{"id":"https://openalex.org/W4294031763","doi":"https://doi.org/10.5005/jp-journals-10081-1370","title":"The Efficacy and Safety of a Bacillus Probiotic Combination for the Treatment of Acute Diarrhea in Children: A Double-blind, Randomized, Placebo-controlled Multicentric Study","display_name":"The Efficacy and Safety of a Bacillus Probiotic Combination for the Treatment of Acute Diarrhea in Children: A Double-blind, Randomized, Placebo-controlled Multicentric Study","publication_year":2022,"publication_date":"2022-08-31","ids":{"openalex":"https://openalex.org/W4294031763","doi":"https://doi.org/10.5005/jp-journals-10081-1370"},"language":"en","primary_location":{"id":"doi:10.5005/jp-journals-10081-1370","doi":"https://doi.org/10.5005/jp-journals-10081-1370","is_oa":true,"landing_page_url":"https://doi.org/10.5005/jp-journals-10081-1370","pdf_url":"https://doi.org/10.5005/jp-journals-10081-1370","source":{"id":"https://openalex.org/S4210237619","display_name":"Pediatric Infectious Disease","issn_l":"2582-4988","issn":["2582-4988"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Infectious Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5005/jp-journals-10081-1370","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016416601","display_name":"Ashish Ramchandra Dhongade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashish Ramchandra Dhongade","raw_affiliation_strings":["Department of Pediatrics, Sant Dnyaneshwar Medical Education and Research Centre, Pune, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Sant Dnyaneshwar Medical Education and Research Centre, Pune, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005576268","display_name":"Sanjay Sudhakar Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255648","display_name":"Jawahar Medical Foundation's Annasaheb Chudaman Patil Memorial Medical College & Hospital","ror":"https://ror.org/038f2eq15","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255648"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjay Sudhakar Joshi","raw_affiliation_strings":["Department of Pediatrics, JMFS ACPM Medical College and Hospital, Dhule, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, JMFS ACPM Medical College and Hospital, Dhule, Maharashtra, India","institution_ids":["https://openalex.org/I4405255648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001764373","display_name":"Suhas Venkatesh Kulkarni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suhas Venkatesh Kulkarni","raw_affiliation_strings":["Department of Pediatrics, Chiranjeevi Hospital, Thane, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chiranjeevi Hospital, Thane, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059372672","display_name":"Shashank S Jadhav","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shashank S Jadhav","raw_affiliation_strings":[",","Synergia Life Sciences Pvt. Ltd., Mumbai, Maharashtra, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",","institution_ids":[]},{"raw_affiliation_string":"Synergia Life Sciences Pvt. Ltd., Mumbai, Maharashtra, India,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062846631","display_name":"Neeta Nargundkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neeta Nargundkar","raw_affiliation_strings":[",","Synergia Life Sciences Pvt. Ltd., Mumbai, Maharashtra, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",","institution_ids":[]},{"raw_affiliation_string":"Synergia Life Sciences Pvt. Ltd., Mumbai, Maharashtra, India,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012019295","display_name":"Deepak Deshmukh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepak Deshmukh","raw_affiliation_strings":["Biosphere Clinical Research Pvt. Ltd., Thane, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosphere Clinical Research Pvt. Ltd., Thane, Maharashtra, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044903323","display_name":"Anirudh Dilip Mehta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anirudh Dilip Mehta","raw_affiliation_strings":["Synergia Life Sciences Pvt. Ltd., Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synergia Life Sciences Pvt. Ltd., Mumbai, Maharashtra, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4408,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.56366002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"3","first_page":"86","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bacillus","display_name":"Bacillus","score":0.8230000138282776},{"id":"https://openalex.org/keywords/acute-diarrhea","display_name":"acute diarrhea","score":0.9589999914169312},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6600000262260437},{"id":"https://openalex.org/keywords/antibiotic-associated-diarrhea","display_name":"antibiotic-associated diarrhea","score":0.6990000009536743},{"id":"https://openalex.org/keywords/gastroenteritis","display_name":"gastroenteritis","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9690206050872803},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.868705153465271},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7519725561141968},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.7345467209815979},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.7299908995628357},{"id":"https://openalex.org/C3019834005","wikidata":"https://www.wikidata.org/wiki/Q156103","display_name":"Acute diarrhea","level":3,"score":0.5231446027755737},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48618072271347046},{"id":"https://openalex.org/C202061045","wikidata":"https://www.wikidata.org/wiki/Q7200267","display_name":"Placebo-controlled study","level":5,"score":0.4736389219760895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37933865189552307},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07294139266014099},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5005/jp-journals-10081-1370","doi":"https://doi.org/10.5005/jp-journals-10081-1370","is_oa":true,"landing_page_url":"https://doi.org/10.5005/jp-journals-10081-1370","pdf_url":"https://doi.org/10.5005/jp-journals-10081-1370","source":{"id":"https://openalex.org/S4210237619","display_name":"Pediatric Infectious Disease","issn_l":"2582-4988","issn":["2582-4988"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Infectious Disease","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a47e044fd3ae431a984af4eeca036314","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a47e044fd3ae431a984af4eeca036314","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatric Infectious Disease, Vol 4, Iss 3, Pp 86-91 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5005/jp-journals-10081-1370","doi":"https://doi.org/10.5005/jp-journals-10081-1370","is_oa":true,"landing_page_url":"https://doi.org/10.5005/jp-journals-10081-1370","pdf_url":"https://doi.org/10.5005/jp-journals-10081-1370","source":{"id":"https://openalex.org/S4210237619","display_name":"Pediatric Infectious Disease","issn_l":"2582-4988","issn":["2582-4988"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Infectious Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294031763.pdf","grobid_xml":"https://content.openalex.org/works/W4294031763.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W755088251","https://openalex.org/W1907898035","https://openalex.org/W1954829662","https://openalex.org/W1970011484","https://openalex.org/W2019006801","https://openalex.org/W2035467833","https://openalex.org/W2059503031","https://openalex.org/W2081686643","https://openalex.org/W2083243465","https://openalex.org/W2087816048","https://openalex.org/W2106744168","https://openalex.org/W2110598631","https://openalex.org/W2114381928","https://openalex.org/W2118266802","https://openalex.org/W2298290033","https://openalex.org/W2591610282","https://openalex.org/W2625390775","https://openalex.org/W2758413065","https://openalex.org/W2758476865","https://openalex.org/W2808268148","https://openalex.org/W2835116092","https://openalex.org/W3040936675","https://openalex.org/W3100752647","https://openalex.org/W4244747000"],"related_works":["https://openalex.org/W4206235229","https://openalex.org/W7095492589","https://openalex.org/W1970011484","https://openalex.org/W2086054568","https://openalex.org/W7122738593","https://openalex.org/W2187000479","https://openalex.org/W2065880519","https://openalex.org/W1501921739","https://openalex.org/W3033729336","https://openalex.org/W4390560060"],"abstract_inverted_index":{"prevention":[0,237],"and":[1,10,103,117,142,153,171,229],"treatment":[2,216,245],"of":[3,19,45,77,83,91,115,133,140,161,177,183,199,246],"gastroenteritis":[4],"in":[5,68,74,94,119,128,196,204,226,243,256],"several":[6,247],"randomized":[7],"controlled":[8],"trials":[9],"meta-analyses.7":[11],"There":[12,63],"have":[13,222],"been":[14,223],"reports":[15],"that":[16,127],"regular":[17],"consumption":[18],"products":[20],"containing":[21],"probiotics":[22,221],"will":[23],"strengthen":[24],"the":[25,34,43,61,69,75,78,95,111,156,184,205,215,227,236,244,257],"body's":[26],"immune":[27],"system,":[28],"produce":[29],"an":[30,66,92],"anti-allergy":[31],"effect,":[32],"reduces":[33],"risk":[35],"for":[36,60,235],"certain":[37],"cancers,":[38],"IntroductIonDiarrhea":[39],"is":[40,58,64,86,98,108,125,181,194,217],"defined":[41],"as":[42,88,110],"passage":[44,56],"three":[46],"or":[47,50,71,208],"more":[48,54],"loose":[49],"liquid":[51],"stools/day":[52],"(or":[53],"frequent":[55],"than":[57],"normal":[59],"individual).1":[62],"either":[65],"increase":[67],"frequency":[70],"a":[72,89,121,240],"decrease":[73],"consistency":[76],"bowel":[79],"movements.Diarrhea":[80],"affects":[81],"people":[82],"all":[84,175],"ages.Diarrhea":[85],"considered":[87,109],"sign":[90],"infection":[93],"intestines,":[96],"which":[97],"caused":[99],"by":[100],"bacteria,":[101,152],"viruses,":[102],"parasites.In":[104],"developing":[105],"countries,":[106],"diarrhea":[107,141],"second":[112],"leading":[113],"cause":[114],"mortality":[116],"morbidity":[118],"children.In":[120],"global":[122],"scenario,":[123],"it":[124],"estimated":[126],"children":[129],"below":[130],"5":[131],"years":[132],"age,":[134],"there":[135],"are":[136,155,174,230,251],"2.5":[137],"billion":[138],"episodes":[139],"almost":[143,197],"1.5":[144],"million":[145],"deaths":[146],"annually":[147],"due":[148],"to":[149,190,211,233,239,253],"diarrhea.2":[150],"Viruses,":[151],"parasites":[154],"most":[157,185],"common":[158],"infectious":[159],"causes":[160],"acute":[162,166],"diarrhea.Medication":[163],"adverse":[164,188],"effects,":[165],"abdominal":[167],"processes,":[168],"gastroenterological":[169],"disease,":[170],"endocrine":[172],"disease":[173],"examples":[176],"noninfectious":[178],"causes.3":[179],"Diarrhea":[180],"one":[182],"commonly":[186],"reported":[187],"reactions":[189],"antibacterial":[191],"medications.4":[192],"AAD":[193],"observed":[195],"5-30%":[198],"patients":[200],"undergoing":[201],"antibiotic":[202],"therapy":[203],"initial":[206],"phase":[207],"even":[209],"up":[210],"2":[212],"months":[213],"after":[214],"over.In":[218],"pediatric":[219],"populations,":[220],"thoroughly":[224],"researched":[225],"past":[228],"still":[231],"continued":[232],"date":[234],"and,":[238],"greater":[241],"extent,":[242],"diarrheal":[248],"diseases.6":[249],"Probiotics":[250],"known":[252],"be":[254],"effective":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-01T00:00:00"}
