{"id":"https://openalex.org/W4292767372","doi":"https://doi.org/10.21203/rs.3.rs-1978048/v1","title":"Cardioprotective effect of aescin on antioxidant and lipid profile in isoproterenol-induced myocardial infarction in rats","display_name":"Cardioprotective effect of aescin on antioxidant and lipid profile in isoproterenol-induced myocardial infarction in rats","publication_year":2022,"publication_date":"2022-08-23","ids":{"openalex":"https://openalex.org/W4292767372","doi":"https://doi.org/10.21203/rs.3.rs-1978048/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1978048/v1","doi":"https://doi.org/10.21203/rs.3.rs-1978048/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1978048/v1","pdf_url":"https://www.researchsquare.com/article/rs-1978048/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1978048/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104215230","display_name":"Kanimozhi Kaliyamoorthi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kanimozhi Kaliyamoorthi","raw_affiliation_strings":["Annamalai University","Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608002, Tamil Nadu, India","Government Arts College","Government Medical College and Hospital Research","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annamalai University","institution_ids":["https://openalex.org/I197081775"]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608002, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]},{"raw_affiliation_string":"Government Arts College","institution_ids":[]},{"raw_affiliation_string":"Government Medical College and Hospital Research","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072043788","display_name":"Loordhurani Asaikumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Asaikumar Loordhurani","raw_affiliation_strings":["Annamalai University","Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annamalai University","institution_ids":["https://openalex.org/I197081775"]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075928632","display_name":"Olikkavi Subashchandrabose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Olikkavi Subashchandrabose","raw_affiliation_strings":["Annamalai University","Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annamalai University","institution_ids":["https://openalex.org/I197081775"]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072059611","display_name":"Lakshmanan Vennila","orcid":"https://orcid.org/0000-0002-8988-9488","observed_orcids":["https://orcid.org/0000-0002-8988-9488","https://orcid.org/0000-0002-4134-5836"]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vennila Lakshmanan","raw_affiliation_strings":["Annamalai University","Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annamalai University","institution_ids":["https://openalex.org/I197081775"]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011818479","display_name":"Sindhu Ganapathi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sindhu Ganapathi","raw_affiliation_strings":["Government Arts College","Assistant Professor, Department of Biochemistry, Government Arts College, Kumbakonam, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Arts College","institution_ids":[]},{"raw_affiliation_string":"Assistant Professor, Department of Biochemistry, Government Arts College, Kumbakonam, Tamil Nadu, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046129160","display_name":"S.Vigil Anbiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098996","display_name":"Government Medical College and Hospital","ror":"https://ror.org/010gbda42","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210098996"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vigil Anbiah Sathiavakoo","raw_affiliation_strings":["Government Medical College and Hospital","Associate professor and Head, Central Animal House, Government Medical College and Hospital, Chidambaram, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Medical College and Hospital","institution_ids":["https://openalex.org/I4210098996"]},{"raw_affiliation_string":"Associate professor and Head, Central Animal House, Government Medical College and Hospital, Chidambaram, Tamil Nadu, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072059611"],"corresponding_institution_ids":["https://openalex.org/I197081775"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13238","display_name":"Botanical Studies and Applications","score":0.14790000021457672,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aescin","display_name":"aescin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9639999866485596},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/isoproterenol-induced-cardiotoxicity","display_name":"isoproterenol-induced cardiotoxicity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiac-biomarkers","display_name":"cardiac biomarkers","score":0.6359999775886536},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.492000013589859},{"id":"https://openalex.org/keywords/cardiac-histopathology","display_name":"cardiac histopathology","score":0.609000027179718},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.675000011920929},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7603728771209717},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.5613303184509277},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5292543768882751},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5010237693786621},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4768032729625702},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47522929310798645},{"id":"https://openalex.org/C8880881","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin complex","level":4,"score":0.46865835785865784},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.460777223110199},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4496394693851471},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.41827985644340515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39760535955429077},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3746749758720398},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23380592465400696}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1978048/v1","doi":"https://doi.org/10.21203/rs.3.rs-1978048/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1978048/v1","pdf_url":"https://www.researchsquare.com/article/rs-1978048/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1978048/v1","doi":"https://doi.org/10.21203/rs.3.rs-1978048/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1978048/v1","pdf_url":"https://www.researchsquare.com/article/rs-1978048/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292767372.pdf","grobid_xml":"https://content.openalex.org/works/W4292767372.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W204998232","https://openalex.org/W1062333943","https://openalex.org/W1510002092","https://openalex.org/W1545709196","https://openalex.org/W1581414347","https://openalex.org/W1599342152","https://openalex.org/W1930479698","https://openalex.org/W1964421861","https://openalex.org/W1985399572","https://openalex.org/W2001157090","https://openalex.org/W2003196491","https://openalex.org/W2022705146","https://openalex.org/W2025388470","https://openalex.org/W2025639892","https://openalex.org/W2029569952","https://openalex.org/W2033898136","https://openalex.org/W2036158870","https://openalex.org/W2045161311","https://openalex.org/W2055499436","https://openalex.org/W2060194897","https://openalex.org/W2072152755","https://openalex.org/W2076598575","https://openalex.org/W2094769841","https://openalex.org/W2096795975","https://openalex.org/W2128473487","https://openalex.org/W2154774609","https://openalex.org/W2157456029","https://openalex.org/W2159103120","https://openalex.org/W2161953275","https://openalex.org/W2168526937","https://openalex.org/W2169968676","https://openalex.org/W2279846398","https://openalex.org/W2397627273","https://openalex.org/W2485662396","https://openalex.org/W2768997853","https://openalex.org/W2790696248","https://openalex.org/W2799773579","https://openalex.org/W2800951902","https://openalex.org/W2943728637","https://openalex.org/W2976533836","https://openalex.org/W2996182370","https://openalex.org/W3011472635","https://openalex.org/W3047905900","https://openalex.org/W4206897266"],"related_works":["https://openalex.org/W2763651397","https://openalex.org/W2186226422","https://openalex.org/W2559284061","https://openalex.org/W2029443467","https://openalex.org/W2890436837","https://openalex.org/W2550639238","https://openalex.org/W2106770941","https://openalex.org/W2613852168","https://openalex.org/W2163620613","https://openalex.org/W1992264604"],"abstract_inverted_index":{"Abstract":[0],"The":[1,92,113,140],"efficacy":[2],"of":[3,33,40,58,94,110,115,134,142,166],"aescin":[4,34,148,197],"on":[5,66],"the":[6,47,52,64,67,87,132,135,143,159,164,180,185,189],"liver":[7,90],"and":[8,13,37,69,72,80,89,100,108,125,153,162,168,172,188],"cardiac":[9,88,106,169,181,199],"markers,":[10],"lipid":[11],"profile,":[12],"antioxidant":[14,95],"status":[15],"in":[16,28,104,131,184],"rats":[17,45,65,136,187,194],"with":[18,138,196,204],"myocardial":[19],"infarction":[20],"(MI)":[21],"induced":[22],"by":[23,157],"isoproterenol":[24],"(ISO)":[25],"was":[26,60,176],"investigated":[27],"this":[29],"study.":[30],"Three":[31],"doses":[32],"(5,":[35],"10,":[36],"20":[38],"mg/kg":[39,57],"b.w)":[41,59],"were":[42,102,128],"administered":[43],"to":[44,63,85,178],"for":[46],"first":[48],"21":[49],"days.":[50],"After":[51],"treatment":[53],"period,":[54],"ISO":[55,111,205],"(60":[56],"given":[61],"subcutaneously":[62],"22nd":[68],"23rdday.":[70],"Cardiovascular":[71],"hepatic":[73],"markers":[74],"(CK,":[75],"ALT,":[76],"CK-MB,":[77],"AST,":[78],"cTnI,":[79],"cTnT)":[81],"have":[82],"been":[83],"analyzed":[84],"investigate":[86],"damage.":[91],"activities":[93],"enzymes":[96],"(CAT,":[97],"GST,":[98],"SOD,":[99],"GPx)":[101],"decreased":[103],"both":[105],"tissue":[107,200],"erythrocytes":[109],"rats.":[112,208],"levels":[114,165],"phospholipids":[116],"(PLs),":[117],"total":[118],"cholesterol":[119],"(TC),":[120],"free":[121,160],"fatty":[122],"acids":[123],"(FFA),":[124],"triglycerides":[126],"(TG)":[127],"increased":[129],"significantly":[130],"serum":[133],"administrated":[137],"ISO.":[139],"results":[141,190],"present":[144],"study":[145],"implies":[146],"that":[147,192],"pretreatment":[149],"reduces":[150],"oxidative":[151],"stress":[152],"exhibits":[154],"cardioprotective":[155],"action":[156],"scavenging":[158],"radicals":[161],"maintaining":[163],"circulatory":[167],"lipids.":[170],"Hematoxylin":[171],"eosin":[173],"staining":[174],"method":[175],"used":[177],"examine":[179],"histological":[182],"changes":[183],"experimental":[186],"showed":[191],"ISO-administered":[193],"pretreated":[195],"reduced":[198],"damage":[201],"when":[202],"compared":[203],"alone":[206],"injected":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-08-23T00:00:00"}