{"id":"https://openalex.org/W4293067023","doi":"https://doi.org/10.1093/sleep/zsac079.546","title":"0549 Prevalence and Impact of Muscle Cramps in Patients with Restless Legs","display_name":"0549 Prevalence and Impact of Muscle Cramps in Patients with Restless Legs","publication_year":2022,"publication_date":"2022-05-25","ids":{"openalex":"https://openalex.org/W4293067023","doi":"https://doi.org/10.1093/sleep/zsac079.546"},"language":"en","primary_location":{"id":"doi:10.1093/sleep/zsac079.546","doi":"https://doi.org/10.1093/sleep/zsac079.546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsac079.546","pdf_url":"https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A242/43843543/zsac079.546.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A242/43843543/zsac079.546.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016945594","display_name":"Khaled Albazli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khaled Albazli","raw_affiliation_strings":["Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences , Washington, DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences , Washington, DC , USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021858302","display_name":"Arthur Scott Walters","orcid":"https://orcid.org/0000-0001-5143-7817","observed_orcids":["https://orcid.org/0000-0001-5143-7817"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur S Walters","raw_affiliation_strings":["Department of Neurology, Vanderbilt University Medical Center , Nashville, Tennessee , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Vanderbilt University Medical Center , Nashville, Tennessee , USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016726609","display_name":"Elias Georges Karroum","orcid":"https://orcid.org/0000-0002-9271-7070","observed_orcids":["https://orcid.org/0000-0002-9271-7070"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias G Karroum","raw_affiliation_strings":["Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences , Washington, DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences , Washington, DC , USA","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4018,"currency":"USD","value_usd":4018},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"Supplement_1","first_page":"A242","last_page":"A242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12569","display_name":"Restless Legs Syndrome Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12569","display_name":"Restless Legs Syndrome Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/restless-legs-syndrome","display_name":"restless legs syndrome","score":0.9120000004768372},{"id":"https://openalex.org/keywords/muscle-cramps","display_name":"muscle cramps","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.8569999933242798},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8679999709129333},{"id":"https://openalex.org/keywords/rls-severity","display_name":"RLS severity","score":0.7070000171661377},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.6790000200271606},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.746999979019165},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.4860000014305115},{"id":"https://openalex.org/keywords/disability","display_name":"disability","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.460999995470047},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.5809999704360962},{"id":"https://openalex.org/keywords/patient-questionnaire","display_name":"patient survey","score":0.5879999995231628},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.6549999713897705},{"id":"https://openalex.org/keywords/pittsburgh-sleep-quality-index","display_name":"Pittsburgh Sleep Quality Index","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2779819292","wikidata":"https://www.wikidata.org/wiki/Q2006818","display_name":"Muscle cramp","level":2,"score":0.8857649564743042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8136410117149353},{"id":"https://openalex.org/C2776750294","wikidata":"https://www.wikidata.org/wiki/Q916280","display_name":"Restless legs syndrome","level":3,"score":0.6871328353881836},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5819277763366699},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.42564675211906433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34971684217453003},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2122240662574768},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.1451006829738617},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13310125470161438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/sleep/zsac079.546","doi":"https://doi.org/10.1093/sleep/zsac079.546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsac079.546","pdf_url":"https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A242/43843543/zsac079.546.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/sleep/zsac079.546","doi":"https://doi.org/10.1093/sleep/zsac079.546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsac079.546","pdf_url":"https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A242/43843543/zsac079.546.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293067023.pdf","grobid_xml":"https://content.openalex.org/works/W4293067023.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3158234640","https://openalex.org/W4229556803","https://openalex.org/W1993547218","https://openalex.org/W2767077030","https://openalex.org/W3081869712","https://openalex.org/W3214420483","https://openalex.org/W4362685490","https://openalex.org/W3007164539","https://openalex.org/W2797423049","https://openalex.org/W4200169186"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Recent":[2],"studies":[3],"have":[4,152,173],"shown":[5],"alterations":[6],"in":[7,12,39,62,206,214,288,324],"Vitamin":[8,15],"D":[9,16],"binding":[10],"protein":[11],"RLS,":[13,130],"and":[14,34,57,131,203,230,255,278,294,304,328],"is":[17,25],"intimately":[18],"related":[19,334],"to":[20,53,70,82,144,172,248,319,335],"calcium":[21,339],"metabolism,":[22],"while":[23,188],"hypocalcemia":[24],"a":[26,80,97,263,298,310],"well-known":[27],"trigger":[28],"for":[29,128,321],"muscle":[30,37,60,94,155,161,174,212,224,276,322],"cramps.":[31,175],"The":[32,87,209],"presence":[33],"consequences":[35],"of":[36,49,59,74,179,211,275,280,291,306,314],"cramps":[38,61,95,156,213,225,277,285,323,330],"RLS":[40,63,76,85,134,138,201,215,219,281,292,325,327],"has":[41],"never":[42],"been":[43],"systematically":[44],"studied.":[45],"Therefore,":[46,308],"the":[47,55,75,103,111,121,132,145,148,184],"aim":[48],"this":[50],"study":[51,349],"was":[52,68,217,262,350],"determine":[54],"prevalence":[56,210],"impact":[58,300],"patients.":[64,86,326],"Methods":[65],"An":[66],"email":[67],"sent":[69],"4222":[71],"active":[72],"members":[73,182],"foundation":[77],"(RLSF)":[78],"with":[79,168,221,297],"link":[81],"survey":[83,88],"adult":[84],"included":[89,205],"demographic":[90],"information,":[91],"questions":[92],"on":[93,236,301],"(including":[96],"visual":[98],"analogue":[99],"scale":[100],"rating":[101],"intensity),":[102],"Pittsburgh":[104],"Sleep":[105],"Quality":[106],"Index":[107],"assessing":[108],"sleep":[109],"disturbances,":[110],"36-Item":[112],"Short":[113],"Form":[114],"Survey":[115],"Instrument":[116],"(SF-36)":[117],"evaluating":[118],"health":[119,239,302],"status,":[120],"13-item":[122],"short-form":[123],"Cambridge-Hopkins":[124],"diagnostic":[125],"questionnaire":[126],"(CH-RLSq13)":[127],"diagnosing":[129],"International":[133],"Severity":[135],"Scale":[136],"measuring":[137],"severity.":[139],"Patients":[140],"who":[141],"answered":[142],"\u201cyes\u201d":[143],"question":[146],"\u201cIn":[147],"last":[149],"3":[150],"months":[151],"you":[153],"experienced":[154],"(defined":[157],"as":[158,200],"involuntary":[159],"painful":[160],"contraction":[162],"occurring":[163],"at":[164],"rest,":[165],"not":[166,351],"associated":[167,296],"exercise)?\u201d":[169],"were":[170,204,226,286,295],"considered":[171],"Results":[176],"A":[177],"total":[178],"509":[180],"RLSF":[181],"completed":[183],"whole":[185],"electronic":[186],"survey,":[187],"317":[189],"participants":[190],"(Age:":[191],"68.9\u00b110.2;":[192],"73.1%":[193],"Women;":[194],"97.8%":[195],"White/Caucasian;":[196],"BMI:":[197],"27.4\u00b15.8)":[198],"qualified":[199],"patients":[202,216,220,293],"further":[207],"analysis.":[208],"60.3%.":[218],"(versus":[222],"without)":[223],"more":[227,256],"overweight":[228],"(p=0.0119)":[229],"had":[231],"lower":[232],"scores":[233],"(more":[234],"disability)":[235],"several":[237],"SF-36":[238],"concepts":[240],"including":[241],"physical":[242],"functioning":[243,253],"(p=0.0093),":[244],"role":[245],"limitations":[246],"due":[247],"emotional":[249],"problems":[250],"(p=0.0429),":[251],"social":[252],"(p=0.0017),":[254],"pain":[257],"(p=0.0387).":[258],"In":[259],"addition,":[260],"there":[261],"weak":[264],"(Spearman":[265],"coefficient":[266],"\u03c1=0.253)":[267],"but":[268],"significant":[269],"positive":[270],"correlation":[271],"(p=0.0004)":[272],"between":[273],"intensity":[274],"severity":[279,305],"symptoms.":[282],"Conclusion":[283],"Muscle":[284],"present":[287],"almost":[289],"two-third":[290],"negative":[299],"status":[303],"RLS.":[307],"from":[309],"clinical":[311],"practice":[312],"point":[313],"view,":[315],"it":[316],"seems":[317],"warranted":[318],"screen":[320],"leg":[329],"may":[331],"theoretically":[332],"be":[333],"each":[336],"other":[337],"through":[338,342],"metabolism":[340],"and/or":[341],"inflammatory":[343],"mechanisms.":[344],"Support":[345],"(If":[346],"Any)":[347],"This":[348],"funded.":[352]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-08-26T00:00:00"}