{"id":"https://openalex.org/W4294127432","doi":"https://doi.org/10.1039/d2fo01663j","title":"Potential roles and molecular mechanisms of phytochemicals against cancer","display_name":"Potential roles and molecular mechanisms of phytochemicals against cancer","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4294127432","doi":"https://doi.org/10.1039/d2fo01663j","pmid":"https://pubmed.ncbi.nlm.nih.gov/36047380"},"language":"en","primary_location":{"id":"doi:10.1039/d2fo01663j","doi":"https://doi.org/10.1039/d2fo01663j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2fo01663j","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food &amp; Function","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018770559","display_name":"Zhaodi Zheng","orcid":"https://orcid.org/0000-0003-1703-1500","observed_orcids":["https://orcid.org/0000-0003-1703-1500"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaodi Zheng","raw_affiliation_strings":["School of Forensics and Laboratory Medicine, Jining Medical University, Jining, 272067, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0003-1703-1500","affiliations":[{"raw_affiliation_string":"School of Forensics and Laboratory Medicine, Jining Medical University, Jining, 272067, Shandong, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769153","display_name":"Leilei Zhang","orcid":"https://orcid.org/0000-0002-9278-0459","observed_orcids":["https://orcid.org/0000-0002-9278-0459","https://orcid.org/0000-0002-1492-9676"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leilei Zhang","raw_affiliation_strings":["School of Forensics and Laboratory Medicine, Jining Medical University, Jining, 272067, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Forensics and Laboratory Medicine, Jining Medical University, Jining, 272067, Shandong, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031268267","display_name":"Xitan Hou","orcid":"https://orcid.org/0000-0002-6733-8407","observed_orcids":["https://orcid.org/0000-0002-6733-8407"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xitan Hou","raw_affiliation_strings":["School of Forensics and Laboratory Medicine, Jining Medical University, Jining, 272067, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Forensics and Laboratory Medicine, Jining Medical University, Jining, 272067, Shandong, China","institution_ids":["https://openalex.org/I51185872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018770559"],"corresponding_institution_ids":["https://openalex.org/I51185872"],"apc_list":null,"apc_paid":null,"fwci":0.802,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.64620939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"13","issue":"18","first_page":"9208","last_page":"9225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.17069999873638153,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.10729999840259552,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":1.0},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.6290000081062317},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dlc1","display_name":"DLC1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9660000205039978},{"id":"https://openalex.org/keywords/glycolytic-enzymes","display_name":"glycolytic enzymes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9580000042915344},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.6779999732971191},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5165230631828308},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47023481130599976},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4192016124725342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39803189039230347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33547163009643555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18251216411590576},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d2fo01663j","doi":"https://doi.org/10.1039/d2fo01663j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2fo01663j","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food &amp; Function","raw_type":"journal-article"},{"id":"pmid:36047380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36047380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & function","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3750317588","display_name":null,"funder_award_id":"600928001","funder_id":"https://openalex.org/F4320325426","funder_display_name":"Jining Medical University"}],"funders":[{"id":"https://openalex.org/F4320325426","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W1540224450","https://openalex.org/W1971916214","https://openalex.org/W2032252999","https://openalex.org/W2072860434","https://openalex.org/W2181583309","https://openalex.org/W2292553225","https://openalex.org/W2345151309","https://openalex.org/W2372619214","https://openalex.org/W2403874820","https://openalex.org/W2549607734","https://openalex.org/W2552243154","https://openalex.org/W2581145348","https://openalex.org/W2592067856","https://openalex.org/W2592815782","https://openalex.org/W2600452401","https://openalex.org/W2735527928","https://openalex.org/W2737511862","https://openalex.org/W2761772094","https://openalex.org/W2767523520","https://openalex.org/W2769462077","https://openalex.org/W2769722271","https://openalex.org/W2772077934","https://openalex.org/W2790388852","https://openalex.org/W2793413224","https://openalex.org/W2795934996","https://openalex.org/W2796031670","https://openalex.org/W2797046395","https://openalex.org/W2806297878","https://openalex.org/W2809489708","https://openalex.org/W2811307574","https://openalex.org/W2883706067","https://openalex.org/W2883994194","https://openalex.org/W2888856643","https://openalex.org/W2889646458","https://openalex.org/W2893086905","https://openalex.org/W2895492364","https://openalex.org/W2898482391","https://openalex.org/W2899863731","https://openalex.org/W2911937431","https://openalex.org/W2921085543","https://openalex.org/W2930491109","https://openalex.org/W2936303124","https://openalex.org/W2946872927","https://openalex.org/W2950462108","https://openalex.org/W2955698429","https://openalex.org/W2958606043","https://openalex.org/W2966483284","https://openalex.org/W2966588503","https://openalex.org/W2969581354","https://openalex.org/W2971366377","https://openalex.org/W2972273695","https://openalex.org/W2973533292","https://openalex.org/W2991035596","https://openalex.org/W2995949547","https://openalex.org/W2998861048","https://openalex.org/W3000070916","https://openalex.org/W3002536054","https://openalex.org/W3003771615","https://openalex.org/W3005307039","https://openalex.org/W3006634772","https://openalex.org/W3006826877","https://openalex.org/W3008660955","https://openalex.org/W3012412616","https://openalex.org/W3013001854","https://openalex.org/W3015472745","https://openalex.org/W3015495936","https://openalex.org/W3016299984","https://openalex.org/W3023795025","https://openalex.org/W3024561493","https://openalex.org/W3029136904","https://openalex.org/W3033303957","https://openalex.org/W3039436229","https://openalex.org/W3040418107","https://openalex.org/W3040665781","https://openalex.org/W3042809372","https://openalex.org/W3042932682","https://openalex.org/W3046137655","https://openalex.org/W3048584869","https://openalex.org/W3048643352","https://openalex.org/W3081418184","https://openalex.org/W3083292212","https://openalex.org/W3083336400","https://openalex.org/W3085108385","https://openalex.org/W3087303804","https://openalex.org/W3091163827","https://openalex.org/W3091271175","https://openalex.org/W3091394035","https://openalex.org/W3092112526","https://openalex.org/W3092278692","https://openalex.org/W3092386927","https://openalex.org/W3093963811","https://openalex.org/W3095323141","https://openalex.org/W3098972353","https://openalex.org/W3112957125","https://openalex.org/W3129616666","https://openalex.org/W3129652797","https://openalex.org/W3131840602","https://openalex.org/W3134300095","https://openalex.org/W3134692065","https://openalex.org/W3136113031","https://openalex.org/W3144576924","https://openalex.org/W3183149668","https://openalex.org/W3189376279","https://openalex.org/W3205407329","https://openalex.org/W4200428404","https://openalex.org/W4210661846"],"related_works":["https://openalex.org/W2391904489","https://openalex.org/W2529660153","https://openalex.org/W3118976757","https://openalex.org/W2090133492","https://openalex.org/W4388776395","https://openalex.org/W3049421282","https://openalex.org/W4362520124","https://openalex.org/W4210725283","https://openalex.org/W4366503787","https://openalex.org/W1986553386"],"abstract_inverted_index":{"the":[0,35,42,54,82,95],"modulation":[1],"of":[2,23,44,98],"reactive":[3],"oxygen":[4],"species":[5],"(ROS),":[6],"mitogen":[7],"activated":[8,24],"protein":[9],"kinase":[10],"(MAPK)":[11],"pathway,":[12],"deleted":[13],"in":[14],"liver":[15],"cancer":[16],"1":[17],"(DLC1),":[18],"nuclear":[19],"factor":[20],"\u03ba":[21],"light-chain-enhancer":[22],"B":[25],"cell":[26],"(NF-\u03baB)":[27],"pathways":[28],"and":[29,63,67,74,84],"glycolytic":[30],"enzymes.":[31],"Here,":[32],"we":[33],"review":[34,79],"molecular":[36],"mechanisms":[37,83],"by":[38],"which":[39],"phytochemicals":[40,47],"prevent":[41],"development":[43],"cancer.":[45],"Furthermore,":[46],"combined":[48],"with":[49],"chemotherapeutic":[50],"agents":[51],"could":[52],"target":[53],"crosstalk":[55],"among":[56],"multiple":[57],"signal":[58],"cascades":[59],"to":[60,89,92],"block":[61],"chemoresistance":[62],"attenuate":[64],"carcinogenic":[65],"properties,":[66],"can":[68],"be":[69,90],"considered":[70],"as":[71],"a":[72],"novel":[73],"potential":[75],"therapeutic":[76],"strategy.":[77],"Our":[78],"highlights":[80],"that":[81],"promising":[85],"applications":[86],"are":[87],"required":[88],"understood":[91],"decisively":[93],"establish":[94],"anti-cancer":[96],"efficacy":[97],"natural":[99],"phytochemicals.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-09-02T00:00:00"}
