{"id":"https://openalex.org/W4294344765","doi":"https://doi.org/10.1158/1078-0432.ccr-22-2104","title":"XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL","display_name":"XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL","publication_year":2022,"publication_date":"2022-08-19","ids":{"openalex":"https://openalex.org/W4294344765","doi":"https://doi.org/10.1158/1078-0432.ccr-22-2104","pmid":"https://pubmed.ncbi.nlm.nih.gov/35984355","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633424"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-22-2104","doi":"https://doi.org/10.1158/1078-0432.ccr-22-2104","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-22-2104","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633424","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088892048","display_name":"Naitao Wang","orcid":"https://orcid.org/0000-0002-0167-1565","observed_orcids":["https://orcid.org/0000-0002-0167-1565"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naitao Wang","raw_affiliation_strings":["1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-0167-1565","affiliations":[{"raw_affiliation_string":"1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089094298","display_name":"A. Ari Hakimi","orcid":"https://orcid.org/0000-0002-0930-8824","observed_orcids":["https://orcid.org/0000-0002-0930-8824","https://orcid.org/0000-0002-5705-5059","https://orcid.org/0000-0001-7504-6044","https://orcid.org/0000-0003-0329-3921"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Ari Hakimi","raw_affiliation_strings":["2Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York","3Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-0930-8824","affiliations":[{"raw_affiliation_string":"2Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"3Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100401992","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-0171-3884","observed_orcids":["https://orcid.org/0000-0002-0171-3884"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yu Chen","raw_affiliation_strings":["1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York","4Department of Medicine, Genitourinary Service, Memorial Sloan Kettering Cancer Center, New York, New York","5Department of Medicine, Weill Cornell Medical College, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-0171-3884","affiliations":[{"raw_affiliation_string":"1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"4Department of Medicine, Genitourinary Service, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"5Department of Medicine, Weill Cornell Medical College, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100401992"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.079553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"28","issue":"21","first_page":"4600","last_page":"4602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9419999718666077},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bcl-xl-inhibition","display_name":"BCL-XL inhibition","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cancer-dependency","display_name":"cancer dependency","score":0.6399999856948853},{"id":"https://openalex.org/keywords/crispr-screening","display_name":"CRISPR screen","score":0.703000009059906},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.8939999938011169},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.6891797780990601},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6854382753372192},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6022230982780457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5694395303726196},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5531448721885681},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.49855566024780273},{"id":"https://openalex.org/C2776789625","wikidata":"https://www.wikidata.org/wiki/Q4875408","display_name":"Bcl-xL","level":4,"score":0.4755639433860779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4627964496612549},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.4313357472419739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4137577414512634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38699984550476074},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.34088534116744995},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2636904716491699},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25876712799072266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1253519058227539}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.ccr-22-2104","doi":"https://doi.org/10.1158/1078-0432.ccr-22-2104","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-22-2104","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:35984355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35984355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Editorial"},{"id":"pmh:oai:pubmedcentral.nih.gov:9633424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633424","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9633424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633424","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2538737708","display_name":null,"funder_award_id":"P30 CA008748","funder_id":"https://openalex.org/F4320338333","funder_display_name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338333","display_name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","ror":"https://ror.org/00vkwep27"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2009333774","https://openalex.org/W2085419794","https://openalex.org/W2149456801","https://openalex.org/W2168632005","https://openalex.org/W2741508285","https://openalex.org/W2756219586","https://openalex.org/W2770858121","https://openalex.org/W2888730977","https://openalex.org/W2946882253","https://openalex.org/W2990669650","https://openalex.org/W3048827006","https://openalex.org/W3081958456","https://openalex.org/W3091771519","https://openalex.org/W3107594221","https://openalex.org/W3128607514","https://openalex.org/W3131063362","https://openalex.org/W3186351348","https://openalex.org/W3215130076","https://openalex.org/W4213142561","https://openalex.org/W4283577197","https://openalex.org/W4283739067"],"related_works":["https://openalex.org/W4283739067","https://openalex.org/W7212308234","https://openalex.org/W2433155765","https://openalex.org/W2042314247","https://openalex.org/W2025894164","https://openalex.org/W2113168515","https://openalex.org/W4413270174","https://openalex.org/W2157541595","https://openalex.org/W4312085009","https://openalex.org/W3145968597"],"abstract_inverted_index":{"Through":[0],"analysis":[1],"of":[2,7],"the":[3,14],"cancer":[4],"dependency":[5,23],"map":[6],"CRISPR":[8],"and":[9,47],"short":[10],"hairpin":[11],"RNA":[12],"datasets,":[13],"antiapoptotic":[15],"BCL-XL":[16,30],"was":[17],"found":[18],"to":[19,49],"be":[20],"a":[21,38,44],"selective":[22],"in":[24,35],"kidney":[25,28],"cancer.":[26],"Among":[27],"cancers,":[29],"inhibition":[31],"is":[32],"most":[33],"active":[34],"those":[36],"with":[37],"mesenchymal":[39],"gene":[40],"signature,":[41],"which":[42],"portends":[43],"poor":[45],"prognosis":[46],"response":[48],"current":[50],"therapies.":[51],"See":[52],"related":[53],"article":[54],"by":[55],"Grubb":[56],"et":[57],"al.,":[58],"p.":[59],"4689.":[60]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-09-03T00:00:00"}
