{"id":"https://openalex.org/W4294189363","doi":"https://doi.org/10.1192/j.eurpsy.2022.2039","title":"Treatment-resistant schizophrenia : the relationship between clozapine plasma concentration and clinical outcome","display_name":"Treatment-resistant schizophrenia : the relationship between clozapine plasma concentration and clinical outcome","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4294189363","doi":"https://doi.org/10.1192/j.eurpsy.2022.2039","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9567787"},"language":"en","primary_location":{"id":"doi:10.1192/j.eurpsy.2022.2039","doi":"https://doi.org/10.1192/j.eurpsy.2022.2039","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2022.2039","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E2988A3E9F3154B973512DACB4BD6DF0/S0924933822020399a.pdf/div-class-title-treatment-resistant-schizophrenia-the-relationship-between-clozapine-plasma-concentration-and-clinical-outcome-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E2988A3E9F3154B973512DACB4BD6DF0/S0924933822020399a.pdf/div-class-title-treatment-resistant-schizophrenia-the-relationship-between-clozapine-plasma-concentration-and-clinical-outcome-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"I. Kammoun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"I. Kammoun","raw_affiliation_strings":["Razi hospital, Psychiatry A Department, Manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry A Department, Manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011172095","display_name":"R. Jouini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"R. Jouini","raw_affiliation_strings":["Razi hospital, Psychiatry F Department, manouba, Tunisia","Razi hospital, Psychiatry F, manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry F Department, manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]},{"raw_affiliation_string":"Razi hospital, Psychiatry F, manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113029433","display_name":"A. Aissa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"A. Aissa","raw_affiliation_strings":["Razi hospital, Psychiatry A Department, Manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry A Department, Manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003038010","display_name":"R. Boukhchina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"R. Boukhchina","raw_affiliation_strings":["Razi hospital, Psychiatry A Department, Manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry A Department, Manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004650677","display_name":"Y. Zgueb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Y. Zgueb","raw_affiliation_strings":["Razi hospital, Psychiatry A Department, Manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry A Department, Manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031055476","display_name":"E. Khelifa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"E. Khelifa","raw_affiliation_strings":["Razi hospital, Psychiatry F Department, manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry F Department, manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006598440","display_name":"U. Ouali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"U. Ouali","raw_affiliation_strings":["Razi hospital, Psychiatry A Department, Manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry A Department, Manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114112892","display_name":"R. Jomli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"R. Jomli","raw_affiliation_strings":["Razi hospital, Psychiatry A Department, Manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry A Department, Manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045022671","display_name":"Fathi Nacef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"F. Nacef","raw_affiliation_strings":["Razi hospital, Psychiatry A Department, Manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry A Department, Manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053398507","display_name":"Z. El Hechmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Z. El Hechmi","raw_affiliation_strings":["Razi hospital, Psychiatry F Department, manouba, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Razi hospital, Psychiatry F Department, manouba, Tunisia","institution_ids":["https://openalex.org/I4210166419"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113029433"],"corresponding_institution_ids":["https://openalex.org/I4210166419"],"apc_list":{"value":2575,"currency":"USD","value_usd":2575},"apc_paid":{"value":2575,"currency":"USD","value_usd":2575},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"S1","first_page":"S789","last_page":"S789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treatment-resistant-schizophrenia","display_name":"treatment-resistant schizophrenia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":1.0},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.859000027179718},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8920000195503235},{"id":"https://openalex.org/keywords/clinical-response","display_name":"clinical response","score":0.5529999732971191},{"id":"https://openalex.org/keywords/brief-psychiatric-rating-scale","display_name":"Brief Psychiatric Rating Scale","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antipsychotic-treatment-response","display_name":"antipsychotic treatment response","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.9842767715454102},{"id":"https://openalex.org/C2778528637","wikidata":"https://www.wikidata.org/wiki/Q4967025","display_name":"Brief Psychiatric Rating Scale","level":3,"score":0.7901067733764648},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7887442111968994},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.5683051347732544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.543493926525116},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.5219618678092957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4932348132133484},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4171481132507324},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.41684579849243164},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32707738876342773},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2879338264465332},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.27816295623779297}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1192/j.eurpsy.2022.2039","doi":"https://doi.org/10.1192/j.eurpsy.2022.2039","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2022.2039","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E2988A3E9F3154B973512DACB4BD6DF0/S0924933822020399a.pdf/div-class-title-treatment-resistant-schizophrenia-the-relationship-between-clozapine-plasma-concentration-and-clinical-outcome-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9567787","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9567787/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Psychiatry","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8d3c6ce1fd0544e285e4e5239c7990aa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8d3c6ce1fd0544e285e4e5239c7990aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Psychiatry, Vol 65, Pp S789-S789 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1192/j.eurpsy.2022.2039","doi":"https://doi.org/10.1192/j.eurpsy.2022.2039","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2022.2039","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E2988A3E9F3154B973512DACB4BD6DF0/S0924933822020399a.pdf/div-class-title-treatment-resistant-schizophrenia-the-relationship-between-clozapine-plasma-concentration-and-clinical-outcome-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294189363.pdf","grobid_xml":"https://content.openalex.org/works/W4294189363.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1962369723","https://openalex.org/W2351702617","https://openalex.org/W2044222389","https://openalex.org/W1537721090","https://openalex.org/W1988457299","https://openalex.org/W59918674","https://openalex.org/W4317639072","https://openalex.org/W3109333384","https://openalex.org/W4372287872","https://openalex.org/W2065748094"],"abstract_inverted_index":{"Introduction":[0],"Clozapine":[1,121],"is":[2,17],"highly":[3],"effective":[4,250],"in":[5,58,69,128,205,225],"patients":[6,72,209],"with":[7,149,169,181,210],"treatment-resistant":[8,75],"schizophrenia":[9,76],"but,":[10],"to":[11,19,37,84,115,165,238],"ensure":[12],"optimal":[13],"clinical":[14,162],"response":[15,34,83,163,173,194,199,227,235,251],"it":[16],"important":[18],"optimize":[20],"its":[21,116],"use":[22],"and":[23,47,61,77,111,155,242,249],"this":[24],"depends":[25],"on":[26],"adequate":[27],"pharmacological":[28],"monitoring.":[29],"Objectives":[30],"Evaluate":[31],"the":[32,59,66,82,87,112,185,206,244],"therapeutic":[33,226,234],"rate":[35,164,195,200],"according":[36,237],"clozapine":[38,85,107,136,143,166,182,212,240],"plasma":[39,144,213,239],"concentration.":[40],"Methods":[41],"It":[42],"was":[43,97,108,118,122,137,146,167,203,220],"a":[44,53,125,150,156,170,193,211,233,247],"cross-sectional,":[45],"retrospective":[46],"analytical":[48],"study,":[49],"carried":[50],"out":[51],"over":[52],"period":[54],"of":[55,65,104,106,130,135,142,152,158,176,188,196,201,208,216,246],"six":[56],"months,":[57],"F":[60],"A":[62,198],"psychiatry":[63],"departments":[64],"Razi":[67],"hospital":[68],"Tunis,":[70],"including":[71],"followed":[73],"for":[74],"receiving":[78],"clozapine.":[79],"We":[80],"evaluated":[81],"using":[86],"Brief":[88],"Psychiatric":[89],"Rating":[90],"Scale":[91],"(BPRS).":[92],"Results":[93],"The":[94,101,132,140,161],"average":[95],"age":[96,103],"37.7":[98],"\u00b1":[99],"9.4.":[100],"mean":[102,113,133,141],"introduction":[105,117],"31":[109],"years":[110],"time":[114],"9.3":[119],"years.":[120],"administered":[123],"as":[124],"single":[126],"drug":[127],"85%":[129],"cases.":[131],"dose":[134],"373":[138],"mg/day.":[139],"concentration":[145,214,241],"386.5":[147],"ng/ml":[148,154,190],"minimum":[151],"89":[153],"maximum":[157],"913":[159],"ng/ml.":[160,218],"25%":[168],"BPRS":[171],"good":[172],"threshold":[174],"value":[175],"less":[177],"than":[178],"35.":[179],"Patients":[180],"levels":[183],"above":[184],"conventional":[186],"cut-off":[187],"350":[189],"(n=34)":[191],"had":[192],"34.6%.":[197],"37%":[202],"observed":[204],"group":[207],"interval":[215],"200-350":[217],"There":[219],"no":[221],"statistically":[222],"significant":[223,255],"difference":[224],"(p=0186)":[228],"Conclusions":[229],"Our":[230],"study":[231],"revealed":[232],"variation":[236],"showed":[243],"existence":[245],"non-negligible":[248],"rate.":[252],"Disclosure":[253],"No":[254],"relationships.":[256]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-09-02T00:00:00"}
