{"id":"https://openalex.org/W4293207233","doi":"https://doi.org/10.3390/molecules27175446","title":"131I-C19 Iodide Radioisotope and Synthetic I-C19 Compounds as K-Ras4B\u2013PDE6\u03b4 Inhibitors: A Novel Approach against Colorectal Cancer\u2014Biological Characterization, Biokinetics and Dosimetry","display_name":"131I-C19 Iodide Radioisotope and Synthetic I-C19 Compounds as K-Ras4B\u2013PDE6\u03b4 Inhibitors: A Novel Approach against Colorectal Cancer\u2014Biological Characterization, Biokinetics and Dosimetry","publication_year":2022,"publication_date":"2022-08-25","ids":{"openalex":"https://openalex.org/W4293207233","doi":"https://doi.org/10.3390/molecules27175446","pmid":"https://pubmed.ncbi.nlm.nih.gov/36080216","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9458062"},"language":"en","primary_location":{"id":"doi:10.3390/molecules27175446","doi":"https://doi.org/10.3390/molecules27175446","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27175446","pdf_url":"https://www.mdpi.com/1420-3049/27/17/5446/pdf?version=1661426914","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/27/17/5446/pdf?version=1661426914","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003550597","display_name":"Pedro Cruz-Nova","orcid":"https://orcid.org/0000-0001-5719-7324","observed_orcids":["https://orcid.org/0000-0001-5719-7324"]},"institutions":[{"id":"https://openalex.org/I4210093685","display_name":"Instituto Nacional de Investigaciones Nucleares","ror":"https://ror.org/00k7h5c65","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210093685"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Pedro Cruz-Nova","raw_affiliation_strings":["Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico","Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]},{"raw_affiliation_string":"Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico","institution_ids":["https://openalex.org/I4210093685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040251027","display_name":"Blanca Ocampo\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-5831-8412","observed_orcids":["https://orcid.org/0000-0002-5831-8412"]},"institutions":[{"id":"https://openalex.org/I4210093685","display_name":"Instituto Nacional de Investigaciones Nucleares","ror":"https://ror.org/00k7h5c65","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210093685"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Blanca Ocampo-Garc\u00eda","raw_affiliation_strings":["Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-5831-8412","affiliations":[{"raw_affiliation_string":"Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico","institution_ids":["https://openalex.org/I4210093685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120659111","display_name":"Dayan Andrea Carri\u00f3n-Estrada","orcid":"https://orcid.org/0000-0001-9168-0918","observed_orcids":["https://orcid.org/0000-0001-9168-0918"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Dayan Andrea Carri\u00f3n-Estrada","raw_affiliation_strings":["Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-9168-0918","affiliations":[{"raw_affiliation_string":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088103395","display_name":"Paola Brise\u00f1o-D\u00edaz","orcid":"https://orcid.org/0000-0002-4072-2433","observed_orcids":["https://orcid.org/0000-0002-4072-2433"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Paola Brise\u00f1o-Diaz","raw_affiliation_strings":["Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000294204","display_name":"Guillermina Ferro\u2010Flores","orcid":"https://orcid.org/0000-0003-0296-7605","observed_orcids":["https://orcid.org/0000-0003-0296-7605"]},"institutions":[{"id":"https://openalex.org/I4210093685","display_name":"Instituto Nacional de Investigaciones Nucleares","ror":"https://ror.org/00k7h5c65","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210093685"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Guillermina Ferro-Flores","raw_affiliation_strings":["Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-0296-7605","affiliations":[{"raw_affiliation_string":"Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico","institution_ids":["https://openalex.org/I4210093685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052574925","display_name":"Nallely Jim\u00e9nez\u2010Mancilla","orcid":"https://orcid.org/0000-0001-9480-4621","observed_orcids":["https://orcid.org/0000-0001-9480-4621"]},"institutions":[{"id":"https://openalex.org/I4210093685","display_name":"Instituto Nacional de Investigaciones Nucleares","ror":"https://ror.org/00k7h5c65","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210093685"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Nallely Jim\u00e9nez-Mancilla","raw_affiliation_strings":["Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-9480-4621","affiliations":[{"raw_affiliation_string":"Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico","institution_ids":["https://openalex.org/I4210093685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041724997","display_name":"Jos\u00e9 Correa\u2010Basurto","orcid":"https://orcid.org/0000-0002-4973-5265","observed_orcids":["https://orcid.org/0000-0002-4973-5265"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Correa-Basurto","raw_affiliation_strings":["Laboratorio de Modelado Molecular y Dise\u00f1o de F\u00e1rmacos de la Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-4973-5265","affiliations":[{"raw_affiliation_string":"Laboratorio de Modelado Molecular y Dise\u00f1o de F\u00e1rmacos de la Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001750465","display_name":"Martiniano Bello","orcid":"https://orcid.org/0000-0002-9686-0755","observed_orcids":["https://orcid.org/0000-0002-9686-0755"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Martiniano Bello","raw_affiliation_strings":["Laboratorio de Modelado Molecular y Dise\u00f1o de F\u00e1rmacos de la Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-9686-0755","affiliations":[{"raw_affiliation_string":"Laboratorio de Modelado Molecular y Dise\u00f1o de F\u00e1rmacos de la Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071756138","display_name":"Libia Vega","orcid":"https://orcid.org/0000-0002-4993-5267","observed_orcids":["https://orcid.org/0000-0002-4993-5267"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Libia Vega-Loyo","raw_affiliation_strings":["Departamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-4993-5267","affiliations":[{"raw_affiliation_string":"Departamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057808245","display_name":"Mar\u00eda del Roc\u00edo Thompson-Bonilla","orcid":"https://orcid.org/0000-0002-8961-0475","observed_orcids":["https://orcid.org/0000-0002-8961-0475"]},"institutions":[{"id":"https://openalex.org/I882076700","display_name":"Institute for Social Security and Services for State Workers","ror":"https://ror.org/02d93ae38","country_code":"MX","type":"government","lineage":["https://openalex.org/I882076700"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mar\u00eda del Roc\u00edo Thompson-Bonilla","raw_affiliation_strings":["Laboratorio de Medicina Gen\u00f3mica, Hospital Regional 1 de Octubre, ISSSTE, Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Medicina Gen\u00f3mica, Hospital Regional 1 de Octubre, ISSSTE, Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I882076700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083842021","display_name":"Rosaura Hern\u00e1ndez\u2010Rivas","orcid":"https://orcid.org/0000-0002-5275-0730","observed_orcids":["https://orcid.org/0000-0002-5275-0730"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rosaura Hern\u00e1ndez-Rivas","raw_affiliation_strings":["Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-5275-0730","affiliations":[{"raw_affiliation_string":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088458670","display_name":"Miguel Angel Vargas","orcid":"https://orcid.org/0000-0002-3031-9798","observed_orcids":["https://orcid.org/0000-0002-3031-9798"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Miguel Vargas","raw_affiliation_strings":["Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-3031-9798","affiliations":[{"raw_affiliation_string":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-I.P.N.), Gustavo A. Madero, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088458670"],"corresponding_institution_ids":["https://openalex.org/I68368234"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.6039,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.56715113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"27","issue":"17","first_page":"5446","last_page":"5446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras4b","display_name":"K-Ras4B","score":0.890999972820282},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/radioiodinated-compounds","display_name":"radioiodinated compounds","score":0.5870000123977661},{"id":"https://openalex.org/keywords/biokinetics","display_name":"biokinetics","score":0.6269999742507935},{"id":"https://openalex.org/keywords/dosimetry","display_name":"dosimetry","score":0.8769999742507935},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6019999980926514},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5799999833106995},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.421999990940094},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6454414129257202},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5727733969688416},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5275948643684387},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5008280277252197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16927388310432434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16481146216392517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16360551118850708}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007454","descriptor_name":"Iodides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules27175446","doi":"https://doi.org/10.3390/molecules27175446","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27175446","pdf_url":"https://www.mdpi.com/1420-3049/27/17/5446/pdf?version=1661426914","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:36080216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36080216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9458062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9458062/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:959c68d2b2ad4ca5bef06490fac95d9a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/959c68d2b2ad4ca5bef06490fac95d9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 27, Iss 17, p 5446 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules27175446","doi":"https://doi.org/10.3390/molecules27175446","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27175446","pdf_url":"https://www.mdpi.com/1420-3049/27/17/5446/pdf?version=1661426914","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293207233.pdf","grobid_xml":"https://content.openalex.org/works/W4293207233.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W127046385","https://openalex.org/W1964599102","https://openalex.org/W1970527559","https://openalex.org/W2004806047","https://openalex.org/W2043282329","https://openalex.org/W2043403539","https://openalex.org/W2044210875","https://openalex.org/W2051193631","https://openalex.org/W2056018387","https://openalex.org/W2069537707","https://openalex.org/W2075464225","https://openalex.org/W2105668062","https://openalex.org/W2118233996","https://openalex.org/W2140923573","https://openalex.org/W2145200068","https://openalex.org/W2151457918","https://openalex.org/W2170445850","https://openalex.org/W2316987218","https://openalex.org/W2337241649","https://openalex.org/W2594082576","https://openalex.org/W2610679599","https://openalex.org/W2781298385","https://openalex.org/W2889646458","https://openalex.org/W2898648097","https://openalex.org/W2908006499","https://openalex.org/W2949671346","https://openalex.org/W2963380782","https://openalex.org/W2970044297","https://openalex.org/W3104946688","https://openalex.org/W3203996092","https://openalex.org/W4256152035"],"related_works":["https://openalex.org/W2898648097","https://openalex.org/W6921284042","https://openalex.org/W6958722998","https://openalex.org/W2950267096","https://openalex.org/W4389008343","https://openalex.org/W3091883109","https://openalex.org/W4387450999","https://openalex.org/W7149426665","https://openalex.org/W3050237059","https://openalex.org/W7010911315"],"abstract_inverted_index":{"In":[0],"40\u201350%":[1],"of":[2,15,52,68,85,94,115,153,197],"colorectal":[3,129,137,206,258],"cancer":[4,47,130,138],"(CRC)":[5],"cases,":[6],"K-Ras":[7],"gene":[8],"mutations":[9],"occur,":[10],"which":[11],"induce":[12],"the":[13,16,27,31,39,50,53,66,86,95,108,112,144,158,217,225,233],"expression":[14],"K-Ras4B":[17,20,119,185,247],"oncogenic":[18],"isoform.":[19],"is":[21,237],"transported":[22],"by":[23],"phosphodiesterase-6\u03b4":[24],"(PDE6\u03b4)":[25],"to":[26,38,75,106,142,224],"plasma":[28,40],"membrane,":[29,41],"where":[30],"K-Ras4B\u2013PDE6\u03b4":[32,54,96,166],"complex":[33],"dissociates":[34],"and":[35,80,89,100,111,127,155,157,172,187,213,216,250],"K-Ras4B,":[36],"coupled":[37],"activates":[42],"signaling":[43,120,191,248],"pathways":[44,121],"that":[45,235],"favor":[46],"aggressiveness.":[48],"Thus,":[49],"inhibition":[51],"dissociation":[55],"using":[56],"specific":[57],"small":[58],"molecules":[59],"could":[60],"be":[61],"a":[62,77,81,174,238,246,252],"new":[63],"strategy":[64],"for":[65],"treatment":[67],"patients":[69],"with":[70,242,254],"CRC.":[71],"This":[72],"research":[73],"aimed":[74],"perform":[76],"preclinical":[78],"proof-of-concept":[79],"therapeutic":[82,146],"potential":[83],"evaluation":[84],"synthetic":[87],"I-C19":[88,116,133,145,154,183,198],"131I-C19":[90,156,236],"compounds":[91],"as":[92,245,251],"inhibitors":[93],"dissociation.":[97],"Molecular":[98],"docking":[99],"molecular":[101],"dynamics":[102],"simulations":[103],"were":[104,122,140,162],"performed":[105],"estimate":[107],"binding":[109],"affinity":[110],"anchorage":[113],"sites":[114],"in":[117,124,149,194,205],"K-Ras4B\u2013PDE6\u03b4.":[118],"assessed":[123],"HCT116,":[125],"LoVo":[126],"SW620":[128],"cells":[131],"after":[132],"treatment.":[134],"Two":[135],"murine":[136],"models":[139],"used":[141],"evaluate":[143],"effect.":[147],"The":[148,165,193,208,230],"vivo":[150,195],"biokinetic":[151,209],"profiles":[152],"tumor":[159,203,226],"radiation":[160,219],"dose":[161,221],"also":[163],"estimated.":[164],"stabilizer,":[167],"131I-C19,":[168],"was":[169,222],"highly":[170],"selective":[171],"demonstrated":[173],"cytotoxic":[175],"effect":[176],"ten":[177],"times":[178],"greater":[179],"than":[180],"unlabeled":[181],"I-C19.":[182],"prevented":[184],"activation":[186],"decreased":[188],"its":[189],"dependent":[190],"pathways.":[192],"administration":[196],"(30":[199],"mg/kg)":[200],"greatly":[201],"reduced":[202],"growth":[204],"cancer.":[207],"profile":[210],"showed":[211],"renal":[212],"hepatobiliary":[214],"elimination,":[215],"highest":[218],"absorbed":[220],"delivered":[223],"(52":[227],"Gy/74":[228],"MBq).":[229],"data":[231],"support":[232],"idea":[234],"novel":[239],"K-Ras4B/PDE6\u03b4":[240],"stabilizer":[241],"two":[243],"functionalities:":[244],"inhibitor":[249],"compound":[253],"radiotherapeutic":[255],"activity":[256],"against":[257],"tumors.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-27T00:00:00"}