{"id":"https://openalex.org/W4293243794","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563","title":"A Human Asthma Exacerbation Model Identifies Pathogenic Cellular and Molecular Programs in the Lower Airway Mucosa Specific to Allergic Asthma","display_name":"A Human Asthma Exacerbation Model Identifies Pathogenic Cellular and Molecular Programs in the Lower Airway Mucosa Specific to Allergic Asthma","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4293243794","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B14. OLD DOGS NEW TRICKS: LATE-BREAKING ABSTRACTS IN OBSTRUCTIVE LUNG DISEASE","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086283407","display_name":"Jehan W. Alladina","orcid":"https://orcid.org/0000-0003-0136-6859","observed_orcids":["https://orcid.org/0000-0003-0136-6859"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Alladina","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003631931","display_name":"Neal Patrick Smith","orcid":"https://orcid.org/0000-0003-1394-3158","observed_orcids":["https://orcid.org/0000-0003-1394-3158"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Smith","raw_affiliation_strings":["Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072599414","display_name":"Kasidet Manakongtreecheep","orcid":"https://orcid.org/0000-0002-4182-9603","observed_orcids":["https://orcid.org/0000-0002-4182-9603"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Manakongtreecheep","raw_affiliation_strings":["Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053833061","display_name":"Jessica Tantivit","orcid":"https://orcid.org/0000-0002-2179-0377","observed_orcids":["https://orcid.org/0000-0002-2179-0377"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Tantivit","raw_affiliation_strings":["Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006194206","display_name":"Kamil Slowikowski","orcid":"https://orcid.org/0000-0002-2843-6370","observed_orcids":["https://orcid.org/0000-0002-2843-6370"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Slowikowski","raw_affiliation_strings":["Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048237916","display_name":"Henry L. Keen","orcid":"https://orcid.org/0009-0008-3548-7839","observed_orcids":["https://orcid.org/0009-0008-3548-7839"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Keen","raw_affiliation_strings":["Iowa Institute of Human Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa Institute of Human Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, United States","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043206527","display_name":"Tristan Kooistra","orcid":"https://orcid.org/0000-0001-7843-0631","observed_orcids":["https://orcid.org/0000-0001-7843-0631"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Kooistra","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050988445","display_name":"Rod A. Rahimi","orcid":"https://orcid.org/0000-0002-7929-2899","observed_orcids":["https://orcid.org/0000-0002-7929-2899"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.A. Rahimi","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030309227","display_name":"Francesca L. Giacona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Giacona","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009374107","display_name":"Susan L. Sheng","orcid":"https://orcid.org/0009-0004-0756-2097","observed_orcids":["https://orcid.org/0009-0004-0756-2097"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Sheng","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025991868","display_name":"Lida P. Hariri","orcid":"https://orcid.org/0000-0002-6190-624X","observed_orcids":["https://orcid.org/0000-0002-6190-624X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.P. Hariri","raw_affiliation_strings":["Pathology, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005766374","display_name":"Daniel L. Hamilos","orcid":"https://orcid.org/0000-0001-7752-6850","observed_orcids":["https://orcid.org/0000-0001-7752-6850"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Hamilos","raw_affiliation_strings":["Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055995920","display_name":"Andrew David Luster","orcid":"https://orcid.org/0000-0001-9679-7912","observed_orcids":["https://orcid.org/0000-0001-9679-7912"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Luster","raw_affiliation_strings":["Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047691305","display_name":"Alexandra\u2013Chlo\u00e9 Villani","orcid":"https://orcid.org/0000-0001-7461-0408","observed_orcids":["https://orcid.org/0000-0001-7461-0408"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.-C. Villani","raw_affiliation_strings":["Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010538676","display_name":"J.L. Cho","orcid":"https://orcid.org/0009-0004-9031-0551","observed_orcids":["https://orcid.org/0009-0004-9031-0551","https://orcid.org/0009-0009-3672-6595"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.L. Cho","raw_affiliation_strings":["Pulmonary, Critical Care and Occupational Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Critical Care and Occupational Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008009598","display_name":"Benjamin D. Medoff","orcid":"https://orcid.org/0000-0002-2558-0449","observed_orcids":["https://orcid.org/0000-0002-2558-0449"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.D. Medoff","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A5563","last_page":"A5563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.8949999809265137},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/human-disease-models","display_name":"human disease models","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8011401295661926},{"id":"https://openalex.org/C2909082789","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma exacerbations","level":3,"score":0.7851921319961548},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.7731897830963135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5716561675071716},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5631281137466431},{"id":"https://openalex.org/C3020633164","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Allergic asthma","level":3,"score":0.5180704593658447},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46704167127609253},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.0695943534374237}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5563","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B14. OLD DOGS NEW TRICKS: LATE-BREAKING ABSTRACTS IN OBSTRUCTIVE LUNG DISEASE","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4372337416","https://openalex.org/W4225329956","https://openalex.org/W2034776407","https://openalex.org/W2779907234","https://openalex.org/W7096650104","https://openalex.org/W1986334458","https://openalex.org/W2022566797","https://openalex.org/W2003437203","https://openalex.org/W6990706570","https://openalex.org/W3194491586"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-27T00:00:00"}