{"id":"https://openalex.org/W4293773758","doi":"https://doi.org/10.3389/fsurg.2022.978407","title":"The clinical efficacy of collagen dressing on chronic wounds: A meta-analysis of 11 randomized controlled trials","display_name":"The clinical efficacy of collagen dressing on chronic wounds: A meta-analysis of 11 randomized controlled trials","publication_year":2022,"publication_date":"2022-08-31","ids":{"openalex":"https://openalex.org/W4293773758","doi":"https://doi.org/10.3389/fsurg.2022.978407","pmid":"https://pubmed.ncbi.nlm.nih.gov/36117827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9473315"},"language":"en","primary_location":{"id":"doi:10.3389/fsurg.2022.978407","doi":"https://doi.org/10.3389/fsurg.2022.978407","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsurg.2022.978407","pdf_url":"https://www.frontiersin.org/articles/10.3389/fsurg.2022.978407/pdf","source":{"id":"https://openalex.org/S2595365928","display_name":"Frontiers in Surgery","issn_l":"2296-875X","issn":["2296-875X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Surgery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fsurg.2022.978407/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082679558","display_name":"Hongxin Shu","orcid":"https://orcid.org/0000-0002-9447-0112","observed_orcids":["https://orcid.org/0000-0002-9447-0112"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxin Shu","raw_affiliation_strings":["Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China","Second Clinical Medical College, Nanchang University Medical School, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China","institution_ids":["https://openalex.org/I4210114086"]},{"raw_affiliation_string":"Second Clinical Medical College, Nanchang University Medical School, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000555854","display_name":"Zhiyu Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyu Xia","raw_affiliation_strings":["Second Clinical Medical College, Nanchang University Medical School, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Clinical Medical College, Nanchang University Medical School, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068412056","display_name":"Xuan Qin","orcid":"https://orcid.org/0000-0002-4397-0328","observed_orcids":["https://orcid.org/0000-0002-4397-0328"]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Qin","raw_affiliation_strings":["Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China","institution_ids":["https://openalex.org/I4210114086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460517","display_name":"Xiaowei Wang","orcid":"https://orcid.org/0000-0003-0940-1882","observed_orcids":["https://orcid.org/0000-0003-0940-1882"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowei Wang","raw_affiliation_strings":["Second Clinical Medical College, Nanchang University Medical School, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Clinical Medical College, Nanchang University Medical School, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102362501","display_name":"Weihang Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihang Lu","raw_affiliation_strings":["Vascular and Endovascular Surgery, the PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular and Endovascular Surgery, the PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qingyu Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyu Luo","raw_affiliation_strings":["Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China","institution_ids":["https://openalex.org/I4210114086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026205697","display_name":"Zhenxiong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxiong Zhang","raw_affiliation_strings":["Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China","institution_ids":["https://openalex.org/I4210114086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078608735","display_name":"Xiaowei Xiong","orcid":"https://orcid.org/0000-0001-6664-4317","observed_orcids":["https://orcid.org/0000-0001-6664-4317"]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaowei Xiong","raw_affiliation_strings":["Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, The First Hospital of Nanchang, Nanchang, China","institution_ids":["https://openalex.org/I4210114086"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078608735"],"corresponding_institution_ids":["https://openalex.org/I4210114086"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":1.1936,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.76421949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"978407","last_page":"978407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-dressing","display_name":"collagen dressing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.9860000014305115},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9490000009536743},{"id":"https://openalex.org/keywords/wound-healing-rate","display_name":"wound healing rate","score":0.8320000171661377},{"id":"https://openalex.org/keywords/chronic-ulcers","display_name":"chronic ulcers","score":0.7680000066757202},{"id":"https://openalex.org/keywords/wound-care","display_name":"wound care","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9564743041992188},{"id":"https://openalex.org/C136524200","wikidata":"https://www.wikidata.org/wiki/Q3136977","display_name":"Jadad scale","level":4,"score":0.8496859073638916},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6884728670120239},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6525943279266357},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5200223922729492},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5101011395454407},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5038325190544128},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.5004007816314697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46214187145233154},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4404257833957672},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4221709966659546},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2460879385471344}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fsurg.2022.978407","doi":"https://doi.org/10.3389/fsurg.2022.978407","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsurg.2022.978407","pdf_url":"https://www.frontiersin.org/articles/10.3389/fsurg.2022.978407/pdf","source":{"id":"https://openalex.org/S2595365928","display_name":"Frontiers in Surgery","issn_l":"2296-875X","issn":["2296-875X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Surgery","raw_type":"journal-article"},{"id":"pmid:36117827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36117827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in surgery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9473315","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9473315/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Surg","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3fc11bda5ae74cb48c8313b65930a117","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3fc11bda5ae74cb48c8313b65930a117","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Surgery, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fsurg.2022.978407","doi":"https://doi.org/10.3389/fsurg.2022.978407","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsurg.2022.978407","pdf_url":"https://www.frontiersin.org/articles/10.3389/fsurg.2022.978407/pdf","source":{"id":"https://openalex.org/S2595365928","display_name":"Frontiers in Surgery","issn_l":"2296-875X","issn":["2296-875X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293773758.pdf","grobid_xml":"https://content.openalex.org/works/W4293773758.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W152502414","https://openalex.org/W1480729244","https://openalex.org/W1642455121","https://openalex.org/W1826528130","https://openalex.org/W1843136257","https://openalex.org/W1845549666","https://openalex.org/W1892619899","https://openalex.org/W1964435302","https://openalex.org/W1964961278","https://openalex.org/W1965497401","https://openalex.org/W1966963393","https://openalex.org/W1970553740","https://openalex.org/W1972229031","https://openalex.org/W1974206701","https://openalex.org/W1982701150","https://openalex.org/W1986215651","https://openalex.org/W1987555596","https://openalex.org/W1992031089","https://openalex.org/W2001272151","https://openalex.org/W2025773541","https://openalex.org/W2038693293","https://openalex.org/W2042269088","https://openalex.org/W2045285226","https://openalex.org/W2051936133","https://openalex.org/W2052028468","https://openalex.org/W2053537523","https://openalex.org/W2060307603","https://openalex.org/W2069157301","https://openalex.org/W2084985458","https://openalex.org/W2090094198","https://openalex.org/W2094842696","https://openalex.org/W2112537103","https://openalex.org/W2120956231","https://openalex.org/W2134892475","https://openalex.org/W2136403658","https://openalex.org/W2144874527","https://openalex.org/W2157823046","https://openalex.org/W2159363192","https://openalex.org/W2166419780","https://openalex.org/W2229477967","https://openalex.org/W2298890574","https://openalex.org/W2403287989","https://openalex.org/W2404574722","https://openalex.org/W2548112651","https://openalex.org/W2613662296","https://openalex.org/W2772800473","https://openalex.org/W2787331297","https://openalex.org/W2790339970","https://openalex.org/W2893185060","https://openalex.org/W2893852470","https://openalex.org/W2895971925","https://openalex.org/W2970684805","https://openalex.org/W2974815819","https://openalex.org/W3012356438","https://openalex.org/W3112426987","https://openalex.org/W3115228040","https://openalex.org/W3123893780","https://openalex.org/W6789516773"],"related_works":["https://openalex.org/W2627517055","https://openalex.org/W6893013938","https://openalex.org/W4387878119","https://openalex.org/W4400924258","https://openalex.org/W2124168727","https://openalex.org/W2996793462","https://openalex.org/W2554261131","https://openalex.org/W4205662515","https://openalex.org/W3007132998","https://openalex.org/W3214929807"],"abstract_inverted_index":{"Objective:":[0],"This":[1],"study":[2],"aims":[3],"to":[4,60,76,85,102,180,222],"evaluate":[5],"the":[6,27,34,61,79,87,104,124,134,165,176,183,199],"clinical":[7],"efficacy":[8],"of":[9,38,63,89,93,106,116,119,130],"collagen":[10,125,140,156],"dressing":[11,141,181,197],"for":[12,108,211],"patients":[13,118],"with":[14,128],"chronic":[15,64,212],"wounds.":[16],"Materials":[17],"and":[18,33,44,49,66,97,203,208],"methods:":[19],"Relevant":[20],"randomized":[21],"controlled":[22],"trials":[23],"were":[24,52,122,186],"searched":[25],"from":[26],"databases":[28],"such":[29],"as":[30,37],"PubMed,":[31],"EMBASE,":[32],"Cochrane":[35],"library":[36],"January":[39],"2022.":[40],"For":[41],"dichotomous":[42],"outcomes":[43],"continuous":[45],"outcomes,":[46],"risk":[47],"ratio":[48],"mean":[50],"difference":[51],"calculated,":[53],"respectively.":[54],"Subgroup":[55],"analysis":[56,72],"was":[57,74,83,100],"performed":[58,75],"according":[59],"type":[62],"ulcer":[65],"follow-up.":[67],"In":[68,111,174],"addition,":[69,175],"trial":[70],"sequential":[71],"(TSA)":[73],"further":[77],"verify":[78],"results.":[80,225],"Jadad":[81],"score":[82],"used":[84],"assess":[86,103],"quality":[88],"trials.":[90],"The":[91,155],"Grading":[92],"Recommendations":[94],"Assessment,":[95],"Development,":[96],"Evaluation":[98],"(GRADE)":[99],"utilized":[101],"level":[105],"evidence":[107],"outcomes.":[109],"Results:":[110],"11":[112],"studies,":[113],"a":[114,143,160],"total":[115],"961":[117],"whom":[120],"485":[121],"in":[123],"group.":[126],"Compared":[127],"standard":[129],"care":[131],"(SOC)":[132],"alone,":[133],"group":[135,157,167],"that":[136],"added":[137],"an":[138,206],"extra":[139],"achieved":[142],"higher":[144,161],"wound":[145,200,213],"healing":[146,162,201],"rate":[147,202],"(Risk":[148,188],"Ratio":[149,189],"=":[150,190],"1.53;":[151],"95%":[152,171,192],"CI,":[153,172,193],"1.33-1.77).":[154],"also":[158],"showed":[159],"velocity":[163],"than":[164],"SOC":[166],"(Mean":[168],"Difference,":[169],"2.69;":[170],"0.87-4.51).":[173],"adverse":[177],"events":[178],"related":[179],"between":[182],"two":[184],"groups":[185],"similar":[187],"0.67;":[191],"0.44-1.01).":[194],"Conclusion:":[195],"Collagen":[196],"increases":[198],"may":[204],"be":[205,220],"effective":[207],"safe":[209],"treatment":[210],"management.":[214],"However,":[215],"more":[216],"extensive":[217],"research":[218],"shall":[219],"conducted":[221],"substantiate":[223],"these":[224],"Systematic":[226],"review":[227],"registration:":[228],"https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=245728,":[229],"identifier:":[230],"CRD42021245728.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-31T00:00:00"}