{"id":"https://openalex.org/W4293483939","doi":"https://doi.org/10.1136/bmjopen-2022-061301","title":"Randomised trial to determine the effect of vitamin D and zinc supplementation for improving treatment outcomes among patients with COVID-19 in India: trial protocol","display_name":"Randomised trial to determine the effect of vitamin D and zinc supplementation for improving treatment outcomes among patients with COVID-19 in India: trial protocol","publication_year":2022,"publication_date":"2022-08-01","ids":{"openalex":"https://openalex.org/W4293483939","doi":"https://doi.org/10.1136/bmjopen-2022-061301","pmid":"https://pubmed.ncbi.nlm.nih.gov/36038172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9437735"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2022-061301","doi":"https://doi.org/10.1136/bmjopen-2022-061301","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2022-061301","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/12/8/e061301.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/12/8/e061301.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100757401","display_name":"Kamal Kant Sharma","orcid":"https://orcid.org/0000-0001-9204-3056","observed_orcids":["https://orcid.org/0000-0001-9204-3056"]},"institutions":[{"id":"https://openalex.org/I4210160584","display_name":"Foundation for Medical Research","ror":"https://ror.org/05npsb488","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210160584"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kamal Kant Sharma","raw_affiliation_strings":["The Foundation for Medical Research, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Foundation for Medical Research, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210160584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052506973","display_name":"Uttara Partap","orcid":"https://orcid.org/0000-0002-2531-1804","observed_orcids":["https://orcid.org/0000-0002-2531-1804"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uttara Partap","raw_affiliation_strings":["Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-2531-1804","affiliations":[{"raw_affiliation_string":"Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035762633","display_name":"Nerges Furdoon Mistry","orcid":"https://orcid.org/0000-0003-3509-4994","observed_orcids":["https://orcid.org/0000-0003-3509-4994"]},"institutions":[{"id":"https://openalex.org/I4210160584","display_name":"Foundation for Medical Research","ror":"https://ror.org/05npsb488","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210160584"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nerges Mistry","raw_affiliation_strings":["The Foundation for Medical Research, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Foundation for Medical Research, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210160584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yogesh Marathe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160584","display_name":"Foundation for Medical Research","ror":"https://ror.org/05npsb488","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210160584"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogesh Marathe","raw_affiliation_strings":["The Foundation for Medical Research, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Foundation for Medical Research, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210160584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103146308","display_name":"Molin Wang","orcid":"https://orcid.org/0000-0003-1951-8961","observed_orcids":["https://orcid.org/0000-0003-1951-8961"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molin Wang","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014842540","display_name":"Sanaa Shaikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160584","display_name":"Foundation for Medical Research","ror":"https://ror.org/05npsb488","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210160584"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanaa Shaikh","raw_affiliation_strings":["The Foundation for Medical Research, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Foundation for Medical Research, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210160584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112860786","display_name":"Pradeep D\u2019costa","orcid":"https://orcid.org/0000-0002-2573-6749","observed_orcids":["https://orcid.org/0000-0002-2573-6749"]},"institutions":[{"id":"https://openalex.org/I4210148958","display_name":"King Edward Memorial Hospital Research Centre","ror":"https://ror.org/056yyyw24","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210148958"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pradeep D'Costa","raw_affiliation_strings":["King Edward Memorial Hospital and Research Centre, Pune, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Edward Memorial Hospital and Research Centre, Pune, Maharashtra, India","institution_ids":["https://openalex.org/I4210148958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690498","display_name":"Gaurav Gupta","orcid":"https://orcid.org/0000-0001-7941-0229","observed_orcids":["https://orcid.org/0000-0001-7941-0229"]},"institutions":[{"id":"https://openalex.org/I2802630937","display_name":"Saifee Hospital","ror":"https://ror.org/05d871a36","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802630937"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gaurav Gupta","raw_affiliation_strings":["Saifee Hospital, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saifee Hospital, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I2802630937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080714994","display_name":"Sabri Bromage","orcid":"https://orcid.org/0000-0002-6552-4871","observed_orcids":["https://orcid.org/0000-0002-6552-4871"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabri Bromage","raw_affiliation_strings":["Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-6552-4871","affiliations":[{"raw_affiliation_string":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053348297","display_name":"Elena Cori Hemler","orcid":"https://orcid.org/0000-0001-6986-9474","observed_orcids":["https://orcid.org/0000-0001-6986-9474"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena C Hemler","raw_affiliation_strings":["Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015314211","display_name":"Kevin C. Kain","orcid":"https://orcid.org/0000-0001-6068-1272","observed_orcids":["https://orcid.org/0000-0001-6068-1272"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kevin C Kain","raw_affiliation_strings":["Department of Medicine, University Health Network, Toronto, Ontario, Canada","Department of Medicine, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034249758","display_name":"Yatin N. Dholakia","orcid":"https://orcid.org/0000-0001-8482-1305","observed_orcids":["https://orcid.org/0000-0001-8482-1305"]},"institutions":[{"id":"https://openalex.org/I4210160584","display_name":"Foundation for Medical Research","ror":"https://ror.org/05npsb488","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210160584"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yatin Dholakia","raw_affiliation_strings":["The Foundation for Medical Research, Mumbai, Maharashtra, India"],"raw_orcid":"https://orcid.org/0000-0001-8482-1305","affiliations":[{"raw_affiliation_string":"The Foundation for Medical Research, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210160584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006605977","display_name":"Wafaie Wahib Fawzi","orcid":"https://orcid.org/0000-0002-2908-600X","observed_orcids":["https://orcid.org/0000-0002-2908-600X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wafaie W Fawzi","raw_affiliation_strings":["Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-2908-600X","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006605977"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":1.3196,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.7796991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"8","first_page":"e061301","last_page":"e061301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/zinc-supplementation","display_name":"zinc supplementation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/micronutrient-deficiency","display_name":"micronutrient deficiency","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8069999814033508},{"id":"https://openalex.org/keywords/time-to-recovery","display_name":"time to recovery","score":0.75},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.5870000123977661},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.878000020980835},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.9440000057220459},{"id":"https://openalex.org/keywords/zinc-gluconate","display_name":"zinc gluconate","score":0.718999981880188},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9340289831161499},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6208113431930542},{"id":"https://openalex.org/C2778596745","wikidata":"https://www.wikidata.org/wiki/Q6839792","display_name":"Micronutrient deficiency","level":3,"score":0.6128481030464172},{"id":"https://openalex.org/C2777106319","wikidata":"https://www.wikidata.org/wiki/Q362104","display_name":"Institutional review board","level":2,"score":0.6038207411766052},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5312673449516296},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5231826901435852},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5137563943862915},{"id":"https://openalex.org/C14522933","wikidata":"https://www.wikidata.org/wiki/Q531507","display_name":"Micronutrient","level":2,"score":0.4275425970554352},{"id":"https://openalex.org/C153997805","wikidata":"https://www.wikidata.org/wiki/Q42240","display_name":"Research ethics","level":2,"score":0.42635682225227356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3357195556163788},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3254292607307434},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1762385368347168},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.15990197658538818},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.13769134879112244},{"id":"https://openalex.org/C551997983","wikidata":"https://www.wikidata.org/wiki/Q12167","display_name":"Malnutrition","level":2,"score":0.0924694836139679},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/bmjopen-2022-061301","doi":"https://doi.org/10.1136/bmjopen-2022-061301","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2022-061301","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/12/8/e061301.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmid:36038172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36038172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Clinical Trial Protocol"},{"id":"pmh:oai:pubmedcentral.nih.gov:9437735","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9437735/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a66286b401414cdd8a8e8cddbbc124df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a66286b401414cdd8a8e8cddbbc124df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, Vol 12, Iss 8 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2022-061301","doi":"https://doi.org/10.1136/bmjopen-2022-061301","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2022-061301","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/12/8/e061301.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[{"id":"https://openalex.org/G162464046","display_name":null,"funder_award_id":"COVID-19 Rapid Research","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G3304509792","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5514976981","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5892370038","display_name":null,"funder_award_id":"447092","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G9000863500","display_name":"Partnership for Global Health Research Training Program(Renewal)","funder_award_id":"D43TW010543","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293483939.pdf","grobid_xml":"https://content.openalex.org/works/W4293483939.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1513279392","https://openalex.org/W1645379154","https://openalex.org/W1963751837","https://openalex.org/W1970029232","https://openalex.org/W1997013992","https://openalex.org/W2027953492","https://openalex.org/W2036255318","https://openalex.org/W2054922449","https://openalex.org/W2058465738","https://openalex.org/W2102264159","https://openalex.org/W2102792873","https://openalex.org/W2114800972","https://openalex.org/W2115434474","https://openalex.org/W2115501222","https://openalex.org/W2117075813","https://openalex.org/W2119163321","https://openalex.org/W2137836062","https://openalex.org/W2140804784","https://openalex.org/W2149175313","https://openalex.org/W2149425411","https://openalex.org/W2230044011","https://openalex.org/W2553590861","https://openalex.org/W2588906490","https://openalex.org/W2605051159","https://openalex.org/W2754714279","https://openalex.org/W2755261988","https://openalex.org/W2783136031","https://openalex.org/W2783299815","https://openalex.org/W2896178057","https://openalex.org/W2901751456","https://openalex.org/W2909863055","https://openalex.org/W2937198408","https://openalex.org/W3006252254","https://openalex.org/W3008443627","https://openalex.org/W3016268727","https://openalex.org/W3032291474","https://openalex.org/W3045728748","https://openalex.org/W3119133581","https://openalex.org/W3119239998","https://openalex.org/W3125790204","https://openalex.org/W3130184808","https://openalex.org/W3132027664","https://openalex.org/W3134716709","https://openalex.org/W3195977920","https://openalex.org/W3197407163","https://openalex.org/W4211129781","https://openalex.org/W6775989453","https://openalex.org/W6780717101"],"related_works":["https://openalex.org/W4383904036","https://openalex.org/W4385304018","https://openalex.org/W4210607112","https://openalex.org/W4287877511","https://openalex.org/W4214864686","https://openalex.org/W4387447790","https://openalex.org/W4381331893","https://openalex.org/W4308483140","https://openalex.org/W3193704019","https://openalex.org/W4310179885"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Presently,":[1],"there":[2],"are":[3,72,81,121],"few":[4],"population-level":[5],"strategies":[6],"to":[7,54,134,150,161,163,168],"address":[8],"SARS-CoV-2":[9],"infection":[10],"except":[11],"preventive":[12],"measures":[13],"such":[14],"as":[15,166],"vaccination.":[16],"Micronutrient":[17],"deficiency,":[18,24],"particularly":[19],"vitamin":[20,59,84],"D":[21,60],"and":[22,32,61,78,116,120,137,175,197],"zinc":[23,62,99],"has":[25],"been":[26],"associated":[27],"with":[28],"dysregulated":[29],"host":[30],"responses,":[31],"may":[33],"play":[34],"an":[35],"important":[36],"role":[37],"in":[38,66,76,124,193,228],"COVID-19.":[39],"METHODS":[40],"AND":[41,208],"ANALYSIS:":[42],"We":[43],"have":[44],"designed":[45],"a":[46,111],"2\u00d72":[47],"factorial,":[48],"randomised,":[49],"double-blind,":[50],"multi-centre":[51],"placebo-controlled":[52],"trial":[53],"evaluate":[55],"the":[56,132,158],"effect":[57],"of":[58,94,157,170,172,177,183,189,218],"on":[63,204],"COVID-19":[64,69],"outcomes":[65,180],"Maharashtra,":[67],"India.":[68],"positive":[70],"individuals":[71],"recruited":[73],"from":[74,214],"hospitals":[75],"Mumbai":[77],"Pune.":[79],"Participants":[80,109],"provided":[82],"(1)":[83],"D3":[85],"bolus":[86],"(180":[87],"000":[88],"IU)":[89],"maintained":[90],"by":[91],"daily":[92,123],"dose":[93],"2000":[95],"IU":[96],"and/or":[97],"(2)":[98],"gluconate":[100],"(40":[101],"mg":[102],"daily),":[103],"versus":[104],"placebo":[105],"for":[106],"8":[107,118],"weeks.":[108],"undergo":[110],"detailed":[112],"assessment":[113],"at":[114,117],"baseline":[115],"weeks,":[119],"monitored":[122],"hospital":[125,133,184],"or":[126],"every":[127],"3":[128],"days":[129],"after":[130],"leaving":[131],"assess":[135,151],"symptoms":[136,199],"other":[138],"clinical":[139],"measures.":[140],"A":[141],"final":[142],"follow-up":[143],"telephone":[144],"call":[145],"occurs":[146],"12":[147],"weeks":[148],"post-enrolment":[149],"long-term":[152],"outcomes.":[153],"The":[154,222],"primary":[155],"outcome":[156],"study":[159,223],"is":[160],"time":[162,167],"recovery,":[164],"defined":[165],"resolution":[169],"all":[171,219],"fever,":[173],"cough":[174],"shortness":[176],"breath.":[178],"Secondary":[179],"include:":[181],"duration":[182],"stay,":[185],"all-cause":[186],"mortality,":[187],"necessity":[188],"assisted":[190],"ventilation,":[191],"change":[192],"blood":[194],"biomarker":[195],"levels":[196],"individual":[198],"duration.":[200],"Participant":[201],"recruitment":[202],"commenced":[203],"April":[205],"2021.":[206],"ETHICS":[207],"DISSEMINATION:":[209],"Ethical":[210],"approval":[211],"was":[212],"obtained":[213],"institutional":[215],"ethical":[216],"committees":[217],"participating":[220],"institutions.":[221],"findings":[224],"will":[225],"be":[226],"presented":[227],"peer-reviewed":[229],"medical":[230],"journals.":[231],"TRIAL":[232],"REGISTRATION":[233],"NUMBERS:":[234],"NCT04641195,":[235],"CTRI/2021/04/032593,":[236],"HMSC":[237],"(GOI)-2021-0060.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-29T00:00:00"}
