{"id":"https://openalex.org/W4293280744","doi":"https://doi.org/10.1093/function/zqac042","title":"Deletion of Mechanosensory \u03b21-integrin From Bladder Smooth Muscle Results in Voiding Dysfunction and Tissue Remodeling","display_name":"Deletion of Mechanosensory \u03b21-integrin From Bladder Smooth Muscle Results in Voiding Dysfunction and Tissue Remodeling","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4293280744","doi":"https://doi.org/10.1093/function/zqac042","pmid":"https://pubmed.ncbi.nlm.nih.gov/38989038","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11234651"},"language":"en","primary_location":{"id":"doi:10.1093/function/zqac042","doi":"https://doi.org/10.1093/function/zqac042","is_oa":true,"landing_page_url":"https://doi.org/10.1093/function/zqac042","pdf_url":null,"source":{"id":"https://openalex.org/S4210215692","display_name":"Function","issn_l":"2633-8823","issn":["2633-8823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/function/zqac042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060216484","display_name":"Weiqun Yu","orcid":"https://orcid.org/0000-0001-8102-8918","observed_orcids":["https://orcid.org/0000-0001-8102-8918"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqun Yu","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081825830","display_name":"Bryce MacIver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryce MacIver","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052218498","display_name":"Lanlan Zhang","orcid":"https://orcid.org/0000-0001-8128-0590","observed_orcids":["https://orcid.org/0000-0001-8128-0590"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lanlan Zhang","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053537873","display_name":"Erica M. Bien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica M Bien","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047657771","display_name":"Nazaakat Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nazaakat Ahmed","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huan Chen","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010549600","display_name":"Sarah Z Hanif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Z Hanif","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023349336","display_name":"Mariana G. de Oliveira","orcid":"https://orcid.org/0000-0003-2226-2530","observed_orcids":["https://orcid.org/0000-0003-2226-2530"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana G de\u00a0Oliveira","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP) , Campinas, SP 13083-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP) , Campinas, SP 13083-970, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082440110","display_name":"Mark L. Zeidel","orcid":"https://orcid.org/0000-0002-5190-9770","observed_orcids":["https://orcid.org/0000-0002-5190-9770"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L Zeidel","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087929660","display_name":"Warren G. Hill","orcid":"https://orcid.org/0000-0002-2772-7264","observed_orcids":["https://orcid.org/0000-0002-2772-7264"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Warren G Hill","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087929660"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":1.3845,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.79296957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"3","issue":"5","first_page":"zqac042","last_page":"zqac042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bladder-smooth-muscle","display_name":"bladder smooth muscle","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.9279999732971191},{"id":"https://openalex.org/keywords/voiding-dysfunction","display_name":"voiding dysfunction","score":0.8529999852180481},{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":0.9110000133514404},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/integrin-alpha1","display_name":"integrin alpha1","score":0.5559999942779541},{"id":"https://openalex.org/keywords/integrin-alpha3","display_name":"integrin alpha3","score":0.996999979019165},{"id":"https://openalex.org/keywords/integrin-alphav","display_name":"ITGAV","score":0.7850000262260437},{"id":"https://openalex.org/keywords/integrin-beta3","display_name":"CD61","score":0.9850000143051147},{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bladder-contractility","display_name":"bladder contractility","score":0.6330000162124634},{"id":"https://openalex.org/keywords/interstitial-cells","display_name":"interstitial cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/s100a4","display_name":"S100A4","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.659558892250061},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.5282936096191406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4701179265975952},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3463195562362671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3447118401527405},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34430843591690063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31321725249290466},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14599663019180298}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/function/zqac042","doi":"https://doi.org/10.1093/function/zqac042","is_oa":true,"landing_page_url":"https://doi.org/10.1093/function/zqac042","pdf_url":null,"source":{"id":"https://openalex.org/S4210215692","display_name":"Function","issn_l":"2633-8823","issn":["2633-8823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11234651","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11234651","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function (Oxf)","raw_type":"Text"},{"id":"pmid:38989038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38989038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:43cd2706a2fc4df7847622caf78cf961","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/43cd2706a2fc4df7847622caf78cf961","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Function, Vol 3, Iss 5 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/function/zqac042","doi":"https://doi.org/10.1093/function/zqac042","is_oa":true,"landing_page_url":"https://doi.org/10.1093/function/zqac042","pdf_url":null,"source":{"id":"https://openalex.org/S4210215692","display_name":"Function","issn_l":"2633-8823","issn":["2633-8823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1504564486","https://openalex.org/W1513185217","https://openalex.org/W1575778540","https://openalex.org/W1597724465","https://openalex.org/W1616669882","https://openalex.org/W1963754791","https://openalex.org/W1966952404","https://openalex.org/W1970985119","https://openalex.org/W1971950732","https://openalex.org/W1983393196","https://openalex.org/W1991658964","https://openalex.org/W1992830759","https://openalex.org/W1998362531","https://openalex.org/W2002755192","https://openalex.org/W2013956923","https://openalex.org/W2051893541","https://openalex.org/W2056047130","https://openalex.org/W2071069055","https://openalex.org/W2072156884","https://openalex.org/W2076027369","https://openalex.org/W2076205235","https://openalex.org/W2088327981","https://openalex.org/W2089461788","https://openalex.org/W2089642295","https://openalex.org/W2097611287","https://openalex.org/W2100678115","https://openalex.org/W2106560234","https://openalex.org/W2115219046","https://openalex.org/W2125728464","https://openalex.org/W2127777722","https://openalex.org/W2139136977","https://openalex.org/W2147711201","https://openalex.org/W2156525733","https://openalex.org/W2169667134","https://openalex.org/W2170032574","https://openalex.org/W2288256636","https://openalex.org/W2523101893","https://openalex.org/W2593443191","https://openalex.org/W2758054633","https://openalex.org/W2771595503","https://openalex.org/W2791869778","https://openalex.org/W2899823918","https://openalex.org/W2955108563","https://openalex.org/W2959654103","https://openalex.org/W2968099720","https://openalex.org/W2969903473","https://openalex.org/W2989177129","https://openalex.org/W2997946065","https://openalex.org/W3016647148","https://openalex.org/W3026175718","https://openalex.org/W3027147459","https://openalex.org/W3136779476","https://openalex.org/W3176819705","https://openalex.org/W3195197139","https://openalex.org/W4200055746","https://openalex.org/W4212884701","https://openalex.org/W4249152240","https://openalex.org/W4297819262"],"related_works":["https://openalex.org/W3173516148","https://openalex.org/W2063963111","https://openalex.org/W2041235961","https://openalex.org/W3173587212","https://openalex.org/W2138975248","https://openalex.org/W2030682772","https://openalex.org/W6945917682","https://openalex.org/W2043385452","https://openalex.org/W7044923223","https://openalex.org/W2127777722"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"bladder":[2,59,150,239],"undergoes":[3],"large":[4],"shape":[5],"changes":[6],"as":[7,29],"it":[8],"fills":[9],"and":[10,12,34,79,83,87,186,194,208,234,237],"empties":[11],"experiences":[13],"complex":[14],"mechanical":[15],"forces.":[16],"These":[17],"forces":[18],"become":[19],"abnormal":[20],"in":[21,57,94,100,130,144,161,189,232,248],"diseases":[22],"of":[23,71,77,85,109,158,174,183,199,203,211,226],"the":[24,38,42,46,172,220,224],"lower":[25,243],"urinary":[26,35,244],"tract":[27,245],"such":[28],"overactive":[30],"bladder,":[31,33],"neurogenic":[32],"retention.":[36],"As":[37],"primary":[39],"mechanosensors":[40],"linking":[41],"actin":[43],"cytoskeleton":[44],"to":[45,53,116,163,171],"extracellular":[47,235],"matrix":[48],"(ECM),":[49],"integrins":[50,230],"are":[51],"likely":[52],"play":[54],"vital":[55],"roles":[56],"maintaining":[58],"smooth":[60,67,95],"muscle":[61,68,96],"(BSM)":[62],"homeostasis.":[63],"In":[64],"a":[65,92,106,141,156,181,201],"tamoxifen-inducible":[66],"conditional":[69],"knockout":[70],"\u03b21-integrin,":[72],"there":[73,124,139],"was":[74,125,140,168],"concomitant":[75,238],"loss":[76,157,173,182,198,225],"\u03b11-":[78],"\u03b13-integrins":[80],"from":[81],"BSM":[82],"upregulation":[84,210],"\u03b1V-":[86],"\u03b23-integrins.":[88],"Masson's":[89],"staining":[90],"showed":[91,180],"reduction":[93,143],"with":[97,128,134,147,217],"an":[98,204,209],"increase":[99],"collagenous":[101],"ECM.":[102],"Functionally,":[103],"mice":[104],"exhibited":[105],"changing":[107],"pattern":[108],"urination":[110],"by":[111],"voiding":[112],"spot":[113],"assay":[114],"up":[115],"8":[117,122],"wk":[118],"after":[119],"tamoxifen.":[120],"By":[121],"wk,":[123],"increased":[126],"frequency":[127],"reductions":[129],"voided":[131],"volume,":[132],"consistent":[133],"overactivity.":[135],"Cystometrograms":[136],"confirmed":[137],"that":[138,167,223,241],"significant":[142],"intercontractile":[145],"interval":[146],"reduced":[148],"maximal":[149],"pressure.":[151],"Muscle":[152],"strip":[153],"myography":[154],"revealed":[155,197],"contraction":[159],"force":[160],"response":[162],"electrical":[164],"field":[165],"stimulation,":[166],"entirely":[169],"due":[170],"muscarinic":[175],"contractility.":[176],"Quantitative":[177],"western":[178],"blotting":[179],"M3":[184],"receptor":[185],"no":[187],"change":[188],"P2X1.":[190],"qPCR":[191],"on":[192],"ECM":[193],"interstitial":[195,205],"genes":[196],"Ntpd2,":[200],"marker":[202],"cell":[206],"subpopulation;":[207],"S100A4,":[212],"which":[213],"is":[214],"often":[215],"associated":[216],"fibroblasts.":[218],"Collectively,":[219],"data":[221],"show":[222],"appropriate":[227],"mechanosensation":[228],"through":[229],"results":[231],"cellular":[233],"remodeling,":[236],"dysfunction":[240],"resembles":[242],"symptoms":[246],"seen":[247],"older":[249],"people.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-27T00:00:00"}