{"id":"https://openalex.org/W4293413486","doi":"https://doi.org/10.1158/1535-7163.mct-21-0750","title":"Sustained Supratherapeutic Paclitaxel Delivery Enhances Irreversible Sarcoma Cell Death","display_name":"Sustained Supratherapeutic Paclitaxel Delivery Enhances Irreversible Sarcoma Cell Death","publication_year":2022,"publication_date":"2022-08-28","ids":{"openalex":"https://openalex.org/W4293413486","doi":"https://doi.org/10.1158/1535-7163.mct-21-0750","pmid":"https://pubmed.ncbi.nlm.nih.gov/36031342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633561"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-21-0750","doi":"https://doi.org/10.1158/1535-7163.mct-21-0750","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-21-0750","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633561","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013497399","display_name":"William A. Blessing","orcid":"https://orcid.org/0000-0002-3145-7762","observed_orcids":["https://orcid.org/0000-0002-3145-7762"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Blessing","raw_affiliation_strings":["1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-3145-7762","affiliations":[{"raw_affiliation_string":"1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073569663","display_name":"Christopher S. Digesu","orcid":"https://orcid.org/0000-0002-3779-1913","observed_orcids":["https://orcid.org/0000-0002-3779-1913"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Digesu","raw_affiliation_strings":["2Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-3779-1913","affiliations":[{"raw_affiliation_string":"2Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014687555","display_name":"Rong Liu","orcid":"https://orcid.org/0000-0001-5876-1986","observed_orcids":["https://orcid.org/0000-0001-5876-1986"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Liu","raw_affiliation_strings":["1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-5876-1986","affiliations":[{"raw_affiliation_string":"1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016461513","display_name":"David A. Mahvi","orcid":"https://orcid.org/0000-0003-2722-8518","observed_orcids":["https://orcid.org/0000-0003-2722-8518"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Mahvi","raw_affiliation_strings":["3Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-2722-8518","affiliations":[{"raw_affiliation_string":"3Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030649022","display_name":"Aya Tal-mason","orcid":"https://orcid.org/0000-0001-6847-1579","observed_orcids":["https://orcid.org/0000-0001-6847-1579"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aya Tal-mason","raw_affiliation_strings":["1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-6847-1579","affiliations":[{"raw_affiliation_string":"1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101719289","display_name":"Anil Kumar","orcid":"https://orcid.org/0000-0001-5242-1323","observed_orcids":["https://orcid.org/0000-0001-5242-1323"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Kumar","raw_affiliation_strings":["1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-5242-1323","affiliations":[{"raw_affiliation_string":"1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089444106","display_name":"Krista J. Hachey","orcid":"https://orcid.org/0000-0002-4603-5490","observed_orcids":["https://orcid.org/0000-0002-4603-5490"]},"institutions":[{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krista J. Hachey","raw_affiliation_strings":["4Department of Surgery, Boston Medical Center, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-4603-5490","affiliations":[{"raw_affiliation_string":"4Department of Surgery, Boston Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090222497","display_name":"Aaron H. Colby","orcid":"https://orcid.org/0000-0001-7161-821X","observed_orcids":["https://orcid.org/0000-0001-7161-821X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron H. Colby","raw_affiliation_strings":["5Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-7161-821X","affiliations":[{"raw_affiliation_string":"5Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073509597","display_name":"Jenny T. Korunes-Miller","orcid":"https://orcid.org/0000-0002-3300-1451","observed_orcids":["https://orcid.org/0000-0002-3300-1451"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny T. Korunes-Miller","raw_affiliation_strings":["5Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-3300-1451","affiliations":[{"raw_affiliation_string":"5Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905613","display_name":"Natalie Agar","orcid":"https://orcid.org/0000-0003-3149-3146","observed_orcids":["https://orcid.org/0000-0003-3149-3146"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Agar","raw_affiliation_strings":["6Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-3149-3146","affiliations":[{"raw_affiliation_string":"6Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075621139","display_name":"Michael Scott Regan","orcid":"https://orcid.org/0000-0001-5252-2829","observed_orcids":["https://orcid.org/0000-0001-5252-2829"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Regan","raw_affiliation_strings":["6Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-5252-2829","affiliations":[{"raw_affiliation_string":"6Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748070","display_name":"Angela R. Shih","orcid":"https://orcid.org/0000-0002-8945-5997","observed_orcids":["https://orcid.org/0000-0002-8945-5997"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Shih","raw_affiliation_strings":["7Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-8945-5997","affiliations":[{"raw_affiliation_string":"7Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056266239","display_name":"Chandrajit P. Raut","orcid":"https://orcid.org/0000-0001-7297-3221","observed_orcids":["https://orcid.org/0000-0001-7297-3221"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chandrajit P. Raut","raw_affiliation_strings":["3Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","8Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-7297-3221","affiliations":[{"raw_affiliation_string":"3Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"8Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001975624","display_name":"Mark W. Grinstaff","orcid":"https://orcid.org/0000-0002-5453-3668","observed_orcids":["https://orcid.org/0000-0002-5453-3668"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark W. Grinstaff","raw_affiliation_strings":["5Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-5453-3668","affiliations":[{"raw_affiliation_string":"5Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034925727","display_name":"Yolonda Lorig Colson","orcid":"https://orcid.org/0000-0002-8229-5636","observed_orcids":["https://orcid.org/0000-0002-8229-5636"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yolonda L. Colson","raw_affiliation_strings":["1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","3Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-8229-5636","affiliations":[{"raw_affiliation_string":"1Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"3Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5001975624","https://openalex.org/A5056266239"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":0.1612,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47467969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"21","issue":"11","first_page":"1663","last_page":"1673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.5929999947547913},{"id":"https://openalex.org/keywords/polymer-films","display_name":"polymer films","score":0.6890000104904175},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/liposarcoma","display_name":"liposarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leiomyosarcoma","display_name":"leiomyosarcoma","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.7689999938011169},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9079999923706055},{"id":"https://openalex.org/keywords/dna-integrity","display_name":"DNA integrity","score":0.6600000262260437},{"id":"https://openalex.org/keywords/locoregional-recurrence","display_name":"locoregional recurrence","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.7640404105186462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7026326656341553},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6778215169906616},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6102384328842163},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5692875385284424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48663219809532166},{"id":"https://openalex.org/C2777532014","wikidata":"https://www.wikidata.org/wiki/Q1504713","display_name":"Leiomyosarcoma","level":2,"score":0.48539695143699646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4821757674217224},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44561246037483215},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4134281277656555},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.4107491374015808},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.38862210512161255},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3853475749492645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26817411184310913},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2223590910434723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16602906584739685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16508889198303223},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.mct-21-0750","doi":"https://doi.org/10.1158/1535-7163.mct-21-0750","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-21-0750","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:36031342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36031342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9633561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9633561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9633561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Ther","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1274943346","display_name":"Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma","funder_award_id":"R01EB017722","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G2661966628","display_name":null,"funder_award_id":"TR001102","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2727982425","display_name":"Large Scale Synthesis and Biodistribution of Expansile Nanoparticles","funder_award_id":"R43CA189215","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3033624170","display_name":"Improving delivery of paclitaxel to ovarian cancer via expansile nanoparticles","funder_award_id":"R43CA213538","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3333529065","display_name":null,"funder_award_id":"CA232708","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G489421352","display_name":"Advanced Training in Surgical Oncology","funder_award_id":"T32CA009535","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5917631193","display_name":"SUPERHYDROPHOBIC DRUG LOADED BUTTRESSES FOR PREVENTION OF LUNGTUMOR RECURRENCE","funder_award_id":"R01CA232708","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6840688124","display_name":null,"funder_award_id":"EB017722","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7205884179","display_name":"TUMOR SPECIFIC DELIVERY OF VERTICILLIN A OVERCOMES EPIGENETIC SILENCING RESPONSIBLE FOR DRUG RESISTANCE","funder_award_id":"R01CA227433","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7864343550","display_name":null,"funder_award_id":"CA227433","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8250551471","display_name":"Harvard Clinical and Translational Science Center","funder_award_id":"UL1TR001102","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000913641","display_name":"Supratherapeutic PTX Buttresses Reduce Locoregional Recurrence Rates Following Surgery for Soft Tissue Sarcomas","funder_award_id":"R01CA272637","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1509669696","https://openalex.org/W1605269201","https://openalex.org/W1616592835","https://openalex.org/W1856793902","https://openalex.org/W1965072143","https://openalex.org/W1966637837","https://openalex.org/W1969686625","https://openalex.org/W1971870570","https://openalex.org/W1972264829","https://openalex.org/W1976457873","https://openalex.org/W1989792740","https://openalex.org/W2000129278","https://openalex.org/W2002215444","https://openalex.org/W2019097500","https://openalex.org/W2027147390","https://openalex.org/W2036521316","https://openalex.org/W2045839111","https://openalex.org/W2045963360","https://openalex.org/W2048363916","https://openalex.org/W2062947816","https://openalex.org/W2066522045","https://openalex.org/W2069348059","https://openalex.org/W2079351888","https://openalex.org/W2086375279","https://openalex.org/W2090619182","https://openalex.org/W2091986411","https://openalex.org/W2108257604","https://openalex.org/W2123304308","https://openalex.org/W2124417306","https://openalex.org/W2129316990","https://openalex.org/W2143202928","https://openalex.org/W2143419708","https://openalex.org/W2144287916","https://openalex.org/W2150312029","https://openalex.org/W2155147356","https://openalex.org/W2158795107","https://openalex.org/W2159023635","https://openalex.org/W2161009819","https://openalex.org/W2162785195","https://openalex.org/W2165739116","https://openalex.org/W2226137333","https://openalex.org/W2320141410","https://openalex.org/W2323526189","https://openalex.org/W2325740123","https://openalex.org/W2346594379","https://openalex.org/W2625747098","https://openalex.org/W2766619138","https://openalex.org/W2897257065","https://openalex.org/W2897570149","https://openalex.org/W3001431784"],"related_works":["https://openalex.org/W2045839111","https://openalex.org/W4387229209","https://openalex.org/W2137205222","https://openalex.org/W7098705889","https://openalex.org/W7139048693","https://openalex.org/W4312138159","https://openalex.org/W3142085441","https://openalex.org/W6981710178","https://openalex.org/W2894003365","https://openalex.org/W1981339676"],"abstract_inverted_index":{"Risk":[0],"of":[1,16,49,58,149,166,173,183],"locoregional":[2],"recurrence":[3,41],"after":[4],"sarcoma":[5,209],"resection":[6],"is":[7,61,74],"high,":[8],"increasing":[9],"both":[10],"morbidity":[11],"and":[12,42,63,76,130,141,155,188,213],"mortality.":[13],"Intraoperative":[14],"implantation":[15],"paclitaxel":[17],"(PTX)-eluting":[18],"polymer":[19],"films":[20,60,115,206],"locally":[21],"delivers":[22],"sustained,":[23],"supratherapeutic":[24,201],"PTX":[25,72,84,107,114,145,192],"concentrations":[26,193,202],"to":[27,122,218],"the":[28,53,65,123,147,171,195],"tumor":[29,124,196],"bed":[30,197],"that":[31],"are":[32],"not":[33],"clinically":[34],"feasible":[35],"with":[36,79,111,204],"systemic":[37,199],"therapy,":[38],"thereby":[39,125],"reducing":[40],"improving":[43],"survival":[44],"in":[45,112,133,151,185,211],"a":[46,117,180],"murine":[47],"model":[48],"recurrent":[50],"sarcoma.":[51],"However,":[52],"biology":[54],"underlying":[55],"increased":[56],"efficacy":[57,73],"PTX-eluting":[59,205],"unknown":[62],"provides":[64],"impetus":[66],"for":[67,87],"this":[68],"work.":[69],"In":[70],"vitro":[71],"time":[75],"dose":[77,118],"dependent":[78],"prolonged":[80],"exposure":[81],"significantly":[82,108],"decreasing":[83],"IC50":[85],"values":[86],"human":[88],"chondrosarcoma":[89],"(CS-1)":[90],"cells":[91,187],"(153.9":[92],"nmol/L":[93,99],"at":[94,100,194],"4":[95,164],"hours":[96,165],"vs.":[97],"14.2":[98],"30":[101],"hours,":[102],"P":[103],"=":[104],"0.0001).":[105],"High-dose":[106],"inhibits":[109],"proliferation":[110],"vivo":[113,212],"delivering":[116],">130":[119],"\u03bcmol/L":[120],"directly":[121],"irreversibly":[126,156],"arresting":[127],"cell":[128,161],"cycle":[129],"inducing":[131],"apoptosis":[132,158,184],"CS-1":[134,186],"as":[135,137,179],"well":[136],"patient-derived":[138],"liposarcoma":[139],"(LP6)":[140],"leiomyosarcoma":[142],"(LMS20).":[143],"Supratherapeutic":[144],"upregulates":[146],"expression":[148],"p21":[150],"G2-M":[152],"arrested":[153],"cells,":[154],"induces":[157],"followed":[159],"by":[160],"death,":[162],"within":[163],"exposure.":[167],"Microarray":[168],"analyses":[169],"corroborate":[170],"finding":[172],"poor":[174],"DNA":[175],"integrity":[176],"commonly":[177],"observed":[178],"final":[181],"step":[182],"tumor.":[189],"Unlike":[190],"low":[191],"during":[198],"delivery,":[200],"achieved":[203],"markedly":[207],"decrease":[208],"lethality":[210],"offer":[214],"an":[215],"alternative":[216],"paradigm":[217],"prevent":[219],"recurrence.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-29T00:00:00"}
