{"id":"https://openalex.org/W4293201560","doi":"https://doi.org/10.1093/function/zqac039","title":"Cellular Bioenergetics: Experimental Evidence for Alcohol-induced Adaptations","display_name":"Cellular Bioenergetics: Experimental Evidence for Alcohol-induced Adaptations","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4293201560","doi":"https://doi.org/10.1093/function/zqac039","pmid":"https://pubmed.ncbi.nlm.nih.gov/36120487","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9469757"},"language":"en","primary_location":{"id":"doi:10.1093/function/zqac039","doi":"https://doi.org/10.1093/function/zqac039","is_oa":true,"landing_page_url":"https://doi.org/10.1093/function/zqac039","pdf_url":null,"source":{"id":"https://openalex.org/S4210215692","display_name":"Function","issn_l":"2633-8823","issn":["2633-8823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/function/zqac039","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075838086","display_name":"Liz Simon","orcid":"https://orcid.org/0000-0003-4149-3406","observed_orcids":["https://orcid.org/0000-0003-4149-3406"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Liz Simon","raw_affiliation_strings":["Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center , 1901 Perdido Street, New Orleans, LA 70112, USA","Department of Physiology & Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA, United States, 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center , 1901 Perdido Street, New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Department of Physiology & Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA, United States, 70112","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068516229","display_name":"Patricia E. Molina","orcid":"https://orcid.org/0000-0002-3598-384X","observed_orcids":["https://orcid.org/0000-0002-3598-384X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia E Molina","raw_affiliation_strings":["Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center , 1901 Perdido Street, New Orleans, LA 70112, USA","Department of Physiology & Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA, United States, 70112"],"raw_orcid":"https://orcid.org/0000-0002-3598-384X","affiliations":[{"raw_affiliation_string":"Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center , 1901 Perdido Street, New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Department of Physiology & Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA, United States, 70112","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075838086"],"corresponding_institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.8334,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.66877297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"3","issue":"5","first_page":"zqac039","last_page":"zqac039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-bioenergetics","display_name":"cellular bioenergetics","score":0.8180000185966492},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.7369999885559082},{"id":"https://openalex.org/keywords/alcoholic-cardiomyopathy","display_name":"alcoholic cardiomyopathy","score":0.777999997138977},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7580000162124634},{"id":"https://openalex.org/keywords/pancreas","display_name":"pancreas","score":0.8920000195503235},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.902999997138977},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.5809999704360962},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.968999981880188},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.7429999709129333},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6570000052452087},{"id":"https://openalex.org/keywords/target-organ-damage","display_name":"target organ damage","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.922371506690979},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6171854734420776},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5771527886390686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5704825520515442},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5508947372436523},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.5277531743049622},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5181238055229187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4730355441570282},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.4377821981906891},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38751399517059326},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2605770230293274}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/function/zqac039","doi":"https://doi.org/10.1093/function/zqac039","is_oa":true,"landing_page_url":"https://doi.org/10.1093/function/zqac039","pdf_url":null,"source":{"id":"https://openalex.org/S4210215692","display_name":"Function","issn_l":"2633-8823","issn":["2633-8823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9469757","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9469757","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function (Oxf)","raw_type":"Text"},{"id":"pmid:36120487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36120487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:daffdc66fd244e2798a5afe2840b515d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/daffdc66fd244e2798a5afe2840b515d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Function, Vol 3, Iss 5 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/function/zqac039","doi":"https://doi.org/10.1093/function/zqac039","is_oa":true,"landing_page_url":"https://doi.org/10.1093/function/zqac039","pdf_url":null,"source":{"id":"https://openalex.org/S4210215692","display_name":"Function","issn_l":"2633-8823","issn":["2633-8823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000913369","display_name":"LSUHSC-NO Comprehensive Alcohol-HIV/AIDS Research Center (CARC)","funder_award_id":"P60AA009803","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":235,"referenced_works":["https://openalex.org/W33517620","https://openalex.org/W80995712","https://openalex.org/W151319228","https://openalex.org/W159390204","https://openalex.org/W610008233","https://openalex.org/W873214643","https://openalex.org/W1583094119","https://openalex.org/W1640170395","https://openalex.org/W1800399702","https://openalex.org/W1806274702","https://openalex.org/W1830307665","https://openalex.org/W1840165326","https://openalex.org/W1907068960","https://openalex.org/W1953785805","https://openalex.org/W1964126982","https://openalex.org/W1965336187","https://openalex.org/W1967183207","https://openalex.org/W1967513977","https://openalex.org/W1967707100","https://openalex.org/W1968522559","https://openalex.org/W1972347931","https://openalex.org/W1972429510","https://openalex.org/W1975521267","https://openalex.org/W1975566288","https://openalex.org/W1977190397","https://openalex.org/W1978048781","https://openalex.org/W1978210683","https://openalex.org/W1978692339","https://openalex.org/W1981245425","https://openalex.org/W1981412702","https://openalex.org/W1981424940","https://openalex.org/W1983677426","https://openalex.org/W1985977889","https://openalex.org/W1986231469","https://openalex.org/W1987845572","https://openalex.org/W1993137461","https://openalex.org/W1996866058","https://openalex.org/W1997234851","https://openalex.org/W1997329503","https://openalex.org/W1998822247","https://openalex.org/W1999753655","https://openalex.org/W2003996880","https://openalex.org/W2005525538","https://openalex.org/W2005596327","https://openalex.org/W2007546912","https://openalex.org/W2008930670","https://openalex.org/W2010189440","https://openalex.org/W2010989776","https://openalex.org/W2011122017","https://openalex.org/W2012821310","https://openalex.org/W2015642381","https://openalex.org/W2016154675","https://openalex.org/W2016716965","https://openalex.org/W2017730825","https://openalex.org/W2019945017","https://openalex.org/W2023258059","https://openalex.org/W2025698440","https://openalex.org/W2030155309","https://openalex.org/W2031184838","https://openalex.org/W2032102101","https://openalex.org/W2032608291","https://openalex.org/W2034976767","https://openalex.org/W2037365078","https://openalex.org/W2040824141","https://openalex.org/W2040931781","https://openalex.org/W2041266617","https://openalex.org/W2041724276","https://openalex.org/W2042916996","https://openalex.org/W2044394582","https://openalex.org/W2044701098","https://openalex.org/W2045506460","https://openalex.org/W2050713315","https://openalex.org/W2051876096","https://openalex.org/W2052199849","https://openalex.org/W2053521594","https://openalex.org/W2053542703","https://openalex.org/W2054036156","https://openalex.org/W2054555185","https://openalex.org/W2055099254","https://openalex.org/W2057104160","https://openalex.org/W2063961327","https://openalex.org/W2064868850","https://openalex.org/W2068991037","https://openalex.org/W2072742323","https://openalex.org/W2073180738","https://openalex.org/W2074717002","https://openalex.org/W2076477263","https://openalex.org/W2079811417","https://openalex.org/W2080109084","https://openalex.org/W2082211388","https://openalex.org/W2083475087","https://openalex.org/W2083837493","https://openalex.org/W2084621494","https://openalex.org/W2085101416","https://openalex.org/W2086099320","https://openalex.org/W2089032599","https://openalex.org/W2089738269","https://openalex.org/W2091861414","https://openalex.org/W2092677426","https://openalex.org/W2093197860","https://openalex.org/W2093472788","https://openalex.org/W2105697998","https://openalex.org/W2107329372","https://openalex.org/W2111030468","https://openalex.org/W2111919147","https://openalex.org/W2113079755","https://openalex.org/W2114958117","https://openalex.org/W2116073503","https://openalex.org/W2119367431","https://openalex.org/W2122310415","https://openalex.org/W2122341467","https://openalex.org/W2124595203","https://openalex.org/W2125199618","https://openalex.org/W2127806759","https://openalex.org/W2133768424","https://openalex.org/W2134027657","https://openalex.org/W2134287168","https://openalex.org/W2137580945","https://openalex.org/W2140488719","https://openalex.org/W2143588920","https://openalex.org/W2145728650","https://openalex.org/W2149108521","https://openalex.org/W2149505706","https://openalex.org/W2149773499","https://openalex.org/W2152844109","https://openalex.org/W2154606893","https://openalex.org/W2155643523","https://openalex.org/W2157286372","https://openalex.org/W2161488345","https://openalex.org/W2163040921","https://openalex.org/W2167393318","https://openalex.org/W2168546428","https://openalex.org/W2170103181","https://openalex.org/W2170352213","https://openalex.org/W2171775338","https://openalex.org/W2177286325","https://openalex.org/W2178337638","https://openalex.org/W2186871044","https://openalex.org/W2199978366","https://openalex.org/W2236651433","https://openalex.org/W2265901329","https://openalex.org/W2277318350","https://openalex.org/W2278060099","https://openalex.org/W2282245079","https://openalex.org/W2283106100","https://openalex.org/W2284277293","https://openalex.org/W2297072437","https://openalex.org/W2327544161","https://openalex.org/W2336187231","https://openalex.org/W2339488706","https://openalex.org/W2343772634","https://openalex.org/W2344501420","https://openalex.org/W2394693883","https://openalex.org/W2395297303","https://openalex.org/W2411302073","https://openalex.org/W2414695852","https://openalex.org/W2417308391","https://openalex.org/W2419024321","https://openalex.org/W2432693409","https://openalex.org/W2466871641","https://openalex.org/W2467095003","https://openalex.org/W2470982690","https://openalex.org/W2475037381","https://openalex.org/W2503953104","https://openalex.org/W2515602957","https://openalex.org/W2530104279","https://openalex.org/W2553876215","https://openalex.org/W2553902009","https://openalex.org/W2568622888","https://openalex.org/W2589349799","https://openalex.org/W2590727623","https://openalex.org/W2592740345","https://openalex.org/W2602278861","https://openalex.org/W2621242862","https://openalex.org/W2622743229","https://openalex.org/W2735925402","https://openalex.org/W2739725666","https://openalex.org/W2792227495","https://openalex.org/W2795022691","https://openalex.org/W2796927648","https://openalex.org/W2884515579","https://openalex.org/W2885614842","https://openalex.org/W2889517514","https://openalex.org/W2893964012","https://openalex.org/W2894188334","https://openalex.org/W2898751096","https://openalex.org/W2901213206","https://openalex.org/W2909341692","https://openalex.org/W2911718219","https://openalex.org/W2920850838","https://openalex.org/W2924703136","https://openalex.org/W2943329679","https://openalex.org/W2960241721","https://openalex.org/W2967205608","https://openalex.org/W2971235367","https://openalex.org/W2977115073","https://openalex.org/W2981333671","https://openalex.org/W2995657759","https://openalex.org/W3007531635","https://openalex.org/W3022081234","https://openalex.org/W3024768985","https://openalex.org/W3026159576","https://openalex.org/W3033326690","https://openalex.org/W3087127847","https://openalex.org/W3087575655","https://openalex.org/W3093683791","https://openalex.org/W3098787407","https://openalex.org/W3107212180","https://openalex.org/W3111366377","https://openalex.org/W3116895961","https://openalex.org/W3123849197","https://openalex.org/W3157487802","https://openalex.org/W3158492489","https://openalex.org/W3160294153","https://openalex.org/W3162817145","https://openalex.org/W3185233478","https://openalex.org/W3198087373","https://openalex.org/W3200771040","https://openalex.org/W3201138704","https://openalex.org/W3201767226","https://openalex.org/W3212949115","https://openalex.org/W4200247823","https://openalex.org/W4205215674","https://openalex.org/W4205586738","https://openalex.org/W4210513306","https://openalex.org/W4210732593","https://openalex.org/W4210958992","https://openalex.org/W4213164945","https://openalex.org/W4230119926","https://openalex.org/W4247896860","https://openalex.org/W4280565686","https://openalex.org/W6681457036","https://openalex.org/W6695807495","https://openalex.org/W6908549761","https://openalex.org/W7083307184"],"related_works":["https://openalex.org/W4404393817","https://openalex.org/W4414588780","https://openalex.org/W4376279139","https://openalex.org/W2408803111","https://openalex.org/W2134277586","https://openalex.org/W7223393306","https://openalex.org/W4210958992","https://openalex.org/W4310613323","https://openalex.org/W4416797326","https://openalex.org/W2053521594"],"abstract_inverted_index":{"At-risk":[0],"alcohol":[1,102,149],"use":[2],"is":[3],"associated":[4],"with":[5,24,67,92,159],"multisystemic":[6],"effects":[7],"and":[8,11,56,60,85,87,113,129,135,151,168,177],"end-organ":[9,178],"injury,":[10],"significantly":[12,65],"contributes":[13],"to":[14,35,96,141],"global":[15],"health":[16],"burden.":[17],"Several":[18],"alcohol-mediated":[19,123],"mechanisms":[20],"have":[21],"been":[22],"identified,":[23],"bioenergetic":[25,48,68,118,138],"maladaptation":[26],"gaining":[27],"credence":[28],"as":[29],"an":[30],"underlying":[31],"pathophysiological":[32,162],"mechanism":[33],"contributing":[34],"cellular":[36,170],"injury.":[37,179],"This":[38],"evidence-based":[39],"review":[40,132],"focuses":[41],"on":[42],"the":[43,73,81,109],"current":[44],"knowledge":[45],"of":[46,78,89,145],"alcohol-induced":[47],"adaptations":[49,139],"in":[50,70,80,125,137],"metabolically":[51],"active":[52],"tissues:":[53],"liver,":[54],"cardiac":[55],"skeletal":[57],"muscle,":[58],"pancreas,":[59],"brain.":[61],"Alcohol":[62,75],"metabolism":[63],"itself":[64],"interferes":[66],"pathways":[69],"tissues,":[71],"particularly":[72],"liver.":[74],"decreases":[76],"states":[77],"respiration":[79],"electron":[82],"transport":[83],"chain,":[84],"activity":[86],"expression":[88],"respiratory":[90],"complexes,":[91],"a":[93],"net":[94],"effect":[95],"decrease":[97],"ATP":[98],"content.":[99],"In":[100],"addition,":[101],"dysregulates":[103],"major":[104],"metabolic":[105],"pathways,":[106],"including":[107,164],"glycolysis,":[108],"tricarboxylic":[110],"acid":[111,115],"cycle,":[112],"fatty":[114],"oxidation.":[116],"These":[117],"alterations":[119],"are":[120],"influenced":[121],"by":[122],"changes":[124],"mitochondrial":[126],"morphology,":[127],"biogenesis,":[128],"dynamics.":[130],"The":[131,155],"highlights":[133],"similarities":[134],"differences":[136],"according":[140],"tissue":[142],"type,":[143],"pattern":[144],"(acute":[146],"vs.":[147],"chronic)":[148],"use,":[150],"energy":[152],"substrate":[153],"availability.":[154],"compromised":[156],"bioenergetics":[157],"synergizes":[158],"other":[160],"critical":[161],"mechanisms,":[163],"increased":[165],"oxidative":[166],"stress":[167],"accelerates":[169],"dysfunction,":[171],"promoting":[172],"senescence,":[173],"programmed":[174],"cell":[175],"death,":[176]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-27T00:00:00"}