{"id":"https://openalex.org/W4294192056","doi":"https://doi.org/10.1016/j.isci.2022.105047","title":"Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland","display_name":"Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland","publication_year":2022,"publication_date":"2022-09-02","ids":{"openalex":"https://openalex.org/W4294192056","doi":"https://doi.org/10.1016/j.isci.2022.105047","pmid":"https://pubmed.ncbi.nlm.nih.gov/36147959","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9485076"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2022.105047","doi":"https://doi.org/10.1016/j.isci.2022.105047","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105047","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.isci.2022.105047","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017964063","display_name":"Paola Serrano Martinez","orcid":"https://orcid.org/0000-0002-0688-0083","observed_orcids":["https://orcid.org/0000-0002-0688-0083"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paola Serrano Martinez","raw_affiliation_strings":["Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031485695","display_name":"Martti Maimets","orcid":"https://orcid.org/0000-0001-7343-2769","observed_orcids":["https://orcid.org/0000-0001-7343-2769"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martti Maimets","raw_affiliation_strings":["Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082008557","display_name":"Reinier Bron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Reinier Bron","raw_affiliation_strings":["Department of Biomedical Engineering, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037757072","display_name":"Ronald P. van Os","orcid":"https://orcid.org/0000-0001-6188-1540","observed_orcids":["https://orcid.org/0000-0001-6188-1540"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ronald van Os","raw_affiliation_strings":["Department of Biology of Aging, Section Stem Cell Biology, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology of Aging, Section Stem Cell Biology, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025350377","display_name":"Gerald de Haan","orcid":"https://orcid.org/0000-0001-9706-0138","observed_orcids":["https://orcid.org/0000-0001-9706-0138"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerald de Haan","raw_affiliation_strings":["Department of Biology of Aging, Section Stem Cell Biology, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology of Aging, Section Stem Cell Biology, European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044168723","display_name":"Sarah A. Pringle","orcid":"https://orcid.org/0000-0002-0779-1680","observed_orcids":["https://orcid.org/0000-0002-0779-1680"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sarah Pringle","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026386651","display_name":"Robert Paul Coppes","orcid":"https://orcid.org/0000-0001-5503-1064","observed_orcids":["https://orcid.org/0000-0001-5503-1064"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Robert P. Coppes","raw_affiliation_strings":["Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-5503-1064","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026386651"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.6193,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6459953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"25","issue":"10","first_page":"105047","last_page":"105047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/submandibular-gland","display_name":"submandibular gland","score":0.9729999899864197},{"id":"https://openalex.org/keywords/stem-and-progenitor-cells","display_name":"stem/progenitor cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cellular-quiescence","display_name":"quiescent cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/label-retaining-cells","display_name":"label-retaining cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-cycling","display_name":"cell cycling","score":0.5389999747276306},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.6970000267028809},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8510000109672546},{"id":"https://openalex.org/keywords/embryonic-origin","display_name":"embryonic origin","score":0.5289999842643738},{"id":"https://openalex.org/keywords/salivary-gland-development","display_name":"salivary gland development","score":0.6050000190734863},{"id":"https://openalex.org/keywords/salivary-gland-regeneration","display_name":"salivary gland regeneration","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7975135445594788},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7483111619949341},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7141382694244385},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.6939730048179626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6806986927986145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6523231863975525},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.562156081199646},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5617884397506714},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.5582171678543091},{"id":"https://openalex.org/C2780266248","wikidata":"https://www.wikidata.org/wiki/Q579886","display_name":"Submandibular gland","level":2,"score":0.43868938088417053},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1771761178970337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05504101514816284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.isci.2022.105047","doi":"https://doi.org/10.1016/j.isci.2022.105047","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105047","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4035854","doi":"https://doi.org/10.2139/ssrn.4035854","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4035854","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9485076","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9485076","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:36147959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36147959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/06cf5848-74a2-4bdb-9429-212a506c93a2","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/06cf5848-74a2-4bdb-9429-212a506c93a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Serrano Martinez, P, Maimets, M, Bron, R, van Os, R, de Haan, G, Pringle, S & Coppes, R P 2022, 'Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland', iScience , vol. 25, no. 10, 105047. https://doi.org/10.1016/j.isci.2022.105047","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:fd23531faa8940f68d9483e35bd2f105","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fd23531faa8940f68d9483e35bd2f105","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 25, Iss 10, Pp 105047- (2022)","raw_type":"article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/06cf5848-74a2-4bdb-9429-212a506c93a2","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/06cf5848-74a2-4bdb-9429-212a506c93a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, 25(10):105047. Elsevier","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2022.105047","doi":"https://doi.org/10.1016/j.isci.2022.105047","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105047","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1723622612","https://openalex.org/W1968034850","https://openalex.org/W1972126834","https://openalex.org/W1976645089","https://openalex.org/W1978944567","https://openalex.org/W1979661652","https://openalex.org/W1979812265","https://openalex.org/W1982603620","https://openalex.org/W1990331450","https://openalex.org/W1996255281","https://openalex.org/W1996340200","https://openalex.org/W2000246621","https://openalex.org/W2015607265","https://openalex.org/W2016835212","https://openalex.org/W2022720300","https://openalex.org/W2025268465","https://openalex.org/W2041553059","https://openalex.org/W2057930172","https://openalex.org/W2062971305","https://openalex.org/W2068511028","https://openalex.org/W2070154483","https://openalex.org/W2075670261","https://openalex.org/W2083048982","https://openalex.org/W2084846485","https://openalex.org/W2085874330","https://openalex.org/W2095397371","https://openalex.org/W2100250587","https://openalex.org/W2111170486","https://openalex.org/W2119727448","https://openalex.org/W2126308474","https://openalex.org/W2129816321","https://openalex.org/W2143498768","https://openalex.org/W2146715932","https://openalex.org/W2157186549","https://openalex.org/W2159133270","https://openalex.org/W2161092951","https://openalex.org/W2200903217","https://openalex.org/W2221253621","https://openalex.org/W2262448048","https://openalex.org/W2279282310","https://openalex.org/W2301997608","https://openalex.org/W2333184417","https://openalex.org/W2339760640","https://openalex.org/W2665902468","https://openalex.org/W2735860933","https://openalex.org/W2782973755","https://openalex.org/W2885618312","https://openalex.org/W2887651021","https://openalex.org/W2888275146","https://openalex.org/W2911631359","https://openalex.org/W2944460826","https://openalex.org/W2944634466","https://openalex.org/W2966677792","https://openalex.org/W2997691860","https://openalex.org/W3049668458","https://openalex.org/W3090220676","https://openalex.org/W3128454048","https://openalex.org/W3176794322"],"related_works":["https://openalex.org/W4413177265","https://openalex.org/W2301997608","https://openalex.org/W6921053852","https://openalex.org/W2891585558","https://openalex.org/W1563959780","https://openalex.org/W7167319172","https://openalex.org/W4312066863","https://openalex.org/W2333184417","https://openalex.org/W1510776391","https://openalex.org/W2129816321"],"abstract_inverted_index":{"Stem/progenitor":[0],"cells":[1,46,69,81,85,119,138],"are":[2],"required":[3],"for":[4,141],"long-term":[5,123],"maintenance":[6],"of":[7,27,44,79,87,137],"salivary":[8,66,143],"gland":[9,67,144],"(SG)":[10],"function":[11],"and":[12,59,122],"serve":[13],"as":[14,126],"untapped":[15],"reservoirs":[16],"to":[17,40,63,112],"create":[18],"functional":[19],"cells.":[20,106],"Despite":[21],"recent":[22],"advancements":[23],"in":[24,31,114],"the":[25,32,38],"identification":[26],"multiple":[28],"stem/progenitor":[29,45],"pools,":[30],"SG":[33,42],"it":[34],"remains":[35,51],"incomplete.":[36],"Furthermore,":[37],"contribution":[39],"adult":[41,60,90],"homeostasis":[43,145],"originating":[47],"from":[48],"embryonic":[49,58,88],"development":[50],"unclear.":[52],"Here,":[53],"we":[54],"employ":[55],"a":[56],"H2B-GFP":[57],"pulse-and-chase":[61],"system":[62],"characterize":[64],"potential":[65,125],"stem":[68],"(SGSCs)":[70],"based":[71],"on":[72],"quiescence":[73],"at":[74],"different":[75],"stages.":[76],"Phenotypical":[77],"profiling":[78],"quiescent":[80],"revealed":[82],"that":[83,132],"label-retaining":[84],"(LRCs)":[86],"or":[89,96,103],"origin":[91],"co-localized":[92],"with":[93,101,146],"CK8+":[94],"ductal":[95],"vimentin+":[97],"mesenchymal,":[98],"but":[99],"not":[100],"CK5+":[102],"CK14+":[104],"progenitor":[105],"In":[107],"accordance,":[108],"these":[109],"LRCs":[110],"failed":[111],"self-renew":[113],"vitro":[115],"while":[116],"non-label":[117],"retaining":[118],"displayed":[120],"differentiation":[121],"expansion":[124],"organoids.":[127],"Collectively,":[128],"our":[129],"data":[130],"suggest":[131],"an":[133],"active":[134],"cycling":[135],"population":[136],"is":[139],"responsible":[140],"submandibular":[142],"organoid":[147],"forming":[148],"potential.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-09-02T00:00:00"}