{"id":"https://openalex.org/W4292851262","doi":"https://doi.org/10.1093/ofid/ofac423","title":"Mid-regional Proadrenomedullin Biomarker Predicts Coronavirus Disease 2019 Clinical Outcomes: A US-Based Cohort Study","display_name":"Mid-regional Proadrenomedullin Biomarker Predicts Coronavirus Disease 2019 Clinical Outcomes: A US-Based Cohort Study","publication_year":2022,"publication_date":"2022-08-24","ids":{"openalex":"https://openalex.org/W4292851262","doi":"https://doi.org/10.1093/ofid/ofac423","pmid":"https://pubmed.ncbi.nlm.nih.gov/36072696"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofac423","doi":"https://doi.org/10.1093/ofid/ofac423","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofac423","pdf_url":"https://academic.oup.com/ofid/article-pdf/9/9/ofac423/45853784/ofac423.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/article-pdf/9/9/ofac423/45853784/ofac423.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036301531","display_name":"Natalie J. Atallah","orcid":"https://orcid.org/0000-0001-5086-8471","observed_orcids":["https://orcid.org/0000-0001-5086-8471"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie J Atallah","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, Massachusetts , USA","Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts , USA","Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078180609","display_name":"Vahe S Panossian","orcid":"https://orcid.org/0000-0001-8085-1021","observed_orcids":["https://orcid.org/0000-0001-8085-1021"]},"institutions":[{"id":"https://openalex.org/I4210104580","display_name":"American University of Beirut Medical Center","ror":"https://ror.org/00wmm6v75","country_code":"LB","type":"healthcare","lineage":["https://openalex.org/I4210104580"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Vahe S Panossian","raw_affiliation_strings":["Faculty of Medicine, American University of Beirut Medical Center , Beirut , Lebanon"],"raw_orcid":"https://orcid.org/0000-0001-8085-1021","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, American University of Beirut Medical Center , Beirut , Lebanon","institution_ids":["https://openalex.org/I4210104580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074163956","display_name":"Christine J. Atallah","orcid":"https://orcid.org/0000-0001-9393-4280","observed_orcids":["https://orcid.org/0000-0001-9393-4280"]},"institutions":[{"id":"https://openalex.org/I168913471","display_name":"University of Balamand","ror":"https://ror.org/01xvwxv41","country_code":"LB","type":"education","lineage":["https://openalex.org/I168913471"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Christine J Atallah","raw_affiliation_strings":["Faculty of Medicine, University of Balamand , Beirut , Lebanon"],"raw_orcid":"https://orcid.org/0000-0001-9393-4280","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Balamand , Beirut , Lebanon","institution_ids":["https://openalex.org/I168913471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062441445","display_name":"Andrej Schwabe","orcid":"https://orcid.org/0009-0003-0983-7333","observed_orcids":["https://orcid.org/0009-0003-0983-7333"]},"institutions":[{"id":"https://openalex.org/I4210153897","display_name":"Thermo Fisher Scientific (Germany)","ror":"https://ror.org/04428zn91","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210142480","https://openalex.org/I4210153897"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrej Schwabe","raw_affiliation_strings":["B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, part of Thermo Fisher Scientific , Hennigsdorf , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, part of Thermo Fisher Scientific , Hennigsdorf , Germany","institution_ids":["https://openalex.org/I4210153897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058630793","display_name":"Sascha Johannes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153897","display_name":"Thermo Fisher Scientific (Germany)","ror":"https://ror.org/04428zn91","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210142480","https://openalex.org/I4210153897"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sascha Johannes","raw_affiliation_strings":["B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, part of Thermo Fisher Scientific , Hennigsdorf , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, part of Thermo Fisher Scientific , Hennigsdorf , Germany","institution_ids":["https://openalex.org/I4210153897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018534148","display_name":"Jan C. Wiemer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153897","display_name":"Thermo Fisher Scientific (Germany)","ror":"https://ror.org/04428zn91","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210142480","https://openalex.org/I4210153897"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Wiemer","raw_affiliation_strings":["B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, part of Thermo Fisher Scientific , Hennigsdorf , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, part of Thermo Fisher Scientific , Hennigsdorf , Germany","institution_ids":["https://openalex.org/I4210153897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003598305","display_name":"Michael K. Mansour","orcid":"https://orcid.org/0000-0001-8892-8695","observed_orcids":["https://orcid.org/0000-0001-8892-8695"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael K Mansour","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, Massachusetts , USA","Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts , USA","Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0001-8892-8695","affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003598305"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3676,"currency":"USD","value_usd":3676},"apc_paid":{"value":3676,"currency":"USD","value_usd":3676},"fwci":0.2289,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52775167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"9","issue":"9","first_page":"ofac423","last_page":"ofac423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mid-regional-pro-adrenomedullin","display_name":"mid-regional pro-adrenomedullin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9760000109672546},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.8650000095367432},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8199999928474426},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.5320000052452087},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9129055142402649},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6524674296379089},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5635275840759277},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5593501925468445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5095265507698059},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45274433493614197},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.44054096937179565},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.41602790355682373},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3421214818954468},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.1417369246482849},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/ofid/ofac423","doi":"https://doi.org/10.1093/ofid/ofac423","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofac423","pdf_url":"https://academic.oup.com/ofid/article-pdf/9/9/ofac423/45853784/ofac423.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:36072696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36072696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open forum infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9439577","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9439577","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofac423","doi":"https://doi.org/10.1093/ofid/ofac423","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofac423","pdf_url":"https://academic.oup.com/ofid/article-pdf/9/9/ofac423/45853784/ofac423.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3393890722","display_name":null,"funder_award_id":"NCT04158804","funder_id":"https://openalex.org/F4320312526","funder_display_name":"Thermo Fisher Scientific"},{"id":"https://openalex.org/G6947153538","display_name":null,"funder_award_id":"R01AI132638","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000069514","display_name":null,"funder_award_id":"AI132638","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320312526","display_name":"Thermo Fisher Scientific","ror":"https://ror.org/012wakq07"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292851262.pdf","grobid_xml":"https://content.openalex.org/works/W4292851262.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1201749067","https://openalex.org/W1975940955","https://openalex.org/W1978554428","https://openalex.org/W1987764661","https://openalex.org/W2006617902","https://openalex.org/W2012152951","https://openalex.org/W2037103499","https://openalex.org/W2046787212","https://openalex.org/W2062599117","https://openalex.org/W2093676627","https://openalex.org/W2109068302","https://openalex.org/W2185333925","https://openalex.org/W2587973613","https://openalex.org/W2790554811","https://openalex.org/W2797283758","https://openalex.org/W2888836219","https://openalex.org/W2907436115","https://openalex.org/W2919615971","https://openalex.org/W2981663786","https://openalex.org/W3009976289","https://openalex.org/W3015190630","https://openalex.org/W3017125154","https://openalex.org/W3020720269","https://openalex.org/W3025160648","https://openalex.org/W3025200871","https://openalex.org/W3025300177","https://openalex.org/W3027918021","https://openalex.org/W3031076369","https://openalex.org/W3039530416","https://openalex.org/W3042141873","https://openalex.org/W3081502886","https://openalex.org/W3093426014","https://openalex.org/W3093604087","https://openalex.org/W3097465023","https://openalex.org/W3106124442","https://openalex.org/W3113676987","https://openalex.org/W3116488354","https://openalex.org/W3118942590","https://openalex.org/W3128307020","https://openalex.org/W3130126061","https://openalex.org/W3133946785","https://openalex.org/W3157025007","https://openalex.org/W3159527627","https://openalex.org/W3185110418","https://openalex.org/W3196461144","https://openalex.org/W3201442945","https://openalex.org/W3217290471","https://openalex.org/W3217380337","https://openalex.org/W4254687493","https://openalex.org/W6666231017"],"related_works":["https://openalex.org/W4205698903","https://openalex.org/W4400613637","https://openalex.org/W4294968941","https://openalex.org/W1606496894","https://openalex.org/W3081332639","https://openalex.org/W2782606626","https://openalex.org/W2055704044","https://openalex.org/W1986135018","https://openalex.org/W2148718224","https://openalex.org/W2103425699"],"abstract_inverted_index":{"Background:":[0],"Mid-regional":[1],"proadrenomedullin":[2],"(MR-proADM)":[3],"is":[4],"a":[5,14,34,37,185],"biomarker":[6,76,187],"released":[7],"following":[8],"endothelial":[9],"damage.":[10],"Studies":[11],"have":[12],"shown":[13],"correlation":[15],"in":[16,46,71,98,121],"predicting":[17,99,122],"coronavirus":[18],"disease":[19,197],"2019":[20],"(COVID-19)":[21],"outcomes":[22,42],"with":[23,49,75,134,156,201],"MR-proADM":[24,32,91,116,150,182,208],"levels.":[25],"Our":[26],"study":[27],"aimed":[28],"to":[29,52,54,81,175,212],"investigate":[30],"baseline":[31],"as":[33,184],"predictor":[35],"of":[36,40,43,93,115,118,143,195,199,206],"wider":[38],"range":[39],"clinical":[41,100],"varying":[44],"severity":[45],"patients":[47,200],"admitted":[48,80],"COVID-19,":[50],"and":[51,78,111,131,168,193],"compare":[53],"other":[55,214],"biomarkers.":[56,217],"Methods:":[57],"Data":[58],"from":[59],"the":[60,82,138,189,204],"Boston":[61],"Area":[62],"COVID-19":[63,171],"Consortium":[64],"(BACC)":[65],"Bay":[66],"Tocilizumab":[67],"Trial":[68],"was":[69,96,153],"used":[70,216],"this":[72],"study.":[73],"Patients":[74],"determinations,":[77],"not":[79],"intensive":[83],"care":[84],"unit":[85],"(ICU)":[86],"on":[87],"admission,":[88,162],"were":[89,127],"included.":[90],"cutoff":[92,117],"0.87":[94,119],"nmol/L":[95,120,152],"assessed":[97],"outcomes.":[101],"Results:":[102],"<":[103],".001).":[104],"The":[105],"sensitivity,":[106],"specificity,":[107],"negative":[108],"predictive":[109,113],"value,":[110],"positive":[112],"value":[114],"mechanical":[123,157],"ventilation":[124,158],"or":[125,159,176],"death":[126],"75%,":[128],"65%,":[129],"95%,":[130],"21%,":[132],"respectively,":[133],"an":[135],"area":[136],"under":[137],"receiver":[139],"operating":[140],"characteristic":[141],"curve":[142],"0.76.":[144],"On":[145],"multivariable":[146],"logistic":[147],"regression":[148],"analysis,":[149],">0.87":[151],"independently":[154],"associated":[155],"death,":[160,207],"ICU":[161],"prolonged":[163],"hospitalization":[164],"beyond":[165],"day":[166,169,179],"4,":[167],"4":[170],"ordinal":[172],"scale":[173],"equal":[174],"worse":[177],"than":[178],"1.":[180],"Conclusions:":[181],"functions":[183],"valuable":[186],"for":[188],"early":[190],"risk":[191],"stratification":[192],"detection":[194],"severe":[196],"progression":[198],"COVID-19.":[202],"In":[203],"prediction":[205],"performed":[209],"better":[210],"compared":[211],"many":[213],"commonly":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}