{"id":"https://openalex.org/W4293769736","doi":"https://doi.org/10.3390/pharmaceutics14091788","title":"Influence of Mechanical Skin Treatments on Dermal Penetration Efficacy of Active Ingredients","display_name":"Influence of Mechanical Skin Treatments on Dermal Penetration Efficacy of Active Ingredients","publication_year":2022,"publication_date":"2022-08-26","ids":{"openalex":"https://openalex.org/W4293769736","doi":"https://doi.org/10.3390/pharmaceutics14091788","pmid":"https://pubmed.ncbi.nlm.nih.gov/36145538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9502347"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics14091788","doi":"https://doi.org/10.3390/pharmaceutics14091788","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14091788","pdf_url":"https://www.mdpi.com/1999-4923/14/9/1788/pdf?version=1661514095","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/14/9/1788/pdf?version=1661514095","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047129430","display_name":"Cornelia M. Keck","orcid":"https://orcid.org/0000-0001-8888-2340","observed_orcids":["https://orcid.org/0000-0001-8888-2340"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Cornelia M. Keck","raw_affiliation_strings":["Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8888-2340","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067936126","display_name":"Em\u2013on Chaiprateep","orcid":"https://orcid.org/0000-0002-0513-4396","observed_orcids":["https://orcid.org/0000-0002-0513-4396"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Em-on Chaiprateep","raw_affiliation_strings":["Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112521133","display_name":"Henriette Dietrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henriette Dietrich","raw_affiliation_strings":["Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071072652","display_name":"Soma Sengupta","orcid":"https://orcid.org/0000-0002-3753-8918","observed_orcids":["https://orcid.org/0000-0002-3753-8918"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Soma Sengupta","raw_affiliation_strings":["Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Biopharmaceutics, Philipps Universit\u00e4t Marburg, 35037 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047129430"],"corresponding_institution_ids":["https://openalex.org/I161103922"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2671,"currency":"EUR","value_usd":2880},"fwci":0.7243,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.60562326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"9","first_page":"1788","last_page":"1788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-penetration","display_name":"skin penetration","score":0.7620000243186951},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.8500000238418579},{"id":"https://openalex.org/keywords/skin-hydration","display_name":"skin hydration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fluorescent-dyes","display_name":"fluorescent dyes","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.7319913506507874},{"id":"https://openalex.org/C175259745","wikidata":"https://www.wikidata.org/wiki/Q179415","display_name":"Massage","level":3,"score":0.6797590255737305},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.4963076710700989},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.4619441628456116},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.45544978976249695},{"id":"https://openalex.org/C175933922","wikidata":"https://www.wikidata.org/wiki/Q3344895","display_name":"Artificial skin","level":2,"score":0.4459720253944397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4006355404853821},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3980167806148529},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22524800896644592},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07988780736923218},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06779828667640686},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06193295121192932},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.06015995144844055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05931851267814636},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pharmaceutics14091788","doi":"https://doi.org/10.3390/pharmaceutics14091788","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14091788","pdf_url":"https://www.mdpi.com/1999-4923/14/9/1788/pdf?version=1661514095","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9502347","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9502347","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:36145538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36145538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ada3680b289f40e5866cb4f02468bef7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ada3680b289f40e5866cb4f02468bef7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 14, Iss 9, p 1788 (2022)","raw_type":"article"},{"id":"pmh:oai:open.uni-marburg.de:10.17192/es.2023.0053","doi":null,"is_oa":true,"landing_page_url":"https://open.uni-marburg.de/handle/10.17192/es.2023.0053","pdf_url":null,"source":{"id":"https://openalex.org/S7407063269","display_name":"open_UMR Marburg DSpace 10.0 (Philipps-Universit\u00e4t Marburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics14091788","doi":"https://doi.org/10.3390/pharmaceutics14091788","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14091788","pdf_url":"https://www.mdpi.com/1999-4923/14/9/1788/pdf?version=1661514095","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293769736.pdf","grobid_xml":"https://content.openalex.org/works/W4293769736.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W401943522","https://openalex.org/W1923409791","https://openalex.org/W1982974441","https://openalex.org/W2115949433","https://openalex.org/W2123830731","https://openalex.org/W2410352229","https://openalex.org/W2416007792","https://openalex.org/W2799779235","https://openalex.org/W2810521555","https://openalex.org/W2897473280","https://openalex.org/W2980988205","https://openalex.org/W3023181670","https://openalex.org/W3091622220","https://openalex.org/W3140534739","https://openalex.org/W3200367505","https://openalex.org/W4200468858","https://openalex.org/W4220878382","https://openalex.org/W4229081618","https://openalex.org/W4280528784"],"related_works":["https://openalex.org/W3200367505","https://openalex.org/W6887677011","https://openalex.org/W4200468858","https://openalex.org/W7093305495","https://openalex.org/W4213345981","https://openalex.org/W4395956766","https://openalex.org/W4280528784","https://openalex.org/W7111823031","https://openalex.org/W3216769171","https://openalex.org/W3164657353"],"abstract_inverted_index":{"The":[0,110,202],"effective":[1,204,209],"dermal":[2,52,236],"penetration":[3,31,115,158,197,205],"of":[4,15,33,54,169,174,199,227],"active":[5],"ingredients":[6],"(AI)":[7],"is":[8,64,212],"a":[9,57,136,192,215,221],"major":[10],"task":[11],"in":[12,72],"the":[13,19,21,30,51,102,114,132,145,157,175,178,183,188,196,200,207],"formulation":[14],"topical":[16],"products.":[17],"Besides":[18],"vehicle,":[20],"mechanical":[22],"skin":[23,38,43,103,108,111,124,133,138,146,151,154,171,210,217,223,228],"treatments":[24,125],"are":[25,45,185],"also":[26],"considered":[27,46],"to":[28,47,130,150,234],"impact":[29,194],"efficacy":[32,116,198],"AI.":[34,55,201],"In":[35],"particular,":[36],"professional":[37,41,107,123,137,153,170,216,222],"treatments,":[39,44],"i.e.,":[40,167],"cosmetic":[42],"be":[48,232],"optimal":[49],"for":[50],"delivery":[53],"However,":[56],"systematic":[58],"study":[59,74],"that":[60,122,163,219],"proves":[61],"these":[62],"theories":[63],"not":[65,143],"yet":[66],"available":[67],"and":[68,89,98,105,113,177,206],"was":[69,161],"therefore":[70,231],"performed":[71],"this":[73],"while":[75],"utilizing":[76],"an":[77],"ex":[78],"vivo":[79],"porcine":[80],"ear":[81],"model":[82],"with":[83,106,126,214],"subsequent":[84],"digital":[85],"image":[86],"analysis.":[87],"Hydrophilic":[88],"lipophilic":[90],"fluorescent":[91],"dyes":[92],"were":[93,99,117,128],"used":[94,233],"as":[95],"AI":[96,184],"surrogates":[97],"applied":[100,186],"onto":[101,187],"without":[104,140,152],"treatments.":[109],"hydration":[112,147,211],"determined,":[118],"respectively.":[119],"Results":[120],"showed":[121],"massage":[127,141],"able":[129],"increase":[131,144],"hydration,":[134],"whereas":[135],"treatment":[139,218,229],"could":[142],"when":[148],"compared":[149],"treatment.":[155],"Regarding":[156],"efficacy,":[159],"it":[160],"found":[162],"all":[164],"parameters":[165],"tested,":[166],"type":[168],"treatment,":[172],"lipophilicity":[173],"AI,":[176],"time":[179],"point":[180],"at":[181],"which":[182],"skin,":[189],"can":[190,230],"have":[191],"tremendous":[193],"on":[195],"most":[203,208],"achieved":[213],"includes":[220],"massage.":[224],"This":[225],"kind":[226],"improve":[235],"drug":[237],"delivery.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-08-31T00:00:00"}
