{"id":"https://openalex.org/W4293247367","doi":"https://doi.org/10.1161/circ.144.suppl_1.12006","title":"Abstract 12006: Smooth Muscle Cell Embryologic Origin Does Not Define Propensity for Phenotype Modulation in Murine Marfan Syndrome Aortic Root Aneurysm","display_name":"Abstract 12006: Smooth Muscle Cell Embryologic Origin Does Not Define Propensity for Phenotype Modulation in Murine Marfan Syndrome Aortic Root Aneurysm","publication_year":2021,"publication_date":"2021-11-16","ids":{"openalex":"https://openalex.org/W4293247367","doi":"https://doi.org/10.1161/circ.144.suppl_1.12006"},"language":"en","primary_location":{"id":"doi:10.1161/circ.144.suppl_1.12006","doi":"https://doi.org/10.1161/circ.144.suppl_1.12006","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.144.suppl_1.12006","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059762317","display_name":"Albert J Pedroza","orcid":"https://orcid.org/0000-0001-5291-5980","observed_orcids":["https://orcid.org/0000-0001-5291-5980"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert J Pedroza","raw_affiliation_strings":["Cardiothoracic Surgery, STANFORD UNIVERSITY, Santa Clara, CA","Albert J Pedroza Cardiothoracic Surgery, STANFORD UNIVERSITY, Santa Clara, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Surgery, STANFORD UNIVERSITY, Santa Clara, CA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Albert J Pedroza Cardiothoracic Surgery, STANFORD UNIVERSITY, Santa Clara, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087640615","display_name":"Alex R. Dalal","orcid":"https://orcid.org/0000-0002-9993-3817","observed_orcids":["https://orcid.org/0000-0002-9993-3817"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex R Dalal","raw_affiliation_strings":["Stanford Univ, Menlo Park, CA","Alex R Dalal Stanford Univ, Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Menlo Park, CA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Alex R Dalal Stanford Univ, Menlo Park, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071294018","display_name":"Rohan Shad","orcid":"https://orcid.org/0000-0002-0453-9041","observed_orcids":["https://orcid.org/0000-0002-0453-9041"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohan Shad","raw_affiliation_strings":["Stanford Univ, Palo Alto, CA","Rohan Shad Stanford Univ, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Palo Alto, CA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Rohan Shad Stanford Univ, Palo Alto, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086338818","display_name":"Nobu Yokoyama","orcid":"https://orcid.org/0000-0002-5378-0261","observed_orcids":["https://orcid.org/0000-0002-5378-0261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobu Yokoyama","raw_affiliation_strings":["Cupertino, CA","Nobu Yokoyama Cupertino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cupertino, CA","institution_ids":[]},{"raw_affiliation_string":"Nobu Yokoyama Cupertino, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039063528","display_name":"Ken Nakamura","orcid":"https://orcid.org/0000-0003-1293-7784","observed_orcids":["https://orcid.org/0000-0003-1293-7784"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Nakamura","raw_affiliation_strings":["Stanford Univ, Stanford, CA","Ken Nakamura Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Ken Nakamura Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008505299","display_name":"Michael P. Fischbein","orcid":"https://orcid.org/0000-0002-0638-2025","observed_orcids":["https://orcid.org/0000-0002-0638-2025"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P Fischbein","raw_affiliation_strings":["STANFORD UNIVERSITY, Stanford, CA","Michael P Fischbein STANFORD UNIVERSITY, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"STANFORD UNIVERSITY, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Michael P Fischbein STANFORD UNIVERSITY, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marfan-syndrome","display_name":"Marfan syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aortic-root-aneurysm","display_name":"aortic root aneurysm","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/second-heart-field","display_name":"second heart field","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.9679999947547913},{"id":"https://openalex.org/keywords/embryonic-origin","display_name":"embryonic origin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hemodynamic-stress","display_name":"hemodynamic stress","score":0.7009999752044678},{"id":"https://openalex.org/keywords/transverse-aortic-constriction","display_name":"transverse aortic constriction","score":0.925000011920929},{"id":"https://openalex.org/keywords/extracellular-matrix-proteoglycans","display_name":"extracellular matrix proteoglycans","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sclerostin","display_name":"sclerostin","score":0.8159999847412109},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":0.9470000267028809},{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":0.6729999780654907},{"id":"https://openalex.org/keywords/lumican","display_name":"lumican","score":0.9919999837875366},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.8740000128746033},{"id":"https://openalex.org/keywords/aortic-remodeling","display_name":"aortic remodeling","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2779457992","wikidata":"https://www.wikidata.org/wiki/Q18028707","display_name":"Lumican","level":5,"score":0.5704002380371094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5641160607337952},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.46206340193748474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4510292112827301},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.4465333819389343},{"id":"https://openalex.org/C2780561598","wikidata":"https://www.wikidata.org/wiki/Q208562","display_name":"Marfan syndrome","level":2,"score":0.43674707412719727},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.4048989415168762},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.40425801277160645},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40062546730041504},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3268175721168518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32235556840896606},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.14309507608413696},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.0748768150806427}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.144.suppl_1.12006","doi":"https://doi.org/10.1161/circ.144.suppl_1.12006","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.144.suppl_1.12006","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4284668913","https://openalex.org/W3045480960","https://openalex.org/W3215275136","https://openalex.org/W4367182068","https://openalex.org/W3134154942","https://openalex.org/W4312728535","https://openalex.org/W2988110807","https://openalex.org/W2766695420","https://openalex.org/W4387343882","https://openalex.org/W2107753444"],"abstract_inverted_index":{"Introduction:":[0],"Vascular":[1],"smooth":[2],"muscle":[3],"cells":[4],"(SMC)":[5],"undergo":[6],"phenotype":[7,51,232,258],"modulation":[8,185,233],"(silenced":[9],"contractile":[10],"genes":[11],"and":[12,33,44,64,106,112,129,141,240],"activated":[13],"proteolytic/synthetic":[14],"genes)":[15],"in":[16,96,148,165,175,237,243,260],"Marfan":[17],"syndrome":[18],"(MFS)":[19],"aortic":[20,55,177,192,198,245,253,286],"aneurysm.":[21,57],"Aortic":[22,59,270],"root":[23,56,217,274],"SMCs":[24,92,103,171],"develop":[25],"from":[26,61,108],"the":[27,176,244],"second":[28],"heart":[29],"field":[30],"(SHF)":[31],"proximally":[32],"neural":[34],"crest":[35],"(NC)":[36],"distally.":[37],"We":[38],"hypothesize":[39],"that":[40],"both":[41,109],"developmental":[42],"lineage":[43,119],"hemodynamic":[45,188,278],"factors":[46],"dictate":[47,252],"SMC":[48,182,231,254,275],"vulnerability":[49],"to":[50,187,235,284],"change,":[52],"promoting":[53],"focal":[54],"Methods/Results:":[58],"roots":[60],"adult":[62],"MFS":[63,97,236,261],"littermate":[65],"control":[66],"mice":[67,239],"(n=4":[68],"each":[69],"sex)":[70],"with":[71],"a":[72,160],"knockin":[73],"fluorescent":[74],"SHF":[75,110,149],"tracing":[76],"construct":[77],"(":[78,126,131,138,143,156],"Nkx2-5":[79],"cre":[80,208],")":[81,128,133,140,145,158],"were":[82,94,146],"sorted":[83],"for":[84,184,256],"lineage-resolved":[85],"single":[86],"cell":[87],"RNA":[88,164],"sequencing":[89],"(scRNAseq).":[90],"Modulated":[91],"(modSMC)":[93],"enriched":[95,147],"vs.":[98,104,224],"controls":[99],"(18.1%":[100],"of":[101],"all":[102],"2.2%)":[105],"originated":[107],"(15.5%)":[111],"NC":[113],"(20.2%)":[114],"lineages,":[115],"ruling":[116],"out":[117],"complete":[118],"specificity.":[120],"NC-derived":[121],"modSMCs":[122],"expressed":[123],"more":[124],"aggrecan":[125],"Acan":[127],"sclerostin":[130],"Sost":[132],"while":[134],"small":[135],"proteoglycans":[136],"decorin":[137],"Dcn":[139],"lumican":[142],"Lum":[144],"modSMCs.":[150],"Insulin-like":[151],"growth":[152],"factor":[153],"binding":[154],"protein-2":[155],"Igfbp2":[157,169],"was":[159],"lineage-independent":[161],"modSMC":[162],"marker.":[163],"situ":[166],"hybridization":[167],"localized":[168],"+":[170],"within":[172],"SHF/NC":[173],"overlap":[174],"root.":[178,246],"To":[179],"study":[180],"regional":[181,282],"propensity":[183,255],"due":[186],"stresses,":[189],"we":[190],"generated":[191],"pressure":[193,271],"overload":[194,272],"via":[195],"27-gauge":[196],"transverse":[197],"arch":[199],"constriction":[200],"(TAC)":[201],"or":[202],"sham":[203,221],"surgery":[204],"on":[205],"healthy":[206],"Myh11":[207],"/":[209],"Rosa":[210],"tdT":[211],"(SMC-traced)":[212],"mice.":[213],"TAC":[214,238],"induced":[215],"mild":[216],"dilation":[218],"vs":[219],".":[220],"(1.93\u00b10.07":[222],"mm":[223],"1.69\u00b10.09":[225],"mm,":[226],"n=4,":[227],"p<0.01).":[228],"scRNAseq":[229],"showed":[230],"comparable":[234],"spatially":[241],"concentrated":[242],"Conclusions:":[247],"Embryologic":[248],"origin":[249],"does":[250,263],"not":[251],"pathologic":[257],"change":[259],"but":[262],"promote":[264,281],"distinct":[265],"ECM":[266],"proteoglycan":[267],"gene":[268],"activation.":[269],"incites":[273],"modulation,":[276],"suggesting":[277],"effects":[279],"may":[280],"susceptibility":[283],"SMC-mediated":[285],"remodeling.":[287]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2022-08-27T00:00:00"}
