{"id":"https://openalex.org/W4293703371","doi":"https://doi.org/10.1158/2159-8290.cd-21-1443","title":"Developmental Deconvolution for Classification of Cancer Origin","display_name":"Developmental Deconvolution for Classification of Cancer Origin","publication_year":2022,"publication_date":"2022-08-30","ids":{"openalex":"https://openalex.org/W4293703371","doi":"https://doi.org/10.1158/2159-8290.cd-21-1443","pmid":"https://pubmed.ncbi.nlm.nih.gov/36041084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9627133"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.cd-21-1443","doi":"https://doi.org/10.1158/2159-8290.cd-21-1443","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-21-1443","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1158/2159-8290.cd-21-1443","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051296942","display_name":"Enrico Moiso","orcid":"https://orcid.org/0000-0002-4405-8357","observed_orcids":["https://orcid.org/0000-0002-4405-8357"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enrico Moiso","raw_affiliation_strings":["Broad Institute of Harvard-MIT, Cambridge MA","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts","2Broad Institute of Harvard-MIT, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard-MIT, Cambridge MA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"2Broad Institute of Harvard-MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018355127","display_name":"Alexander A. Farahani","orcid":"https://orcid.org/0000-0002-0977-530X","observed_orcids":["https://orcid.org/0000-0002-0977-530X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Farahani","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048670338","display_name":"Hetal D. Marble","orcid":"https://orcid.org/0000-0001-8203-0622","observed_orcids":["https://orcid.org/0000-0001-8203-0622"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hetal Marble","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008477927","display_name":"Austin Hendricks","orcid":"https://orcid.org/0000-0003-4819-3174","observed_orcids":["https://orcid.org/0000-0003-4819-3174"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin Hendricks","raw_affiliation_strings":["Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044186325","display_name":"Samuel Mildrum","orcid":"https://orcid.org/0000-0001-6658-3171","observed_orcids":["https://orcid.org/0000-0001-6658-3171"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Mildrum","raw_affiliation_strings":["Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026357113","display_name":"Stuart S. Levine","orcid":"https://orcid.org/0000-0001-7363-562X","observed_orcids":["https://orcid.org/0000-0001-7363-562X"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Levine","raw_affiliation_strings":["Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067299042","display_name":"Jochen K. Lennerz","orcid":"https://orcid.org/0000-0003-2434-4978","observed_orcids":["https://orcid.org/0000-0003-2434-4978"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jochen Lennerz","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060471255","display_name":"Salil Garg","orcid":"https://orcid.org/0000-0002-7198-1833","observed_orcids":["https://orcid.org/0000-0002-7198-1833"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Salil Garg","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts","3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-7198-1833","affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060471255"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4390039253","https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":1.9853,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88077288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"11","first_page":"2566","last_page":"2585"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-of-unknown-primary","display_name":"cancer of unknown primary","score":0.9419999718666077},{"id":"https://openalex.org/keywords/developmental-trajectories","display_name":"developmental trajectories","score":0.890999972820282},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7879999876022339},{"id":"https://openalex.org/keywords/deep-learning-classifier","display_name":"deep learning classifier","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.7632116079330444},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6239380240440369},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6238948106765747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46043533086776733},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3817828297615051},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3463534414768219},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26175457239151},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.07505461573600769}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/2159-8290.cd-21-1443","doi":"https://doi.org/10.1158/2159-8290.cd-21-1443","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-21-1443","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},{"id":"doi:10.1101/2021.11.15.21266314","doi":"https://doi.org/10.1101/2021.11.15.21266314","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.11.15.21266314","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/11/20/2021.11.15.21266314.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:36041084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36041084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer discovery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9627133","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9627133/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Discov","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.cd-21-1443","doi":"https://doi.org/10.1158/2159-8290.cd-21-1443","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-21-1443","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2360436881","display_name":null,"funder_award_id":"P30-CA14051","funder_id":"https://openalex.org/F4320316943","funder_display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology"},{"id":"https://openalex.org/G7773550652","display_name":"Mechanisms of non-genetic variation in melanoma","funder_award_id":"K08CA237856","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7868354891","display_name":"Illuminating the evolutionary history of colorectal cancer metastasis: basic principles and clinical applications","funder_award_id":"R37CA225655","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891960","display_name":"Cancer Center Support (Core) Grant","funder_award_id":"P30CA014051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320316943","display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","ror":"https://ror.org/01xd6q208"},{"id":"https://openalex.org/F4320317924","display_name":"Ludwig Family Foundation","ror":"https://ror.org/0432hrf20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293703371.pdf","grobid_xml":"https://content.openalex.org/works/W4293703371.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W10502790","https://openalex.org/W969551692","https://openalex.org/W1506208106","https://openalex.org/W1902577542","https://openalex.org/W1965224467","https://openalex.org/W1999574084","https://openalex.org/W2010248689","https://openalex.org/W2018528339","https://openalex.org/W2038364849","https://openalex.org/W2040215246","https://openalex.org/W2051549807","https://openalex.org/W2107114586","https://openalex.org/W2127178682","https://openalex.org/W2129018774","https://openalex.org/W2134932622","https://openalex.org/W2145036915","https://openalex.org/W2146512944","https://openalex.org/W2158485828","https://openalex.org/W2160888498","https://openalex.org/W2169456326","https://openalex.org/W2206969062","https://openalex.org/W2329674354","https://openalex.org/W2332292689","https://openalex.org/W2468676672","https://openalex.org/W2470965540","https://openalex.org/W2504150216","https://openalex.org/W2540894442","https://openalex.org/W2581199190","https://openalex.org/W2582555581","https://openalex.org/W2761786675","https://openalex.org/W2766845401","https://openalex.org/W2766959028","https://openalex.org/W2769322745","https://openalex.org/W2771542157","https://openalex.org/W2796153844","https://openalex.org/W2809201980","https://openalex.org/W2896480326","https://openalex.org/W2902652978","https://openalex.org/W2910996719","https://openalex.org/W2916020270","https://openalex.org/W2916458303","https://openalex.org/W2941121701","https://openalex.org/W2954610188","https://openalex.org/W2956244858","https://openalex.org/W2961217357","https://openalex.org/W2991151034","https://openalex.org/W2993905360","https://openalex.org/W2996698847","https://openalex.org/W3004765765","https://openalex.org/W3015092199","https://openalex.org/W3027774968","https://openalex.org/W3036843909","https://openalex.org/W3036895040","https://openalex.org/W3037083567","https://openalex.org/W3044347277","https://openalex.org/W3091783136","https://openalex.org/W3092995520","https://openalex.org/W3103797259","https://openalex.org/W3113226902","https://openalex.org/W3118017075","https://openalex.org/W3121990740","https://openalex.org/W3168048358","https://openalex.org/W4226337627","https://openalex.org/W4378953806"],"related_works":["https://openalex.org/W4282981322","https://openalex.org/W4308054137","https://openalex.org/W3183224096","https://openalex.org/W4362543780","https://openalex.org/W2947455891","https://openalex.org/W7117879541","https://openalex.org/W7172400620","https://openalex.org/W2809879579","https://openalex.org/W3091783136","https://openalex.org/W4394855233"],"abstract_inverted_index":{"Cancer":[0],"is":[1,23,206],"partly":[2],"a":[3,17,63,133,144,175],"developmental":[4,33,54,64,114,130,140,155,167,192],"disease,":[5],"with":[6,87],"malignancies":[7],"named":[8],"based":[9],"on":[10],"cell":[11],"or":[12],"tissue":[13],"of":[14,20,31,38,89,128,157,194],"origin.":[15,72],"However,":[16],"systematic":[18],"atlas":[19,127],"tumor":[21,48,106,129,161,181],"origins":[22,193],"lacking.":[24],"Here":[25,151],"we":[26,61,152],"map":[27,153],"the":[28,36,94,154,185,191,209],"single-cell":[29],"organogenesis":[30],"56":[32],"trajectories":[34,156],"to":[35,173,187],"transcriptomes":[37,49,162],"over":[39],"10,000":[40],"tumors":[41,84],"across":[42],"33":[43],"cancer":[44,71,88],"types.":[45],"We":[46,82,159,183],"deconvolute":[47,160],"into":[50,163],"signals":[51,58,164],"for":[52,76,120,135,147,165],"individual":[53],"trajectories.":[55],"Using":[56],"these":[57],"as":[59],"inputs,":[60],"construct":[62,174],"multilayer":[65],"perceptron":[66],"(D-MLP)":[67],"classifier":[68,178,186],"that":[69,179],"outputs":[70,180],"D-MLP":[73],"(ROC-AUC:":[74],"0.974":[75],"top":[77],"prediction)":[78],"outperforms":[79],"benchmark":[80],"classifiers.":[81],"analyze":[83],"from":[85],"patients":[86],"unknown":[90],"primary":[91],"(CUP),":[92],"selecting":[93],"most":[95],"difficult":[96],"cases":[97],"in":[98,208],"which":[99],"extensive":[100],"multimodal":[101],"workup":[102],"yielded":[103],"no":[104],"definitive":[105],"type.":[107,182],"Interestingly,":[108],"CUPs":[109],"form":[110],"groups":[111],"distinguished":[112],"by":[113,200],"trajectories,":[115],"and":[116,138,169,189],"classification":[117,141],"reveals":[118],"diagnosis":[119],"patient":[121,148,195],"tumors.":[122,149,158,196],"Our":[123],"results":[124],"provide":[125,132],"an":[126],"origins,":[131],"tool":[134],"diagnostic":[136],"pathology,":[137],"suggest":[139],"may":[142],"be":[143],"useful":[145],"approach":[146],"SIGNIFICANCE:":[150],"mammalian":[166],"programs":[168],"use":[170],"this":[171],"information":[172],"deep":[176],"learning":[177],"apply":[184],"CUP":[188],"reveal":[190],"See":[197],"related":[198],"commentary":[199],"Wang,":[201],"p.":[202,214],"2498.":[203],"This":[204,211],"article":[205],"highlighted":[207],"In":[210],"Issue":[212],"feature,":[213],"2483.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-31T00:00:00"}
