{"id":"https://openalex.org/W4293170341","doi":"https://doi.org/10.25004/ijpsdr.2021.130515","title":"Isolation of Ferulic Acid - A Bioactive Phenolic Compound from Pineapple Peel and Evaluation of its In-vitro Anti-inflammatory Potential","display_name":"Isolation of Ferulic Acid - A Bioactive Phenolic Compound from Pineapple Peel and Evaluation of its In-vitro Anti-inflammatory Potential","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W4293170341","doi":"https://doi.org/10.25004/ijpsdr.2021.130515"},"language":"en","primary_location":{"id":"doi:10.25004/ijpsdr.2021.130515","doi":"https://doi.org/10.25004/ijpsdr.2021.130515","is_oa":true,"landing_page_url":"https://doi.org/10.25004/ijpsdr.2021.130515","pdf_url":"https://ijpsdr.com/index.php/ijpsdr/article/download/3479/845","source":{"id":"https://openalex.org/S2764983607","display_name":"International Journal of Pharmaceutical Sciences and Drug Research","issn_l":"0975-248X","issn":["0975-248X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Drug Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ijpsdr.com/index.php/ijpsdr/article/download/3479/845","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077552415","display_name":"Abdulhadeef Shereefa Lubaina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdulhadeef S. Lubaina","raw_affiliation_strings":["Department of Botany, Christian College, Kattakada, Thiruvananthapuram, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany, Christian College, Kattakada, Thiruvananthapuram, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077682458","display_name":"Pallathu R. Renjit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pallathu R. Renjit","raw_affiliation_strings":["Department of Botany, Christian College, Kattakada, Thiruvananthapuram, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany, Christian College, Kattakada, Thiruvananthapuram, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009770249","display_name":"Ramamoorthy Ananthakrishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramamoorthy Ananthakrishnan","raw_affiliation_strings":["Department of Chemistry, P. A. Aziz College of Engineering and Technology, Thiruvananthapuram- 695564, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, P. A. Aziz College of Engineering and Technology, Thiruvananthapuram- 695564, Kerala, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104106115","display_name":"Ragesh R. Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ragesh R. Nair","raw_affiliation_strings":["Department of Botany, NSS College, Nilamel, Kollam, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany, NSS College, Nilamel, Kollam, Kerala, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.1529193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"565","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferulic-acid","display_name":"ferulic acid","score":1.0},{"id":"https://openalex.org/keywords/pineapple-peel","display_name":"pineapple peel","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fruit-waste-valorization","display_name":"fruit waste valorization","score":0.875},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.871999979019165},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lipoxygenase-inhibition","display_name":"lipoxygenase inhibition","score":0.9589999914169312},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7599999904632568},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.7350000143051147},{"id":"https://openalex.org/keywords/raw-cells","display_name":"RAW cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/bioactive-phenolic-compounds","display_name":"bioactive phenolic compounds","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2780213334","wikidata":"https://www.wikidata.org/wiki/Q417362","display_name":"Ferulic acid","level":2,"score":0.9082998037338257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6541041135787964},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5561231970787048},{"id":"https://openalex.org/C2777903452","wikidata":"https://www.wikidata.org/wiki/Q10910417","display_name":"Coumaric acid","level":3,"score":0.4582774341106415},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.4462524354457855},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.44019970297813416},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.41639450192451477},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3489009737968445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19145548343658447},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14351552724838257}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25004/ijpsdr.2021.130515","doi":"https://doi.org/10.25004/ijpsdr.2021.130515","is_oa":true,"landing_page_url":"https://doi.org/10.25004/ijpsdr.2021.130515","pdf_url":"https://ijpsdr.com/index.php/ijpsdr/article/download/3479/845","source":{"id":"https://openalex.org/S2764983607","display_name":"International Journal of Pharmaceutical Sciences and Drug Research","issn_l":"0975-248X","issn":["0975-248X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Drug Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25004/ijpsdr.2021.130515","doi":"https://doi.org/10.25004/ijpsdr.2021.130515","is_oa":true,"landing_page_url":"https://doi.org/10.25004/ijpsdr.2021.130515","pdf_url":"https://ijpsdr.com/index.php/ijpsdr/article/download/3479/845","source":{"id":"https://openalex.org/S2764983607","display_name":"International Journal of Pharmaceutical Sciences and Drug Research","issn_l":"0975-248X","issn":["0975-248X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Drug Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.8799999952316284},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335111","display_name":"Kerala State Council for Science, Technology and Environment","ror":"https://ror.org/030fy4q75"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293170341.pdf","grobid_xml":"https://content.openalex.org/works/W4293170341.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W43203608","https://openalex.org/W1480033064","https://openalex.org/W1505955094","https://openalex.org/W1556422350","https://openalex.org/W1974118800","https://openalex.org/W1975497750","https://openalex.org/W1979272297","https://openalex.org/W2007901537","https://openalex.org/W2008152405","https://openalex.org/W2009864927","https://openalex.org/W2010114015","https://openalex.org/W2016057578","https://openalex.org/W2026973132","https://openalex.org/W2030329046","https://openalex.org/W2043750435","https://openalex.org/W2062145190","https://openalex.org/W2101116633","https://openalex.org/W2103704271","https://openalex.org/W2137851026","https://openalex.org/W2144660326","https://openalex.org/W2150206066","https://openalex.org/W2419261045","https://openalex.org/W2559932310","https://openalex.org/W3132071562"],"related_works":["https://openalex.org/W4244037880","https://openalex.org/W7065875761","https://openalex.org/W3198377255","https://openalex.org/W4388449361","https://openalex.org/W3191427057","https://openalex.org/W7163082274","https://openalex.org/W7014505368","https://openalex.org/W7054617986","https://openalex.org/W2610826087","https://openalex.org/W7036081161"],"abstract_inverted_index":{"Fruit":[0],"wastes":[1],"and":[2,20,78,89,111,134,156,159,176,184,201,230,257,265,268],"their":[3],"byproducts":[4],"may":[5],"cause":[6],"serious":[7],"environmental":[8,52],"problems,":[9],"since":[10],"it":[11,88],"accumulates":[12],"in":[13,35,61,97,149,205,225,272],"agro-industrial":[14],"yards":[15],"without":[16],"having":[17],"any":[18],"significant":[19],"commercial":[21],"value.":[22],"Pineapple(Family":[23],"-":[24],"Bromeliaceae)":[25],"is":[26,40,106],"one":[27],"of":[28,67,72,144,167,215],"the":[29,36,41,46,65,185,221,231],"leading":[30,50],"edible":[31],"tropical":[32],"fruit":[33],"produced":[34,44],"world.":[37],"Pineapple":[38],"peel":[39],"massive":[42],"waste":[43],"by":[45,75,117,198],"pineapple":[47],"processing":[48],"industry":[49],"to":[51,63,235],"pollution.":[53],"In":[54],"this":[55,68,109],"regard,":[56],"efforts":[57],"have":[58],"been":[59,115],"made":[60],"order":[62],"tap":[64],"potential":[66,143],"bio-waste":[69,110],"as":[70,81,83,171],"source":[71],"bioactive":[73],"compounds":[74],"isolating,":[76],"purifying":[77],"characterizing":[79],"known":[80],"well":[82],"novel":[84],"secondary":[85],"metabolites":[86],"from":[87,108],"can":[90],"be":[91],"used":[92],"for":[93],"studying":[94],"its":[95,112],"application":[96],"various":[98],"industries.":[99],"A":[100],"phenolic":[101,241],"compound":[102],"namely":[103],"Ferulic":[104,145,193,216],"acid":[105,146,194],"isolated":[107,240],"structure":[113],"has":[114],"elucidated":[116],"Fourier":[118],"Transform":[119],"Infrared":[120],"(FT-IR)":[121],"spectroscopy,":[122],"Liquid":[123,129],"Chromatography-Mass":[124],"Spectrometry":[125],"(LC-MS),":[126],"High":[127],"Performance":[128],"Chromatography":[130],"(HPLC),":[131],"1H":[132],"NMR":[133],"13C":[135],"Nuclear":[136],"Magnetic":[137],"Resonance":[138],"(NMR)":[139],"spectra.":[140],"The":[141,165,239],"anti-inflammatory":[142,191],"was":[147],"studied":[148],"vitro":[150],"on":[151,180],"Lipopolysaccharide":[152],"(LPS)":[153],"stimulated":[154,207,274],"Ralph":[155],"Williams":[157],"(RAW)":[158],"Tamm-Horsefall":[160],"Protein-1":[161],"(THP-1)":[162],"cell":[163,182],"lines.":[164],"levels":[166,271],"pro-inflammatory":[168],"enzymes":[169],"such":[170],"cyclooxygenase":[172],"(COX),":[173],"lipooxygenase":[174],"(LOX),":[175],"myeloperoxidase":[177],"(MPOX)":[178],"activities":[179],"THP-1":[181,208],"lines":[183],"tested":[186],"compound,":[187,242],"exhibited":[188],"a":[189,226],"dose-dependent":[190],"activity.":[192],"showed":[195],"remarkable":[196],"activity":[197],"COX":[199],"(78.47%)":[200],"LOX":[202],"(78.63%)":[203],"inhibition":[204],"LPS":[206,273],"cells":[209],"at":[210],"100":[211],"\u03bcg/mL.":[212],"Different":[213],"concentrations":[214],"Acid":[217],"(FER)":[218],"effectively":[219,245],"decreased":[220],"MPOX":[222],"(92.76\u2105)":[223],"level":[224],"dose":[227],"dependent":[228],"manner":[229],"results":[232],"were":[233],"comparable":[234],"standard":[236],"drug":[237],"Indomethacin.":[238],"ferulic":[243],"acid,":[244],"lowered":[246],"inflammatory":[247],"cytokines":[248],"like":[249],"Tumour":[250],"Necrosis":[251],"Factor":[252],"Alpha":[253],"(TNF-\u03b1),":[254],"Interleukin-6":[255],"(IL-6)":[256],"Interleukin-1":[258],"Beta":[259],"(IL-1\u03b2)":[260],"along":[261],"with":[262],"prostaglandin":[263],"E2":[264],"leukotriene":[266],"C4":[267],"cellular":[269],"nitrate":[270],"RAW":[275],"cells.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-27T00:00:00"}
