{"id":"https://openalex.org/W4294309286","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1975","title":"Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer","display_name":"Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer","publication_year":2013,"publication_date":"2013-09-28","ids":{"openalex":"https://openalex.org/W4294309286","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1975","pmid":"https://pubmed.ncbi.nlm.nih.gov/24077350","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882158"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-13-1975","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1975","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-13-1975","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090831643","display_name":"Robert J. Cardnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Cardnell","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101904571","display_name":"Ying Feng","orcid":"https://orcid.org/0000-0002-1175-2051","observed_orcids":["https://orcid.org/0000-0002-1175-2051"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Feng","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089771018","display_name":"Lixia Diao","orcid":"https://orcid.org/0000-0001-6995-4492","observed_orcids":["https://orcid.org/0000-0001-6995-4492"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lixia Diao","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102985214","display_name":"You-Hong Fan","orcid":"https://orcid.org/0000-0002-1668-8271","observed_orcids":["https://orcid.org/0000-0002-1668-8271"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"You-Hong Fan","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023922689","display_name":"Fatemah Masrorpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatemah Masrorpour","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378341","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0009-0006-4171-5397","https://orcid.org/0000-0002-8911-9555","https://orcid.org/0009-0003-0661-5954"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090079774","display_name":"Yuqiao Shen","orcid":"https://orcid.org/0009-0003-8444-8127","observed_orcids":["https://orcid.org/0009-0003-8444-8127"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuqiao Shen","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048865240","display_name":"John Dorrance Minna","orcid":"https://orcid.org/0000-0002-7776-0767","observed_orcids":["https://orcid.org/0000-0002-7776-0767"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Minna","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048380048","display_name":"John Victor Heymach","orcid":"https://orcid.org/0000-0001-9068-8942","observed_orcids":["https://orcid.org/0000-0001-9068-8942"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John V. Heymach","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067755477","display_name":"Lauren A. Byers","orcid":"https://orcid.org/0000-0002-0780-2677","observed_orcids":["https://orcid.org/0000-0002-0780-2677"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lauren A. Byers","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","Bioinformatics and Computational Biology","Biomarin Pharmaceuticals Inc., Novato, California","Systems Biology, UT MD Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Thoracic/Head and Neck Medical Oncology; 2Bioinformatics and Computational Biology; 3Systems Biology, UT MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas; and 5Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology","institution_ids":[]},{"raw_affiliation_string":"Biomarin Pharmaceuticals Inc., Novato, California","institution_ids":[]},{"raw_affiliation_string":"Systems Biology, UT MD Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067755477"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039370","https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":8.8895,"has_fulltext":false,"cited_by_count":176,"citation_normalized_percentile":{"value":0.98735552,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"19","issue":"22","first_page":"6322","last_page":"6328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":0.9620000123977661},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.847000002861023},{"id":"https://openalex.org/keywords/dna-repair-proteins","display_name":"DNA repair proteins","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pi3k-mtor-pathway","display_name":"PI3K/mTOR pathway","score":0.9739999771118164},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9789999723434448},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.6700000166893005},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6949999928474426},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cisplatin-sensitivity","display_name":"cisplatin sensitivity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6979389190673828},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6836146712303162},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6669445037841797},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.6574752926826477},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6529756784439087},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.5769914984703064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5250177979469299},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5226107239723206},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4874315559864044},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4026838541030884},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2647727131843567},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2147267758846283},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13939407467842102},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09942930936813354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07077276706695557},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.ccr-13-1975","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1975","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-13-1975","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:24077350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24077350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3882158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3882158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2149024233","display_name":"MD Anderson Gynecologic SPORE for Uterine Cancers","funder_award_id":"P50CA098258","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5746294","display_name":"Targeting Lung Cancer Vulnerabilities","funder_award_id":"P50CA070907","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1827740955","https://openalex.org/W1967058699","https://openalex.org/W1998625630","https://openalex.org/W1999659306","https://openalex.org/W2004393499","https://openalex.org/W2071185061","https://openalex.org/W2098161852","https://openalex.org/W2113382133","https://openalex.org/W2115950635","https://openalex.org/W2120806256","https://openalex.org/W2126983941","https://openalex.org/W2130084494","https://openalex.org/W2131664752","https://openalex.org/W2146717458","https://openalex.org/W2166923287","https://openalex.org/W2169276102","https://openalex.org/W2171972386","https://openalex.org/W2603397280","https://openalex.org/W4317675252"],"related_works":["https://openalex.org/W2080085348","https://openalex.org/W2095240617","https://openalex.org/W2105007834","https://openalex.org/W2317040753","https://openalex.org/W2504509590","https://openalex.org/W2098161852","https://openalex.org/W3126627078","https://openalex.org/W2598546211","https://openalex.org/W1654311348","https://openalex.org/W4308027436"],"abstract_inverted_index":{"PURPOSE:":[0],"Small":[1],"cell":[2,128],"lung":[3],"carcinoma":[4],"(SCLC)":[5],"is":[6],"an":[7],"aggressive":[8],"malignancy":[9],"affecting":[10],"nearly":[11],"30,000":[12],"people":[13],"annually":[14],"in":[15,26,30,79,88,126,138,166,220,221,230],"the":[16,34,173],"United":[17],"States.":[18],"We":[19,117],"have":[20],"previously":[21],"identified":[22],"elevated":[23,151],"PARP1":[24],"levels":[25,154],"SCLC":[27,72,89,127,167,223],"and":[28,39,53,81,94,104,130,179,246],"demonstrated":[29],"vitro":[31,80,222],"sensitivity":[32],"to":[33,142,145,217,238],"PARP":[35,49,108,239],"inhibitors":[36],"AZD":[37],"2281":[38],"AG014699.":[40],"Here,":[41],"we":[42,177],"evaluate":[43],"activity":[44,122,140],"of":[45,56,71,123,155,172,190,193,201],"a":[46,59,113,184,191,209],"novel,":[47],"potent":[48],"inhibitor,":[50],"BMN":[51,75,124,135,146,218],"673,":[52],"identify":[54],"markers":[55,64],"response":[57,216],"as":[58,206,208],"basis":[60],"for":[61,65],"developing":[62],"predictive":[63],"clinical":[66],"application.":[67],"EXPERIMENTAL":[68],"DESIGN:":[69],"Inhibition":[70],"proliferation":[73],"by":[74,99],"673":[76,125,136,147,219],"was":[77,97,110,148,164],"assayed":[78],"effects":[82],"on":[83],"tumor":[84],"growth":[85],"were":[86],"measured":[87],"xenograft":[90],"models.":[91,224],"Protein":[92],"expression":[93,153,200],"pathway":[95],"activation":[96,171],"assessed":[98],"reverse":[100],"phase":[101],"protein":[102,213],"array":[103],"western":[105],"blot":[106],"analysis.":[107],"inhibition":[109,233],"confirmed":[111,180],"using":[112],"PAR":[114],"ELISA.":[115],"RESULTS:":[116],"demonstrate":[118],"striking,":[119],"single":[120,133],"agent":[121,134],"lines":[129],"xenografts,":[131],"with":[132,150,169,183],"exhibiting":[137],"vivo":[139],"similar":[141],"cisplatin.":[143],"Sensitivity":[144],"associated":[149],"baseline":[152,170],"several":[156],"DNA":[157,195,203,244],"repair":[158,187,196,204,212,245],"proteins,":[159,205],"whereas":[160],"greater":[161],"drug":[162],"resistance":[163],"observed":[165],"models":[168,237],"PI3K/mTOR":[174],"pathway.":[175],"Furthermore,":[176],"developed":[178],"these":[181],"data":[182],"novel":[185],"\"DNA":[186,211],"score\"":[188],"consisting":[189],"group":[192],"17":[194],"proteins.":[197],"CONCLUSIONS:":[198],"Elevated":[199],"multiple":[202],"well":[207],"corresponding":[210],"score,\"":[214],"predict":[215],"These":[225],"observations":[226],"complement":[227],"recent":[228],"work":[229],"which":[231],"PI3K":[232,247],"sensitizes":[234],"breast":[235],"cancer":[236],"inhibition,":[240],"suggesting":[241],"cooperation":[242],"between":[243],"pathways.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-09-02T00:00:00"}
