{"id":"https://openalex.org/W4293740503","doi":"https://doi.org/10.3389/fphar.2022.946548","title":"Herbal medicine for amyotrophic lateral sclerosis: A systematic review and meta-analysis","display_name":"Herbal medicine for amyotrophic lateral sclerosis: A systematic review and meta-analysis","publication_year":2022,"publication_date":"2022-08-31","ids":{"openalex":"https://openalex.org/W4293740503","doi":"https://doi.org/10.3389/fphar.2022.946548","pmid":"https://pubmed.ncbi.nlm.nih.gov/36120351","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9473725"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.946548","doi":"https://doi.org/10.3389/fphar.2022.946548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.946548","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2022.946548","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109382607","display_name":"Yuebo Song","orcid":"https://orcid.org/0000-0003-4346-2582","observed_orcids":["https://orcid.org/0000-0003-4346-2582"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuebo Song","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]},{"raw_affiliation_string":"Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086125218","display_name":"Qiuyang Jia","orcid":"https://orcid.org/0000-0003-0308-0491","observed_orcids":["https://orcid.org/0000-0003-0308-0491"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuyang Jia","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]},{"raw_affiliation_string":"Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaorui Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorui Guan","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]},{"raw_affiliation_string":"Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009582070","display_name":"Kazuo Sugimoto","orcid":"https://orcid.org/0000-0002-7585-1278","observed_orcids":["https://orcid.org/0000-0002-7585-1278"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sugimoto Kazuo","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]},{"raw_affiliation_string":"Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jia Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Liu","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]},{"raw_affiliation_string":"Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weisong Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weisong Duan","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China","Neurological Laboratory of Hebei Province, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I4210099373"]},{"raw_affiliation_string":"Neurological Laboratory of Hebei Province, Shijiazhuang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013936186","display_name":"Luda Feng","orcid":"https://orcid.org/0000-0002-7259-4421","observed_orcids":["https://orcid.org/0000-0002-7259-4421"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luda Feng","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]},{"raw_affiliation_string":"Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458188","display_name":"Chi Zhang","orcid":"https://orcid.org/0000-0002-5785-4934","observed_orcids":["https://orcid.org/0000-0002-5785-4934"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chi Zhang","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062802638","display_name":"Ying Gao","orcid":"https://orcid.org/0000-0001-6972-3846","observed_orcids":["https://orcid.org/0000-0001-6972-3846"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Gao","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]},{"raw_affiliation_string":"Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062802638","https://openalex.org/A5100458188"],"corresponding_institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5715,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.53838678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"946548","last_page":"946548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.11400000005960464,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":1.0},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8640000224113464},{"id":"https://openalex.org/keywords/shenmai-injection","display_name":"Shenmai injection","score":1.0},{"id":"https://openalex.org/keywords/astragalus-mongholicus","display_name":"Astragalus mongholicus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/atractylodes-macrocephala","display_name":"Atractylodes macrocephala","score":0.9950000047683716},{"id":"https://openalex.org/keywords/licorice","display_name":"licorice","score":0.9990000128746033},{"id":"https://openalex.org/keywords/riluzole","display_name":"riluzole","score":0.949999988079071},{"id":"https://openalex.org/keywords/motor-neuron-degeneration","display_name":"motor neuron degeneration","score":0.8809999823570251},{"id":"https://openalex.org/keywords/activity-limitation","display_name":"activity limitation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8980000019073486},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5609999895095825},{"id":"https://openalex.org/keywords/quality-of-evidence","display_name":"quality of evidence","score":0.4819999933242798},{"id":"https://openalex.org/keywords/abductor-pollicis-brevis","display_name":"abductor pollicis brevis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/abductor-pollicis-longus","display_name":"abductor pollicis longus","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8552597761154175},{"id":"https://openalex.org/C2779319286","wikidata":"https://www.wikidata.org/wiki/Q415744","display_name":"Riluzole","level":4,"score":0.8231997489929199},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.6876572370529175},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.615287184715271},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5927084684371948},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46927300095558167},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4645184576511383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44927653670310974},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44215282797813416},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4372822940349579},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.24675095081329346},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18641623854637146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10587286949157715}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2022.946548","doi":"https://doi.org/10.3389/fphar.2022.946548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.946548","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9473725","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9473725","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:36120351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36120351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Systematic Review"},{"id":"pmh:oai:doaj.org/article:c58b6d966bf146a28545fe128942224e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c58b6d966bf146a28545fe128942224e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.946548","doi":"https://doi.org/10.3389/fphar.2022.946548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.946548","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322935","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1580068968","https://openalex.org/W1964177214","https://openalex.org/W1966318487","https://openalex.org/W2019840264","https://openalex.org/W2030057835","https://openalex.org/W2037377025","https://openalex.org/W2044448185","https://openalex.org/W2085165928","https://openalex.org/W2089038365","https://openalex.org/W2104744657","https://openalex.org/W2108381339","https://openalex.org/W2119390360","https://openalex.org/W2139560421","https://openalex.org/W2142064395","https://openalex.org/W2142241246","https://openalex.org/W2144536780","https://openalex.org/W2146404696","https://openalex.org/W2160809902","https://openalex.org/W2161938104","https://openalex.org/W2163119148","https://openalex.org/W2314689571","https://openalex.org/W2339648830","https://openalex.org/W2616124858","https://openalex.org/W2794654744","https://openalex.org/W2807002945","https://openalex.org/W2883918859","https://openalex.org/W2884528651","https://openalex.org/W2884621959","https://openalex.org/W2905561928","https://openalex.org/W2961326765","https://openalex.org/W2970684805","https://openalex.org/W3015372504","https://openalex.org/W3030353689","https://openalex.org/W3081033880","https://openalex.org/W3082122716","https://openalex.org/W3115439136","https://openalex.org/W3118615836","https://openalex.org/W3183534540","https://openalex.org/W3207414509","https://openalex.org/W3208849487","https://openalex.org/W3210157956","https://openalex.org/W4237126259","https://openalex.org/W4252979096","https://openalex.org/W4292806894","https://openalex.org/W4320164613"],"related_works":["https://openalex.org/W4200171312","https://openalex.org/W4402583551","https://openalex.org/W4302773408","https://openalex.org/W4402404630","https://openalex.org/W4296191097","https://openalex.org/W6943981091","https://openalex.org/W4390260700","https://openalex.org/W4399886933","https://openalex.org/W7171460042","https://openalex.org/W3094128751"],"abstract_inverted_index":{"Background:":[0],"The":[1,90,133],"effect":[2,117],"of":[3,22,40,53,62,92,101,287,306,322],"herbal":[4],"medicine":[5],"(HM)":[6],"on":[7],"amyotrophic":[8],"lateral":[9],"sclerosis":[10],"(ALS)":[11],"is":[12,24],"controversial.":[13],"Clinical":[14],"trials":[15,47,85],"investigating":[16],"HMs":[17,54,172,310],"continue;":[18],"however,":[19],"the":[20,32,36,51,82,97,107,116,137,146,232,271,291,297],"use":[21],"HM":[23,41],"still":[25],"questioned.":[26],"We":[27],"aimed":[28],"to":[29,35,59,77,114,209,220,252,263,303,312,340],"systematically":[30],"review":[31],"literature":[33],"pertaining":[34],"effects":[37],"and":[38,68,88,119,126,167,184,194,214,257,282,294,333],"safety":[39],"in":[42,55,191,290,296],"ALS.":[43],"Methods:":[44],"Randomised":[45],"controlled":[46],"(RCTs)":[48],"that":[49,309],"investigated":[50],"efficacy":[52],"ALS":[56,148,318],"patients":[57],"compared":[58],"any":[60],"types":[61],"controls":[63],"were":[64,71,86,112,129,158,165,169,176,188,225],"identified.":[65],"Nine":[66,277],"databases":[67],"six":[69,195],"registers":[70],"searched":[72],"from":[73],"their":[74],"inception":[75],"dates":[76],"25":[78],"March":[79],"2022.":[80],"Per":[81],"PRISMA":[83],"guidelines,":[84],"identified":[87],"extracted.":[89],"risk":[91,321],"bias":[93],"was":[94,103,136,234,268,273],"evaluated":[95],"using":[96,123],"Cochrane\u2019s":[98],"tool.":[99],"Certainty":[100],"evidence":[102,233,272,307],"assessed":[104],"as":[105,145],"per":[106],"GRADE":[108],"criteria.":[109],"Forest":[110],"plots":[111],"constructed":[113],"assess":[115],"size":[118],"corresponding":[120],"95%":[121,206],"CIs":[122],"fixed-effect":[124],"models,":[125],"random-effect":[127],"models":[128],"employed":[130],"when":[131],"required.":[132],"primary":[134],"outcome":[135,336],"activity":[138,200],"limitation":[139],"measured":[140],"by":[141],"validated":[142],"tools,":[143],"such":[144],"revised":[147],"Functional":[149],"Rating":[150],"Scale.":[151],"Results:":[152],"Twenty":[153],"studies":[154,164,278,326],"(N":[155],"=":[156,212,255,266],"1,218)":[157],"eligible.":[159],"Of":[160],"these,":[161],"only":[162],"five":[163],"double-blinded,":[166],"two":[168],"placebo-controlled.":[170],"Fourteen":[171],"(fifty-one":[173],"single":[174],"botanicals)":[175],"involved;":[177],"Astragalus":[178],"mongholicus":[179],"Bunge,":[180],"Atractylodes":[181],"macrocephala":[182],"Koidz.,":[183],"Glycyrrhiza":[185],"glabra":[186],"L.":[187],"commonly":[189],"used":[190],"nine,":[192],"eight,":[193],"trials,":[196],"respectively.":[197],"For":[198,237],"delaying":[199],"limitation,":[201],"Jiweiling":[202,242],"injection":[203,216,243],"(MD,":[204],"2.84;":[205],"CI,":[207],"1.21":[208],"4.46;":[210],"p":[211,222,254,265],"0.0006)":[213],"Shenmai":[215],"(SMD,":[217],"1.07;":[218],"0.69":[219],"1.45;":[221],"<":[223],"0.00001)":[224],"significantly":[226],"more":[227,334],"efficacious":[228],"than":[229],"Riluzole,":[230],"but":[231,270],"low":[235,275,302,304],"quality.":[236,276],"ameliorating":[238],"motor":[239],"neuron":[240],"loss,":[241],"[right":[244],"abductor":[245],"pollicis":[246],"brevis":[247],"(APB):":[248],"MD,":[249,260],"32.42;":[250],"7.91":[251],"56.93;":[253],"0.01":[256],"left":[258],"APB:":[259],"34.44;":[261],"12.85":[262],"56.03;":[264],"0.002]":[267],"favoured,":[269],"very":[274],"reported":[279],"one":[280],"hundred":[281],"twenty-three":[283],"adverse":[284,323],"events,":[285],"twenty-six":[286],"which":[288],"occurred":[289],"treatment":[292,315],"groups":[293],"ninety-seven":[295],"control":[298],"groups.":[299],"Conclusion:":[300],"Very":[301],"quality":[305],"suggests":[308],"seem":[311],"produce":[313],"superior":[314],"responses":[316],"for":[317],"without":[319],"increased":[320],"events.":[324],"Additional":[325],"with":[327],"homogeneous":[328],"participants,":[329],"reduced":[330],"methodological":[331],"issues,":[332],"efficient":[335],"measures":[337],"are":[338],"required":[339],"provide":[341],"confirmatory":[342],"evidence.":[343],"Systematic":[344],"Review":[345],"Registration:":[346],"https://www.crd.york.ac.uk/PROSPERO/":[347],",":[348],"identifier":[349],"CRD42021277443.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-31T00:00:00"}