392916e10","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Pathology Reports, Vol 29, Iss , Pp 300671- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.hpr.2022.300671","doi":"https://doi.org/10.1016/j.hpr.2022.300671","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpr.2022.300671","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000834/pdf","source":{"id":"https://openalex.org/S4210225720","display_name":"Human Pathology Reports","issn_l":"2772-736X","issn":["2772-736X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294437410.pdf","grobid_xml":"https://content.openalex.org/works/W4294437410.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1966823852","https://openalex.org/W1975303234","https://openalex.org/W1994959821","https://openalex.org/W2032504112","https://openalex.org/W2050351305","https://openalex.org/W2053520756","https://openalex.org/W2077517114","https://openalex.org/W2081835814","https://openalex.org/W2085729689","https://openalex.org/W2125340759","https://openalex.org/W2144420455","https://openalex.org/W2332223399","https://openalex.org/W2336353198","https://openalex.org/W2499311996","https://openalex.org/W2578954892","https://openalex.org/W2583207773","https://openalex.org/W2784491205","https://openalex.org/W2810833783","https://openalex.org/W2895684263","https://openalex.org/W2900348050","https://openalex.org/W2904840484","https://openalex.org/W2906900722","https://openalex.org/W2963555074","https://openalex.org/W2968854665","https://openalex.org/W2986497192","https://openalex.org/W3005073090","https://openalex.org/W3135649779","https://openalex.org/W3153167650","https://openalex.org/W3172276449","https://openalex.org/W3208495104","https://openalex.org/W4221128604","https://openalex.org/W6649111686"],"related_works":["https://openalex.org/W4283375679","https://openalex.org/W2336353198","https://openalex.org/W2810833783","https://openalex.org/W4401564480","https://openalex.org/W3135649779","https://openalex.org/W2784491205","https://openalex.org/W4411964768","https://openalex.org/W4403721456","https://openalex.org/W4414160947","https://openalex.org/W4221128604"],"abstract_inverted_index":{"GNAQ":[0,10,179],",":[1,3],"GNA11":[2,108],"and":[4,61,115,123,129,138,147,157,187],"GNA14":[5],"are":[6,13],"paralogues":[7],"in":[8,17,37,174],"the":[9,132,141,159],"family":[11,180],"that":[12,54,166],"mutually":[14],"exclusively":[15],"mutated":[16],"a":[18,49,79,107,116],"group":[19],"of":[20,99,193],"vascular":[21,52,84,176],"neoplasms":[22,177],"with":[23,86,178],"thin-walled":[24],"capillary-like":[25],"vasoformative":[26],"growth,":[27],"which":[28,47,62],"occur":[29],"at":[30],"multiple":[31],"sites.":[32],"The":[33],"primary":[34,81],"liver":[35,154],"tumor":[36,133,155],"this":[38,74],"category":[39],"is":[40,48],"termed":[41],"hepatic":[42,59,83,175],"small":[43],"vessel":[44],"neoplasm":[45,53,85],"(HSVN),":[46],"rare":[50],"infiltrative":[51,87],"can":[55],"be":[56],"misdiagnosed":[57],"as":[58,66,94,96],"angiosarcoma":[60],"has":[63],"been":[64],"described":[65],"having":[67],"likely":[68],"very":[69],"low":[70,88,121],"malignant":[71,82,185],"potential.":[72],"In":[73],"study,":[75],"we":[76,188],"report":[77],"on":[78],"novel":[80],"grade":[89,101,113,122,125,153,168],"regions":[90,97],"morphologically":[91],"resembling":[92],"HSVN,":[93],"well":[95],"suggestive":[98],"high":[100,112,124,152,167],"transformation.":[102],"Next":[103],"generation":[104,191],"sequencing":[105,192],"demonstrated":[106],"p.Gln209Leu":[109],"mutation":[110,119],"(in":[111,120],"regions)":[114],"RAF1":[117,161],"p.Met469Ile":[118],"regions).":[126],"On":[127],"radiographic":[128],"gross":[130],"examination,":[131],"was":[134],"unencapsulated,":[135],"poorly":[136],"circumscribed,":[137],"multifocal":[139],"throughout":[140],"liver.":[142],"Splenic":[143],"metastases":[144],"were":[145,148],"identified":[146],"histologically":[149],"similar":[150],"to":[151],"regions,":[156],"shared":[158],"same":[160],"mutation.":[162],"These":[163],"findings":[164],"argue":[165],"morphology":[169],"and/or":[170],"additional":[171],"oncogenic":[172],"mutations":[173,181],"heighten":[182],"concern":[183],"for":[184,195],"potential":[186],"advise":[189],"next":[190],"HSVN":[194],"risk":[196],"stratification.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-09-03T00:00:00"}
