{"id":"https://openalex.org/W4293027869","doi":"https://doi.org/10.3390/antiox11091636","title":"Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway","display_name":"Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway","publication_year":2022,"publication_date":"2022-08-23","ids":{"openalex":"https://openalex.org/W4293027869","doi":"https://doi.org/10.3390/antiox11091636","pmid":"https://pubmed.ncbi.nlm.nih.gov/36139710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9495840"},"language":"en","primary_location":{"id":"doi:10.3390/antiox11091636","doi":"https://doi.org/10.3390/antiox11091636","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11091636","pdf_url":"https://www.mdpi.com/2076-3921/11/9/1636/pdf?version=1661481552","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3921/11/9/1636/pdf?version=1661481552","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024603306","display_name":"Moon\u2010Hee Choi","orcid":"https://orcid.org/0000-0003-1149-0394","observed_orcids":["https://orcid.org/0000-0003-1149-0394"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Moon-Hee Choi","raw_affiliation_strings":["Department of Beauty and Cosmetology, Graduate School of Industrial Technology and Entrepreneurship, Chosun University, Gwangju 61452, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1149-0394","affiliations":[{"raw_affiliation_string":"Department of Beauty and Cosmetology, Graduate School of Industrial Technology and Entrepreneurship, Chosun University, Gwangju 61452, Korea","institution_ids":["https://openalex.org/I152238500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031462990","display_name":"Seung-Hwa Yang","orcid":"https://orcid.org/0000-0003-1160-0864","observed_orcids":["https://orcid.org/0000-0003-1160-0864"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Hwa Yang","raw_affiliation_strings":["Department of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1160-0864","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea","institution_ids":["https://openalex.org/I152238500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034557143","display_name":"Nam Doo Kim","orcid":"https://orcid.org/0000-0002-7567-9420","observed_orcids":["https://orcid.org/0000-0002-7567-9420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nam Doo Kim","raw_affiliation_strings":["VORONOI BIO Inc., Incheon 21984, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7567-9420","affiliations":[{"raw_affiliation_string":"VORONOI BIO Inc., Incheon 21984, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054521549","display_name":"Hyun\u2010Jae Shin","orcid":"https://orcid.org/0000-0002-2618-5643","observed_orcids":["https://orcid.org/0000-0002-2618-5643"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyun-Jae Shin","raw_affiliation_strings":["Department of Beauty and Cosmetology, Graduate School of Industrial Technology and Entrepreneurship, Chosun University, Gwangju 61452, Korea","Department of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2618-5643","affiliations":[{"raw_affiliation_string":"Department of Beauty and Cosmetology, Graduate School of Industrial Technology and Entrepreneurship, Chosun University, Gwangju 61452, Korea","institution_ids":["https://openalex.org/I152238500"]},{"raw_affiliation_string":"Department of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea","institution_ids":["https://openalex.org/I152238500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054521549"],"corresponding_institution_ids":["https://openalex.org/I152238500"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":1.3493,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75965333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"9","first_page":"1636","last_page":"1636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nomilin","display_name":"nomilin","score":1.0},{"id":"https://openalex.org/keywords/citrus-junos","display_name":"Citrus junos","score":0.953000009059906},{"id":"https://openalex.org/keywords/tyrosinase-inhibition","display_name":"tyrosinase inhibition","score":0.9599999785423279},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/b16f10-melanoma-cells","display_name":"B16F10 melanoma cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pka-creb-signaling","display_name":"PKA/CREB signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/skin-lightening","display_name":"skin lightening","score":0.7229999899864197},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.9070000052452087},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/trp-2","display_name":"TRP-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.6499999761581421},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7263452410697937},{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.7118882536888123},{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.6766847968101501},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.6366503238677979},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5646534562110901},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5075372457504272},{"id":"https://openalex.org/C2779078452","wikidata":"https://www.wikidata.org/wiki/Q1416124","display_name":"Skin whitening","level":3,"score":0.46798965334892273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4614817500114441},{"id":"https://openalex.org/C2781424683","wikidata":"https://www.wikidata.org/wiki/Q416446","display_name":"Arbutin","level":2,"score":0.41951581835746765},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3650118410587311},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3496982157230377},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18574589490890503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16241773962974548},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11711758375167847},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.09552708268165588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0744275450706482},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/antiox11091636","doi":"https://doi.org/10.3390/antiox11091636","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11091636","pdf_url":"https://www.mdpi.com/2076-3921/11/9/1636/pdf?version=1661481552","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmid:36139710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36139710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9495840","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9495840/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:88f936ed0586496a91fd39a6861d8e18","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/88f936ed0586496a91fd39a6861d8e18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 11, Iss 9, p 1636 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antiox11091636","doi":"https://doi.org/10.3390/antiox11091636","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11091636","pdf_url":"https://www.mdpi.com/2076-3921/11/9/1636/pdf?version=1661481552","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G311910195","display_name":null,"funder_award_id":"NRF-2020R1I1A1A01073631","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G879455303","display_name":null,"funder_award_id":"2020R1I1A1A01073631","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293027869.pdf","grobid_xml":"https://content.openalex.org/works/W4293027869.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W335223328","https://openalex.org/W1948054324","https://openalex.org/W1955247927","https://openalex.org/W1963538221","https://openalex.org/W1970530499","https://openalex.org/W1977065719","https://openalex.org/W1985588649","https://openalex.org/W1987841769","https://openalex.org/W1996635313","https://openalex.org/W2002918515","https://openalex.org/W2005338518","https://openalex.org/W2009423060","https://openalex.org/W2010599689","https://openalex.org/W2013756866","https://openalex.org/W2021213720","https://openalex.org/W2027827700","https://openalex.org/W2035568958","https://openalex.org/W2049846041","https://openalex.org/W2058130441","https://openalex.org/W2062767635","https://openalex.org/W2068861600","https://openalex.org/W2082809988","https://openalex.org/W2091854427","https://openalex.org/W2097985608","https://openalex.org/W2129153475","https://openalex.org/W2147137265","https://openalex.org/W2152495451","https://openalex.org/W2162730446","https://openalex.org/W2253293231","https://openalex.org/W2283501233","https://openalex.org/W2302524766","https://openalex.org/W2471321097","https://openalex.org/W2524048505","https://openalex.org/W2724407422","https://openalex.org/W2724837721","https://openalex.org/W2737707281","https://openalex.org/W2792871679","https://openalex.org/W2794022576","https://openalex.org/W2802414991","https://openalex.org/W2912818999","https://openalex.org/W2945996322","https://openalex.org/W2955889537","https://openalex.org/W2982196149","https://openalex.org/W3017925323","https://openalex.org/W3030172672","https://openalex.org/W3036810437","https://openalex.org/W3080250107","https://openalex.org/W3123475032","https://openalex.org/W3152992971","https://openalex.org/W3184930822","https://openalex.org/W4220796896","https://openalex.org/W4282012649","https://openalex.org/W4283383104","https://openalex.org/W4283391928","https://openalex.org/W6695593509"],"related_works":["https://openalex.org/W2570353020","https://openalex.org/W2026430306","https://openalex.org/W2100108786","https://openalex.org/W2416726682","https://openalex.org/W4415304483","https://openalex.org/W2135417727","https://openalex.org/W2335856640","https://openalex.org/W2090957398","https://openalex.org/W2900341010","https://openalex.org/W2772443712"],"abstract_inverted_index":{"Yuzu":[0,16],"(Citrus":[1],"junos)":[2],"is":[3,57],"a":[4,84,146,179,192],"citrus":[5,36],"plant":[6],"native":[7],"to":[8,100],"Asian":[9],"countries,":[10],"including":[11],"Korea,":[12],"Japan,":[13],"and":[14,18,26,31,38,67,69,93,97,111,140,156,162,172],"China.":[15],"peel":[17],"seed":[19,55,186],"contain":[20],"abundant":[21],"vitamin":[22],"C,":[23],"citric":[24],"acid,":[25],"polyphenols.":[27],"Although":[28],"the":[29,44,49,64,80,108,152,159,164,175],"antioxidative":[30,109],"antimelanogenic":[32,112],"activities":[33],"of":[34,48,73,79,114,122,136,154,166],"other":[35],"fruits":[37],"yuzu":[39,54,61,185],"extract":[40,56],"have":[41],"been":[42],"reported,":[43],"tyrosinase":[45,86,90],"inhibitory":[46,91],"activity":[47,72,92,113],"limonoid":[50,76],"aglycone":[51],"contained":[52],"in":[53,116,145,178,195],"unknown.":[58],"We":[59,88],"separated":[60],"seeds":[62],"into":[63],"husk,":[65],"shell,":[66],"meal":[68],"evaluated":[70,107],"antioxidant":[71],"each.":[74],"The":[75,120],"glucoside":[77],"fraction":[78],"husk":[81,187],"identified":[82],"nomilin,":[83],"novel":[85],"inhibitor.":[87],"performed":[89],"noncompetitive":[94],"inhibition":[95],"assays":[96],"docking":[98],"studies":[99],"determine":[101],"nomilin":[102,115,123,183],"binding":[103],"sites.":[104],"Furthermore,":[105],"we":[106],"mechanism":[110],"B16F10":[117],"melanoma":[118],"cells.":[119],"concentration":[121],"that":[124],"did":[125],"not":[126],"show":[127],"toxicity":[128],"was":[129],"<100":[130],"\u00b5g/mL.":[131],"Nomilin":[132,149],"suppressed":[133],"protein":[134,160],"expression":[135],"TYR,":[137],"TRP-1,":[138,171],"TRP-2,":[139],"microphthalmia-associated":[141],"transcription":[142],"factor":[143],"(MITF)":[144],"concentration-dependent":[147,180],"manner.":[148,181],"significantly":[150],"reduced":[151],"levels":[153,165],"p-CREB":[155],"p-PKA":[157],"at":[158,174],"level":[161,177],"decreased":[163],"skin-whitening-related":[167],"factors":[168],"MITF,":[169],"tyrosinase,":[170],"TRP-2":[173],"mRNA":[176],"Thus,":[182],"from":[184],"can":[188],"be":[189],"used":[190],"as":[191],"skin-whitening":[193],"agent":[194],"cosmetics.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-25T00:00:00"}
