{"id":"https://openalex.org/W4294216765","doi":"https://doi.org/10.1016/j.reth.2022.08.006","title":"A silk fibroin/chitosan/nanohydroxyapatite biomimetic bone scaffold combined with autologous concentrated growth factor promotes the proliferation and osteogenic differentiation of BMSCs and repair of critical bone defects","display_name":"A silk fibroin/chitosan/nanohydroxyapatite biomimetic bone scaffold combined with autologous concentrated growth factor promotes the proliferation and osteogenic differentiation of BMSCs and repair of critical bone defects","publication_year":2022,"publication_date":"2022-09-02","ids":{"openalex":"https://openalex.org/W4294216765","doi":"https://doi.org/10.1016/j.reth.2022.08.006","pmid":"https://pubmed.ncbi.nlm.nih.gov/36110973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9459434"},"language":"en","primary_location":{"id":"doi:10.1016/j.reth.2022.08.006","doi":"https://doi.org/10.1016/j.reth.2022.08.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reth.2022.08.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352320422000840/pdf","source":{"id":"https://openalex.org/S2898509233","display_name":"Regenerative Therapy","issn_l":"2352-3204","issn":["2352-3204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regenerative Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2352320422000840/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091841028","display_name":"Yi Zhou","orcid":"https://orcid.org/0000-0001-9616-7283","observed_orcids":["https://orcid.org/0000-0001-9616-7283"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhou","raw_affiliation_strings":["Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China","institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210117574"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoyan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Liu","raw_affiliation_strings":["Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China","institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210117574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089336188","display_name":"Hongjiang She","orcid":"https://orcid.org/0000-0001-6081-1161","observed_orcids":["https://orcid.org/0000-0001-6081-1161"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjiang She","raw_affiliation_strings":["Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China","institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210117574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431432","display_name":"Rui Wang","orcid":"https://orcid.org/0009-0003-1516-3865","observed_orcids":["https://orcid.org/0009-0003-1516-3865"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China","institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210117574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031695152","display_name":"Fan Bai","orcid":"https://orcid.org/0000-0001-6802-869X","observed_orcids":["https://orcid.org/0000-0001-6802-869X"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Bai","raw_affiliation_strings":["Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China","institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210117574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074386624","display_name":"Bingyan Xiang","orcid":"https://orcid.org/0000-0002-1069-2990","observed_orcids":["https://orcid.org/0000-0002-1069-2990"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bingyan Xiang","raw_affiliation_strings":["Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China"],"raw_orcid":"https://orcid.org/0000-0002-1069-2990","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi 563000, China","institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210117574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074386624"],"corresponding_institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210117574"],"apc_list":{"value":1100,"currency":"USD","value_usd":1100},"apc_paid":{"value":1100,"currency":"USD","value_usd":1100},"fwci":2.1507,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.87805783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"21","issue":null,"first_page":"307","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silk-fibroin","display_name":"silk fibroin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":1.0},{"id":"https://openalex.org/keywords/nano-hydroxyapatite","display_name":"hydroxyapatite nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/radial-bone-defect","display_name":"radial bone defect","score":0.7269999980926514},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.8500000238418579},{"id":"https://openalex.org/keywords/vacuum-freeze-drying","display_name":"vacuum freeze-drying","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.7300000190734863},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/endogenous-growth-factors","display_name":"endogenous growth factors","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C122302759","wikidata":"https://www.wikidata.org/wiki/Q2345087","display_name":"Fibroin","level":3,"score":0.8031355142593384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6369937658309937},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5401630997657776},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.520225465297699},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4958532750606537},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.48011302947998047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46418824791908264},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.4395013749599457},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4286990761756897},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.41574087738990784},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2908429503440857},{"id":"https://openalex.org/C2780431358","wikidata":"https://www.wikidata.org/wiki/Q653622","display_name":"SILK","level":2,"score":0.2735730707645416},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21217256784439087},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21051433682441711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13037145137786865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10353782773017883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06956562399864197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.reth.2022.08.006","doi":"https://doi.org/10.1016/j.reth.2022.08.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reth.2022.08.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352320422000840/pdf","source":{"id":"https://openalex.org/S2898509233","display_name":"Regenerative Therapy","issn_l":"2352-3204","issn":["2352-3204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regenerative Therapy","raw_type":"journal-article"},{"id":"pmid:36110973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36110973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regenerative therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9459434","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9459434/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regen Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:485ea697b2dc47e8bbf988382f66cb7f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/485ea697b2dc47e8bbf988382f66cb7f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regenerative Therapy, Vol 21, Iss , Pp 307-321 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.reth.2022.08.006","doi":"https://doi.org/10.1016/j.reth.2022.08.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reth.2022.08.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352320422000840/pdf","source":{"id":"https://openalex.org/S2898509233","display_name":"Regenerative Therapy","issn_l":"2352-3204","issn":["2352-3204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regenerative Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317797","display_name":"Health Commission of Guizhou Province","ror":"https://ror.org/027yzwq33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294216765.pdf","grobid_xml":"https://content.openalex.org/works/W4294216765.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1992667806","https://openalex.org/W1995197358","https://openalex.org/W2081212964","https://openalex.org/W2139776494","https://openalex.org/W2168440095","https://openalex.org/W2338638866","https://openalex.org/W2462418500","https://openalex.org/W2511643530","https://openalex.org/W2520684170","https://openalex.org/W2586983997","https://openalex.org/W2770757276","https://openalex.org/W2793852848","https://openalex.org/W2806004230","https://openalex.org/W2899379724","https://openalex.org/W2925303492","https://openalex.org/W2935152089","https://openalex.org/W2942143115","https://openalex.org/W2979128317","https://openalex.org/W2998281820","https://openalex.org/W3004457329","https://openalex.org/W3005211630","https://openalex.org/W3007830114","https://openalex.org/W3008341268","https://openalex.org/W3033264461","https://openalex.org/W3034359565","https://openalex.org/W3036594701","https://openalex.org/W3036935292","https://openalex.org/W3087332512","https://openalex.org/W3087346097","https://openalex.org/W3095461449","https://openalex.org/W3106482867","https://openalex.org/W3109480798","https://openalex.org/W3122904318","https://openalex.org/W3123094292","https://openalex.org/W3124114265","https://openalex.org/W3128902690","https://openalex.org/W3129013255","https://openalex.org/W3145134137","https://openalex.org/W3175816403","https://openalex.org/W3177327727","https://openalex.org/W3178725098","https://openalex.org/W3190855693","https://openalex.org/W3203627555","https://openalex.org/W3211320284","https://openalex.org/W3212156407","https://openalex.org/W3213374739","https://openalex.org/W3216589315","https://openalex.org/W4200209323","https://openalex.org/W4205766845","https://openalex.org/W4205825742","https://openalex.org/W4220794027","https://openalex.org/W4226474956","https://openalex.org/W6773192977","https://openalex.org/W6797699532","https://openalex.org/W6805697419"],"related_works":["https://openalex.org/W2767907870","https://openalex.org/W2759816798","https://openalex.org/W2058774857","https://openalex.org/W2398805299","https://openalex.org/W2357264020","https://openalex.org/W1415722263","https://openalex.org/W2954411811","https://openalex.org/W2023345288","https://openalex.org/W7134920528","https://openalex.org/W2053417826"],"abstract_inverted_index":{"Purpose:":[0],"With":[1],"the":[2,6,60,66,79,112,115,163,180,215,224,241,258,272,292,303,316],"goal":[3],"of":[4,9,62,71,81,89,97,114,136,166,211,238,297,306],"increasing":[5],"translational":[7],"efficiency":[8,80,266,305],"bone":[10,28,72,174,193,220,268,285,308],"tissue":[11],"engineering":[12],"for":[13,26,218,247,278,318],"practical":[14],"clinical":[15,319],"applications,":[16],"biomimetic":[17,46,92,284],"composite":[18,45,91,283],"scaffolds":[19,93,116,274],"combined":[20,50,185,226,261,287],"with":[21,52,94,186,262,288],"autologous":[22,53,289],"endogenous":[23],"growth":[24,55],"factors":[25],"repairing":[27,82,219],"defects":[29,309],"have":[30,315],"become":[31],"a":[32,41,170],"current":[33],"research":[34],"hotspot.":[35],"In":[36,119,168,222,249],"this":[37,63],"study,":[38],"we":[39],"prepared":[40,103],"silk":[42],"fibroin/chitosan/nanohydroxyapatite":[43],"(SF/CS/nHA)":[44],"scaffold":[47,182,260,286],"and":[48,68,78,100,107,111,127,134,145,156,179,206,235,253,294,301],"then":[49,128],"it":[51],"concentrated":[54],"factor":[56],"(CGF)":[57],"to":[58,161,322],"explore":[59],"effect":[61,191],"combination":[64,313],"on":[65,124,192],"proliferation":[67,135,293],"osteogenic":[69,164,236,295],"differentiation":[70,165,237,296],"marrow":[73],"mesenchymal":[74],"stem":[75],"cells":[76],"(BMSCs)":[77],"critical":[83,173,307],"radial":[84],"defects.":[85,221],"Methods:":[86],"Three":[87],"kinds":[88],"SF/CS/nHA":[90,125,213,225,259,282],"mass":[95],"fractions":[96],"3%,":[98],"4%,":[99],"5%":[101],"were":[102,117,122,138,159,214],"by":[104,140,198],"vacuum":[105],"freeze-drying":[106],"chemical":[108],"cross-linking":[109],"methods,":[110],"characteristics":[113,210],"evaluated.":[118],"vitro,":[120,223],"BMSCs":[121,137,239,298],"seeded":[123],"scaffolds,":[126],"CGF":[129,187,227,263,290],"was":[130,177,188,196],"added.":[131],"The":[132,190,209],"morphology":[133],"evaluated":[139,197],"live-dead":[141],"staining,":[142,144,149,152,203,205],"phalloidin":[143],"CCK-8":[146],"assays.":[147],"ALP":[148],"alizarin":[150],"red":[151],"cellular":[153],"immunofluorescence,":[154],"RT-PCR,":[155],"Western":[157],"blotting":[158],"used":[160],"detect":[162],"BMSCs.":[167],"vivo,":[169],"rabbit":[171],"radius":[172],"defect":[175,194,269],"model":[176],"constructed,":[178],"SF/CS/nHA-BMSC":[181],"cell":[183,232],"complex":[184],"implanted.":[189],"repair":[195,270,304],"3D":[199],"CT":[200],"scanning,":[201],"HE":[202],"Masson":[204],"immunohistochemistry.":[207],"Results:":[208],"4%":[212],"most":[216],"suitable":[217],"group":[228],"showed":[229],"better":[230,265],"adhesion,":[231],"morphology,":[233],"proliferation,":[234],"than":[240,271],"other":[242,273],"groups":[243],"(P":[244,275],"<":[245,276],"0.05":[246,277],"all).":[248,279],"vivo":[250],"imaging":[251],"examination":[252],"histological":[254],"analysis":[255],"demonstrated":[256],"that":[257],"had":[264],"in":[267,299,310],"Conclusions:":[280],"A":[281],"promoted":[291],"vitro":[300],"improved":[302],"vivo.":[311],"This":[312],"may":[314],"potential":[317],"translation":[320],"due":[321],"its":[323],"excellent":[324],"biocompatibility.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-02T00:00:00"}
