{"id":"https://openalex.org/W4293705301","doi":"https://doi.org/10.1159/000526627","title":"Intranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats","display_name":"Intranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4293705301","doi":"https://doi.org/10.1159/000526627","pmid":"https://pubmed.ncbi.nlm.nih.gov/36041414","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9928603"},"language":"en","primary_location":{"id":"doi:10.1159/000526627","doi":"https://doi.org/10.1159/000526627","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000526627","pdf_url":null,"source":{"id":"https://openalex.org/S88959177","display_name":"Developmental Neuroscience","issn_l":"0378-5866","issn":["0378-5866","1421-9859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9928603","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020596076","display_name":"Lauren McClure Yauch","orcid":"https://orcid.org/0000-0002-8142-4379","observed_orcids":["https://orcid.org/0000-0002-8142-4379"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren McClure Yauch","raw_affiliation_strings":["Division of Endocrinology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA","Division of Endocrinology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-8142-4379","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052431739","display_name":"Kathleen M. Ennis-Czerniak","orcid":"https://orcid.org/0000-0002-5586-9497","observed_orcids":["https://orcid.org/0000-0002-5586-9497"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Ennis-Czerniak","raw_affiliation_strings":["Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA","Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-5586-9497","affiliations":[{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046805860","display_name":"William H. Frey","orcid":"https://orcid.org/0000-0002-6373-0794","observed_orcids":["https://orcid.org/0000-0002-6373-0794"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H. Frey, II","raw_affiliation_strings":["Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA","HealthPartners Center for Memory and Aging, HealthPartners Neurosciences, St. Paul, Minnesota, USA","Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA","HealthPartners Center for Memory and Aging, HealthPartners Neurosciences, St. Paul, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-6373-0794","affiliations":[{"raw_affiliation_string":"Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"HealthPartners Center for Memory and Aging, HealthPartners Neurosciences, St. Paul, Minnesota, USA","institution_ids":["https://openalex.org/I52792670"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"HealthPartners Center for Memory and Aging, HealthPartners Neurosciences, St. Paul, MN, USA","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037570416","display_name":"Ivan Tk\u00e1\u010d","orcid":"https://orcid.org/0000-0001-5054-0150","observed_orcids":["https://orcid.org/0000-0001-5054-0150"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Tkac","raw_affiliation_strings":["Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA","Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":"https://orcid.org/0000-0001-5054-0150","affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056325740","display_name":"Raghavendra Rao","orcid":"https://orcid.org/0000-0002-6089-5972","observed_orcids":["https://orcid.org/0000-0002-6089-5972"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghavendra B. Rao","raw_affiliation_strings":["Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA","Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA","Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, Minnesota, USA","Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA","Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA","Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-6089-5972","affiliations":[{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6465,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82088646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"44","issue":"6","first_page":"590","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.10249999910593033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intranasal-insulin","display_name":"intranasal insulin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neonatal-hyperglycemia","display_name":"neonatal hyperglycemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8090000152587891},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.800000011920929},{"id":"https://openalex.org/keywords/streptozotocin-induced-hyperglycemia","display_name":"streptozotocin-induced hyperglycemia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7599999904632568},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.878000020980835},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.6800000071525574},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.9179999828338623},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.6840000152587891},{"id":"https://openalex.org/keywords/brain-glucose","display_name":"brain glucose","score":0.5659999847412109},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.49799999594688416},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.46399998664855957},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6925188899040222},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6621044278144836},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6585309505462646},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.608838677406311},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5762350559234619},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44434553384780884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43257245421409607},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35738110542297363},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17919981479644775}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000526627","doi":"https://doi.org/10.1159/000526627","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000526627","pdf_url":null,"source":{"id":"https://openalex.org/S88959177","display_name":"Developmental Neuroscience","issn_l":"0378-5866","issn":["0378-5866","1421-9859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Neuroscience","raw_type":"journal-article"},{"id":"pmid:36041414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36041414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental neuroscience","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:9928603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9928603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9928603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9928603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7346411908","display_name":"Institutional Center Cores for Advanced Neuroimaging","funder_award_id":"P30NS076408","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000867741","display_name":"Technology to Realize the Full Potential of UHF MRI","funder_award_id":"P41EB027061","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G902492306","display_name":"Pre-faculty Research Training in Pediatric Endocrinology","funder_award_id":"T32DK065519","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W986677348","https://openalex.org/W1524305582","https://openalex.org/W1533097000","https://openalex.org/W1612293997","https://openalex.org/W1733397228","https://openalex.org/W1768846296","https://openalex.org/W1850075831","https://openalex.org/W1965520272","https://openalex.org/W1967364478","https://openalex.org/W1970779072","https://openalex.org/W1973124364","https://openalex.org/W1984506721","https://openalex.org/W1984652659","https://openalex.org/W1988423146","https://openalex.org/W1990301502","https://openalex.org/W1999403853","https://openalex.org/W2002116629","https://openalex.org/W2012669528","https://openalex.org/W2013632767","https://openalex.org/W2025420290","https://openalex.org/W2028780273","https://openalex.org/W2035876488","https://openalex.org/W2035924985","https://openalex.org/W2038332974","https://openalex.org/W2043381283","https://openalex.org/W2045572016","https://openalex.org/W2050557825","https://openalex.org/W2057854944","https://openalex.org/W2061944863","https://openalex.org/W2064652639","https://openalex.org/W2064877107","https://openalex.org/W2065419663","https://openalex.org/W2066462712","https://openalex.org/W2076760455","https://openalex.org/W2088882744","https://openalex.org/W2094140057","https://openalex.org/W2107135340","https://openalex.org/W2110223477","https://openalex.org/W2114170743","https://openalex.org/W2119211650","https://openalex.org/W2124155129","https://openalex.org/W2130517230","https://openalex.org/W2135591161","https://openalex.org/W2144475809","https://openalex.org/W2152774501","https://openalex.org/W2158811812","https://openalex.org/W2168420558","https://openalex.org/W2168921195","https://openalex.org/W2188302565","https://openalex.org/W2744358282","https://openalex.org/W2754220037","https://openalex.org/W2769468932","https://openalex.org/W2780572960","https://openalex.org/W2792502988","https://openalex.org/W2792833847","https://openalex.org/W2799602845","https://openalex.org/W2888852351","https://openalex.org/W2939368402","https://openalex.org/W2948203983","https://openalex.org/W2980471106","https://openalex.org/W3003659319","https://openalex.org/W3035056934","https://openalex.org/W3122668078","https://openalex.org/W3195158802","https://openalex.org/W4248694092"],"related_works":["https://openalex.org/W3158733859","https://openalex.org/W2792502988","https://openalex.org/W2792833847","https://openalex.org/W7203488127","https://openalex.org/W4390278220","https://openalex.org/W3032207191","https://openalex.org/W2375131404","https://openalex.org/W2016261115","https://openalex.org/W1995873923","https://openalex.org/W2591987936"],"abstract_inverted_index":{"Hyperglycemia":[0],"due":[1],"to":[2,25,88,109,189,202],"relative":[3],"hypoinsulinism":[4],"is":[5,12],"common":[6],"in":[7,34,50,55,81,160,204,220,234,244,250,261,267,286,290,298,317,322,343,359],"extremely":[8],"preterm":[9],"infants":[10],"and":[11,31,47,53,107,132,144,146,166,176,185,207,229,248,270,282,310,315,341,355],"associated":[13,336],"with":[14,58,305,337],"hippocampus-mediated":[15],"long-term":[16,169],"cognitive":[17],"impairment.":[18],"In":[19],"neonatal":[20,82],"rats,":[21],"hypoinsulinemic":[22,89],"hyperglycemia":[23,90,334,350],"leads":[24],"oxidative":[26,153],"stress,":[27],"altered":[28],"neurochemistry,":[29],"microgliosis,":[30,175],"abnormal":[32,338],"synaptogenesis":[33,49,177],"the":[35,41,45,67,172,190,205,235,245,251,262,268,287,291,299,306,318,323,344,360],"hippocampus.":[36,346,361],"Intranasal":[37],"insulin":[38,71,137],"(INS)":[39],"bypasses":[40],"blood-brain":[42],"barrier,":[43],"targets":[44],"brain,":[46],"improves":[48,78],"rodent":[51],"models,":[52],"memory":[54],"adult":[56,345],"humans":[57],"Alzheimer's":[59],"disease":[60],"or":[61,72,120],"type":[62],"2":[63,106],"diabetes,":[64],"without":[65],"altering":[66],"blood":[68,195,258],"levels":[69],"of":[70,98,136,152],"glucose.":[73],"To":[74],"test":[75],"whether":[76],"INS":[77,118,210,254,273,302,326,347],"hippocampal":[79,129,288,319],"development":[80],"hyperglycemia,":[83],"rat":[84],"pups":[85],"were":[86,155,178,313],"subjected":[87],"by":[91],"injecting":[92],"streptozotocin":[93],"(STZ)":[94],"at":[95,180],"a":[96,150],"dose":[97],"80":[99],"mg/kg":[100],"i.p.":[101],"on":[102,128,157,171],"postnatal":[103],"day":[104],"(P)":[105],"randomized":[108],"INS,":[110],"0.3U":[111],"twice":[112],"daily":[113],"from":[114,200],"P3-P6":[115],"(STZ":[116,123],"+":[117,209,253,272,301,325],"group),":[119],"no":[121],"treatment":[122],"group).":[124],"The":[125,168],"acute":[126],"effects":[127,170,354],"neurochemical":[130,173],"profile":[131],"transcript":[133],"mRNA":[134],"expression":[135,233,240],"receptor":[138],"(Insr),":[139],"glucose":[140,196,259,280,295,339],"transporters":[141],"(Glut1,":[142],"Glut4,":[143],"Glut8),":[145],"poly(ADP-ribose)":[147],"polymerase-1":[148],"(Parp1,":[149],"marker":[151],"stress)":[154],"determined":[156,179],"P7":[158],"using":[159,182],"vivo":[161],"1H":[162,183],"MR":[163],"spectroscopy":[164],"(MRS)":[165],"qPCR.":[167],"profile,":[174],"adulthood":[181],"MRS":[184,214,275],"histochemical":[186],"analysis.":[187],"Relative":[188],"control":[191],"(CONT)":[192],"group,":[193,308],"mean":[194],"concentration":[197,219,260,281],"was":[198,241,265,296,335],"higher":[199,217,227,231,243,266,278],"P3":[201],"P6":[203],"STZ":[206,208,222,237,246,252,269,271,292,300,307,324],"groups.":[211,223,238,274],"On":[212],"P7,":[213],"showed":[215,225,276,284],"10%":[216],"taurine":[218],"both":[221],"qPCR":[224],"3-folds":[226],"Insr":[228],"5-folds":[230],"Glut8":[232],"two":[236],"Parp1":[239],"18%":[242],"group":[247,327],"normal":[249,297],"group.":[255,293,303],"At":[256],"adulthood,":[257],"fed":[263],"state":[264],"59%":[277],"brain":[279],"histochemistry":[283],"microgliosis":[285,342],"subareas":[289,320],"Brain":[294],"Compared":[304],"phosphocreatine":[309],"phosphocreatine/creatine":[311],"ratio":[312],"higher,":[314],"microglia":[316],"fewer":[321],"(p":[328],"<":[329],"0.05":[330],"for":[331],"all).":[332],"Neonatal":[333],"metabolism":[340,358],"administration":[348],"during":[349],"attenuated":[351],"these":[352],"adverse":[353],"improved":[356],"energy":[357]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-31T00:00:00"}
