{"id":"https://openalex.org/W4293412928","doi":"https://doi.org/10.21037/dmr-22-29","title":"Branched chain amino acid-to-tyrosine ratio: not only an indicator of the amino acid imbalance","display_name":"Branched chain amino acid-to-tyrosine ratio: not only an indicator of the amino acid imbalance","publication_year":2022,"publication_date":"2022-08-29","ids":{"openalex":"https://openalex.org/W4293412928","doi":"https://doi.org/10.21037/dmr-22-29"},"language":"en","primary_location":{"id":"doi:10.21037/dmr-22-29","doi":"https://doi.org/10.21037/dmr-22-29","is_oa":true,"landing_page_url":"https://doi.org/10.21037/dmr-22-29","pdf_url":null,"source":{"id":"https://openalex.org/S4210210052","display_name":"Digestive Medicine Research","issn_l":"2617-1627","issn":["2617-1627"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Medicine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.21037/dmr-22-29","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027049654","display_name":"Hirayuki Enomoto","orcid":"https://orcid.org/0000-0003-1334-1149","observed_orcids":["https://orcid.org/0000-0003-1334-1149"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirayuki Enomoto","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102275721","display_name":"Takashi Nishimura","orcid":"https://orcid.org/0009-0008-0576-1251","observed_orcids":["https://orcid.org/0009-0008-0576-1251"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nishimura","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061904257","display_name":"Nobuhiro Aizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiro Aizawa","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013706732","display_name":"Tomoyuki Takashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Takashima","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113604388","display_name":"Naoto Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Ikeda","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041801287","display_name":"Yukihisa Yuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihisa Yuri","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068357362","display_name":"Aoi Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aoi Fujiwara","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kohei Yoshihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Yoshihara","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040181618","display_name":"Ryota Yoshioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryota Yoshioka","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054648164","display_name":"Shoki Kawata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoki Kawata","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013414838","display_name":"Shogo Ota","orcid":"https://orcid.org/0000-0001-5171-1847","observed_orcids":["https://orcid.org/0000-0001-5171-1847"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Ota","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082196727","display_name":"Ryota Nakano","orcid":"https://orcid.org/0000-0002-1844-2865","observed_orcids":["https://orcid.org/0000-0002-1844-2865"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryota Nakano","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017352054","display_name":"Hideyuki Shiomi","orcid":"https://orcid.org/0000-0002-7461-8538","observed_orcids":["https://orcid.org/0000-0002-7461-8538"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Shiomi","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061999363","display_name":"Hiroko Iijima","orcid":"https://orcid.org/0000-0002-5841-8827","observed_orcids":["https://orcid.org/0000-0002-5841-8827"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Iijima","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine , Hyogo Medical University , Nishinomiya, Hyogo , Japan","institution_ids":["https://openalex.org/I137459256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I137459256"],"apc_list":null,"apc_paid":null,"fwci":0.3823,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.56220344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amino-acid-imbalance","display_name":"amino acid imbalance","score":0.9419999718666077},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/esophageal-varices","display_name":"esophageal varices","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hypoalbuminemia","display_name":"hypoalbuminemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7901992797851562},{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.7546496391296387},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7128699421882629},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7024953365325928},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.6166186332702637},{"id":"https://openalex.org/C2780677274","wikidata":"https://www.wikidata.org/wiki/Q420726","display_name":"Branched-chain amino acid","level":4,"score":0.6115272045135498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5975801348686218},{"id":"https://openalex.org/C2776009029","wikidata":"https://www.wikidata.org/wiki/Q1640780","display_name":"Hypoalbuminemia","level":2,"score":0.5035457015037537},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4796103239059448},{"id":"https://openalex.org/C2777992278","wikidata":"https://www.wikidata.org/wiki/Q705605","display_name":"Aromatic amino acids","level":3,"score":0.4316588342189789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20748242735862732},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.19171056151390076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13863512873649597}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21037/dmr-22-29","doi":"https://doi.org/10.21037/dmr-22-29","is_oa":true,"landing_page_url":"https://doi.org/10.21037/dmr-22-29","pdf_url":null,"source":{"id":"https://openalex.org/S4210210052","display_name":"Digestive Medicine Research","issn_l":"2617-1627","issn":["2617-1627"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Medicine Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21037/dmr-22-29","doi":"https://doi.org/10.21037/dmr-22-29","is_oa":true,"landing_page_url":"https://doi.org/10.21037/dmr-22-29","pdf_url":null,"source":{"id":"https://openalex.org/S4210210052","display_name":"Digestive Medicine Research","issn_l":"2617-1627","issn":["2617-1627"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Medicine Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106752835","https://openalex.org/W2626579064","https://openalex.org/W7098199160","https://openalex.org/W3143054119","https://openalex.org/W2170097301","https://openalex.org/W1987928923","https://openalex.org/W1498499835","https://openalex.org/W7099931637","https://openalex.org/W2109269085","https://openalex.org/W4393191644"],"abstract_inverted_index":{"Chronic":[0],"liver":[1,75,86,117,176,185],"diseases":[2],"induce":[3],"various":[4,70],"metabolic":[5],"disorders.":[6],"Amino":[7],"acid":[8,28,44,63,195],"imbalance":[9,196],"is":[10,54,92,157],"known":[11],"to":[12,59,142,203],"be":[13,143,215],"associated":[14,144],"with":[15,50,82,115,145,153,192],"the":[16,42,61,66,83,99,138,146,165,173,212,219],"symptoms":[17],"of":[18,41,73,85,101,151,167,175,179,184,221],"hepatic":[19],"encephalopathy,":[20],"especially":[21],"in":[22,57,80,113],"decompensated":[23],"cirrhosis.":[24],"The":[25,46,77],"branched-chain":[26],"amino":[27,43,62,194],"(BCAA)-to-tyrosine":[29],"ratio":[30,52],"(BTR)":[31],"was":[32,122,140],"proposed":[33,123],"as":[34,94,124,172],"an":[35,193],"easily":[36],"measurable":[37],"and":[38,53,88,110,133,149,182,189,197],"inexpensive":[39],"indicator":[40],"imbalance.":[45,64],"BTR":[47,67,78,91,121,139,200,213],"well":[48],"correlates":[49],"Fischer\u2019s":[51],"commonly":[55],"used":[56],"Japan":[58],"assess":[60],"However,":[65],"also":[68],"reflects":[69],"pathophysiological":[71],"disorders":[72],"chronic":[74,116],"diseases.":[76,118],"decreases":[79],"line":[81],"progression":[84,183],"fibrosis,":[87],"a":[89,95,125,134,198],"low":[90,120],"considered":[93],"risk":[96,166],"factor":[97],"for":[98,129,217],"presence":[100],"sarcopenia":[102],"(decreased":[103],"skeletal":[104],"muscle":[105],"volume),":[106],"high-risk":[107],"varices,":[108,181],"hypoalbuminemia,":[109],"insulin":[111],"resistance":[112],"patients":[114,152],"A":[119],"possible":[126],"predictive":[127],"marker":[128],"undesired":[130],"cirrhosis-related":[131],"events":[132],"poor":[135],"prognosis.":[136],"Furthermore,":[137],"suggested":[141,158],"treatment":[147],"efficacy":[148],"prognosis":[150],"hepatocellular":[154],"carcinoma.":[155],"It":[156],"that":[159],"long-term":[160],"BCAA":[161,209,222],"administration":[162],"can":[163],"suppress":[164],"all":[168],"fatal":[169],"events,":[170],"such":[171],"development":[174],"cancer,":[177],"bleeding":[178],"esophagogastric":[180],"failure":[186],"(encephalopathy,":[187],"icterus":[188],"ascites).":[190],"Patients":[191],"decreased":[199],"are":[201],"expected":[202],"effectively":[204],"obtain":[205],"clinical":[206],"benefits":[207],"from":[208],"treatment,":[210],"so":[211],"may":[214],"useful":[216],"determining":[218],"indication":[220],"treatment.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-08-29T00:00:00"}