{"id":"https://openalex.org/W4293764016","doi":"https://doi.org/10.1039/d2ew00194b","title":"Wastewater surveillance using ddPCR accurately tracked Omicron emergence due to altered N1 probe binding efficiency","display_name":"Wastewater surveillance using ddPCR accurately tracked Omicron emergence due to altered N1 probe binding efficiency","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4293764016","doi":"https://doi.org/10.1039/d2ew00194b"},"language":"en","primary_location":{"id":"doi:10.1039/d2ew00194b","doi":"https://doi.org/10.1039/d2ew00194b","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2ew00194b","pdf_url":null,"source":{"id":"https://openalex.org/S4210190644","display_name":"Environmental Science Water Research & Technology","issn_l":"2053-1400","issn":["2053-1400","2053-1419"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science: Water Research &amp; Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2022/02/21/2022.02.18.22271188.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085068582","display_name":"Melissa K. Schussman","orcid":"https://orcid.org/0000-0002-3508-8239","observed_orcids":["https://orcid.org/0000-0002-3508-8239"]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa K. Schussman","raw_affiliation_strings":["School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA"],"raw_orcid":"https://orcid.org/0000-0002-3508-8239","affiliations":[{"raw_affiliation_string":"School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I43579087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052503664","display_name":"Ad\u00e9la\u00efde Roguet","orcid":"https://orcid.org/0000-0003-3688-4525","observed_orcids":["https://orcid.org/0000-0003-3688-4525"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ad\u00e9la\u00efde Roguet","raw_affiliation_strings":["Wisconsin State Laboratory of Hygiene, University of Wisconsin-Madison, USA"],"raw_orcid":"https://orcid.org/0000-0003-3688-4525","affiliations":[{"raw_affiliation_string":"Wisconsin State Laboratory of Hygiene, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021503503","display_name":"Angela Schmoldt","orcid":"https://orcid.org/0000-0002-2836-5939","observed_orcids":["https://orcid.org/0000-0002-2836-5939"]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Schmoldt","raw_affiliation_strings":["School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I43579087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066996788","display_name":"Brooke Dinan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Dinan","raw_affiliation_strings":["School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I43579087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017334057","display_name":"Sandra L. McLellan","orcid":"https://orcid.org/0000-0003-3283-1151","observed_orcids":["https://orcid.org/0000-0003-3283-1151"]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandra L. McLellan","raw_affiliation_strings":["School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA"],"raw_orcid":"https://orcid.org/0000-0003-3283-1151","affiliations":[{"raw_affiliation_string":"School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I43579087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017334057"],"corresponding_institution_ids":["https://openalex.org/I43579087"],"apc_list":null,"apc_paid":null,"fwci":1.4708,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83583962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"10","first_page":"2190","last_page":"2195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wastewater-surveillance","display_name":"wastewater surveillance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/omicron-variant","display_name":"Omicron variant","score":0.9919999837875366},{"id":"https://openalex.org/keywords/delta-variant","display_name":"Delta variant","score":0.9520000219345093},{"id":"https://openalex.org/keywords/droplet-digital-pcr","display_name":"droplet digital PCR","score":0.9829999804496765},{"id":"https://openalex.org/keywords/n1-gene","display_name":"N1 gene","score":0.6620000004768372},{"id":"https://openalex.org/keywords/virus-quantification","display_name":"virus quantification","score":0.4869999885559082},{"id":"https://openalex.org/keywords/wastewater-based-epidemiology","display_name":"wastewater-based epidemiology","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.5617476105690002},{"id":"https://openalex.org/C94061648","wikidata":"https://www.wikidata.org/wiki/Q336191","display_name":"Wastewater","level":2,"score":0.46421411633491516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.443208783864975},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3414892256259918},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3230532109737396},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32010629773139954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2976834774017334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2557511329650879},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.21972787380218506},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.13391047716140747},{"id":"https://openalex.org/C87717796","wikidata":"https://www.wikidata.org/wiki/Q146326","display_name":"Environmental engineering","level":1,"score":0.09736257791519165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08596792817115784}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d2ew00194b","doi":"https://doi.org/10.1039/d2ew00194b","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2ew00194b","pdf_url":null,"source":{"id":"https://openalex.org/S4210190644","display_name":"Environmental Science Water Research & Technology","issn_l":"2053-1400","issn":["2053-1400","2053-1419"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science: Water Research &amp; Technology","raw_type":"journal-article"},{"id":"doi:10.1101/2022.02.18.22271188","doi":"https://doi.org/10.1101/2022.02.18.22271188","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.18.22271188","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/02/21/2022.02.18.22271188.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:dc.uwm.edu:freshwater_facarticles-1015","doi":null,"is_oa":false,"landing_page_url":"https://dc.uwm.edu/freshwater_facarticles/14","pdf_url":null,"source":{"id":"https://openalex.org/S4377196567","display_name":"UWM Digital Commons (University of Wisconsin\u2013Milwaukee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43579087","host_organization_name":"University of Wisconsin\u2013Milwaukee","host_organization_lineage":["https://openalex.org/I43579087"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Freshwater Faculty Articles","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1101/2022.02.18.22271188","doi":"https://doi.org/10.1101/2022.02.18.22271188","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.18.22271188","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/02/21/2022.02.18.22271188.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243},{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.6618000268936157}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2344040679","display_name":null,"funder_award_id":"DUNS: 6279063990000","funder_id":"https://openalex.org/F4320318198","funder_display_name":"Wisconsin Department of Health Services"},{"id":"https://openalex.org/G5382552241","display_name":null,"funder_award_id":"MIL117795","funder_id":"https://openalex.org/F4320315550","funder_display_name":"Milwaukee Metropolitan Sewerage District"},{"id":"https://openalex.org/G6286282764","display_name":null,"funder_award_id":"Opportunity Package ID: PKG00261433","funder_id":"https://openalex.org/F4320318198","funder_display_name":"Wisconsin Department of Health Services"},{"id":"https://openalex.org/G8038941834","display_name":null,"funder_award_id":"MIL118144","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"}],"funders":[{"id":"https://openalex.org/F4320315550","display_name":"Milwaukee Metropolitan Sewerage District","ror":"https://ror.org/03n5rw513"},{"id":"https://openalex.org/F4320318198","display_name":"Wisconsin Department of Health Services","ror":"https://ror.org/02psedk13"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293764016.pdf","grobid_xml":"https://content.openalex.org/works/W4293764016.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1981846119","https://openalex.org/W2123269588","https://openalex.org/W2124626367","https://openalex.org/W2125348886","https://openalex.org/W2916406266","https://openalex.org/W3035294517","https://openalex.org/W3128016658","https://openalex.org/W3138834115","https://openalex.org/W3178987874","https://openalex.org/W3180313767","https://openalex.org/W3189154046","https://openalex.org/W3194120601","https://openalex.org/W3198177518","https://openalex.org/W4200011561","https://openalex.org/W4200137031","https://openalex.org/W4206757477","https://openalex.org/W4207020509"],"related_works":["https://openalex.org/W4324056389","https://openalex.org/W4283383157","https://openalex.org/W4385699157","https://openalex.org/W4285601504","https://openalex.org/W4283787473","https://openalex.org/W4385830580","https://openalex.org/W4323075901","https://openalex.org/W4391916008","https://openalex.org/W4298007237","https://openalex.org/W4400686131"],"abstract_inverted_index":{"Abstract":[0],"Wastewater":[1],"surveillance":[2,79],"for":[3,24,77,107,173],"SARS-CoV-2":[4,124,175],"is":[5,169],"being":[6],"used":[7],"worldwide":[8],"to":[9,44,135],"understand":[10],"COVID-19":[11],"infection":[12],"trends":[13],"in":[14,33,57,130,138,159],"a":[15,55,112,143,170,177],"community.":[16],"We":[17,41],"found":[18],"the":[19,27,48,58,65,83,103,119],"emergence":[20],"and":[21,121,141,149],"rapid":[22],"timeline":[23,146],"dominance":[25,150],"of":[26,82,105,114,128,147],"Omicron":[28,46,53,129],"variant":[29,51],"was":[30,132],"accurately":[31],"reflected":[32],"wastewater":[34,78,131,168],"when":[35],"measured":[36],"with":[37,116],"droplet":[38],"digital":[39],"(dd)PCR.":[40],"were":[42,157],"able":[43],"distinguish":[45,111],"from":[47,89],"circulating":[49],"Delta":[50],"because":[52],"has":[54],"mutation":[56],"N1":[59],"probe":[60],"binding":[61],"region":[62],"that":[63,99],"diminished":[64],"fluorescent":[66,87],"signal":[67],"within":[68],"individual":[69,91],"droplets.":[70],"The":[71,126],"ddPCR":[72],"platform":[73],"may":[74],"be":[75],"advantageous":[76],"since":[80],"analysis":[81],"data":[84],"can":[85],"segregate":[86],"signals":[88],"different":[90],"templates.":[92],"In":[93],"contrast,":[94],"platforms":[95],"such":[96],"as":[97],"qPCR":[98],"rely":[100],"solely":[101],"on":[102],"intensity":[104],"fluorescence":[106],"quantification":[108],"would":[109],"not":[110],"subset":[113],"variants":[115],"mutations":[117],"affecting":[118],"reaction":[120],"could":[122],"underestimate":[123],"concentrations.":[125],"proportion":[127],"tightly":[133],"correlated":[134],"clinical":[136,154],"cases":[137],"five":[139],"cities":[140],"provided":[142],"higher":[144],"resolution":[145],"appearance":[148],"(>75%)":[151],"than":[152],"sequenced":[153],"samples,":[155],"which":[156],"limited":[158],"less":[160],"populated":[161],"areas.":[162],"Taken":[163],"together,":[164],"this":[165],"work":[166],"demonstrates":[167],"reliable":[171],"metric":[172],"tracking":[174],"at":[176],"population":[178],"level.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-08-31T00:00:00"}
