{"id":"https://openalex.org/W4294176752","doi":"https://doi.org/10.12701/jyms.2022.00325","title":"Regenerative potential of biphasic calcium phosphate and enamel matrix derivatives in the treatment of isolated interproximal intrabony defects: a randomized controlled trial","display_name":"Regenerative potential of biphasic calcium phosphate and enamel matrix derivatives in the treatment of isolated interproximal intrabony defects: a randomized controlled trial","publication_year":2022,"publication_date":"2022-09-02","ids":{"openalex":"https://openalex.org/W4294176752","doi":"https://doi.org/10.12701/jyms.2022.00325","pmid":"https://pubmed.ncbi.nlm.nih.gov/36050839","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9580055"},"language":"en","primary_location":{"id":"doi:10.12701/jyms.2022.00325","doi":"https://doi.org/10.12701/jyms.2022.00325","is_oa":true,"landing_page_url":"https://doi.org/10.12701/jyms.2022.00325","pdf_url":null,"source":{"id":"https://openalex.org/S4210230485","display_name":"Journal of Yeungnam Medical Science","issn_l":"1225-7737","issn":["1225-7737","2234-8042","2384-0293","2799-8010"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","kci-registered"],"host_organization":"https://openalex.org/P4362643773","host_organization_name":"Yeungnam University College of Medicine","host_organization_lineage":["https://openalex.org/P4362643773"],"host_organization_lineage_names":["Yeungnam University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Yeungnam Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.12701/jyms.2022.00325","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056496377","display_name":"Pritish Chandra Pal","orcid":"https://orcid.org/0000-0002-7654-7649","observed_orcids":["https://orcid.org/0000-0002-7654-7649"]},"institutions":[{"id":"https://openalex.org/I4210110304","display_name":"Pacific Dental College and Hospital","ror":"https://ror.org/01vfwah22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210110304"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Pritish Chandra Pal","raw_affiliation_strings":["Department of Periodontology, Pacific Dental College and Hospital, PAHER University, Udaipur, India"],"raw_orcid":"https://orcid.org/0000-0002-7654-7649","affiliations":[{"raw_affiliation_string":"Department of Periodontology, Pacific Dental College and Hospital, PAHER University, Udaipur, India","institution_ids":["https://openalex.org/I4210110304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022656748","display_name":"Ashish Bali","orcid":"https://orcid.org/0000-0003-1618-3959","observed_orcids":["https://orcid.org/0000-0003-1618-3959"]},"institutions":[{"id":"https://openalex.org/I4210110304","display_name":"Pacific Dental College and Hospital","ror":"https://ror.org/01vfwah22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210110304"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashish Bali","raw_affiliation_strings":["Department of Periodontology, Pacific Dental College and Hospital, PAHER University, Udaipur, India"],"raw_orcid":"https://orcid.org/0000-0003-1618-3959","affiliations":[{"raw_affiliation_string":"Department of Periodontology, Pacific Dental College and Hospital, PAHER University, Udaipur, India","institution_ids":["https://openalex.org/I4210110304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034064117","display_name":"Ramanarayana Boyapati","orcid":"https://orcid.org/0000-0002-9196-0183","observed_orcids":["https://orcid.org/0000-0002-9196-0183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramanarayana Boyapati","raw_affiliation_strings":["Department of Periodontology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur, India"],"raw_orcid":"https://orcid.org/0000-0002-9196-0183","affiliations":[{"raw_affiliation_string":"Department of Periodontology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067625151","display_name":"Sangita Show","orcid":"https://orcid.org/0000-0002-1609-8044","observed_orcids":["https://orcid.org/0000-0002-1609-8044"]},"institutions":[{"id":"https://openalex.org/I189266452","display_name":"Dr. R. Ahmed Dental College and Hospital","ror":"https://ror.org/021aj5d10","country_code":"IN","type":"education","lineage":["https://openalex.org/I189266452"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sangita Show","raw_affiliation_strings":["Department of Periodontology, DR. R Ahmed Dental College and Hospital, Kolkata, India"],"raw_orcid":"https://orcid.org/0000-0002-1609-8044","affiliations":[{"raw_affiliation_string":"Department of Periodontology, DR. R Ahmed Dental College and Hospital, Kolkata, India","institution_ids":["https://openalex.org/I189266452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055317483","display_name":"Kanikanti Siva Tejaswi","orcid":"https://orcid.org/0000-0002-2994-8538","observed_orcids":["https://orcid.org/0000-0002-2994-8538"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanikanti Siva Tejaswi","raw_affiliation_strings":["Department of Periodontology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur, India"],"raw_orcid":"https://orcid.org/0000-0002-2994-8538","affiliations":[{"raw_affiliation_string":"Department of Periodontology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014842305","display_name":"Sourabh Khandelwal","orcid":"https://orcid.org/0000-0001-5747-1397","observed_orcids":["https://orcid.org/0000-0001-5747-1397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sourabh Khandelwal","raw_affiliation_strings":["Department of Prosthodontics and Crown & Bridge, Index Institute of Dental Sciences, Indore, India"],"raw_orcid":"https://orcid.org/0000-0001-5747-1397","affiliations":[{"raw_affiliation_string":"Department of Prosthodontics and Crown & Bridge, Index Institute of Dental Sciences, Indore, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056496377"],"corresponding_institution_ids":["https://openalex.org/I4210110304"],"apc_list":null,"apc_paid":null,"fwci":0.1698,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.38674121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"39","issue":"4","first_page":"322","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biphasic-calcium-phosphate","display_name":"biphasic calcium phosphate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/enamel-matrix-derivative","display_name":"enamel matrix derivative","score":0.9890000224113464},{"id":"https://openalex.org/keywords/intrabony-defects","display_name":"intrabony defects","score":0.8610000014305115},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/periodontal-regeneration","display_name":"periodontal regeneration","score":0.800000011920929},{"id":"https://openalex.org/keywords/amelogenin","display_name":"amelogenin","score":0.7289999723434448},{"id":"https://openalex.org/keywords/bone-grafting","display_name":"bone grafting","score":0.5740000009536743},{"id":"https://openalex.org/keywords/clinical-attachment-level","display_name":"clinical attachment level","score":0.8820000290870667},{"id":"https://openalex.org/keywords/probing-depth","display_name":"probing depth","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.7336607575416565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5339105725288391},{"id":"https://openalex.org/C156887251","wikidata":"https://www.wikidata.org/wiki/Q2386424","display_name":"Enamel paint","level":2,"score":0.5135038495063782},{"id":"https://openalex.org/C2778185831","wikidata":"https://www.wikidata.org/wiki/Q5375195","display_name":"Enamel matrix derivative","level":3,"score":0.5111358761787415},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4756193459033966},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.41158196330070496},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.2809988856315613},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22321200370788574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17094331979751587},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.12701/jyms.2022.00325","doi":"https://doi.org/10.12701/jyms.2022.00325","is_oa":true,"landing_page_url":"https://doi.org/10.12701/jyms.2022.00325","pdf_url":null,"source":{"id":"https://openalex.org/S4210230485","display_name":"Journal of Yeungnam Medical Science","issn_l":"1225-7737","issn":["1225-7737","2234-8042","2384-0293","2799-8010"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","kci-registered"],"host_organization":"https://openalex.org/P4362643773","host_organization_name":"Yeungnam University College of Medicine","host_organization_lineage":["https://openalex.org/P4362643773"],"host_organization_lineage_names":["Yeungnam University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Yeungnam Medical Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9580055","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9580055/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9580055/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Yeungnam Med Sci","raw_type":"Text"},{"id":"pmid:36050839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36050839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Yeungnam medical science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:861bfecd326c498a9f19ccc4c3e3ce2e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/861bfecd326c498a9f19ccc4c3e3ce2e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Yeungnam Medical Science, Vol 39, Iss 4, Pp 322-331 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.12701/jyms.2022.00325","doi":"https://doi.org/10.12701/jyms.2022.00325","is_oa":true,"landing_page_url":"https://doi.org/10.12701/jyms.2022.00325","pdf_url":null,"source":{"id":"https://openalex.org/S4210230485","display_name":"Journal of Yeungnam Medical Science","issn_l":"1225-7737","issn":["1225-7737","2234-8042","2384-0293","2799-8010"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","kci-registered"],"host_organization":"https://openalex.org/P4362643773","host_organization_name":"Yeungnam University College of Medicine","host_organization_lineage":["https://openalex.org/P4362643773"],"host_organization_lineage_names":["Yeungnam University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Yeungnam Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294176752.pdf","grobid_xml":"https://content.openalex.org/works/W4294176752.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W137212987","https://openalex.org/W259985756","https://openalex.org/W1573198203","https://openalex.org/W1877344259","https://openalex.org/W1968908733","https://openalex.org/W1982897806","https://openalex.org/W1985350142","https://openalex.org/W1988319607","https://openalex.org/W1989128329","https://openalex.org/W1991086731","https://openalex.org/W2057357230","https://openalex.org/W2061624478","https://openalex.org/W2066616037","https://openalex.org/W2068148174","https://openalex.org/W2070348874","https://openalex.org/W2089036040","https://openalex.org/W2089386111","https://openalex.org/W2099646579","https://openalex.org/W2123666002","https://openalex.org/W2125001075","https://openalex.org/W2131359783","https://openalex.org/W2131887016","https://openalex.org/W2134107641","https://openalex.org/W2143089031","https://openalex.org/W2151509508","https://openalex.org/W2165799178","https://openalex.org/W2166589963","https://openalex.org/W2167133510","https://openalex.org/W2253797577","https://openalex.org/W2297594805","https://openalex.org/W2398108652","https://openalex.org/W2409549366","https://openalex.org/W2415268718","https://openalex.org/W2419048858","https://openalex.org/W2809416758","https://openalex.org/W2899017778","https://openalex.org/W3159958678","https://openalex.org/W3212063059","https://openalex.org/W4246944221","https://openalex.org/W4248816297","https://openalex.org/W4249319158","https://openalex.org/W4291982393"],"related_works":["https://openalex.org/W2151293799","https://openalex.org/W2165799178","https://openalex.org/W2992585419","https://openalex.org/W1909699964","https://openalex.org/W2253594394","https://openalex.org/W6921801751","https://openalex.org/W897404361","https://openalex.org/W1991086731","https://openalex.org/W3159789397","https://openalex.org/W2125001075"],"abstract_inverted_index":{"BACKGRUOUND:":[0],"The":[1,154,182],"combined":[2],"use":[3],"of":[4,21,38,75,171,248],"biomaterials":[5],"for":[6,35,104,146,201,233,245],"regeneration":[7,37,247],"may":[8],"have":[9],"great":[10],"biological":[11],"relevance.":[12],"This":[13,45],"study":[14],"aimed":[15],"to":[16,137,143],"compare":[17,138],"the":[18,36,105,139,151,166,172,208,227,246],"regenerative":[19],"potential":[20],"biphasic":[22],"calcium":[23],"phosphate":[24],"(BCP)":[25],"alone":[26,69],"and":[27,59,77,88,99,125,132,149,168,174,188,218,238],"with":[28,55,67],"growth":[29],"factor":[30],"enamel":[31],"matrix":[32],"derivatives":[33],"(EMDs)":[34],"intrabony":[39,62,249],"defects":[40,63],"at":[41,160,197,229],"1":[42],"year.":[43],"METHODS:":[44],"randomized":[46],"controlled":[47],"trial":[48],"included":[49],"40":[50],"sites":[51],"in":[52,194],"29":[53],"patients":[54],"stage":[56],"II/III":[57],"periodontitis":[58],"2/3":[60],"wall":[61],"that":[64,207],"were":[65,102,135,156,177,191,223],"treated":[66],"BCP":[68,76,81,237],"(control":[70],"group)":[71],"or":[72],"a":[73,242],"combination":[74,240],"EMD":[78],"(test":[79],"group).":[80],"alloplastic":[82],"bone":[83,90],"grafts":[84],"provide":[85],"better":[86],"bio-absorbability":[87],"accelerate":[89],"formation.":[91],"EMDs":[92,239],"are":[93],"commercially":[94],"available":[95],"amelogenins.":[96],"Mean":[97],"values":[98],"standard":[100],"deviations":[101],"calculated":[103],"following":[106],"parameters:":[107],"plaque":[108],"index":[109,113],"(PI),":[110],"papillary":[111],"bleeding":[112],"(PBI),":[114],"vertical":[115,120],"probing":[116],"pocket":[117],"depth":[118,128],"(V-PPD),":[119],"clinical":[121],"attachment":[122],"level":[123],"(V-CAL),":[124],"radiographic":[126],"defect":[127],"(RDD).":[129],"Student":[130],"paired":[131],"unpaired":[133],"t-tests":[134],"used":[136],"data":[140],"from":[141],"baseline":[142],"12":[144,164,198,230],"months":[145,199,231],"each":[147],"group":[148],"between":[150,226],"groups,":[152],"respectively.":[153],"results":[155],"considered":[157],"statistically":[158,192,224],"significant":[159,193,225],"p<0.05.":[161],"RESULTS:":[162],"At":[163],"months,":[165],"PI":[167],"PBI":[169],"scores":[170],"control":[173],"test":[175],"groups":[176,196,228],"not":[178],"significantly":[179],"different":[180],"(p>0.05).":[181],"mean":[183,209],"V-PPD":[184,210],"difference,":[185],"V-CAL":[186,214],"gain,":[187],"RDD":[189,219],"difference":[190],"both":[195],"(p<0.001":[200,232],"all":[202,234],"parameters).":[203,235],"Intergroup":[204],"comparisons":[205],"showed":[206],"reduction":[211],"(2.13\u00b11.35":[212],"mm),":[213,217],"gain":[215],"(2.53\u00b11.2":[216],"fill":[220],"(1.33\u00b11.0":[221],"mm)":[222],"CONCLUSION:":[236],"is":[241],"promising":[243],"modality":[244],"defects.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-09-02T00:00:00"}