{"id":"https://openalex.org/W4293020909","doi":"https://doi.org/10.1158/1541-7786.663.2.12","title":"Enhancement of the Antiangiogenic Activity of Interleukin-12 by Peptide Targeted Delivery of the Cytokine to \u03b1v\u03b23 Integrin","display_name":"Enhancement of the Antiangiogenic Activity of Interleukin-12 by Peptide Targeted Delivery of the Cytokine to \u03b1v\u03b23 Integrin","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W4293020909","doi":"https://doi.org/10.1158/1541-7786.663.2.12","mag":"2191187737","pmid":"https://pubmed.ncbi.nlm.nih.gov/15634755"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.663.2.12","doi":"https://doi.org/10.1158/1541-7786.663.2.12","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.663.2.12","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049136467","display_name":"Erin B. Dickerson","orcid":"https://orcid.org/0000-0002-9757-4961","observed_orcids":["https://orcid.org/0000-0002-9757-4961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erin B. Dickerson","raw_affiliation_strings":["1Medical Sciences, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical Sciences, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nasim Akhtar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nasim Akhtar","raw_affiliation_strings":["1Medical Sciences, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical Sciences, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113768823","display_name":"Howard N. Steinberg","orcid":"https://orcid.org/0000-0002-8518-6566","observed_orcids":["https://orcid.org/0000-0002-8518-6566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard Steinberg","raw_affiliation_strings":["2Pathobiological Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Pathobiological Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108773492","display_name":"Zunyi Wang","orcid":"https://orcid.org/0000-0002-0406-4664","observed_orcids":["https://orcid.org/0000-0002-0406-4664","https://orcid.org/0000-0002-6560-250X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zun-Yi Wang","raw_affiliation_strings":["3Surgical Sciences, School of Veterinary Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Surgical Sciences, School of Veterinary Medicine;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040257835","display_name":"Mary J. Lindstrom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary J. Lindstrom","raw_affiliation_strings":["4Department of Biostatisticss and Medical Informatics; and","6Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Biostatisticss and Medical Informatics; and","institution_ids":[]},{"raw_affiliation_string":"6Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110932131","display_name":"Marcia L. Padilla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcia L. Padilla","raw_affiliation_strings":["1Medical Sciences, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical Sciences, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112398816","display_name":"Robert Auerbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Auerbach","raw_affiliation_strings":["5Laboratory of Developmental Biology, Department of Zoology; and","6Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Laboratory of Developmental Biology, Department of Zoology; and","institution_ids":[]},{"raw_affiliation_string":"6Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029701926","display_name":"Stuart C. Helfand","orcid":"https://orcid.org/0000-0001-8908-8747","observed_orcids":["https://orcid.org/0000-0001-8908-8747"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart C. Helfand","raw_affiliation_strings":["1Medical Sciences, Departments of","6Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical Sciences, Departments of","institution_ids":[]},{"raw_affiliation_string":"6Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0736,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.73011859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"12","first_page":"663","last_page":"673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.9179999828338623},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.8339999914169312},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumor-neovasculature","display_name":"tumor neovasculature","score":0.8479999899864197},{"id":"https://openalex.org/keywords/corneal-neovascularization","display_name":"corneal neovascularization","score":0.9900000095367432},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7900000214576721},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cytokine-toxicity","display_name":"cytokine toxicity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.828000009059906},{"id":"https://openalex.org/keywords/endothelial-signaling","display_name":"endothelial signaling","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7483923435211182},{"id":"https://openalex.org/C2777844972","wikidata":"https://www.wikidata.org/wiki/Q1266519","display_name":"Corneal neovascularization","level":4,"score":0.7296465635299683},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6110336780548096},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6060431599617004},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5574755072593689},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5561434626579285},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5532386898994446},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4912545084953308},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4387431740760803},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.430853933095932},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4167477488517761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4116986095905304},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4106016457080841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3757476210594177},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36264777183532715},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.23073247075080872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11432275176048279},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.08411753177642822},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053707","descriptor_name":"Receptors, Interleukin-12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1541-7786.663.2.12","doi":"https://doi.org/10.1158/1541-7786.663.2.12","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.663.2.12","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:15634755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15634755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"mag:2191187737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15634755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8793682494","display_name":"PEPTIDE TARGETING OF IL12 TO MALIGNANT ENDOTHELIUM","funder_award_id":"R01CA086264","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W283720115","https://openalex.org/W1498677439","https://openalex.org/W1507883482","https://openalex.org/W1517571912","https://openalex.org/W1521620824","https://openalex.org/W1525077036","https://openalex.org/W1530677453","https://openalex.org/W1561485846","https://openalex.org/W1583796784","https://openalex.org/W1587050401","https://openalex.org/W1598996496","https://openalex.org/W1644502582","https://openalex.org/W1821988420","https://openalex.org/W1886264513","https://openalex.org/W1912635098","https://openalex.org/W1968821724","https://openalex.org/W1970279697","https://openalex.org/W1970847065","https://openalex.org/W1980969801","https://openalex.org/W1989729627","https://openalex.org/W1990036692","https://openalex.org/W1996690207","https://openalex.org/W2001753204","https://openalex.org/W2006178861","https://openalex.org/W2008181555","https://openalex.org/W2013417615","https://openalex.org/W2022199199","https://openalex.org/W2025211405","https://openalex.org/W2029773366","https://openalex.org/W2031630601","https://openalex.org/W2038788376","https://openalex.org/W2040283898","https://openalex.org/W2043751870","https://openalex.org/W2055206234","https://openalex.org/W2058418451","https://openalex.org/W2060136332","https://openalex.org/W2071587956","https://openalex.org/W2074348188","https://openalex.org/W2100510996","https://openalex.org/W2102156468","https://openalex.org/W2115791536","https://openalex.org/W2118719170","https://openalex.org/W2121136366","https://openalex.org/W2122042627","https://openalex.org/W2137951967","https://openalex.org/W2145263059","https://openalex.org/W2149694154","https://openalex.org/W2149710982","https://openalex.org/W2151707711","https://openalex.org/W2169102763","https://openalex.org/W2170103734"],"related_works":["https://openalex.org/W2191187737","https://openalex.org/W1970847065","https://openalex.org/W2074348188","https://openalex.org/W2022199199","https://openalex.org/W2035799596","https://openalex.org/W1498677439","https://openalex.org/W2158616782","https://openalex.org/W2046767915","https://openalex.org/W1496810115","https://openalex.org/W2137759562"],"abstract_inverted_index":{"We":[0],"engineered":[1],"a":[2,21,100,120,234],"fusion":[3,36,168],"protein,":[4],"mrIL-12vp":[5,57,83,91,118,139,179],"[mouse":[6],"recombinant":[7],"interleukin":[8],"(IL)-12":[9],"linked":[10],"to":[11,26,28,32,60,66,155,218],"vascular":[12,16],"peptide],":[13],"linking":[14],"the":[15,107,124,163,167,222],"homing":[17],"peptide":[18],"CDCRGDCFC":[19],"(RGD-4C),":[20],"ligand":[22],"for":[23,237,242],"alphavbeta3":[24,61,67],"integrin,":[25],"mrIL-12":[27,85,191],"target":[29],"IL-12":[30,113,201,217,241],"directly":[31],"tumor":[33,184],"neovasculature.":[34],"The":[35],"protein":[37],"stimulated":[38],"IFN-gamma":[39],"production":[40],"in":[41,44,104,106,123,212],"vitro":[42],"and":[43,144,147,176,228],"vivo,":[45],"indicating":[46],"its":[47,148],"biological":[48],"activity":[49,151],"was":[50,210],"consistent":[51],"with":[52,78,98,130,133,172,178,187,190,205],"mrIL-12.":[53,134],"Immunofluorescence":[54],"techniques":[55],"showed":[56,119,180],"specifically":[58],"bound":[59],"integrin-positive":[62],"cells":[63,175],"but":[64],"not":[65,197],"integrin-negative":[68],"cells.":[69],"In":[70],"corneal":[71,93,127],"angiogenesis":[72,105,141],"assays":[73],"using":[74],"BALB/c":[75],"mice":[76,116,131,188],"treated":[77,132,177,189,204],"either":[79],"0.5":[80],"microg/mouse/d":[81],"of":[82,126,157,166,183,200,216,231,240,244],"or":[84],"delivered":[86],"by":[87,95,162],"subcutaneous":[88],"continuous":[89],"infusion,":[90],"inhibited":[92],"neovascularization":[94,128],"67%":[96],"compared":[97,129,186],"only":[99],"slight":[101],"reduction":[102],"(13%)":[103],"mrIL-12-treated":[108,213],"animals":[109],"(P":[110,192],"=":[111,193],"0.008).":[112],"receptor":[114],"knockout":[115],"given":[117],"marked":[121],"decrease":[122],"area":[125],"These":[135],"results":[136],"indicate":[137],"that":[138],"inhibits":[140],"through":[142],"IL-12-dependent":[143],"IL-12-independent":[145],"mechanisms,":[146],"augmented":[149],"antiangiogenic":[150,223],"may":[152],"be":[153],"due":[154],"suppression":[156,182],"endothelial":[158],"cell":[159],"signaling":[160],"pathways":[161],"RGD-4C":[164],"portion":[165],"protein.":[169],"Mice":[170,195],"injected":[171],"NXS2":[173],"neuroblastoma":[174],"significant":[181],"growth":[185],"0.03).":[194],"did":[196],"show":[198],"signs":[199],"toxicity":[202,230],"when":[203],"mrIL-12vp,":[206],"although":[207],"hepatic":[208],"necrosis":[209],"present":[211],"mice.":[214],"Localization":[215],"neovasculature":[219],"significantly":[220],"enhances":[221],"effect,":[224],"augments":[225],"antitumor":[226],"activity,":[227],"decreases":[229],"IL-12,":[232],"offering":[233],"promising":[235],"strategy":[236],"expanding":[238],"development":[239],"treatment":[243],"cancer":[245],"patients.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-25T00:00:00"}