{"id":"https://openalex.org/W4293181985","doi":"https://doi.org/10.1111/bjh.18427","title":"Obinutuzumab as consolidation after chemo\u2010immunotherapy: Results of the UK National Cancer Research Institute phase II / III GALACTIC trial","display_name":"Obinutuzumab as consolidation after chemo\u2010immunotherapy: Results of the UK National Cancer Research Institute phase II / III GALACTIC trial","publication_year":2022,"publication_date":"2022-08-26","ids":{"openalex":"https://openalex.org/W4293181985","doi":"https://doi.org/10.1111/bjh.18427","pmid":"https://pubmed.ncbi.nlm.nih.gov/36017875"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.18427","doi":"https://doi.org/10.1111/bjh.18427","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.18427","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.18427","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.18427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041332488","display_name":"Talha Munir","orcid":"https://orcid.org/0000-0002-2901-0769","observed_orcids":["https://orcid.org/0000-0002-2901-0769"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Talha Munir","raw_affiliation_strings":["St James's Institute of Oncology, St James's University Hospital, Leeds, UK"],"raw_orcid":"https://orcid.org/0000-0002-2901-0769","affiliations":[{"raw_affiliation_string":"St James's Institute of Oncology, St James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041202070","display_name":"Jake Emmerson","orcid":"https://orcid.org/0000-0002-8198-8043","observed_orcids":["https://orcid.org/0000-0002-8198-8043"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jake Emmerson","raw_affiliation_strings":["Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073907684","display_name":"Anna Hockaday","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Hockaday","raw_affiliation_strings":["Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045899108","display_name":"Jamie B. Oughton","orcid":"https://orcid.org/0000-0002-2047-804X","observed_orcids":["https://orcid.org/0000-0002-2047-804X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jamie B. Oughton","raw_affiliation_strings":["Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067810727","display_name":"Dena R. Howard","orcid":"https://orcid.org/0000-0003-3333-9783","observed_orcids":["https://orcid.org/0000-0003-3333-9783"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dena Howard","raw_affiliation_strings":["Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK"],"raw_orcid":"https://orcid.org/0000-0003-3333-9783","affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692078","display_name":"David Phillips","orcid":"https://orcid.org/0000-0002-1891-886X","observed_orcids":["https://orcid.org/0000-0002-1891-886X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Phillips","raw_affiliation_strings":["Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109466928","display_name":"Jeff Neilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800117171","display_name":"Russells Hall Hospital","ror":"https://ror.org/04qs81248","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800117171","https://openalex.org/I2801954517"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeff Neilson","raw_affiliation_strings":["Russell Hall Hospital, Dudley, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russell Hall Hospital, Dudley, UK","institution_ids":["https://openalex.org/I2800117171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086501466","display_name":"Nicholas Pemberton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112848","display_name":"Worcestershire Royal Hospital","ror":"https://ror.org/01d6tbx77","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800951516","https://openalex.org/I4210112848"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Pemberton","raw_affiliation_strings":["Worcestershire Royal Hospital, Worcestershire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcestershire Royal Hospital, Worcestershire, UK","institution_ids":["https://openalex.org/I4210112848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066232993","display_name":"Shankara Paneesha","orcid":"https://orcid.org/0000-0002-7446-011X","observed_orcids":["https://orcid.org/0000-0002-7446-011X"]},"institutions":[{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shankara Paneesha","raw_affiliation_strings":["Birmingham Heartlands Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham Heartlands Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008546299","display_name":"Ben Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ben Kennedy","raw_affiliation_strings":["Leicester Royal Infirmary, Leicester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Royal Infirmary, Leicester, UK","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001511648","display_name":"Andy C. Rawstron","orcid":"https://orcid.org/0000-0003-0798-9790","observed_orcids":["https://orcid.org/0000-0003-0798-9790"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andy Rawstron","raw_affiliation_strings":["Haematological Malignancy Diagnostic Service, St James's Institute of Oncology, St James's University Hospital, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematological Malignancy Diagnostic Service, St James's Institute of Oncology, St James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047631289","display_name":"Peter Hillmen","orcid":"https://orcid.org/0000-0001-5617-4403","observed_orcids":["https://orcid.org/0000-0001-5617-4403"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Hillmen","raw_affiliation_strings":["Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK","St James's Institute of Oncology, St James's University Hospital, Leeds, UK"],"raw_orcid":"https://orcid.org/0000-0001-5617-4403","affiliations":[{"raw_affiliation_string":"Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"St James's Institute of Oncology, St James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041332488"],"corresponding_institution_ids":["https://openalex.org/I2801331674"],"apc_list":{"value":4800,"currency":"USD","value_usd":4800},"apc_paid":{"value":4800,"currency":"USD","value_usd":4800},"fwci":0.7242,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70817363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"199","issue":"5","first_page":"707","last_page":"719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obinutuzumab","display_name":"obinutuzumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/consolidation-therapy","display_name":"consolidation therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.906000018119812},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6209999918937683},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8449310064315796},{"id":"https://openalex.org/C2777607594","wikidata":"https://www.wikidata.org/wiki/Q389496","display_name":"Obinutuzumab","level":4,"score":0.7011370658874512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6449133157730103},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49543845653533936},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.4943215847015381},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2667464017868042},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2643663287162781},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.25512343645095825}],"mesh":[{"descriptor_ui":"D000047","descriptor_name":"Academies and Institutes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/bjh.18427","doi":"https://doi.org/10.1111/bjh.18427","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.18427","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.18427","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9805170","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9805170","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Haematol","raw_type":"Text"},{"id":"pmid:36017875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36017875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:eprints.whiterose.ac.uk:191401","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/191401/6/Br%20J%20Haematol%20-%202022%20-%20Munir%20-%20Obinutuzumab%20as%20consolidation%20after%20chemo%E2%80%90immunotherapy%20%20Results%20of%20the%20UK%20National%20Cancer.pdf","pdf_url":"https://eprints.whiterose.ac.uk/191401/6/Br%20J%20Haematol%20-%202022%20-%20Munir%20-%20Obinutuzumab%20as%20consolidation%20after%20chemo%E2%80%90immunotherapy%20%20Results%20of%20the%20UK%20National%20Cancer.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/bjh.18427","doi":"https://doi.org/10.1111/bjh.18427","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.18427","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.18427","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G414919524","display_name":null,"funder_award_id":"25447","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320298","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293181985.pdf","grobid_xml":"https://content.openalex.org/works/W4293181985.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W944951343","https://openalex.org/W1973810603","https://openalex.org/W2009009231","https://openalex.org/W2022401246","https://openalex.org/W2029409133","https://openalex.org/W2086296392","https://openalex.org/W2108696783","https://openalex.org/W2119466358","https://openalex.org/W2120319857","https://openalex.org/W2135802989","https://openalex.org/W2143715586","https://openalex.org/W2146682305","https://openalex.org/W2168874755","https://openalex.org/W2169269721","https://openalex.org/W2193060933","https://openalex.org/W2207800748","https://openalex.org/W2235523093","https://openalex.org/W2322176051","https://openalex.org/W2337485820","https://openalex.org/W2481029616","https://openalex.org/W2561188085","https://openalex.org/W2563872746","https://openalex.org/W2590154459","https://openalex.org/W2602893476","https://openalex.org/W2779713036","https://openalex.org/W2902138071","https://openalex.org/W2993886923","https://openalex.org/W4220965078"],"related_works":["https://openalex.org/W3163581766","https://openalex.org/W6902733284","https://openalex.org/W2907383716","https://openalex.org/W7136079727","https://openalex.org/W1981177563","https://openalex.org/W3130331670","https://openalex.org/W2086296392","https://openalex.org/W4236969777","https://openalex.org/W2229658642","https://openalex.org/W2019922359"],"abstract_inverted_index":{"Summary":[0],"The":[1,81],"GA101":[2],"(obinutuzumab)":[3],"monocLonal":[4],"Antibody":[5],"as":[6],"Consolidation":[7],"Therapy":[8],"In":[9,93],"chronic":[10],"lymphocytic":[11],"leukaemia":[12],"(CLL)":[13],"(GALACTIC)":[14],"was":[15,149,164],"a":[16,58],"seamless":[17],"phase":[18,86],"II/III":[19],"trial":[20,82],"designed":[21],"to":[22,41,54,72,90,115,120,156,218],"test":[23],"whether":[24,38],"consolidation":[25,74,117,182,197,217],"with":[26,48,57,76,183,234],"obinutuzumab":[27,77,228],"is":[28,229],"safe":[29],"and":[30,104,118,129,144,202,226],"eradicates":[31],"minimal":[32],"residual":[33],"disease":[34],"(MRD)":[35],"and,":[36],"subsequently,":[37],"this":[39],"leads":[40],"prolonged":[42],"progression\u2010free":[43],"survival":[44,169],"(PFS)":[45],"in":[46,141,152,166,188,195,224,232],"patients":[47,69,96,132,154,158,180,187,233],"CLL":[49,225],"who":[50],"have":[51],"recently":[52],"responded":[53],"chemo\u2010immunotherapy.":[55],"Patients":[56],"response":[59],"3\u201324":[60],"months":[61,125],"after":[62,84,126,181],"chemotherapy":[63],"were":[64,70,101,105,113,199,208],"assessed":[65],"for":[66],"MRD.":[67],"MRD\u2010positive":[68,110],"randomised":[71,114],"receive":[73,116],"therapy":[75],"or":[78,170],"no":[79,121],"consolidation.":[80,122],"closed":[83],"the":[85,108,177,184,189,196],"II":[87],"part":[88],"due":[89],"slow":[91],"recruitment.":[92],"all,":[94],"48":[95],"enrolled":[97],"of":[98,172,206,237],"whom":[99],"19":[100,185],"MRD":[102,134,173,220],"negative":[103],"monitored.":[106],"Of":[107],"29":[109],"patients,":[111],"14":[112],"15":[119],"At":[123],"6":[124],"randomisation,":[127],"10":[128,178],"13":[130],"consolidated":[131,153],"achieved":[133],"negativity":[135,174,221],"by":[136],"flow":[137],"cytometry":[138],"(sensitivity":[139],"10\u22124)":[140],"bone":[142],"marrow":[143],"peripheral":[145],"blood":[146],"respectively.":[147],"PFS":[148],"significantly":[150],"better":[151],"compared":[155],"non\u2010consolidated":[157],"(p":[159],"=":[160],"0.001).":[161],"No":[162],"difference":[163],"observed":[165],"PFS,":[167],"overall":[168],"duration":[171],"when":[175],"comparing":[176],"MRD\u2010negative":[179,186],"monitoring":[190],"group.":[191],"Common":[192],"adverse":[193],"events":[194,207],"arm":[198],"thrombocytopenia,":[200],"infection,":[201],"cough.":[203],"Only":[204],"1%":[205],"infusion\u2010related":[209],"reactions.":[210],"This":[211],"observation":[212],"provides":[213],"further":[214],"evidence":[215],"that":[216,227],"achieve":[219],"improves":[222],"outcomes":[223],"well":[230],"tolerated":[231],"low":[235],"levels":[236],"disease.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-27T00:00:00"}
