{"id":"https://openalex.org/W4294053531","doi":"https://doi.org/10.1038/s41598-022-18309-2","title":"Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental 13C-DHA-metabolism, altering their relationships with birthweight","display_name":"Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental 13C-DHA-metabolism, altering their relationships with birthweight","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4294053531","doi":"https://doi.org/10.1038/s41598-022-18309-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/36050341","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437079"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-18309-2","doi":"https://doi.org/10.1038/s41598-022-18309-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-18309-2","pdf_url":"https://www.nature.com/articles/s41598-022-18309-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-18309-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050804071","display_name":"Oliver Claire Watkins","orcid":"https://orcid.org/0000-0001-8202-6412","observed_orcids":["https://orcid.org/0000-0001-8202-6412"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Oliver C. Watkins","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007716687","display_name":"Preben Selvam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Preben Selvam","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025903033","display_name":"Reshma Appukuttan Pillai","orcid":"https://orcid.org/0000-0003-2362-2825","observed_orcids":["https://orcid.org/0000-0003-2362-2825"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Reshma Appukuttan Pillai","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086872889","display_name":"Victoria K. B. Cracknell-Hazra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Victoria K. B. Cracknell-Hazra","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore","Faculty of Medicine, University of Southampton, Southampton, UK","Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Faculty of Medicine, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016277603","display_name":"Hannah E. J. Yong","orcid":"https://orcid.org/0000-0002-8814-752X","observed_orcids":["https://orcid.org/0000-0002-8814-752X"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hannah E. J. Yong","raw_affiliation_strings":["Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101430880","display_name":"Neha Sharma","orcid":"https://orcid.org/0000-0001-7208-5806","observed_orcids":["https://orcid.org/0000-0001-7208-5806"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Neha Sharma","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001384000","display_name":"Amaury Cazenave\u2010Gassiot","orcid":"https://orcid.org/0000-0002-3050-634X","observed_orcids":["https://orcid.org/0000-0002-3050-634X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405278259","display_name":"Life Sciences Institute","ror":"https://ror.org/05gtb7e09","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405278259"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Amaury Cazenave-Gassiot","raw_affiliation_strings":["Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405278259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020014001","display_name":"Anne K. Bendt","orcid":"https://orcid.org/0000-0001-8198-6104","observed_orcids":["https://orcid.org/0000-0001-8198-6104"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405278259","display_name":"Life Sciences Institute","ror":"https://ror.org/05gtb7e09","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405278259"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anne K. Bendt","raw_affiliation_strings":["Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405278259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031184713","display_name":"Keith M. Godfrey","orcid":"https://orcid.org/0000-0002-4643-0618","observed_orcids":["https://orcid.org/0000-0002-4643-0618"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210118229","display_name":"NIHR Southampton Biomedical Research Centre","ror":"https://ror.org/01qqpzg67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I4210148293","display_name":"MRC Lifecourse Epidemiology Unit","ror":"https://ror.org/04j4a6x59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210148293","https://openalex.org/I43439940","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keith M. Godfrey","raw_affiliation_strings":["Faculty of Medicine, University of Southampton, Southampton, UK","MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I4210148293","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083838863","display_name":"Rohan M. Lewis","orcid":"https://orcid.org/0000-0003-4044-9104","observed_orcids":["https://orcid.org/0000-0003-4044-9104"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rohan M. Lewis","raw_affiliation_strings":["Faculty of Medicine, University of Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076808018","display_name":"Markus Rene Wenk","orcid":"https://orcid.org/0000-0001-5447-7881","observed_orcids":["https://orcid.org/0000-0001-5447-7881"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405278259","display_name":"Life Sciences Institute","ror":"https://ror.org/05gtb7e09","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405278259"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Markus R. Wenk","raw_affiliation_strings":["Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405278259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013087727","display_name":"Shiao\u2010Yng Chan","orcid":"https://orcid.org/0000-0002-3530-3023","observed_orcids":["https://orcid.org/0000-0002-3530-3023"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Shiao-Yng Chan","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. obgchan@nus.edu.sg","Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore. obgchan@nus.edu.sg","Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. obgchan@nus.edu.sg","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore. obgchan@nus.edu.sg","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5013087727"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I165932596","https://openalex.org/I4210101200","https://openalex.org/I4210150261"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":0.4632,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58235782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"14895","last_page":"14895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.19509999454021454,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":1.0},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/maternal-obesity","display_name":"maternal obesity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/maternal-glycemia","display_name":"maternal glycemia","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/birth-weight","display_name":"birth weight","score":0.9850000143051147},{"id":"https://openalex.org/keywords/placental-lipid-metabolism","display_name":"placental lipid metabolism","score":0.6359999775886536},{"id":"https://openalex.org/keywords/maternal-bmi","display_name":"maternal body mass index","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7105437517166138},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.704330325126648},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6287965774536133},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.6102563738822937},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.5795015096664429},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5564078092575073},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.49886441230773926},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.49674850702285767},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.4961327016353607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4707660675048828},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.4501115381717682},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.44184327125549316},{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.41096359491348267},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.3439485430717468},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.31328126788139343},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.3128001391887665},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.30415427684783936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2536205053329468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23678138852119446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001724","descriptor_name":"Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016640","descriptor_name":"Diabetes, Gestational","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-022-18309-2","doi":"https://doi.org/10.1038/s41598-022-18309-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-18309-2","pdf_url":"https://www.nature.com/articles/s41598-022-18309-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9437079","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437079","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:36050341","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36050341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:470346","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1038/s41598-022-18309-2>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:9ebbcd9015ba45948a66e5716d3de860","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9ebbcd9015ba45948a66e5716d3de860","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-18309-2","doi":"https://doi.org/10.1038/s41598-022-18309-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-18309-2","pdf_url":"https://www.nature.com/articles/s41598-022-18309-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1727471521","display_name":null,"funder_award_id":"CSA-INV/0010/2016","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G195975639","display_name":null,"funder_award_id":"NMRC/CSA-INV/0010/2016","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G2082313848","display_name":null,"funder_award_id":"I1901E0040","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G3236441892","display_name":null,"funder_award_id":"MOH-CSAINV19nov-0002","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3433087023","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0515-10042","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3567992497","display_name":null,"funder_award_id":"MOH-CSAINV19nov-0002","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G3689308889","display_name":null,"funder_award_id":"NRFI2015-05","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G466435702","display_name":"NIHR Senior Investigator Award","funder_award_id":"NIHR200286","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6228189793","display_name":null,"funder_award_id":"MOH-CSAINV19nov-0002","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"},{"id":"https://openalex.org/G6556664770","display_name":null,"funder_award_id":"MOH-CSAINV19nov-0002","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G7084813794","display_name":null,"funder_award_id":"NRFI2015-05","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G7166139961","display_name":null,"funder_award_id":"NRFI2015-05","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7865205193","display_name":null,"funder_award_id":"NMRC/CSA-INV/0010/2016","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G8385395667","display_name":null,"funder_award_id":"NMRC/CSA-INV/0010/2016","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8664383871","display_name":null,"funder_award_id":"IAF-ICP I1901E0040","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320320701","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320327250","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294053531.pdf","grobid_xml":"https://content.openalex.org/works/W4294053531.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W192007921","https://openalex.org/W1483315851","https://openalex.org/W1513344681","https://openalex.org/W1513833217","https://openalex.org/W1525299471","https://openalex.org/W1544702576","https://openalex.org/W1587256810","https://openalex.org/W1915498150","https://openalex.org/W1967190893","https://openalex.org/W1972948495","https://openalex.org/W1976072516","https://openalex.org/W1995453682","https://openalex.org/W2008494466","https://openalex.org/W2012959588","https://openalex.org/W2017145248","https://openalex.org/W2029420109","https://openalex.org/W2034664451","https://openalex.org/W2041753839","https://openalex.org/W2042824385","https://openalex.org/W2046071642","https://openalex.org/W2054551869","https://openalex.org/W2067556814","https://openalex.org/W2075967749","https://openalex.org/W2081579726","https://openalex.org/W2091433140","https://openalex.org/W2092474731","https://openalex.org/W2097543172","https://openalex.org/W2099648584","https://openalex.org/W2104216656","https://openalex.org/W2115116275","https://openalex.org/W2135069653","https://openalex.org/W2137898985","https://openalex.org/W2142672690","https://openalex.org/W2152988021","https://openalex.org/W2154726067","https://openalex.org/W2156619423","https://openalex.org/W2159025006","https://openalex.org/W2163980725","https://openalex.org/W2171177397","https://openalex.org/W2227264641","https://openalex.org/W2287777339","https://openalex.org/W2300509662","https://openalex.org/W2307551430","https://openalex.org/W2411084682","https://openalex.org/W2414963813","https://openalex.org/W2465985071","https://openalex.org/W2584084420","https://openalex.org/W2604805987","https://openalex.org/W2606758461","https://openalex.org/W2768194049","https://openalex.org/W2775434197","https://openalex.org/W2789642184","https://openalex.org/W2793131855","https://openalex.org/W2804040865","https://openalex.org/W2806354746","https://openalex.org/W2900264756","https://openalex.org/W2940283903","https://openalex.org/W2967000504","https://openalex.org/W2990427812","https://openalex.org/W3013970849","https://openalex.org/W3028080591","https://openalex.org/W3080805910","https://openalex.org/W3101372680","https://openalex.org/W3113368079","https://openalex.org/W3154937914","https://openalex.org/W3192979595","https://openalex.org/W3209998314","https://openalex.org/W4210989643","https://openalex.org/W4241151929","https://openalex.org/W4292337504"],"related_works":["https://openalex.org/W3192979595","https://openalex.org/W4386019505","https://openalex.org/W4297224631","https://openalex.org/W4415976874","https://openalex.org/W6902020384","https://openalex.org/W7057277376","https://openalex.org/W3101372680","https://openalex.org/W2765742251","https://openalex.org/W6958371291","https://openalex.org/W6902033214"],"abstract_inverted_index":{"Abstract":[0],"Transplacental":[1],"docosahexaenoic-acid":[2],"(DHA)":[3],"supply":[4],"for":[5,37,85],"fetal":[6,24],"development":[7],"is":[8,33,175],"regulated":[9],"by":[10,104],"placental":[11,29,51,67,116,161,180],"DHA-lipid":[12,162],"metabolism.":[13],"Both":[14],"maternal":[15,56],"diabetes":[16,39],"and":[17,27,59,61,78,166],"obesity":[18,60],"are":[19],"linked":[20],"to":[21,43],"possible":[22],"decreased":[23,112],"circulating":[25],"DHA":[26,52,181],"increased":[28,127,137,169],"DHA-lipids.":[30],"Since":[31],"myo-inositol":[32,46,111],"a":[34,74,184],"promising":[35],"intervention":[36],"gestational":[38],"(GDM),":[40],"we":[41],"aimed":[42],"determine":[44],"whether":[45],"could":[47],"rectify":[48],"perturbations":[49],"in":[50,88,115,140,156,189],"metabolism":[53,182],"associated":[54],"with":[55,64,83,107,110,120,129,158],"increasing":[57],"glycemia":[58],"examine":[62],"links":[63],"birthweight.":[65,192],"Term":[66],"villous":[68],"explants":[69,117],"from":[70,118],"17":[71],"women":[72,119],"representing":[73],"range":[75],"of":[76,142],"BMIs":[77],"mid-gestational":[79],"glycemia,":[80,125],"were":[81,102],"incubated":[82],"13C-labeled-DHA":[84],"48":[86],"h,":[87],"0.3":[89],"\u00b5mol/L":[90,94],"(control)":[91],"or":[92,123,132],"60":[93],"myo-inositol.":[95],"Individual":[96],"newly":[97],"synthesized":[98],"13C-DHA-labeled":[99,138],"lipid":[100],"species":[101],"quantified":[103],"liquid-chromatography-mass-spectrometry.":[105],"Compared":[106],"controls,":[108],"incubation":[109],"most":[113],"13C-DHA-lipids":[114,128],"higher":[121,124,150],"BMI":[122,131,165],"but":[126,146,168],"normal":[130],"lower":[133,143],"glycemia.":[134],"Myo-inositol":[135,152,177],"also":[136],"lipids":[139],"cases":[141],"birthweight":[144],"centile,":[145],"induced":[147],"decreases":[148],"at":[149],"centiles.":[151],"therefore":[153],"lowered":[154],"DHA-lipids":[155,170],"placenta":[157],"high":[159],"basal":[160,172],"production":[163],"(higher":[164],"glycemia)":[167],"where":[171],"processing":[173],"capacity":[174],"low.":[176],"thus":[178],"moderates":[179],"towards":[183],"physiological":[185],"mean":[186],"which":[187],"may":[188],"turn":[190],"moderate":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-01T00:00:00"}
