{"id":"https://openalex.org/W4294152273","doi":"https://doi.org/10.3390/ijms23179971","title":"Implication of Irisin in Different Types of Cancer: A Systematic Review and Meta-Analysis","display_name":"Implication of Irisin in Different Types of Cancer: A Systematic Review and Meta-Analysis","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4294152273","doi":"https://doi.org/10.3390/ijms23179971","pmid":"https://pubmed.ncbi.nlm.nih.gov/36077366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9456043"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23179971","doi":"https://doi.org/10.3390/ijms23179971","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23179971","pdf_url":"https://www.mdpi.com/1422-0067/23/17/9971/pdf?version=1662096630","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/17/9971/pdf?version=1662096630","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045107156","display_name":"Maria Vliora","orcid":"https://orcid.org/0000-0002-1884-1057","observed_orcids":["https://orcid.org/0000-0002-1884-1057"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["GR","IT"],"is_corresponding":false,"raw_author_name":"Maria Vliora","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy","FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece","Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy; FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece"],"raw_orcid":"https://orcid.org/0000-0002-1884-1057","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece","institution_ids":["https://openalex.org/I145722265"]},{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy; FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece","institution_ids":["https://openalex.org/I145722265","https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027663783","display_name":"Eleni Nintou","orcid":"https://orcid.org/0000-0003-2182-2356","observed_orcids":["https://orcid.org/0000-0003-2182-2356"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Nintou","raw_affiliation_strings":["FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece"],"raw_orcid":"https://orcid.org/0000-0003-2182-2356","affiliations":[{"raw_affiliation_string":"FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027375366","display_name":"Eleni Karligiotou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Karligiotou","raw_affiliation_strings":["FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060622383","display_name":"Leonidas G. Ioannou","orcid":"https://orcid.org/0000-0001-5460-8167","observed_orcids":["https://orcid.org/0000-0001-5460-8167"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Leonidas G. Ioannou","raw_affiliation_strings":["FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece"],"raw_orcid":"https://orcid.org/0000-0001-5460-8167","affiliations":[{"raw_affiliation_string":"FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007702218","display_name":"Elisabetta Grillo","orcid":"https://orcid.org/0000-0002-8403-0607","observed_orcids":["https://orcid.org/0000-0002-8403-0607"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Grillo","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8403-0607","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053652045","display_name":"Stefania Maria Filomena Mitola","orcid":"https://orcid.org/0000-0002-5557-738X","observed_orcids":["https://orcid.org/0000-0002-5557-738X"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Mitola","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5557-738X","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045905012","display_name":"Andreas D. Flouris","orcid":"https://orcid.org/0000-0002-9823-3915","observed_orcids":["https://orcid.org/0000-0002-9823-3915"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Andreas D. Flouris","raw_affiliation_strings":["FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece"],"raw_orcid":"https://orcid.org/0000-0002-9823-3915","affiliations":[{"raw_affiliation_string":"FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece","institution_ids":["https://openalex.org/I145722265"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045905012"],"corresponding_institution_ids":["https://openalex.org/I145722265"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.3859,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.40845797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"17","first_page":"9971","last_page":"9971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.16500000655651093,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.16500000655651093,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irisin","display_name":"irisin","score":1.0},{"id":"https://openalex.org/keywords/fndc5","display_name":"FNDC5","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6570000052452087},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9779999852180481},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.707776665687561},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7072674632072449},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6494982838630676},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5982853770256042},{"id":"https://openalex.org/C206810289","wikidata":"https://www.wikidata.org/wiki/Q21118157","display_name":"FNDC5","level":4,"score":0.5686354637145996},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5172191858291626},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.45206767320632935},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4301765561103821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4210168123245239},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4129686653614044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41106608510017395},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.39298388361930847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3202160596847534},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3121955394744873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13795438408851624}],"mesh":[{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms23179971","doi":"https://doi.org/10.3390/ijms23179971","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23179971","pdf_url":"https://www.mdpi.com/1422-0067/23/17/9971/pdf?version=1662096630","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:36077366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36077366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9456043","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9456043/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cf7637593cb94932befcc4bdc929204c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cf7637593cb94932befcc4bdc929204c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 9971, p 9971 (2022)","raw_type":"article"},{"id":"pmh:oai:ir.lib.uth.gr:11615/80697","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11615/80697","pdf_url":null,"source":{"id":"https://openalex.org/S4306400243","display_name":"University of Thessaly Institutional Repository (University of Thessaly)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145722265","host_organization_name":"University of Thessaly","host_organization_lineage":["https://openalex.org/I145722265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"other"},{"id":"pmh:oai:iris.unibs.it:11379/575409","doi":null,"is_oa":true,"landing_page_url":"https://www.mdpi.com/1422-0067/23/17/9971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms23179971","doi":"https://doi.org/10.3390/ijms23179971","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23179971","pdf_url":"https://www.mdpi.com/1422-0067/23/17/9971/pdf?version=1662096630","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294152273.pdf","grobid_xml":"https://content.openalex.org/works/W4294152273.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W2000770184","https://openalex.org/W2034825007","https://openalex.org/W2039065701","https://openalex.org/W2039650731","https://openalex.org/W2045072263","https://openalex.org/W2052774494","https://openalex.org/W2069972139","https://openalex.org/W2085397620","https://openalex.org/W2115226530","https://openalex.org/W2117692326","https://openalex.org/W2132429770","https://openalex.org/W2139360948","https://openalex.org/W2141783082","https://openalex.org/W2293720453","https://openalex.org/W2315035682","https://openalex.org/W2411469867","https://openalex.org/W2499535497","https://openalex.org/W2513372575","https://openalex.org/W2556204527","https://openalex.org/W2564436755","https://openalex.org/W2566865698","https://openalex.org/W2586781519","https://openalex.org/W2598350092","https://openalex.org/W2605675711","https://openalex.org/W2750597077","https://openalex.org/W2755398419","https://openalex.org/W2763977787","https://openalex.org/W2765400080","https://openalex.org/W2768317241","https://openalex.org/W2769478603","https://openalex.org/W2774981484","https://openalex.org/W2801023584","https://openalex.org/W2885299722","https://openalex.org/W2890050246","https://openalex.org/W2890072015","https://openalex.org/W2896286698","https://openalex.org/W2922881318","https://openalex.org/W2923895741","https://openalex.org/W2943560735","https://openalex.org/W2958483210","https://openalex.org/W2968029771","https://openalex.org/W2972150427","https://openalex.org/W2979998765","https://openalex.org/W2990903697","https://openalex.org/W2998665105","https://openalex.org/W3008108683","https://openalex.org/W3008226130","https://openalex.org/W3023348092","https://openalex.org/W3024781666","https://openalex.org/W3029475285","https://openalex.org/W3036721677","https://openalex.org/W3097348470","https://openalex.org/W3097431889","https://openalex.org/W3127643036","https://openalex.org/W3157820116","https://openalex.org/W3165797423","https://openalex.org/W3169753396","https://openalex.org/W3175266171","https://openalex.org/W3216954151","https://openalex.org/W4200323234","https://openalex.org/W4205183758","https://openalex.org/W4205231063","https://openalex.org/W4206114945","https://openalex.org/W4206235165","https://openalex.org/W4220808078","https://openalex.org/W4220891910","https://openalex.org/W4238031806","https://openalex.org/W6766970584","https://openalex.org/W6774488334"],"related_works":["https://openalex.org/W2996583715","https://openalex.org/W3024781666","https://openalex.org/W4412488663","https://openalex.org/W4413310849","https://openalex.org/W4220891910","https://openalex.org/W4206235165","https://openalex.org/W4392933755","https://openalex.org/W4313544831","https://openalex.org/W4376278963","https://openalex.org/W2290405182"],"abstract_inverted_index":{"Cancer":[0],"is":[1,41,49,58,109,150],"a":[2,30,42,89,120],"set":[3],"of":[4,32,61,77,82,101,126,129],"diseases":[5],"characterized":[6],"by":[7],"several":[8,80,127],"hallmark":[9],"properties,":[10],"such":[11],"as":[12,119],"increased":[13,20],"angiogenesis,":[14],"proliferation,":[15],"invasion,":[16],"and":[17,29,92,146,160],"metastasis.":[18],"The":[19],"angiogenic":[21],"activity":[22],"constantly":[23],"supplies":[24],"the":[25,52,59,75,124],"tumors":[26],"with":[27],"nutrients":[28],"plethora":[31],"cytokines":[33,40],"to":[34,94],"ensure":[35],"cell":[36,158],"survival.":[37],"Along":[38],"these":[39],"newly":[43],"discovered":[44],"protein,":[45],"called":[46],"irisin,":[47],"which":[48],"released":[50],"into":[51],"circulation":[53],"after":[54],"physical":[55],"exercise.":[56],"Irisin":[57],"product":[60],"fibronectin":[62],"type":[63],"III":[64],"domain-containing":[65],"protein":[66],"5":[67],"(FNDC5)":[68],"proteolytic":[69],"cleavage.":[70],"Recently":[71],"it":[72,115,149],"has":[73],"been":[74],"topic":[76],"investigation":[78],"in":[79,98,111,143,152],"types":[81,100,128],"cancer.":[83,102,130],"In":[84,131],"this":[85],"study,":[86],"we":[87],"conducted":[88],"systematic":[90],"review":[91],"meta-analysis":[93],"investigate":[95],"its":[96],"implication":[97],"different":[99],"Our":[103],"results":[104,134],"suggest":[105],"that":[106,136,156],"irisin":[107,137],"expression":[108],"decreased":[110],"cancer":[112],"patients,":[113],"thus":[114],"can":[116],"be":[117],"used":[118],"valid":[121],"biomarker":[122],"for":[123],"diagnosis":[125],"addition,":[132],"our":[133],"indicate":[135],"may":[138],"have":[139],"an":[140],"important":[141],"role":[142],"tumor":[144],"progression":[145],"metastasis":[147],"since":[148],"involved":[151],"multiple":[153],"signaling":[154],"pathways":[155],"promote":[157],"proliferation":[159],"migration.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-02T00:00:00"}
