{"id":"https://openalex.org/W4293843095","doi":"https://doi.org/10.1016/j.jacbts.2022.04.007","title":"Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction","display_name":"Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction","publication_year":2022,"publication_date":"2022-08-31","ids":{"openalex":"https://openalex.org/W4293843095","doi":"https://doi.org/10.1016/j.jacbts.2022.04.007","pmid":"https://pubmed.ncbi.nlm.nih.gov/36337924","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9626903"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacbts.2022.04.007","doi":"https://doi.org/10.1016/j.jacbts.2022.04.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2022.04.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2452302X22001449/pdf","source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2452302X22001449/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101528104","display_name":"Gang Li","orcid":"https://orcid.org/0000-0001-9661-8304","observed_orcids":["https://orcid.org/0000-0001-9661-8304"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Li","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University McKelvey School of Engineering in St. Louis, Missouri, USA","Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University McKelvey School of Engineering in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065635909","display_name":"Brittany D. Brumback","orcid":"https://orcid.org/0000-0002-8376-4959","observed_orcids":["https://orcid.org/0000-0002-8376-4959"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany D. Brumback","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University McKelvey School of Engineering in St. Louis, Missouri, USA","Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University McKelvey School of Engineering in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784422","display_name":"Lei Huang","orcid":"https://orcid.org/0000-0002-0568-0645","observed_orcids":["https://orcid.org/0000-0002-0568-0645","https://orcid.org/0009-0008-1728-3509"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Huang","raw_affiliation_strings":["Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074561190","display_name":"David M. Zhang","orcid":"https://orcid.org/0000-0002-4054-3312","observed_orcids":["https://orcid.org/0000-0002-4054-3312"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Zhang","raw_affiliation_strings":["Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027908817","display_name":"Tiankai Yin","orcid":"https://orcid.org/0000-0003-0584-8791","observed_orcids":["https://orcid.org/0000-0003-0584-8791"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiankai Yin","raw_affiliation_strings":["Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067472899","display_name":"Catherine E. Lipovsky","orcid":"https://orcid.org/0000-0001-9639-366X","observed_orcids":["https://orcid.org/0000-0001-9639-366X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine E. Lipovsky","raw_affiliation_strings":["Department of Developmental Biology, Washington University School of Medicine in St. Louis, Missouri, USA","Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028505800","display_name":"Stephanie C. Hicks","orcid":"https://orcid.org/0000-0002-7858-0231","observed_orcids":["https://orcid.org/0000-0002-7858-0231"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie C. Hicks","raw_affiliation_strings":["Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003681797","display_name":"Jes\u00fas Jim\u00e9nez","orcid":"https://orcid.org/0000-0001-5399-8538","observed_orcids":["https://orcid.org/0000-0001-5399-8538"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Jimenez","raw_affiliation_strings":["Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077129710","display_name":"Patrick M. Boyle","orcid":"https://orcid.org/0000-0001-9048-1239","observed_orcids":["https://orcid.org/0000-0001-9048-1239"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M. Boyle","raw_affiliation_strings":["Department of Bioengineering, Center for Cardiovascular Biology, and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Center for Cardiovascular Biology, and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063597171","display_name":"Stacey Rentschler","orcid":"https://orcid.org/0000-0002-1744-1238","observed_orcids":["https://orcid.org/0000-0002-1744-1238"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stacey L. Rentschler","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University McKelvey School of Engineering in St. Louis, Missouri, USA","Department of Developmental Biology, Washington University School of Medicine in St. Louis, Missouri, USA","Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA"],"raw_orcid":"https://orcid.org/0000-0002-1744-1238","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University McKelvey School of Engineering in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063597171"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":2.4168,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.89885006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"10","first_page":"1001","last_page":"1017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.878000020980835},{"id":"https://openalex.org/keywords/gsk-3-inhibition","display_name":"GSK3 inhibition","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sb216763","display_name":"SB216763","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiac-conduction-velocity","display_name":"cardiac conduction velocity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/human-myocardium","display_name":"human myocardium","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tissue-electrical-conductivity","display_name":"tissue conductivity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/arrhythmogenic-substrate","display_name":"arrhythmogenic substrate","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.8316043615341187},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5954151153564453},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.5339993238449097},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.525938093662262},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5045639276504517},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.4911801517009735},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.45449984073638916},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.4443158805370331},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.4310429096221924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42013463377952576},{"id":"https://openalex.org/C179253579","wikidata":"https://www.wikidata.org/wiki/Q6276958","display_name":"Nerve conduction velocity","level":2,"score":0.4129894971847534},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40982869267463684},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3820059299468994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35643070936203003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3410760760307312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3124675154685974},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2880990505218506},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26396316289901733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.229063481092453},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.15709024667739868},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jacbts.2022.04.007","doi":"https://doi.org/10.1016/j.jacbts.2022.04.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2022.04.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2452302X22001449/pdf","source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},{"id":"pmid:36337924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36337924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Basic to translational science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9626903","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9626903/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC Basic Transl Sci","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-2314","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/1320","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/j.jacbts.2022.04.007","doi":"https://doi.org/10.1016/j.jacbts.2022.04.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2022.04.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2452302X22001449/pdf","source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1279881641","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1745038","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3549828030","display_name":null,"funder_award_id":"NIH T32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G659425685","display_name":null,"funder_award_id":"DGE-1745038","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6671700682","display_name":"A 3D IN VITRO DISEASE MODEL OF ATRIAL CONDUCTION","funder_award_id":"UH3HL141800","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7827189999","display_name":"National Research Service Award-Medical Scientist","funder_award_id":"T32GM007200","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8438780346","display_name":"Wnt Signaling in Cardiac Conduction and Arrhythmogenesis","funder_award_id":"R01HL130212","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8858689572","display_name":"Pediatric Cardiovascular and Pulmonary Research Training Program","funder_award_id":"T32HL125241","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293843095.pdf","grobid_xml":"https://content.openalex.org/works/W4293843095.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1577577364","https://openalex.org/W1716978847","https://openalex.org/W1970105142","https://openalex.org/W1970727687","https://openalex.org/W1971085650","https://openalex.org/W1978714931","https://openalex.org/W1985326986","https://openalex.org/W1989219638","https://openalex.org/W1989950796","https://openalex.org/W2006419043","https://openalex.org/W2008421466","https://openalex.org/W2013676086","https://openalex.org/W2014514899","https://openalex.org/W2017375178","https://openalex.org/W2026125882","https://openalex.org/W2037613535","https://openalex.org/W2043612224","https://openalex.org/W2046349936","https://openalex.org/W2064027874","https://openalex.org/W2069466450","https://openalex.org/W2070249204","https://openalex.org/W2077636676","https://openalex.org/W2090863421","https://openalex.org/W2103447315","https://openalex.org/W2105423509","https://openalex.org/W2106587421","https://openalex.org/W2108359388","https://openalex.org/W2114570899","https://openalex.org/W2115765852","https://openalex.org/W2117433535","https://openalex.org/W2121234157","https://openalex.org/W2124194346","https://openalex.org/W2128734908","https://openalex.org/W2130321115","https://openalex.org/W2134208169","https://openalex.org/W2137654131","https://openalex.org/W2138681004","https://openalex.org/W2138839726","https://openalex.org/W2144450331","https://openalex.org/W2147553923","https://openalex.org/W2148294117","https://openalex.org/W2152895099","https://openalex.org/W2166946152","https://openalex.org/W2297240546","https://openalex.org/W2316302203","https://openalex.org/W2341491381","https://openalex.org/W2472601291","https://openalex.org/W2525491190","https://openalex.org/W2528124823","https://openalex.org/W2594875809","https://openalex.org/W2621361823","https://openalex.org/W2761288083","https://openalex.org/W2783963967","https://openalex.org/W2793301708","https://openalex.org/W2799684901","https://openalex.org/W2803862800","https://openalex.org/W2891957794","https://openalex.org/W2897260567","https://openalex.org/W2905431864","https://openalex.org/W2910977478","https://openalex.org/W2913951143","https://openalex.org/W2914056829","https://openalex.org/W2943753055","https://openalex.org/W2945301052","https://openalex.org/W2956154393","https://openalex.org/W3009375540","https://openalex.org/W3088400103"],"related_works":["https://openalex.org/W4307289116","https://openalex.org/W3129933114","https://openalex.org/W2097846779","https://openalex.org/W2341491381","https://openalex.org/W4395060953","https://openalex.org/W1574653524","https://openalex.org/W2143334616","https://openalex.org/W3003630972","https://openalex.org/W4403324488","https://openalex.org/W2887045529"],"abstract_inverted_index":{"Glycogen":[0],"synthase":[1],"kinase":[2],"3":[3],"(GSK-3)":[4],"inhibition":[5,77],"has":[6],"emerged":[7],"as":[8],"a":[9,34],"potential":[10],"therapeutic":[11],"target":[12],"for":[13,21,92],"several":[14],"diseases,":[15],"including":[16],"cancer.":[17],"However,":[18],"the":[19,69],"role":[20],"GSK-3":[22,35,56,76],"regulation":[23],"of":[24],"human":[25,43,79],"cardiac":[26,44],"electrophysiology":[27,82],"remains":[28],"ill-defined.":[29],"We":[30],"demonstrate":[31],"that":[32,60,75],"SB216763,":[33],"inhibitor,":[36],"can":[37],"acutely":[38],"reduce":[39],"conduction":[40],"velocity":[41],"in":[42,78],"slices.":[45],"Combined":[46],"computational":[47],"modeling":[48],"and":[49,64,83],"experimental":[50],"approaches":[51],"provided":[52],"mechanistic":[53],"insight":[54],"into":[55],"inhibition-mediated":[57],"changes,":[58],"revealing":[59],"decreased":[61],"sodium-channel":[62],"conductance":[63],"tissue":[65],"conductivity":[66],"may":[67,84],"underlie":[68],"observed":[70],"phenotypes.":[71],"Our":[72],"study":[73],"demonstrates":[74],"myocardium":[80],"alters":[81],"predispose":[85],"to":[86],"an":[87],"arrhythmogenic":[88,94],"substrate;":[89],"therefore,":[90],"monitoring":[91],"adverse":[93],"events":[95],"could":[96],"be":[97],"considered.":[98]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-08-31T00:00:00"}
