{"id":"https://openalex.org/W4292764310","doi":"https://doi.org/10.1101/2022.08.22.22279086","title":"Perspectives on the enhancement of commercially available antibiotics by natural products","display_name":"Perspectives on the enhancement of commercially available antibiotics by natural products","publication_year":2022,"publication_date":"2022-08-23","ids":{"openalex":"https://openalex.org/W4292764310","doi":"https://doi.org/10.1101/2022.08.22.22279086"},"language":"en","primary_location":{"id":"doi:10.1101/2022.08.22.22279086","doi":"https://doi.org/10.1101/2022.08.22.22279086","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.22.22279086","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/08/23/2022.08.22.22279086.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2022/08/23/2022.08.22.22279086.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090779733","display_name":"Luc\u00eda Nitsch-Vel\u00e1squez","orcid":"https://orcid.org/0000-0002-8804-2875","observed_orcids":["https://orcid.org/0000-0002-8804-2875"]},"institutions":[{"id":"https://openalex.org/I32046576","display_name":"Universidad Rafael Land\u00edvar","ror":"https://ror.org/03jzm5a44","country_code":"GT","type":"education","lineage":["https://openalex.org/I32046576"]}],"countries":["GT"],"is_corresponding":true,"raw_author_name":"Lucia Nitsch-Velasquez","raw_affiliation_strings":["Facultad de Ingenieria, Universidad Rafael Landivar, Guatemala, Guatemala","Research Department, Centro Universitario de Zacapa, Zacapa, Guatemala","Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 01002 Guatemala, Guatemala","Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 0002 Guatemala, Guatemala"],"raw_orcid":"https://orcid.org/0000-0002-8804-2875","affiliations":[{"raw_affiliation_string":"Facultad de Ingenieria, Universidad Rafael Landivar, Guatemala, Guatemala","institution_ids":["https://openalex.org/I32046576"]},{"raw_affiliation_string":"Research Department, Centro Universitario de Zacapa, Zacapa, Guatemala","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 01002 Guatemala, Guatemala","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 0002 Guatemala, Guatemala","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097397905","display_name":"Sara B. Barrios","orcid":"https://orcid.org/0000-0001-7674-9673","observed_orcids":["https://orcid.org/0000-0001-7674-9673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara B. Barrios","raw_affiliation_strings":["Research Department, Centro Universitario de Zacapa, Zacapa, Guatemala","Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 01002 Guatemala, Guatemala","Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 0002 Guatemala, Guatemala"],"raw_orcid":"https://orcid.org/0000-0001-7674-9673","affiliations":[{"raw_affiliation_string":"Research Department, Centro Universitario de Zacapa, Zacapa, Guatemala","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 01002 Guatemala, Guatemala","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 0002 Guatemala, Guatemala","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ricardo A. Montoya","orcid":"https://orcid.org/0000-0002-1468-6934","observed_orcids":["https://orcid.org/0000-0002-1468-6934"]},"institutions":[{"id":"https://openalex.org/I32046576","display_name":"Universidad Rafael Land\u00edvar","ror":"https://ror.org/03jzm5a44","country_code":"GT","type":"education","lineage":["https://openalex.org/I32046576"]}],"countries":["GT"],"is_corresponding":false,"raw_author_name":"Ricardo A. Montoya","raw_affiliation_strings":["TEC, Universidad Rafael Landivar, Guatemala, Guatemala"],"raw_orcid":"https://orcid.org/0000-0002-1468-6934","affiliations":[{"raw_affiliation_string":"TEC, Universidad Rafael Landivar, Guatemala, Guatemala","institution_ids":["https://openalex.org/I32046576"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072604392","display_name":"Rosy Canales","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosy Canales","raw_affiliation_strings":["Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 01002 Guatemala, Guatemala","Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 0002 Guatemala, Guatemala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 01002 Guatemala, Guatemala","institution_ids":[]},{"raw_affiliation_string":"Research and Development Department, Proyectos Educativos Regionales de Autoayuda, Simeon Canas Avenue 8-25a zona 2, 0002 Guatemala, Guatemala","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090779733"],"corresponding_institution_ids":["https://openalex.org/I32046576"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.628000020980835},{"id":"https://openalex.org/keywords/plant-secondary-metabolites","display_name":"plant secondary metabolites","score":0.7570000290870667},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.8690000176429749},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":1.0},{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":0.7390000224113464},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.996999979019165},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.9819999933242798},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.8700000047683716},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9039999842643738},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.7210000157356262},{"id":"https://openalex.org/keywords/efflux-pump-inhibition","display_name":"efflux pump inhibition","score":0.7900000214576721},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/foodborne-pathogens","display_name":"foodborne pathogens","score":0.7310000061988831},{"id":"https://openalex.org/keywords/listeria","display_name":"Listeria","score":0.7559999823570251},{"id":"https://openalex.org/keywords/salmonella","display_name":"Salmonella","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7468365430831909},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5758025646209717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49575933814048767},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.44283628463745117},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.43697863817214966},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.41399645805358887},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.41348525881767273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1939045488834381},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.08.22.22279086","doi":"https://doi.org/10.1101/2022.08.22.22279086","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.22.22279086","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/08/23/2022.08.22.22279086.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.08.22.22279086","doi":"https://doi.org/10.1101/2022.08.22.22279086","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.22.22279086","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/08/23/2022.08.22.22279086.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332641","display_name":"University at Buffalo","ror":"https://ror.org/01y64my43"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292764310.pdf","grobid_xml":"https://content.openalex.org/works/W4292764310.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W856957622","https://openalex.org/W1594980315","https://openalex.org/W1749342571","https://openalex.org/W1888387400","https://openalex.org/W2042004889","https://openalex.org/W2047802691","https://openalex.org/W2095469556","https://openalex.org/W2097838343","https://openalex.org/W2146157756","https://openalex.org/W2175526208","https://openalex.org/W2179768127","https://openalex.org/W2235225096","https://openalex.org/W2266612683","https://openalex.org/W2336779264","https://openalex.org/W2337938739","https://openalex.org/W2344057052","https://openalex.org/W2402899738","https://openalex.org/W2404210389","https://openalex.org/W2462456389","https://openalex.org/W2479416141","https://openalex.org/W2493238416","https://openalex.org/W2502546097","https://openalex.org/W2510696379","https://openalex.org/W2519461793","https://openalex.org/W2522281760","https://openalex.org/W2529737889","https://openalex.org/W2534563352","https://openalex.org/W2546282236","https://openalex.org/W2549408501","https://openalex.org/W2556194215","https://openalex.org/W2559321734","https://openalex.org/W2577950870","https://openalex.org/W2588586950","https://openalex.org/W2590308006","https://openalex.org/W2590336671","https://openalex.org/W2590765402","https://openalex.org/W2602690334","https://openalex.org/W2620133107","https://openalex.org/W2622165662","https://openalex.org/W2625028711","https://openalex.org/W2625505695","https://openalex.org/W2710639310","https://openalex.org/W2735775722","https://openalex.org/W2736480333","https://openalex.org/W2738050193","https://openalex.org/W2746132447","https://openalex.org/W2746133770","https://openalex.org/W2751113012","https://openalex.org/W2756287978","https://openalex.org/W2760799263","https://openalex.org/W2765833669","https://openalex.org/W2765951699","https://openalex.org/W2766098536","https://openalex.org/W2766179306","https://openalex.org/W2766778684","https://openalex.org/W2767268833","https://openalex.org/W2774247745","https://openalex.org/W2784300996","https://openalex.org/W2792435636","https://openalex.org/W2801106257","https://openalex.org/W2805029829","https://openalex.org/W2807861760","https://openalex.org/W2808642287","https://openalex.org/W2809080798","https://openalex.org/W2809573697","https://openalex.org/W2810689047","https://openalex.org/W2811000681","https://openalex.org/W2889157647","https://openalex.org/W2890317547","https://openalex.org/W2890850841","https://openalex.org/W2899491487","https://openalex.org/W2903259271","https://openalex.org/W2903498478","https://openalex.org/W2903745398","https://openalex.org/W2910784311","https://openalex.org/W2912131781","https://openalex.org/W2913145975","https://openalex.org/W2947197168","https://openalex.org/W2953285292","https://openalex.org/W2955020749","https://openalex.org/W2957102650","https://openalex.org/W2959755595","https://openalex.org/W2965872938","https://openalex.org/W2971998565","https://openalex.org/W2976166946","https://openalex.org/W2994073994","https://openalex.org/W2994919229","https://openalex.org/W2996104554","https://openalex.org/W2996352810","https://openalex.org/W3008126794","https://openalex.org/W3012609581","https://openalex.org/W3013377147","https://openalex.org/W3015832687","https://openalex.org/W3016760385","https://openalex.org/W3017003147","https://openalex.org/W3024476155","https://openalex.org/W3034741772","https://openalex.org/W3037745700","https://openalex.org/W3040001022","https://openalex.org/W3041641488","https://openalex.org/W3041985628","https://openalex.org/W3045459367","https://openalex.org/W3045939436","https://openalex.org/W3046914108","https://openalex.org/W3047309225","https://openalex.org/W3049745076","https://openalex.org/W3082255586","https://openalex.org/W3089665683","https://openalex.org/W3091936707","https://openalex.org/W3197644493","https://openalex.org/W4254381882"],"related_works":["https://openalex.org/W3087404479","https://openalex.org/W4236853490","https://openalex.org/W4402991867","https://openalex.org/W2998887340","https://openalex.org/W3089237991","https://openalex.org/W4403888545","https://openalex.org/W7215038760","https://openalex.org/W7214015193","https://openalex.org/W4385875974","https://openalex.org/W2978373170"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Opportunistic":[2],"resistant":[3,23],"bacteria":[4,24],"are":[5,313],"health":[6,12],"and":[7,15,51,64,75,98,124,154,233,248,285,301,307,322,331],"economically":[8],"relevant":[9,304],"in":[10,16,20,59],"the":[11,21,28,49,84,149,157,202,205,217,224,256,263,293,319],"care":[13],"systems":[14],"industries":[17],"worldwide,":[18],"especially":[19],"so-called":[22],"era":[25],"(RBE).":[26],"Enhancing":[27],"activity":[29,169,295],"of":[30,38,93,96,159,180,195,204,240,277,296,311],"commercially":[31],"available":[32],"antibiotics":[33],"(CAAs)":[34],"with":[35,70,133,177,260],"different":[36],"types":[37],"natural":[39,105],"products":[40,106],"(NPs)":[41],"is":[42,326],"a":[43,275],"successful":[44],"antimicrobial":[45],"strategy,":[46],"for":[47,167,335],"instance":[48],"amoxicillin":[50],"clavulanate":[52],"mixture.":[53],"Objective":[54],"To":[55],"find":[56],"research":[57,325],"trends":[58],"this":[60,346],"field":[61],"during":[62],"2015-2020":[63],"to":[65,72,82,135,291,305,315,328],"detect":[66],"potential":[67,71,134,164,178],"drug":[68,165],"hits":[69,166],"diversify":[73],"formulations":[74],"materials":[76,332],"design":[77,333],"that":[78,338],"can":[79,339],"be":[80,316,341],"useful":[81,334],"manage":[83],"RBE.":[85],"Systematic":[86],"review":[87],"results":[88,290],"It":[89],"yielded":[90],"190":[91],"reports":[92,151],"synergistic":[94,172],"effects":[95],"CAAs":[97,297],"NPs.":[99],"The":[100,131,238],"analyzed":[101],"variables":[102],"were:":[103],"a)":[104],"origin:":[107],"plant":[108,272],"family,":[109,127],"genera,":[110,118],"secondary":[111],"metabolite":[112],"type;":[113],"b)":[114],"strains:":[115],"+/-":[116],"Gram,":[117],"most":[119,128,218,228,258,264],"frequent":[120,129],"species,":[121],"application":[122],"field;":[123],"c)":[125],"CAAs:":[126],"CAAs.":[130],"families":[132],"have":[136,287],"more":[137],"bioactive":[138],"species":[139],"were":[140,156,174,208,251,255],"Apocynaceae,":[141],"Rubiaceae,":[142],"Euphorbiaceae":[143],"(I":[144],"sbio":[145],"factor).":[146],"Lonicera":[147],"had":[148],"highest":[150],"amount.":[152],"Polyphenols":[153],"flavonoids":[155,284],"majority":[158],"pure":[160],"NPs":[161,268],"tested.":[162,220],"Several":[163],"antibiotic":[168,294],"enhancement":[170],"at":[171],"level":[173],"identified":[175],"together":[176],"mechanisms":[179,310],"action:":[181],"berberine":[182],"(drug":[183],"efflux":[184],"inhibitor\u2013DEI,":[185],"biofilm":[186],"inhibitor\u2013BI),":[187],"curcumin":[188],"(BI),":[189,192],"essential":[190],"oils":[191],"3-o-metyl-butylgallato":[193],"(inhibition":[194],"fatty":[196],"acid":[197],"saturation),":[198],"among":[199],"others.":[200],"About":[201],"half":[203],"tested":[206],"strains":[207,303],"gram":[209,225,299],"positive,":[210],"being":[211],"Methicillin":[212],"Resistant":[213],"Staphylococcus":[214],"aureus":[215],"(MRSA)":[216],"frequently":[219,229],"Escherichia":[221],"coli":[222],"was":[223],"negative":[226,302],"strain":[227],"reported,":[230,259],"including":[231],"enterotoxigenic":[232],"extended":[234],"spectrum":[235],"beta-lactamases":[236],"producers.":[237],"growth":[239],"other":[241],"foodborne":[242],"genera":[243],"strains,":[244],"such":[245],"as":[246,262,269,271,280,318],"Listeria":[247],"Salmonella":[249],",":[250],"also":[252],"inhibited.":[253],"Aminoglycosides":[254],"family":[257],"gentamicin":[261],"commonly":[265],"studied.":[266],"Conclusions":[267],"either":[270],"extracts":[273],"from":[274],"variety":[276],"families,":[278],"or":[279],"purified":[281],"compounds":[282],"specially":[283],"polyphenols,":[286],"shown":[288],"effective":[289],"enhance":[292],"against":[298],"positive":[300],"HC":[306],"FI.":[308],"Their":[309],"action":[312],"starting":[314],"determined,":[317],"case":[320],"EPIs":[321],"BIs.":[323],"Further":[324],"needed":[327],"achieve":[329],"co-formulations":[330],"those":[336],"fields,":[337],"certainly":[340],"positively":[342],"impacted":[343],"by":[344],"pursuing":[345],"strategy.":[347]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-08-23T00:00:00"}