{"id":"https://openalex.org/W4293797286","doi":"https://doi.org/10.3389/fphar.2022.944735","title":"Identification of a potential diagnostic signature for postmenopausal osteoporosis via transcriptome analysis","display_name":"Identification of a potential diagnostic signature for postmenopausal osteoporosis via transcriptome analysis","publication_year":2022,"publication_date":"2022-08-29","ids":{"openalex":"https://openalex.org/W4293797286","doi":"https://doi.org/10.3389/fphar.2022.944735","pmid":"https://pubmed.ncbi.nlm.nih.gov/36105211","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9464864"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.944735","doi":"https://doi.org/10.3389/fphar.2022.944735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.944735","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2022.944735","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054919439","display_name":"Rui Zeng","orcid":"https://orcid.org/0000-0002-4328-2699","observed_orcids":["https://orcid.org/0000-0002-4328-2699"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zeng","raw_affiliation_strings":["Department of Physiology, School of Medicine, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037429625","display_name":"Tian-Cheng Ke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian-Cheng Ke","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059350222","display_name":"Mao-Ta Ou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mao-Ta Ou","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013455148","display_name":"Li-Liang Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Liang Duan","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421459","display_name":"Yi Li","orcid":"https://orcid.org/0000-0002-2309-0163","observed_orcids":["https://orcid.org/0000-0002-2309-0163"]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Li","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082791503","display_name":"Zhijing Chen","orcid":"https://orcid.org/0000-0003-3234-9357","observed_orcids":["https://orcid.org/0000-0003-3234-9357"]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Jing Chen","raw_affiliation_strings":["Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086203281","display_name":"Zhibin Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Bin Xing","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043021326","display_name":"Xiaochen Fu","orcid":"https://orcid.org/0000-0003-0002-1795","observed_orcids":["https://orcid.org/0000-0003-0002-1795"]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Chen Fu","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheng-Yu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-Yu Huang","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162753"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.6971,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62657409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":null,"first_page":"944735","last_page":"944735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":1.0},{"id":"https://openalex.org/keywords/diagnostic-signature","display_name":"diagnostic signature","score":0.8220000267028809},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8889999985694885},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lasso","display_name":"LASSO","score":0.7160000205039978},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.777999997138977},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/therapeutic-target-prediction","display_name":"therapeutic target prediction","score":0.49300000071525574},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6337664723396301},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5675579309463501},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5233492255210876},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5187968611717224},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5031673312187195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4885891377925873},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.47477054595947266},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.46683135628700256},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4347420334815979},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4312213659286499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38242408633232117},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.36629727482795715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36068058013916016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2823942303657532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15321889519691467},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14108669757843018},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2022.944735","doi":"https://doi.org/10.3389/fphar.2022.944735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.944735","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:36105211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36105211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9464864","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9464864/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c11d63f3947f4e3bad04a29a72f48b3a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c11d63f3947f4e3bad04a29a72f48b3a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.944735","doi":"https://doi.org/10.3389/fphar.2022.944735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.944735","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322292","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W929068048","https://openalex.org/W1567679605","https://openalex.org/W1966327575","https://openalex.org/W1984132051","https://openalex.org/W1996348498","https://openalex.org/W1998269616","https://openalex.org/W2006617902","https://openalex.org/W2035618305","https://openalex.org/W2065255355","https://openalex.org/W2070633381","https://openalex.org/W2081113032","https://openalex.org/W2093260830","https://openalex.org/W2101078720","https://openalex.org/W2108281583","https://openalex.org/W2109072040","https://openalex.org/W2115114064","https://openalex.org/W2115587655","https://openalex.org/W2116634113","https://openalex.org/W2118258530","https://openalex.org/W2146512944","https://openalex.org/W2154348064","https://openalex.org/W2285040145","https://openalex.org/W2327395725","https://openalex.org/W2420779462","https://openalex.org/W2806044760","https://openalex.org/W2951797289","https://openalex.org/W2990027149","https://openalex.org/W2993347499","https://openalex.org/W3009468546","https://openalex.org/W3012952700","https://openalex.org/W3047416605","https://openalex.org/W3093194543","https://openalex.org/W3096754190","https://openalex.org/W3104537585","https://openalex.org/W3166873110","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2905537553","https://openalex.org/W4388378634","https://openalex.org/W4289712118","https://openalex.org/W4403134175","https://openalex.org/W4385938110","https://openalex.org/W4382985056","https://openalex.org/W4414139611","https://openalex.org/W4385769717","https://openalex.org/W4389609344","https://openalex.org/W3138120997"],"abstract_inverted_index":{"Purpose:":[0],"We":[1,154],"aimed":[2],"to":[3,13,21,68,89,125,176,197,253],"establish":[4],"the":[5,40,53,70,101,127,162,169,180,183,199,206,211,228,232,237,266],"transcriptome":[6],"diagnostic":[7,15,92,105,189,233,254,261],"signature":[8,190,234,262],"of":[9,107,201,213,227,241,268],"postmenopausal":[10,134],"osteoporosis":[11,202],"(PMOP)":[12],"identify":[14,69],"biomarkers":[16,109,215],"and":[17,23,82,94,118,139,146,165,194,216,239,276],"score":[18],"patient":[19],"risk":[20,200,267],"prevent":[22],"treat":[24],"PMOP.":[25],"Methods:":[26],"Peripheral":[27],"blood":[28],"mononuclear":[29],"cell":[30],"(PBMC)":[31],"expression":[32,212],"data":[33],"from":[34,39,132,161],"PMOP":[35,242],"patients":[36],"were":[37,50,110,144,256],"retrieved":[38],"Gene":[41],"Expression":[42],"Omnibus":[43],"(GEO)":[44],"database.":[45],"Differentially":[46],"expressed":[47,158],"genes":[48,159,181],"(DEGs)":[49,160],"screened":[51,155,257],"using":[52],"\u201climma\u201d":[54],"package.":[55],"The":[56,104,223],"\u201cWGCNA\u201d":[57],"package":[58],"was":[59,87,98,123,148,172,203],"used":[60,88,124],"for":[61,150,273],"a":[62,91,188,218],"weighted":[63],"gene":[64,71],"co-expression":[65],"network":[66],"analysis":[67],"modules":[72],"associated":[73],"with":[74,136,141,191,221,270],"bone":[75],"mineral":[76],"density":[77],"(BMD).":[78],"Least":[79],"absolute":[80],"shrinkage":[81],"selection":[83],"operator":[84],"(LASSO)":[85],"regression":[86],"construct":[90],"signature,":[93],"its":[95,195],"predictive":[96],"ability":[97,196],"verified":[99,204,210],"in":[100,182,205],"discovery":[102,207],"cohort.":[103,208],"values":[106],"potential":[108,214,271],"evaluated":[111],"by":[112],"receiver":[113],"operating":[114],"characteristic":[115],"curve":[116],"(ROC)":[117],"coefficient":[119],"analysis.":[120],"Network":[121],"pharmacology":[122],"predict":[126,198,265],"candidate":[128,250,278],"therapeutic":[129],"molecules.":[130],"PBMCs":[131],"14":[133,140],"women":[135],"normal":[137],"BMD":[138,143],"low":[142],"collected,":[145],"RNA":[147],"extracted":[149],"RT-qPCR":[151,209],"validation.":[152],"Results:":[153],"2420":[156],"differentially":[157],"pilot":[163],"cohort,":[164],"WGCNA":[166],"showed":[167,217,230],"that":[168,231],"blue":[170,184],"module":[171],"most":[173],"closely":[174],"related":[175,252],"BMD.":[177,222],"Based":[178],"on":[179],"module,":[185],"we":[186],"constructed":[187],"15":[192],"genes,":[193],"strong":[219],"correlation":[220],"functional":[224],"annotation":[225],"results":[226],"DEGs":[229],"might":[235],"affect":[236],"occurrence":[238],"development":[240],"through":[243],"multiple":[244],"biological":[245],"pathways.":[246],"In":[247],"addition,":[248],"5":[249],"molecules":[251],"signatures":[255],"out.":[258],"Conclusion:":[259],"Our":[260],"can":[263],"effectively":[264],"PMOP,":[269],"application":[272],"clinical":[274],"decisions":[275],"drug":[277],"selection.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-31T00:00:00"}